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  1. Article ; Online: Ankyloglossia and Tethered Oral Tissue: An Evidence-Based Review.

    Talmor, Guy / Caloway, Christen L

    Pediatric clinics of North America

    2022  Volume 69, Issue 2, Page(s) 235–245

    Abstract: Tethered oral tissue may represent anatomic variation or true pathology with functional limitations. The most prevalent functional limitation is impaired feeding due to ankyloglossia. Treatment options include conservative management with feeding support ...

    Abstract Tethered oral tissue may represent anatomic variation or true pathology with functional limitations. The most prevalent functional limitation is impaired feeding due to ankyloglossia. Treatment options include conservative management with feeding support versus intervention such as frenotomy or frenuloplasty. The benefits of intervention have yet to be fully elucidated. Many can agree that intervention may improve maternal pain during breastfeeding, but the impact of these procedures on feeding efficiency and intake is debated. Alternate ties such as posterior ankyloglossia and lip tie have been proposed as pathologic oral ties, but their true impact on feeding and speech articulation remains unclear.
    MeSH term(s) Ankyloglossia/surgery ; Breast Feeding ; Family ; Female ; Humans ; Lingual Frenum/surgery
    Language English
    Publishing date 2022-03-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 215711-1
    ISSN 1557-8240 ; 0031-3955
    ISSN (online) 1557-8240
    ISSN 0031-3955
    DOI 10.1016/j.pcl.2021.12.007
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  2. Article ; Online: Chronic invasive fungal rhinosinusitis and granulomatous invasive fungal sinusitis: A systematic review of symptomatology and outcomes.

    Bahethi, Rohini / Talmor, Guy / Choudhry, Hannaan / Lemdani, Mehdi / Singh, Priyanka / Patel, Rushi / Hsueh, Wayne

    American journal of otolaryngology

    2023  Volume 45, Issue 1, Page(s) 104064

    Abstract: Introduction: Chronic invasive fungal rhinosinusitis (CIFRS) and granulomatous invasive fungal sinusitis are two uncommon diseases differentiated primarily by the pathologic finding of non-caseating granulomas in GIFRS. Both share many similarities in ... ...

    Abstract Introduction: Chronic invasive fungal rhinosinusitis (CIFRS) and granulomatous invasive fungal sinusitis are two uncommon diseases differentiated primarily by the pathologic finding of non-caseating granulomas in GIFRS. Both share many similarities in presentation. We aim to characterize the symptomatology and outcomes of these diseases.
    Methods: A comprehensive search strategy was designed to identify studies in the Cochrane, EMBASE and PubMed databases from database inception to January 2022. Inclusion criteria included all patients with a diagnosis of either CIFRS or GIFRS. All studies were screened by two reviewers. Chi-square analyses were used where appropriate.
    Results: 51 studies were included totaling 513 patients. The majority were diagnosed with CIFRS (389, 75.8 %) compared to GIFRS (124, 24.4 %). CIFRS was more common in immunocompromised or diabetic patients (p < 0.0001; p = 0.02). Patients with CIFRS were more likely to exhibit nasal symptoms including discharge (p = 0.0001), obstruction (p = 0.03) and congestion (p = 0.001) as well as systemic symptoms including fever, which no GIFRS patient exhibited, facial pain (p = 0.007), headache (p = 0.004). Aspergillus was the most common organism identified in both groups with a slight predominance among GIFRS patients (p = 0.01). GIFRS patients were also more likely to present with no identifiable organisms (p = 0.0006). CIFRS patients were more likely to die of disease (p = 0.0008).
    Conclusions: CIFRS generally presents with more symptoms and is associated with poorer outcomes primarily occurring in an immunocompromised population. GIFRS likely follows a more insidious course in immunocompetent patients. Understanding the key differences in symptomatology and outcomes for these two populations is critical for appropriate diagnosis and prognostication.
    MeSH term(s) Humans ; Rhinosinusitis ; Rhinitis/complications ; Sinusitis/complications ; Invasive Fungal Infections/diagnosis ; Chronic Disease
    Language English
    Publishing date 2023-09-23
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 604541-8
    ISSN 1532-818X ; 0196-0709
    ISSN (online) 1532-818X
    ISSN 0196-0709
    DOI 10.1016/j.amjoto.2023.104064
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  3. Article ; Online: Analyzing Patient Questions before and after Injectable Facial Aesthetic Procedures Using Machine Learning.

