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  1. Article ; Online: Exhaled and nasal NO measurement: NO in your breath doesn't imply a negative attitude!

    Silkoff, Philip E

    Nitric oxide : biology and chemistry

    2021  Volume 117, Page(s) 34–39

    Abstract: ... that can cast light on eosinophilic airway inflammation and the response to anti-inflammatory medications e.g ...

    Abstract Measurement of exhaled nitric oxide (NO) and nasal nitric oxide commenced in the 1990s shortly after the scientific world learned about the endogenous production of NO and its multiple roles in physiologic and pathologic processes. Exhaled NO is an established approved clinical test in asthma that can cast light on eosinophilic airway inflammation and the response to anti-inflammatory medications e.g., inhaled corticosteroids. Nasal NO which is extremely low in primary ciliary dyskinesia is an established screening test for this condition. This review is a high-level practical guide for those wishing to use exhaled and nasal NO for research and clinical application.
    MeSH term(s) Breath Tests/methods ; Electrochemical Techniques ; Exhalation/physiology ; Humans ; Nitric Oxide/analysis ; Nose/physiology
    Chemical Substances Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2021-09-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1362794-6
    ISSN 1089-8611 ; 1089-8603
    ISSN (online) 1089-8611
    ISSN 1089-8603
    DOI 10.1016/j.niox.2021.09.007
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  2. Article ; Online: Three Major Efforts to Phenotype Asthma: Severe Asthma Research Program, Asthma Disease Endotyping for Personalized Therapeutics, and Unbiased Biomarkers for the Prediction of Respiratory Disease Outcome.

    Silkoff, Philip E / Moore, Wendy C / Sterk, Peter J

    Clinics in chest medicine

    2018  Volume 40, Issue 1, Page(s) 13–28

    Abstract: The SARP, ADEPT, and U-BIOPRED programs are all significant efforts in characterizing asthma and reporting clusters that will assist in designing personalized therapies for asthma, and especially severe asthma. Key aspects of the design of these programs ...

    Abstract The SARP, ADEPT, and U-BIOPRED programs are all significant efforts in characterizing asthma and reporting clusters that will assist in designing personalized therapies for asthma, and especially severe asthma. Key aspects of the design of these programs are summarized and major findings are reported in this review.
    MeSH term(s) Asthma/genetics ; Biomarkers/metabolism ; Cluster Analysis ; Humans ; Phenotype ; Respiration Disorders/diagnosis
    Chemical Substances Biomarkers
    Language English
    Publishing date 2018-12-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 447455-7
    ISSN 1557-8216 ; 0272-5231
    ISSN (online) 1557-8216
    ISSN 0272-5231
    DOI 10.1016/j.ccm.2018.10.016
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  3. Article ; Online: Perspectives on exhaled nitric oxide.

    Ricciardolo, Fabio L M / Silkoff, Philip E

    Journal of breath research

    2017  Volume 11, Issue 4, Page(s) 47104

    Abstract: The history of nitric oxide (NO) in the respiratory field dates back to the beginning of the 1990s with the pioneering study by Lars Gustafsson et al describing the presence of endogenous NO in the exhaled breath of human beings. Soon after, independent ... ...

    Abstract The history of nitric oxide (NO) in the respiratory field dates back to the beginning of the 1990s with the pioneering study by Lars Gustafsson et al describing the presence of endogenous NO in the exhaled breath of human beings. Soon after, independent studies showed that exhaled NO concentrations (F
    Language English
    Publishing date 2017-09-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2381007-5
    ISSN 1752-7163 ; 1752-7155
    ISSN (online) 1752-7163
    ISSN 1752-7155
    DOI 10.1088/1752-7163/aa7f0e
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  4. Article ; Online: Concordance for changes in allergic asthma domain variables after short-term corticosteroid therapy.

