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  1. Article: Pneumatosis intestinalis.

    Saul, Turandot / Palamidessi, Nicholas

    The Journal of emergency medicine

    2011  Volume 40, Issue 5, Page(s) 545–546

    MeSH term(s) Aged, 80 and over ; Diagnosis, Differential ; Fatal Outcome ; Humans ; Male ; Pneumatosis Cystoides Intestinalis/diagnosis ; Tomography, X-Ray Computed
    Language English
    Publishing date 2011-05
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 605559-x
    ISSN 0736-4679
    ISSN 0736-4679
    DOI 10.1016/j.jemermed.2008.10.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Nasogastric aspiration and lavage in emergency department patients with hematochezia or melena without hematemesis.

    Palamidessi, Nicholas / Sinert, Richard / Falzon, Louise / Zehtabchi, Shahriar

    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine

    2010  Volume 17, Issue 2, Page(s) 126–132

    Abstract: Objectives: The utility of nasogastric aspiration and lavage in the emergency management of patients with melena or hematochezia without hematemesis is controversial. This evidence-based emergency medicine review evaluates the following question: does ... ...

    Abstract Objectives: The utility of nasogastric aspiration and lavage in the emergency management of patients with melena or hematochezia without hematemesis is controversial. This evidence-based emergency medicine review evaluates the following question: does nasogastric aspiration and lavage in patients with melena or hematochezia and no hematemesis differentiate an upper from lower source of gastrointestinal (GI) bleeding?
    Methods: MEDLINE, EMBASE, the Cochrane Library, and other databases were searched. Studies were selected for inclusion in the review if the authors had performed nasogastric aspiration (with or without lavage) in all patients with hematochezia or melena and performed esophagogastroduodenal endoscopy (EGD) in all patients. Studies were excluded if they enrolled patients with history of esophageal varices or included patients with hematemesis or coffee ground emesis (unless the data for patients without hematemesis or coffee ground emesis could be separated out). The outcome was identifying upper GI hemorrhage (active bleeding or high-risk lesions potentially responsible for hemorrhage) and the rate of complications associated with the nasogastric tube insertion. Quality of the included studies was assessed using standard criteria for diagnostic accuracy studies.
    Results: Three retrospective studies met our inclusion and exclusion criteria. The prevalence of an upper GI source for patients with melena or hematochezia without hematemesis was 32% to 74%. According to the included studies, the diagnostic performance of the nasogastric aspiration and lavage for predicting upper GI bleeding is poor. The sensitivity of this test ranged from 42% to 84%, the specificity from 54% to 91%, and negative likelihood ratios from 0.62 to 0.20. Only one study reported the rate complications associated with nasogastric aspiration and lavage (1.6%).
    Conclusions: Nasogastric aspiration, with or without lavage, has a low sensitivity and poor negative likelihood ratio, which limits its utility in ruling out an upper GI source of bleeding in patients with melena or hematochezia without hematemesis.
    MeSH term(s) Aged ; Emergency Service, Hospital ; Endoscopy, Digestive System ; Gastrointestinal Hemorrhage/diagnosis ; Gastrointestinal Hemorrhage/etiology ; Gastrointestinal Hemorrhage/therapy ; Humans ; Intubation, Gastrointestinal ; Male ; Melena/diagnosis ; Melena/therapy ; Predictive Value of Tests ; Rectum ; Therapeutic Irrigation
    Language English
    Publishing date 2010-02
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 1329813-6
    ISSN 1553-2712 ; 1069-6563
    ISSN (online) 1553-2712
    ISSN 1069-6563
    DOI 10.1111/j.1553-2712.2009.00609.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Increasing ventilator surge capacity in disasters: ventilation of four adult-human-sized sheep on a single ventilator with a modified circuit.

    Paladino, Lorenzo / Silverberg, Mark / Charchaflieh, Jean G / Eason, Julie K / Wright, Brian J / Palamidessi, Nicholas / Arquilla, Bonnie / Sinert, Richard / Manoach, Seth

    Resuscitation

    2008  Volume 77, Issue 1, Page(s) 121–126

    Abstract: Objective: Recent manmade and natural disasters have focused attention on the need to provide care to large groups of patients. Clinicians, ethicists, and public health officials have been particularly concerned about mechanical ventilator surge ... ...

    Abstract Objective: Recent manmade and natural disasters have focused attention on the need to provide care to large groups of patients. Clinicians, ethicists, and public health officials have been particularly concerned about mechanical ventilator surge capacity and have suggested stock-piling ventilators, rationing, and providing manual ventilation. These possible solutions are complex and variously limited by legal, monetary, physical, and human capital restraints. We conducted a study to determine if a single mechanical ventilator can adequately ventilate four adult-human-sized sheep for 12h.
    Methods: We utilized a four-limbed ventilator circuit connected in parallel. Four 70-kg sheep were intubated, sedated, administered neuromuscular blockade and placed on a single ventilator for 12h. The initial ventilator settings were: synchronized intermittent mandatory ventilation with 100% oxygen at 16 breaths/min and tidal volume of 6 ml/kg combined sheep weight. Arterial blood gas, heart rate, and mean arterial pressure measurements were obtained from all four sheep at time zero and at pre-determined times over the course of 12h.
    Results: The ventilator and modified circuit successfully oxygenated and ventilated the four sheep for 12h. All sheep remained hemodynamically stable.
    Conclusion: It is possible to ventilate four adult-human-sized sheep on a single ventilator for at least 12h. This technique has the potential to improve disaster preparedness by expanding local ventilator surge capacity until emergency supplies can be delivered from central stockpiles. Further research should be conducted on ventilating individuals with different lung compliances and on potential microbial cross-contamination.
    MeSH term(s) Animals ; Disasters ; Equipment Design ; Female ; Respiratory Insufficiency/therapy ; Sheep, Domestic ; Ventilators, Mechanical/supply & distribution
    Language English
    Publishing date 2008-04
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 189901-6
    ISSN 1873-1570 ; 0300-9572
    ISSN (online) 1873-1570
    ISSN 0300-9572
    DOI 10.1016/j.resuscitation.2007.10.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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