    Gao, Jeff / Tseng, Christopher C / Talmor, Guy / Kaye, Rachel / Paskhover, Boris

    Plastic and reconstructive surgery

    2022  Volume 151, Issue 2, Page(s) 353e–354e

    MeSH term(s) Humans ; Face/surgery ; Cosmetic Techniques ; Esthetics ; Machine Learning
    Language English
    Publishing date 2022-11-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208012-6
    ISSN 1529-4242 ; 0032-1052 ; 0096-8501
    ISSN (online) 1529-4242
    ISSN 0032-1052 ; 0096-8501
    DOI 10.1097/PRS.0000000000009877
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  4. Article ; Online: Characterizing Patient Questions Before and After Rhinoplasty on Social Media: A Big Data Approach.

    Tseng, Christopher C / Gao, Jeff / Talmor, Guy / Paskhover, Boris

    Aesthetic plastic surgery

    2021  Volume 45, Issue 4, Page(s) 1685–1692

    Abstract: Background: As an aesthetic surgery, a successful rhinoplasty is often assessed by patient satisfaction, subject to a diverse array of qualitative factors including patient expectations and happiness with care provided. While substantial effort has been ...

    Abstract Background: As an aesthetic surgery, a successful rhinoplasty is often assessed by patient satisfaction, subject to a diverse array of qualitative factors including patient expectations and happiness with care provided. While substantial effort has been dedicated to understanding patients' post-operative concerns, addressing patients' pre-operative questions has been comparatively less studied. This study analysed pre- and post-operative questions about rhinoplasty on social media to gain insights into patients' concerns and develop targeted educational material.
    Methods: The most viewed rhinoplasty questions on Realself.com, a social media platform for discussions about cosmetic surgeries, were collected and analysed. Questions were then stratified into pre- and post-operative and further assigned categories based on common topics found in the data. Using a machine learning approach, the most common pre- and post-operative questions were determined.
    Results: 2014 rhinoplasty questions were collected in total, with 957 pre-operative and 1057 post-operative. The most commonly asked pre-operative questions were about appearance (n = 441, 46.1%), function (n = 102, 10.7%), and cost (n = 94, 9.8%). The most commonly asked post-operative questions were about appearance (n = 502, 47.5%), behaviour allowed/disallowed (n = 283, 26.8%), and symptoms after surgery (n = 235, 22.2%). An educational handout with the 10 most common pre- and post-operative questions was developed using machine learning analysis, with the majority of questions about appearance.
    Conclusions: Patients primarily expressed concern about appearance when asking questions about rhinoplasty on social media, along with other aspects of their pre- and post-operative course. The educational handout developed by this study can be applied to address commonly asked patient questions during pre-operative education.
    Level of evidence v: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
    MeSH term(s) Big Data ; Humans ; Patient Satisfaction ; Rhinoplasty ; Social Media ; Surgery, Plastic ; Treatment Outcome
    Language English
    Publishing date 2021-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 532791-x
    ISSN 1432-5241 ; 0364-216X
    ISSN (online) 1432-5241
    ISSN 0364-216X
    DOI 10.1007/s00266-021-02203-9
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  5. Article ; Online: Facility volume and survival: Human papilloma virus positive oropharyngeal squamous cell carcinoma.

    Patel, Rushi / Didzbalis, Christopher J / Tseng, Christopher C / Talmor, Guy / Park, Richard Chan Woo

    American journal of otolaryngology

    2022  Volume 44, Issue 2, Page(s) 103762

    Abstract: Background: To analyze the impact of facility volume on survival for human papilloma virus positive oropharyngeal squamous cell carcinoma (HPV+ OPSCC) patients.: Methods: Patients treated for HPV+ OPSCC from 2010 to 2017 were queried from the ... ...

    Abstract Background: To analyze the impact of facility volume on survival for human papilloma virus positive oropharyngeal squamous cell carcinoma (HPV+ OPSCC) patients.
    Methods: Patients treated for HPV+ OPSCC from 2010 to 2017 were queried from the National Cancer Database. Facilities of average annual case volume <50th percentile were categorized as low-volume (LV) and >95th percentile as high-volume (HV).
    Results: 11,546 were included, with 10,305 patients (89.3 %) treated at LV and 1241 (10.7 %) at HV facilities. A greater proportion of cases involving resection of base of tongue and lingual tonsil were treated at HV (30.3 %) compared to LV (22.3 %) facilities (p < 0.001). Patients treated at a HV facility had greater percentage of clinical T4 (11.2 % vs. 8.6 %, p = 0.001) and N+ disease (90.5 % vs. 85.7 %, p < 0.001) patients. Survival analysis showed no statistically significant difference between five-year overall survival rates by facility volume (p = 0.388) for all patients. On multivariable analysis, facility volume was not associated with survival (HR: 0.968 [0.758-1.235], p = 0.791). These trends were found for both patients undergoing primary surgery or chemoradiotherapy.
    Conclusion: Our data indicates that patients with HPV+ OPSCC do not experience a survival benefit with treatment at HV facility, suggesting these patients may be adequately treated at LV centers.
    MeSH term(s) Humans ; Squamous Cell Carcinoma of Head and Neck ; Human Papillomavirus Viruses ; Papillomavirus Infections ; Oropharyngeal Neoplasms/surgery ; Head and Neck Neoplasms/complications ; Papillomaviridae ; Retrospective Studies
    Language English
    Publishing date 2022-12-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604541-8
    ISSN 1532-818X ; 0196-0709
    ISSN (online) 1532-818X
    ISSN 0196-0709
    DOI 10.1016/j.amjoto.2022.103762
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    Zs.A 1637: Show issues Location:
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  6. Article ; Online: Applying Machine Learning to Determine Popular Patient Questions About Mentoplasty on Social Media.

