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  1. Article ; Online: Utilizing machine learning in predictive modeling: what's next?

    Muhsen, Ibrahim N / Hashmi, Shahrukh K

    Bone marrow transplantation

    2022  Volume 57, Issue 5, Page(s) 699–700

    MeSH term(s) Humans ; Machine Learning
    Language English
    Publishing date 2022-03-15
    Publishing country England
    Document type Editorial
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-022-01622-9
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    Zs.A 2168: Show issues Location:
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  2. Article ; Online: A Novel Combination for Graft-versus-Host-Disease Prophylaxis: Lessons Learned from the Birth of Sushi Burrito!

    Hashmi, Shahrukh K

    Acta haematologica

    2020  Volume 144, Issue 2, Page(s) 126–129

    MeSH term(s) Cyclophosphamide ; Graft vs Host Disease/prevention & control ; Humans ; Pilot Projects ; Primary Myelofibrosis ; Prospective Studies ; Pyrazoles
    Chemical Substances Pyrazoles ; ruxolitinib (82S8X8XX8H) ; Cyclophosphamide (8N3DW7272P)
    Language English
    Publishing date 2020-08-19
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 80008-9
    ISSN 1421-9662 ; 0001-5792
    ISSN (online) 1421-9662
    ISSN 0001-5792
    DOI 10.1159/000508742
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  3. Article: The strange case of Dr. Hashmi and Mr. Hyde.

    Hashmi, Shahrukh K

    Hematology/oncology and stem cell therapy

    2019  Volume 13, Issue 4, Page(s) 244–247

    MeSH term(s) Allografts ; Hematopoietic Stem Cell Transplantation ; Humans ; Male ; Middle Aged ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/therapy
    Language English
    Publishing date 2019-01-09
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2651893-4
    ISSN 1658-3876
    ISSN 1658-3876
    DOI 10.1016/j.hemonc.2018.12.001
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    Zs.A 6950: Show issues Location:
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  4. Article ; Online: A personalized, organ-based approach to the treatment of chronic steroid-refractory graft-versus-host disease.

    Fatoum, Hanaa / Zeiser, Robert / Hashmi, Shahrukh K

    Blood reviews

    2023  Volume 63, Page(s) 101142

    Abstract: Chronic graft-versus-host-disease (cGvHD) remains the leading cause of morbidity among transplant recipients. The efficacy of second-line treatments varies widely based on many factors, including wide differences in the organ overall response-rate ... ...

    Abstract Chronic graft-versus-host-disease (cGvHD) remains the leading cause of morbidity among transplant recipients. The efficacy of second-line treatments varies widely based on many factors, including wide differences in the organ overall response-rate response and in the current era where multiple agents are approved, and optimal sequencing of drugs based on organ ORR is unknown. We aimed to evaluate outcomes based on ORRs to the most common agents for the treatment of steroid-refractory/steroid-dependent cGvHD by conducting a systematic literature review. A total of 387 studies were evaluated for the ORRs of 12 cGvHD treatments. The highest skin ORR was observed to be 77% though some agents had an acceptable ORR. Most agents had an ocular response ranging from 17 to 50% Some agents resulted in a GI ORR of ≥88%. Rituximab showed the best response for musculoskeletal-GvHD. In the case of lung-GvHD (bronchiolitis obliterans syndrome [BOS]), negligible response was observed in patients treated with various agents. No clinically meaningful responses to treatments were reported for genital-GvHD. Most GvHD trials are focused on the ORR and partial response rates (PRR). The evidence for optimal agents for each organ is limited, and therefore, our study results are striking for differences in organ-ORR yields for a clinically meaningful difference. Thus, a personalized organ-based approach to the selection of therapeutic agents in cGvHD could result in favorable outcomes.
    MeSH term(s) Humans ; Graft vs Host Disease/diagnosis ; Graft vs Host Disease/drug therapy ; Graft vs Host Disease/etiology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Rituximab/therapeutic use ; Steroids/therapeutic use ; Chronic Disease
    Chemical Substances Rituximab (4F4X42SYQ6) ; Steroids
    Language English
    Publishing date 2023-11-11
    Publishing country England
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 639015-8
    ISSN 1532-1681 ; 0268-960X
    ISSN (online) 1532-1681
    ISSN 0268-960X
    DOI 10.1016/j.blre.2023.101142
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    Zs.A 2207: Show issues Location:
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  5. Article: Ovarian Tissue Cryopreservation versus Other Fertility Techniques for Chemoradiation-Induced Premature Ovarian Insufficiency in Women: A Systematic Review and Future Directions.

    Chaudhri, Eman N / Salman, Ayman / Awartani, Khalid / Khan, Zaraq / Hashmi, Shahrukh K

    Life (Basel, Switzerland)

    2024  Volume 14, Issue 3

    Abstract: Current advances in cancer therapy have increased survival, emphasizing the need for life quality improvement. Fertility loss is common post-chemotherapy. Current guidelines establish embryo and oocyte cryopreservation to address premature ovarian ... ...

