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  1. Article ; Online: Commensal collaborations: Food allergy and the microbiome.

    Arditi, Zoe / Bunyavanich, Supinda

    The Journal of allergy and clinical immunology

    2023  Volume 152, Issue 6, Page(s) 1417–1419

    Language English
    Publishing date 2023-08-07
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2023.08.001
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  2. Article ; Online: Food allergy: could the gut microbiota hold the key?

    Bunyavanich, Supinda

    Nature reviews. Gastroenterology & hepatology

    2019  Volume 16, Issue 4, Page(s) 201–202

    MeSH term(s) Bacteria ; Food Hypersensitivity ; Gastrointestinal Microbiome ; Humans ; Infant
    Language English
    Publishing date 2019-03-01
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2493722-8
    ISSN 1759-5053 ; 1759-5045
    ISSN (online) 1759-5053
    ISSN 1759-5045
    DOI 10.1038/s41575-019-0123-0
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  3. Article ; Online: Epigenomic and epigenetic investigations of food allergy.

    Chun, Yoojin / Lee, Jo Hsuan / Bunyavanich, Supinda

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2024  Volume 35, Issue 1, Page(s) e14065

    Abstract: As a potential link between genetic predisposition, environmental exposures, and food allergy outcomes, epigenetics has been a molecular variable of interest in ongoing efforts to understand food allergy mechanisms and outcomes. Here we review population- ...

    Abstract As a potential link between genetic predisposition, environmental exposures, and food allergy outcomes, epigenetics has been a molecular variable of interest in ongoing efforts to understand food allergy mechanisms and outcomes. Here we review population-based investigations of epigenetic loci associated with food allergy, focusing on established clinical food allergy. We first provide an overview of epigenetic mechanisms that have been studied in cohorts with food allergy, predominantly DNA methylation but also microRNA. We then discuss investigations that have implemented epigenome-wide approaches aimed at genome-wide profiling and discovery. Such epigenome-wide studies have collectively identified differentially methylated and differentially regulated loci associated with T cell development, antigen presentation, reaction severity, and causal mediation in food allergy. We then discuss candidate-gene investigations that have honed in on Th1, Th2, T regulatory, and innate genes of a priori interest in food allergy. These studies have highlighted methylation changes in specific candidate genes as associated with T regulatory cell activity as well as differential methylation of Type 1 and Type 2 cytokine genes associated with various food allergies. Intriguingly, epigenetic loci associated with food allergy have also been explored as potential biomarkers for the clinical management of food allergy. We conclude by highlighting several priority directions for advancing population-based epigenomic and epigenetic understandings of food allergy.
    MeSH term(s) Humans ; Epigenomics ; MicroRNAs ; Food Hypersensitivity/genetics ; Cell Differentiation ; Epigenesis, Genetic
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.14065
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  4. Article ; Online: Climate change and epigenetic biomarkers in allergic and airway diseases.

    Cardenas, Andres / Fadadu, Raj / Bunyavanich, Supinda

    The Journal of allergy and clinical immunology

    2023  Volume 152, Issue 5, Page(s) 1060–1072

    Abstract: Human epigenetic variation is associated with both environmental exposures and allergic diseases and can potentially serve as a biomarker connecting climate change with allergy and airway diseases. In this narrative review, we summarize recent human ... ...

    Abstract Human epigenetic variation is associated with both environmental exposures and allergic diseases and can potentially serve as a biomarker connecting climate change with allergy and airway diseases. In this narrative review, we summarize recent human epigenetic studies examining exposure to temperature, precipitation, extreme weather events, and malnutrition to discuss findings as they relate to allergic and airway diseases. Temperature has been the most widely studied exposure, with the studies implicating both short-term and long-term exposures with epigenetic alterations and epigenetic aging. Few studies have examined natural disasters or extreme weather events. The studies available have reported differential DNA methylation of multiple genes and pathways, some of which were previously associated with asthma or allergy. Few studies have integrated climate-related events, epigenetic biomarkers, and allergic disease together. Prospective longitudinal studies are needed along with the collection of target tissues beyond blood samples, such as nasal and skin cells. Finally, global collaboration to increase diverse representation of study participants, particularly those most affected by climate injustice, as well as strengthen replication, validation, and harmonization of measurements will be needed to elucidate the impacts of climate change on the human epigenome.
    MeSH term(s) Humans ; Climate Change ; Prospective Studies ; Hypersensitivity/genetics ; Biomarkers ; DNA Methylation ; Respiration Disorders ; Epigenesis, Genetic
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2023.09.011
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  5. Article ; Online: The airway microbiome and pediatric asthma.