    Patel, Rushi / Tseng, Christopher C / Choudhry, Hannaan S / Lemdani, Mehdi S / Talmor, Guy / Paskhover, Boris

    Aesthetic plastic surgery

    2022  Volume 46, Issue 5, Page(s) 2273–2279

    Abstract: Purpose: Patient satisfaction in esthetic surgery often necessitates synergy between patient and physician goals. The authors aim to characterize patient questions before and after mentoplasty to reflect the patient perspective and enhance the physician- ...

    Abstract Purpose: Patient satisfaction in esthetic surgery often necessitates synergy between patient and physician goals. The authors aim to characterize patient questions before and after mentoplasty to reflect the patient perspective and enhance the physician-patient relationship.
    Methods: Mentoplasty reviews were gathered from Realself.com using an automated web crawler. Questions were defined as preoperative or postoperative. Each question was reviewed and characterized by the authors into general categories to best reflect the overall theme of the question. A machine learning approach was utilized to create a list of the most common patient questions, asked both preoperatively and postoperatively.
    Results: A total of 2,012 questions were collected. Of these, 1,708 (84.9%) and 304 (15.1%) preoperative and postoperative questions, respectively. The primary category for patients preoperatively was "eligibility for surgery" (86.3%), followed by "surgical techniques and logistics" (5.4%) and "cost" (5.4%). Of the postoperative questions, the most common questions were about "options to revise surgery" (44.1%), "symptoms after surgery" (27.0%), and "appearance" (26.3%). Our machine learning approach generated the 10 most common pre- and postoperative questions about mentoplasty. The majority of preoperative questions dealt with potential surgical indications, while most postoperative questions principally addressed appearance.
    Conclusions: The majority of mentoplasty patient questions were preoperative and asked about eligibility of surgery. Our study also found a significant proportion of postoperative questions inquired about revision, suggesting a small but nontrivial subset of patients highly dissatisfied with their results. Our 10 most common preoperative and postoperative question handout can help better inform physicians about the patient perspective on mentoplasty throughout their surgical course. Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
    MeSH term(s) Humans ; Esthetics ; Social Media ; Genioplasty ; Surgery, Plastic/methods ; Patient Satisfaction ; Machine Learning ; Treatment Outcome
    Language English
    Publishing date 2022-02-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 532791-x
    ISSN 1432-5241 ; 0364-216X
    ISSN (online) 1432-5241
    ISSN 0364-216X
    DOI 10.1007/s00266-022-02808-8
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  7. Article ; Online: Petrous Apicitis: A Systematic Review and Case Presentation.

    Talmor, Guy / Vakil, Mayand / Tseng, Chris / Svider, Peter / Ying, Mary / Eloy, Jean Anderson

    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

    2022  Volume 43, Issue 7, Page(s) 753–765

    Abstract: Introduction: Petrous apicitis (PA) is a rare but dangerous complication of acute otitis media. The objective of this study is to present a case of PA and systematically review the existing literature on PA to characterize clinical presentation, ... ...

