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  1. Article ; Online: What's on the Horizon for the Targeted Treatment of Type 2-low Asthma?

    Yao, Xianglan / Barochia, Amisha V / Levine, Stewart J

    Chest

    2023  Volume 163, Issue 6, Page(s) 1362–1364

    MeSH term(s) Humans ; Asthma/drug therapy ; Cytokines
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-06-09
    Publishing country United States
    Document type Editorial
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2022.12.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui III Zs.45: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 349: Show issues

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  2. Article ; Online: Scavenger Hunt: SR-B1, Adrenal Insufficiency, IL-17A, and Neutrophilic Airway Inflammation in Asthma.

    Yao, Xianglan / Levine, Stewart J

    American journal of respiratory cell and molecular biology

    2021  Volume 64, Issue 6, Page(s) 650–651

    MeSH term(s) Adrenal Insufficiency ; Asthma ; Humans ; Inflammation ; Interleukin-17
    Chemical Substances Interleukin-17
    Language English
    Publishing date 2021-04-07
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Intramural ; Comment
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2021-0089ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2851: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: The Long and Winding Road from GWAS to Obstructive Lung Disease: Is There a Role for LRP1?

    Yao, Xianglan / Levine, Stewart J

    American journal of respiratory cell and molecular biology

    2021  Volume 64, Issue 3, Page(s) 279–280

    MeSH term(s) Animals ; Follow-Up Studies ; Genome-Wide Association Study ; Humans ; Low Density Lipoprotein Receptor-Related Protein-1/genetics ; Lung ; Lung Diseases, Obstructive ; Lung Neoplasms ; Mice
    Chemical Substances LRP1 protein, human ; Low Density Lipoprotein Receptor-Related Protein-1 ; Lrp1 protein, mouse
    Language English
    Publishing date 2021-01-06
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Intramural ; Comment
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2020-0567ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2851: Show issues Location:
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  4. Article: Editorial: Organellar dynamics in cell fate.

    Li, Yuzhen / Yao, Xianglan / Levine, Stewart J / Ong, Sang-Bing

    Frontiers in molecular biosciences

    2022  Volume 9, Page(s) 977014

    Language English
    Publishing date 2022-08-05
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2022.977014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Editorial

    Yuzhen Li / Xianglan Yao / Stewart J. Levine / Sang-Bing Ong

    Frontiers in Molecular Biosciences, Vol

    Organellar dynamics in cell fate

    2022  Volume 9

    Keywords organellar dynamics ; cardiac differentiation ; non-coding RNA ; endoplasmic reticulum ; mitochondria ; cardiomyocyte fate ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Reply: Not all HDL particles are equal in idiopathic pulmonary fibrosis.

    Barochia, Amisha V / Barnett, Scott D / Weir, Nargues / Levine, Stewart J / Nathan, Steven D

    The European respiratory journal

    2022  Volume 59, Issue 4

    MeSH term(s) Humans ; Idiopathic Pulmonary Fibrosis
    Language English
    Publishing date 2022-04-14
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00151-2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2322: Show issues Location:
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    Zs.MO 292: Show issues

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  7. Article ; Online: Treatment options in type-2 low asthma.

    Hinks, Timothy S C / Levine, Stewart J / Brusselle, Guy G

    The European respiratory journal

    2021  Volume 57, Issue 1

    Abstract: Monoclonal antibodies targeting IgE or the type-2 cytokines interleukin (IL)-4, IL-5 and IL-13 are proving highly effective in reducing exacerbations and symptoms in people with severe allergic and eosinophilic asthma, respectively. However, these ... ...

