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  1. Article ; Online: Effectiveness of Molnupiravir and Nirmatrelvir-Ritonavir in Hospitalized Patients With COVID-19.

    Focosi, Daniele / Nicastri, Emanuele

    Annals of internal medicine

    2023  Volume 176, Issue 10, Page(s) eL230264

    MeSH term(s) Humans ; Ritonavir/therapeutic use ; COVID-19 ; COVID-19 Drug Treatment ; Antiviral Agents/therapeutic use
    Chemical Substances molnupiravir (YA84KI1VEW) ; nirmatrelvir (7R9A5P7H32) ; Ritonavir (O3J8G9O825) ; Antiviral Agents
    Language English
    Publishing date 2023-10-16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L23-0264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.178/2: Show issues Location:
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  2. Article ; Online: Editorial

    Emanuele Nicastri / Edwin Michael / Alfonso J. Rodriguez-Morales

    Frontiers in Tropical Diseases, Vol

    The intersection of COVID-19 and tropical diseases

    2024  Volume 4

    Keywords COVID - 19 ; tuberculosis ; dengue ; Chagas ; SARS ; Arctic medicine. Tropical medicine ; RC955-962
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Correction: The unmet need for COVID-19 treatment in immunocompromised patients.

    D'Abramo, Alessandra / Vita, Serena / Nicastri, Emanuele

    BMC infectious diseases

    2023  Volume 23, Issue 1, Page(s) 61

    Language English
    Publishing date 2023-01-31
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-023-08034-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Re: Remdesivir for the treatment of COVID-19 by Lee et al.

    Beccacece, Alessia / Ascoli Bartoli, Tommaso / Nicastri, Emanuele

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2022  Volume 29, Issue 1, Page(s) 114

    MeSH term(s) Humans ; COVID-19 ; COVID-19 Drug Treatment ; Antiviral Agents/therapeutic use ; SARS-CoV-2
    Chemical Substances remdesivir (3QKI37EEHE) ; Antiviral Agents
    Language English
    Publishing date 2022-10-04
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2022.09.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4541: Show issues Location:
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    Zs.MO 284: Show issues

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  5. Article ; Online: The unmet need for COVID-19 treatment in immunocompromised patients.

    D'Abramo, Alessandra / Vita, Serena / Nicastri, Emanuele

    BMC infectious diseases

    2022  Volume 22, Issue 1, Page(s) 930

    Abstract: Background: Immunocompromised (IC) patients are at increased risk of severe and/or prolonged COVID-19.: Main text: The recent study by Scaglione et al., addresses the issue of IC outpatients with SARS-CoV-2 infection. Authors describe the real-life ... ...

    Abstract Background: Immunocompromised (IC) patients are at increased risk of severe and/or prolonged COVID-19.
    Main text: The recent study by Scaglione et al., addresses the issue of IC outpatients with SARS-CoV-2 infection. Authors describe the real-life use of SARS-CoV-2 antivirals and/or monoclonal antibodies and the clinical benefit in high-risk COVID-19 patients. The study supports the use of early combination therapy in a subgroup of extremely high risk patients, and considers the combined strategy as a gold standard regimen to both increase the effectiveness of early treatment, especially in IC individuals, and, reduce the emergence of SARS-CoV-2 escape mutants.
    Conclusion: A tailored and standardised therapeutic approach in case of IC out and inpatients with SARS-CoV-2 infection is needed.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; COVID-19 Drug Treatment ; Antibodies, Viral ; Immunocompromised Host
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2022-12-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-022-07918-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Convalescent Plasma Versus Hyperimmune Immunoglobulins.

    Focosi, Daniele / Franchini, Massimo / Nicastri, Emanuele / Sullivan, David J / Casadevall, Arturo

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  Volume 77, Issue 9, Page(s) 1356–1357

    MeSH term(s) Humans ; Immunoglobulins/therapeutic use ; COVID-19
    Chemical Substances Immunoglobulins
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad406
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1505: Show issues Location:
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    Zs.MO 480: Show issues

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  7. Article ; Online: Antiviral combination therapies for persistent COVID-19 in immunocompromised patients.

    Focosi, Daniele / Maggi, Fabrizio / D'Abramo, Alessandra / Nicastri, Emanuele / Sullivan, David J

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2023  Volume 137, Page(s) 55–59

    Abstract: Objectives: After the third year of the COVID-19 pandemic, most of the severe COVID-19 burden falls upon immunocompromised patients who cannot mount an endogenous immune response after both vaccination and/or natural infection. They also experience ... ...