    Silkoff, Philip E / Sarno, Mark / Ssenyange, Solomon / Balasubramanyam, Vivek / Awabdy, Brian / Leard, Ryan

    BMC pulmonary medicine

    2020  Volume 20, Issue 1, Page(s) 139

    Abstract: Background: Asthma is a complex syndrome with multiple domains including symptoms, lung function, asthma control, and airway inflammation. A study of Fenom PRO™, a novel monitor for exhaled nitric oxide (FeNO), provided an opportunity to look at ... ...

    Abstract Background: Asthma is a complex syndrome with multiple domains including symptoms, lung function, asthma control, and airway inflammation. A study of Fenom PRO™, a novel monitor for exhaled nitric oxide (FeNO), provided an opportunity to look at concordance/discordance (C/D) for changes in multiple asthma domains over a 2-week period after corticosteroid therapy.
    Methods: Non-steroid-treated adults and children with uncontrolled asthma had asthma domain measures, (FeNO), forced expired volume in 1 s (FEV
    Results: There was a highly significant fall in mean FeNO of 51.7% over 2 weeks (p < 0.0001) accompanied by significant improvements in mean FEV
    Conclusion: This data demonstrates that the concordance between changes in the asthma domains is often substantially less than 100%. Reasons for this may include different time courses for change of the separate domains, the degree of abnormality for each domain at baseline, as well as intrinsic limitations of each parameter.
    MeSH term(s) Adolescent ; Adrenal Cortex Hormones/administration & dosage ; Adult ; Aged ; Asthma/drug therapy ; Asthma/metabolism ; Asthma/physiopathology ; Breath Tests ; Child ; Exhalation ; Female ; Humans ; Male ; Middle Aged ; Nitric Oxide/analysis ; Prospective Studies ; Respiratory Function Tests ; Spirometry ; United States ; Young Adult
    Chemical Substances Adrenal Cortex Hormones ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2020-05-14
    Publishing country England
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2059871-3
    ISSN 1471-2466 ; 1471-2466
    ISSN (online) 1471-2466
    ISSN 1471-2466
    DOI 10.1186/s12890-020-1166-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Patterns and determinants of exhaled nitric oxide trajectories in schoolchildren over a 7-year period.

    Garcia, Erika / Zhang, Yue / Rappaport, Edward B / Berhane, Kiros / Muchmore, Patrick / Silkoff, Philip E / Molshatzki, Noa / Gilliland, Frank D / Eckel, Sandrah P

    The European respiratory journal

    2020  Volume 56, Issue 1

    Abstract: Fractional exhaled nitric oxide ( ...

    Abstract Fractional exhaled nitric oxide (
    MeSH term(s) Adolescent ; Aged ; Asthma/diagnosis ; Asthma/epidemiology ; Body Mass Index ; Child ; Exhalation ; Female ; Humans ; Male ; Nitric Oxide ; Puberty
    Chemical Substances Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2020-07-02
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00011-2020
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    Zs.MO 292: Show issues

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  6. Article ; Online: Clinical precision, accuracy, number and durations of exhalations for a novel electrochemical monitor for exhaled nitric oxide.

    Silkoff, Philip E / Awabdy, Brian / Sarno, Mark / Ssenyange, Solomon / Balsubramanyam, Vivek / Leard, Ryan

    Journal of breath research

    2019  Volume 14, Issue 1, Page(s) 16011

    Abstract: Background: Exhaled nitric oxide (FeNO) is a validated marker of eosinophilic inflammation. Fenom Pro: Methods: Clinical precision, 6 versus 10 s exhalations, the first versus the average of the first two valid exhalation methods comparison were ... ...