    Shah, Rhia / Bunyavanich, Supinda

    Current opinion in pediatrics

    2021  Volume 33, Issue 6, Page(s) 639–647

    Abstract: Purpose of review: Asthma is the most common chronic disease of childhood. Investigations of the lower and upper airway microbiomes have significantly progressed over recent years, and their roles in pediatric asthma are becoming increasingly clear.: ... ...

    Abstract Purpose of review: Asthma is the most common chronic disease of childhood. Investigations of the lower and upper airway microbiomes have significantly progressed over recent years, and their roles in pediatric asthma are becoming increasingly clear.
    Recent findings: Early studies identified the existence of upper and lower airway microbiomes, including imbalances in both associated with pediatric asthma. The infant airway microbiome may offer predictive value for the development of asthma in later childhood, and it may also be influenced by external factors such as respiratory viral illness. The airway microbiome has also been associated with the clinical course of asthma, including rates of exacerbation and level of control. Advances in -omics sciences have enabled improved identification of the airway microbiome's relationships with host response and function in children with asthma. Investigations are now moving toward the application of the above findings to explore risk modification and treatment options.
    Summary: The airway microbiome provides an intriguing window into pediatric asthma, offering insights into asthma diagnosis, clinical course, and perhaps treatment. Further investigation is needed to solidify these associations and translate research findings into clinical practice.
    MeSH term(s) Asthma/diagnosis ; Asthma/therapy ; Child ; Humans ; Infant ; Microbiota ; Respiratory System
    Language English
    Publishing date 2021-07-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1049374-8
    ISSN 1531-698X ; 1040-8703
    ISSN (online) 1531-698X
    ISSN 1040-8703
    DOI 10.1097/MOP.0000000000001054
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  6. Article ; Online: Socioeconomic Status and Diet Quality in Children with and without Food Allergy.

    Vo, Thanh Viet Anh / Irizar, Haritz / Gibson, Kyle / Stanley, Stephanie / Agarwal, Shradha / Groetch, Marion / Do, Anh / Bunyavanich, Supinda

    The Journal of pediatrics

    2023  Volume 260, Page(s) 113337

    MeSH term(s) Child ; Humans ; Diet ; Food Hypersensitivity ; Social Class
    Language English
    Publishing date 2023-01-31
    Publishing country United States
    Document type Case Reports ; Research Support, N.I.H., Extramural
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2022.12.039
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  7. Article ; Online: The Environmental Microbiome, Allergic Disease, and Asthma.

    Kelly, Michael S / Bunyavanich, Supinda / Phipatanakul, Wanda / Lai, Peggy S

    The journal of allergy and clinical immunology. In practice

    2022  Volume 10, Issue 9, Page(s) 2206–2217.e1

    Abstract: The environmental microbiome represents the entirety of the microbes and their metabolites that we encounter in our environments. A growing body of evidence supports the role of the environmental microbiome in risk for and severity of allergic diseases ... ...

    Abstract The environmental microbiome represents the entirety of the microbes and their metabolites that we encounter in our environments. A growing body of evidence supports the role of the environmental microbiome in risk for and severity of allergic diseases and asthma. The environmental microbiome represents a ubiquitous, lifelong exposure to non-self antigens. During the critical window between birth and 1 year of life, interactions between our early immune system and the environmental microbiome have 2 consequences: our individual microbiome is populated by environmental microbes, and our immune system is trained regarding which antigens to tolerate. During this time, a diversity of exposures appears largely protective, dramatically decreasing the risk of developing allergic diseases and asthma. As we grow older, our interactions with the environmental microbiome change. While it continues to exert influence over the composition of the human microbiome, the environmental microbiome becomes increasingly a source for antigenic stimulation and infection. The same microbial exposure protective against disease development may exacerbate disease severity. Although much has been learned about the importance of the environmental microbiome in allergic disease, much more remains to be understood about these complicated interactions between our environment, our microbiome, our immune system, and disease.
    MeSH term(s) Asthma/complications ; Environmental Exposure/adverse effects ; Humans ; Hypersensitivity/epidemiology ; Hypersensitivity/etiology ; Microbiota
    Language English
    Publishing date 2022-06-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2022.06.006
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  8. Article ; Online: Comparison of dietary intake between milk-allergic and non-food-allergic children.