    Abstract Monoclonal antibodies targeting IgE or the type-2 cytokines interleukin (IL)-4, IL-5 and IL-13 are proving highly effective in reducing exacerbations and symptoms in people with severe allergic and eosinophilic asthma, respectively. However, these therapies are not appropriate for 30-50% of patients in severe asthma clinics who present with non-allergic, non-eosinophilic, "type-2 low" asthma. These patients constitute an important and common clinical asthma phenotype, driven by distinct, yet poorly understood pathobiological mechanisms. In this review we describe the heterogeneity and clinical characteristics of type-2 low asthma and summarise current knowledge on the underlying pathobiological mechanisms, which includes neutrophilic airway inflammation often associated with smoking, obesity and occupational exposures and may be driven by persistent bacterial infections and by activation of a recently described IL-6 pathway. We review the evidence base underlying existing treatment options for specific treatable traits that can be identified and addressed. We focus particularly on severe asthma as opposed to difficult-to-treat asthma, on emerging data on the identification of airway bacterial infection, on the increasing evidence base for the use of long-term low-dose macrolides, a critical appraisal of bronchial thermoplasty, and evidence for the use of biologics in type-2 low disease. Finally, we review ongoing research into other pathways including tumour necrosis factor, IL-17, resolvins, apolipoproteins, type I interferons, IL-6 and mast cells. We suggest that type-2 low disease frequently presents opportunities for identification and treatment of tractable clinical problems; it is currently a rapidly evolving field with potential for the development of novel targeted therapeutics.
    MeSH term(s) Anti-Asthmatic Agents/therapeutic use ; Asthma/drug therapy ; Bronchial Thermoplasty ; Humans ; Hypersensitivity ; Pulmonary Eosinophilia
    Chemical Substances Anti-Asthmatic Agents
    Language English
    Publishing date 2021-01-21
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00528-2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2322: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 292: Show issues

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  8. Article ; Online: Where There Is Smoke, There Is Fire.

    Wolska, Anna / Levine, Stewart J / Remaley, Alan T

    Arteriosclerosis, thrombosis, and vascular biology

    2019  Volume 39, Issue 3, Page(s) 306–308

    MeSH term(s) Adult ; Air Pollution ; Fires ; Humans ; Lipoproteins, HDL ; Smoke ; Nicotiana
    Chemical Substances Lipoproteins, HDL ; Smoke
    Language English
    Publishing date 2019-03-11
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Intramural ; Comment
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.119.312398
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1705: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Meeting the Challenge of Identifying New Treatments for Type 2-Low Neutrophilic Asthma.

    Kalchiem-Dekel, Or / Yao, Xianglan / Levine, Stewart J

    Chest

    2019  Volume 157, Issue 1, Page(s) 26–33

    MeSH term(s) Anti-Asthmatic Agents/therapeutic use ; Asthma/blood ; Asthma/drug therapy ; Asthma/immunology ; Biomarkers/blood ; Cytokines/blood ; Eosinophils/drug effects ; Eosinophils/immunology ; Humans ; Neutrophils/drug effects ; Neutrophils/immunology
    Chemical Substances Anti-Asthmatic Agents ; Biomarkers ; Cytokines
    Language English
    Publishing date 2019-09-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2019.08.2192
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui III Zs.45: Show issues Location:
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  10. Article: De novo

    Jiang, Hanlun / Jude, Kevin M / Wu, Kejia / Fallas, Jorge / Ueda, George / Brunette, T J / Hicks, Derrick / Pyles, Harley / Yang, Aerin / Carter, Lauren / Lamb, Mila / Li, Xinting / Levine, Paul M / Stewart, Lance / Garcia, K Christopher / Baker, David

    bioRxiv : the preprint server for biology

    2023  

    Abstract: In natural proteins, structured loops play central roles in molecular recognition, signal transduction and enzyme catalysis. However, because of the intrinsic flexibility and irregularity of loop regions, organizing multiple structured loops at protein ... ...

    Abstract In natural proteins, structured loops play central roles in molecular recognition, signal transduction and enzyme catalysis. However, because of the intrinsic flexibility and irregularity of loop regions, organizing multiple structured loops at protein functional sites has been very difficult to achieve by
    Language English
    Publishing date 2023-08-23
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.08.22.554384
    Database MEDical Literature Analysis and Retrieval System OnLINE

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