    Abstract Introduction: Petrous apicitis (PA) is a rare but dangerous complication of acute otitis media. The objective of this study is to present a case of PA and systematically review the existing literature on PA to characterize clinical presentation, diagnosis, management, and outcomes in the antibiotic era.
    Methods: A comprehensive search from 1983 to June 1, 2020, of PubMed, MEDLINE, Cochrane Library, and EmBase databases was conducted. Studies with clinical data regarding patients with PA were included. Non-English literature or studies with insufficient individual patient data were excluded. Sixty-seven studies were included with a total of 134 patients.
    Results: A total of 67 articles were found to meet criteria for inclusion. The mean age of presentation was 33 years. Recent acute otitis media was reported in 78 patients (58.2%). Only 3 patients (2.2%) were immunocompromised, and 8 patients (6.0%) had a history of diabetes. Gradenigo's triad of abducens palsy, otorrhea, and retro-orbital or facial pain was reported in 28 patients (20.9%); however, these presenting symptoms were common individually (51.5%, 48.5%, and 64.2%, respectively). Hearing loss (35.8%), facial weakness (17.9%), and vertigo (7.5%) were also reported.The most frequently cultured pathogen was Pseudomonas (34.2%), followed by Streptococcus and Staphylococcus. All 134 patients underwent imaging, with computed tomography being the most frequently used modality (56.0%). Nearly all patients received antibiotic therapy (95.6%), with 91 (67.9%) undergoing surgery ranging from myringotomy (26.9%) to petrosectomy (25.4%). Five patients (5.7%) died because of complications related to PA. Mean follow-up was 11.0 months.
    Conclusions: Petrous apicitis has a variable presentation with potential for severe morbidity. Mortality rates are low, and presentation with Gradenigo's triad is uncommon. Appropriate medical management with surgical drainage can avoid long-term sequelae.
    MeSH term(s) Abducens Nerve Diseases/complications ; Abducens Nerve Diseases/diagnosis ; Adult ; Anti-Bacterial Agents/therapeutic use ; Humans ; Middle Ear Ventilation/adverse effects ; Otitis Media/complications ; Petrositis/complications ; Petrositis/diagnosis ; Tomography, X-Ray Computed
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-07-25
    Publishing country United States
    Document type Case Reports ; Journal Article ; Systematic Review
    ZDB-ID 2036790-9
    ISSN 1537-4505 ; 1531-7129
    ISSN (online) 1537-4505
    ISSN 1531-7129
    DOI 10.1097/MAO.0000000000003600
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    Zs.A 1554: Show issues Location:
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  8. Article ; Online: Effect of obesity on outcomes after open laryngeal surgery including total laryngectomy: A NSQIP database analysis.

    Chen, Tiffany / Meng, Marvin L / Hong, Ellen M / Durrant, Frederick / Talmor, Guy / Park, Richard Chan Woo / Benson, Brian

    Head & neck

    2023  Volume 45, Issue 8, Page(s) 1913–1921

    Abstract: Background: The impact of obesity on outcomes after open laryngeal surgery has not been well-described.: Methods: The NSQIP database was queried for all open laryngeal surgeries including total laryngectomies between 2005 and 2018. Outcomes of ... ...

    Abstract Background: The impact of obesity on outcomes after open laryngeal surgery has not been well-described.
    Methods: The NSQIP database was queried for all open laryngeal surgeries including total laryngectomies between 2005 and 2018. Outcomes of patients identified as obese or nonobese by BMI were compared.
    Results: Of 1865 patients, 20.1% classified as obese. The most common operation performed was total laryngectomy with or without radical neck dissection (73.2%). Operation time and length of hospital stay were significantly less for obese patients. On multivariate analysis, obesity was associated with less bleeding transfusions occurrences (aOR, 0.395, p = 0.0052), surgical complications (aOR, 0.604, p < 0.001), and any complication (aOR, 0.730, p = 0.0019).
    Conclusion: Though there may be an inverse association of obesity with complications and bleeding transfusion occurrences, as well as decreased operation time and length of hospital stay, several confounders and bias may exist; therefore, it is difficult to conclude that the obesity paradox is present.
    MeSH term(s) Humans ; Laryngectomy/adverse effects ; Postoperative Complications/etiology ; Obesity/complications ; Obesity/epidemiology ; Laryngeal Neoplasms/surgery ; Laryngeal Neoplasms/complications ; Retrospective Studies
    Language English
    Publishing date 2023-05-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.27403
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  9. Article ; Online: Trimethylamine-N-Oxide and Related Metabolites: Assessing Cardiovascular Risk in the Dallas Heart Study.

    Talmor-Barkan, Yeela / Yu, Jiao / Yacovzada, Nancy-Sarah / Pravda, Nili Schamroth / Ayers, Colby / de Lemos, James A / Tang, W H Wilson / Hazen, Stanley L / Eisen, Alon / Witberg, Guy / Kornowski, Ran / Neeland, Ian J

    Mayo Clinic proceedings

    2024  

    Abstract: Objective: To evaluate the association between trimethylamine N-oxide (TMAO) and related metabolites with adverse cardiovascular events in a multiethnic urban primary prevention population.: Methods: We performed a case-control study of 361 ... ...