    Gibson, Kyle / Stanley, Stephanie / Agarwal, Shradha / Groetch, Marion / Bunyavanich, Supinda

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2021  Volume 32, Issue 8, Page(s) 1872–1876

    MeSH term(s) Allergens ; Animals ; Child ; Diet ; Eating ; Humans ; Hypersensitivity ; Milk
    Chemical Substances Allergens
    Language English
    Publishing date 2021-07-16
    Publishing country England
    Document type Letter ; Research Support, N.I.H., Extramural
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.13581
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  9. Article ; Online: Microbial Adjuncts for Food Allergen Immunotherapy.

    Ho, Hsi-En / Bunyavanich, Supinda

    Current allergy and asthma reports

    2019  Volume 19, Issue 5, Page(s) 25

    Abstract: Purpose of review: Food allergen immunotherapy may benefit from adjunct therapies to enhance safety and efficacy. We review preclinical studies investigating the effects of probiotics and other microbial-based interventions on oral tolerance, describe ... ...

    Abstract Purpose of review: Food allergen immunotherapy may benefit from adjunct therapies to enhance safety and efficacy. We review preclinical studies investigating the effects of probiotics and other microbial-based interventions on oral tolerance, describe the human clinical trial evidence thus far for microbial adjuncts, and discuss steps for translating research findings in this area to clinical therapy.
    Recent findings: Murine studies support that microbial-based interventions confer protection against sensitization and may augment treatment efficacy for food allergy. Microbial adjunct therapies can promote regulatory T cells and modulate Th1 vs. Th2 responses. There is a wide array of novel modalities utilizing microbial components. Ongoing efforts are focused on translating preclinical data into potential treatments. Probiotics, prebiotics, and microbial components have all been examined as microbial adjunct therapies in murine models of food allergy. The effects of probiotics appear to be strain-specific. Prebiotics and bacterial components are innovative modalities to modulate oral tolerance. Better characterization of dysbiosis in human cohorts with food allergy, deeper mechanistic understanding of microbial adjunct therapies, safety evaluation, and careful clinical trial design will be crucial for the development of microbial adjuncts for food allergen immunotherapy. Microbial adjunct therapies have the potential to enhance the efficacy, safety, and durability of food allergen immunotherapy.
    MeSH term(s) Allergens/immunology ; Animals ; Desensitization, Immunologic/methods ; Food Hypersensitivity/therapy ; Humans ; Mice ; Microbiota/physiology
    Chemical Substances Allergens
    Language English
    Publishing date 2019-03-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057370-4
    ISSN 1534-6315 ; 1529-7322
    ISSN (online) 1534-6315
    ISSN 1529-7322
    DOI 10.1007/s11882-019-0859-1
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  10. Article ; Online: Leveraging -omics for asthma endotyping.

    Tyler, Scott R / Bunyavanich, Supinda

    The Journal of allergy and clinical immunology

    2019  Volume 144, Issue 1, Page(s) 13–23

    Abstract: Asthma is a highly heterogeneous disease, often manifesting with wheeze, dyspnea, chest tightness, and cough as prominent symptoms. The eliciting factors, natural history, underlying molecular biology, and clinical management of asthma vary highly among ... ...

    Abstract Asthma is a highly heterogeneous disease, often manifesting with wheeze, dyspnea, chest tightness, and cough as prominent symptoms. The eliciting factors, natural history, underlying molecular biology, and clinical management of asthma vary highly among affected subjects. Because of this variation, many efforts have gone into subtyping asthma. Endotypes are subtypes of disease based on distinct pathophysiologic mechanisms. Endotypes can be clinically useful because they organize our mechanistic understanding of heterogeneous diseases and can direct treatment toward modalities that are likely to be the most effective. Asthma endotyping can be shaped by clinical features, laboratory parameters, and/or -omics approaches. We discuss the application of -omics approaches, including transcriptomics, epigenomics, microbiomics, metabolomics, and proteomics, to asthma endotyping. -Omics approaches have provided supporting evidence for many existing endotyping paradigms and also suggested novel ways to conceptualize asthma endotypes. Although endotypes based on single -omics approaches are relatively common, their integrated multi-omics application to asthma endotyping has been more limited thus far. We discuss paths forward to integrate multi-omics with clinical features and laboratory parameters to achieve the goal of precise asthma endotypes.
    MeSH term(s) Animals ; Asthma/classification ; Asthma/genetics ; Asthma/metabolism ; Asthma/microbiology ; Genomics ; Humans ; Metabolomics ; Microbiota
    Language English
    Publishing date 2019-07-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2019.05.015
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