    Abstract Background: Exhaled nitric oxide (FeNO) is a validated marker of eosinophilic inflammation. Fenom Pro
    Methods: Clinical precision, 6 versus 10 s exhalations, the first versus the average of the first two valid exhalation methods comparison were evaluated for Fenom Pro
    Results: The intent-to-treat population (n = 126) consisted of 83 adults, and 43 pediatric subjects with 16 subjects under 12 years of age. Clinical precision for 10 s exhalations on Fenom Pro
    Conclusion: Fenom Pro
    MeSH term(s) Adult ; Breath Tests/methods ; Child ; Child, Preschool ; Electrochemistry/instrumentation ; Exhalation ; Female ; Humans ; Intention to Treat Analysis ; Luminescent Measurements ; Male ; Monitoring, Physiologic/instrumentation ; Nitric Oxide/analysis ; Regression Analysis ; Reproducibility of Results
    Chemical Substances Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2019-12-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2381007-5
    ISSN 1752-7163 ; 1752-7155
    ISSN (online) 1752-7163
    ISSN 1752-7155
    DOI 10.1088/1752-7163/ab5422
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  7. Article ; Online: Exhaled nitric oxide and asthma.

    Silkoff, Philip E

    The New England journal of medicine

    2005  Volume 353, Issue 7, Page(s) 732–3; author reply 732–3

    MeSH term(s) Administration, Inhalation ; Adrenal Cortex Hormones/administration & dosage ; Asthma/diagnosis ; Asthma/drug therapy ; Asthma/physiopathology ; Breath Tests ; Forced Expiratory Flow Rates ; Humans ; Nitric Oxide/analysis ; Research Design
    Chemical Substances Adrenal Cortex Hormones ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2005-08-18
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJM200508183530716
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  8. Article ; Online: Bruxism Relieved Under CPAP Treatment in a Patient With OSA Syndrome.

    Martinot, Jean-Benoit / Borel, Jean-Christian / Le-Dong, Nhat-Nam / Silkoff, Philip E / Denison, Stephane / Gozal, David / Pépin, Jean-Louis

    Chest

    2020  Volume 157, Issue 3, Page(s) e59–e62

    Abstract: Bruxism is a heterogeneous condition related to various underlying mechanisms, including the presence of OSA. This case report illustrates that sleep mandibular movement monitoring and analysis could provide a useful opportunity for detection of both ... ...

    Abstract Bruxism is a heterogeneous condition related to various underlying mechanisms, including the presence of OSA. This case report illustrates that sleep mandibular movement monitoring and analysis could provide a useful opportunity for detection of both sleep bruxism and respiratory effort. The current case suggests that tracking of respiratory effort could enable evaluation of bruxism and its potential interactions. Successful treatment of sleep-related respiratory effort may lead to improved or resolution of bruxism in cases where such a causal relationship does exist.
    MeSH term(s) Continuous Positive Airway Pressure ; Electromyography ; Female ; Humans ; Masseter Muscle/physiopathology ; Middle Aged ; Polysomnography ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/therapy ; Sleep Bruxism/complications ; Sleep Bruxism/diagnosis ; Sleep Bruxism/physiopathology
    Language English
    Publishing date 2020-03-07
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2019.07.032
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  9. Article: Nasal nitric oxide: clue to a diagnosis of ciliary dyskinesia.

    Silkoff, Philip E

    Chest

    2004  Volume 126, Issue 4, Page(s) 1013–1014

    MeSH term(s) Body Fluids/chemistry ; Ciliary Motility Disorders/diagnosis ; Ciliary Motility Disorders/physiopathology ; Humans ; Nitric Oxide/analysis ; Nose
    Chemical Substances Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2004-10
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1378/chest.126.4.1013
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  10. Article ; Online: Exhaled nitric oxide in prednisone-dependent asthma to identify the eosinophilic positive phenotype.

    Silkoff, Philip E / Loza, Matthew J

    The Journal of allergy and clinical immunology

    2011  Volume 127, Issue 3, Page(s) 834; author reply 834

    MeSH term(s) Anti-Inflammatory Agents/therapeutic use ; Asthma/drug therapy ; Eosinophils/immunology ; Exhalation ; Humans ; Nitric Oxide/metabolism ; Phenotype ; Prednisone/therapeutic use
    Chemical Substances Anti-Inflammatory Agents ; Nitric Oxide (31C4KY9ESH) ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2011-03
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2010.10.046
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