    Abstract Objectives: After the third year of the COVID-19 pandemic, most of the severe COVID-19 burden falls upon immunocompromised patients who cannot mount an endogenous immune response after both vaccination and/or natural infection. They also experience persistent SARS-CoV-2 infection with high viral loads often unsuccessfully managed by the standard antiviral monotherapy regimen initially validated for treatment of COVID-19 immunocompetent patients, only. The off-label prescription of such monotherapy regimens in immunocompromised patients is likely to drive the emergence of treatment-related immune escape, relapses, excess morbidity, and mortality from both COVID-19 and delayed treatment of the underlying disorders. A possible treatment approach to mitigate such consequence is based on combined antiviral therapies.
    Methods: We searched PubMed for case reports, case series and clinical trials reporting the usage of combined antiviral therapies for COVID-19.
    Results: In this narrative review, we show that combinations of either small molecule antivirals or small molecule antiviral plus passive immunotherapies are safe and effective in small cohorts reported so far.
    Conclusion: Considering the progressive loss of efficacy of all authorized anti-spike monoclonal antibodies, promising regimen options are reserved to combinations of small molecule antivirals and COVID-19 convalescent plasma from vaccinated donors.
    MeSH term(s) Humans ; COVID-19/therapy ; SARS-CoV-2 ; Pandemics ; COVID-19 Serotherapy ; Antiviral Agents/therapeutic use ; Immunocompromised Host
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2023-09-30
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2023.09.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4516: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Monkeypox virus in human body sites and fluids: evidence for transmission.

    Colavita, Francesca / Antinori, Andrea / Nicastri, Emanuele / Focosi, Daniele / Girardi, Enrico / Vaia, Francesco / Maggi, Fabrizio

    The Lancet. Infectious diseases

    2022  Volume 23, Issue 1, Page(s) 6–8

    MeSH term(s) Humans ; Monkeypox virus ; Human Body ; Mpox (monkeypox)/epidemiology ; Disease Outbreaks ; Feces
    Language English
    Publishing date 2022-09-29
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(22)00639-9
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5743: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article: Combined antiviral therapy as effective and feasible option in allogenic hematopoietic stem cell transplantation during SARS-COV-2 infection: a case report.

    Vita, Serena / D'Abramo, Alessandra / Coppola, Andrea / Farroni, Chiara / Iori, Anna Paola / Faraglia, Francesca / Sette, Alessandro / Grifoni, Alba / Lindestam Arlehamn, Cecilia / Bibas, Michele / Goletti, Delia / Nicastri, Emanuele

    Frontiers in oncology

    2024  Volume 14, Page(s) 1290614

    Abstract: Here we describe the case of a 51 years old Italian woman with acute lymphoblastic leukemia who underwent to hematopoietic stem cell transplantation (HSCT) during SARS-COV-2 infection. She presented a prolonged COVID-19 successfully treated with dual ... ...

    Abstract Here we describe the case of a 51 years old Italian woman with acute lymphoblastic leukemia who underwent to hematopoietic stem cell transplantation (HSCT) during SARS-COV-2 infection. She presented a prolonged COVID-19 successfully treated with dual anti SARS-COV-2 antiviral plus monoclonal antibody therapy.
    Language English
    Publishing date 2024-02-13
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2024.1290614
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Efficacy and Safety of Anticoagulant Therapy in COVID-19-Related Pulmonary Embolism with Different Extension.

    Gatto, Maria Chiara / Oliva, Alessandra / Palazzolo, Claudia / Picariello, Claudio / Garascia, Andrea / Nicastri, Emanuele / Girardi, Enrico / Antinori, Andrea

    Biomedicines

    2023  Volume 11, Issue 5

    Abstract: Pulmonary embolism (PE) has been associated with SARS-CoV-2 infection, and its incidence is highly variable. The aim of our study was to describe the radiological and clinical presentations, as well as the therapeutic management, of PEs that occurred ... ...

    Abstract Pulmonary embolism (PE) has been associated with SARS-CoV-2 infection, and its incidence is highly variable. The aim of our study was to describe the radiological and clinical presentations, as well as the therapeutic management, of PEs that occurred during SARS-CoV-2 infection in a cohort of hospitalized patients. In this observational study, we enrolled patients with moderate COVID-19 who developed PE during hospitalization. Clinical, laboratory, and radiological features were recorded. PE was diagnosed on clinical suspicion and/or CT angiography. According to CT angiography results, two groups of patients were further distinguished: those with proximal or central pulmonary embolism (cPE) and those with distal or micro-pulmonary embolism (mPE). A total of 56 patients with a mean age of 78 ± 15 years were included. Overall, PE occurred after a median of 2 days from hospitalization (range 0-47 days) and, interestingly, the majority of them (89%) within the first 10 days of hospitalization, without differences between the groups. Patients with cPE were younger (
    Language English
    Publishing date 2023-04-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11051282
    Database MEDical Literature Analysis and Retrieval System OnLINE

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