    Abstract Objective: To evaluate the association between trimethylamine N-oxide (TMAO) and related metabolites with adverse cardiovascular events in a multiethnic urban primary prevention population.
    Methods: We performed a case-control study of 361 participants of the Dallas Heart Study, including 88 participants with an incident atherosclerotic cardiovascular disease (ASCVD) event and 273 controls matched for age, sex, and body mass index without an ASCVD event during 12 years of follow-up (January 1, 2000, through December 31, 2015). Plasma levels of TMAO, choline, carnitine, betaine, and butyrobetaine were measured by mass spectrometry. The differential odds for incident ASCVD by metabolite levels between cases and controls were compared by a conditional logistic regression model adjusted for cardiovascular risk factors.
    Results: Participants with incident ASCVD had higher levels of TMAO and related metabolites compared with those without ASCVD (P<.05 for all). Those with plasma TMAO concentrations in quartile 4 had a more than 2-fold higher odds of ASCVD compared with those in quartile 1 (odds ratio, 2.77 [95% CI, 1.05 to 7.7; P=.04] for hard ASCVD and 2.41 [95% CI, 1.049 to 5.709; P=.04]). Similar trends were seen with the related metabolites choline, betaine, carnitine, and butyrobetaine.
    Conclusion: Our results suggest that TMAO and related metabolites are independently associated with ASCVD events. Although further studies are needed, measurement of TMAO and related metabolites may have a role in ASCVD risk stratification for primary prevention.
    Language English
    Publishing date 2024-04-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2023.12.021
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  10. Article ; Online: Novel plasma biomarkers of coronary artery calcium incidence or progression: Insights from the prospective multi-ethnic Dallas Heart Study cohort.

    Grinberg, Tzlil / Eisen, Alon / Talmor-Barkan, Yeela / Kornowski, Ran / Hamdan, Ashraf / Witberg, Guy / Ayers, Colby / Joshi, Parag / Rohatgi, Anand / Khera, Amit / de Lemos, James A / Neeland, Ian J

    Atherosclerosis

    2024  Volume 390, Page(s) 117469

    Abstract: Background and aims: Identifying the association of novel plasma biomarkers with coronary artery calcium (CAC) incidence or progression may provide insights into the pathophysiology of atherogenesis and plaque formation.: Methods: Participants of the ...

    Abstract Background and aims: Identifying the association of novel plasma biomarkers with coronary artery calcium (CAC) incidence or progression may provide insights into the pathophysiology of atherogenesis and plaque formation.
    Methods: Participants of the Dallas Heart Study (DHS), a multi-ethnic cohort of ambulatory individuals at low-intermediate risk for future atherosclerotic cardiovascular disease (ASCVD), who had their blood tested for 31 biomarkers reflecting multiple pathophysiological pathways, underwent 2 serial non-contrast computed tomography assessments for CAC a median ∼7 years apart. The collected biomarkers were explored for association with CAC incidence or progression using univariate and multivariate analysis.
    Results: A total of 1424 participants were included; mean age 43 years, 39 % male, and nearly half African-American. Over a 7-year interval between the two CAC measurements, 340 participants (23.9 %) had CAC incidence or progression, 105 (7.4 %) with incident CAC, and 309 (21.7 %) with CAC progression. Although several plasma biomarkers were associated with CAC incidence or progression in a univariate model, only soluble intercellular adhesion molecule-1 (sICAM-1), related to atherosclerosis by the inflammatory pathway, remained independently associated in a multivariate model adjusted for traditional risk factors.
    Conclusions: Further studies are needed to characterize the role of sICAM-1 in CAC evolvement to establish whether it has a pivotal mechanistic contribution or is rather an innocent bystander. Alternate measures of coronary atherosclerosis may be needed to elucidate contributors to atherosclerosis incidence or progression.
    MeSH term(s) Humans ; Male ; Adult ; Female ; Calcium/metabolism ; Prospective Studies ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/metabolism ; Incidence ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/epidemiology ; Atherosclerosis/metabolism ; Risk Factors ; Biomarkers/metabolism ; Calcium, Dietary ; Vascular Calcification/diagnostic imaging ; Vascular Calcification/epidemiology ; Vascular Calcification/metabolism
    Chemical Substances Calcium (SY7Q814VUP) ; Biomarkers ; Calcium, Dietary
    Language English
    Publishing date 2024-02-01
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 80061-2
    ISSN 1879-1484 ; 0021-9150
    ISSN (online) 1879-1484
    ISSN 0021-9150
    DOI 10.1016/j.atherosclerosis.2024.117469
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    ab Jg. 2022: Lesesaal (EG)

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