    Abstract Current advances in cancer therapy have increased survival, emphasizing the need for life quality improvement. Fertility loss is common post-chemotherapy. Current guidelines establish embryo and oocyte cryopreservation to address premature ovarian insufficiency (POI). Ovarian tissue cryopreservation has also recently become an acceptable option for fertility preservation, particularly as it is the only option for pre-pubertal patients. Few definitions for optimum fertility outcomes, and few systematic reviews comparing embryo, oocyte, and ovarian tissue cryopreservation as a means of fertility preservation (FP) in pre- and post-pubertal female cancer patients exist. This systematic review aims to improve understanding of gonadotoxic effects of chemoradiation therapy in cancer patients, to analyze the different fertility preservation techniques and procedures available to women with chemoradiation induced ovarian insufficiency, and to compare and recognize the benefits of each technique in restoring fertility, sexual hormone function, and quality of life. Searches were conducted electronically on PubMed, Cochrane, and EBSCOHost, including clinical trials, prospective, and retrospective studies of female cancer patients undergoing anti-cancer therapy, with predefined MeSH terminology. Data were collected, analyzed, and compared. Non-randomized clinical studies were evaluated for risk bias through the Newcastle-Ottawa Scale. In total, 23 studies were included. From there, 647 patients opted for oocyte cryopreservation, 267 for embryo cryopreservation, and 1382 for ovarian tissue cryopreservation (OTC). A total of 175, 18, and 121 live births resulted respectively from oocyte, embryo, and OTC, respectively. Studies without live births discussed other fertility markers as indicators of improvement in sexual hormone function and fertility. The gonadotoxic effects of chemotherapy call for FP intervention. Oocyte and embryo cryopreservation/implantation are well-established procedures. With changing trends and life quality consideration, OTC is a promising interventional method for pre-pubertal patients facing the prospect of fertility loss.
    Language English
    Publishing date 2024-03-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life14030393
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  6. Article ; Online: Individualizing Optimal Dosing of Antithymocyte Globulin in Allogeneic Hematopoietic Cell Transplantation.

    Hashmi, Shahrukh K

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

    2017  Volume 24, Issue 1, Page(s) 2–3

    MeSH term(s) Antilymphocyte Serum ; Hematopoietic Stem Cell Transplantation ; Lymphocyte Count ; Transplantation Conditioning ; Unrelated Donors
    Chemical Substances Antilymphocyte Serum
    Language English
    Publishing date 2017-11-16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1474865-4
    ISSN 1523-6536 ; 1083-8791
    ISSN (online) 1523-6536
    ISSN 1083-8791
    DOI 10.1016/j.bbmt.2017.11.002
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    Zs.A 5082: Show issues Location:
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  7. Article ; Online: Challenges and opportunities in shared care for international patients treated with cellular therapy for nonmalignant disease.

    Mina, Syeda A / Muhsen, Ibrahim N / Hashmi, Shahrukh K

    Current opinion in hematology

    2022  Volume 30, Issue 1, Page(s) 22–27

    Abstract: As cellular therapies gradually become the mainstay of treatment for several nonmalignant diseases, there appears to be varied accessibility to these therapies globally. Despite considerable burden of nonmalignant conditions, such as sickle cell disease, ...

    Abstract As cellular therapies gradually become the mainstay of treatment for several nonmalignant diseases, there appears to be varied accessibility to these therapies globally. Despite considerable burden of nonmalignant conditions, such as sickle cell disease, thalassemia, and aplastic anemia in populations of low-middle-income countries, the utilization of cellular therapies remain sparse because of lack of resources. Globally, the frequency of hematopoietic stem cell transplant (HSCT) has increased disproportionately in countries with higher gross national income (GNI) per capita, governmental healthcare expenditures, and a high human development index. This leads to a large subset of international patients seeking care in the United States. This review summarizes the unique set of challenges that often arise when offering sophisticated therapies such as HSCT to international patients constituting of cross-cultural, logistical, financial, and medical challenges and the opportunities that are available to bridge the gap.
    MeSH term(s) Humans ; Income ; Health Expenditures ; Anemia, Aplastic ; Anemia, Sickle Cell/therapy ; Hematopoietic Stem Cell Transplantation
    Language English
    Publishing date 2022-12-17
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1153887-9
    ISSN 1531-7048 ; 1065-6251
    ISSN (online) 1531-7048
    ISSN 1065-6251
    DOI 10.1097/MOH.0000000000000742
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    Zs.A 3703: Show issues Location:
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  8. Article ; Online: Association of graft-versus-host-disease with neurologic complications: clinical paradigm and future directions.

    Sheikh, Mohammad Abdurrehman / Im, Annie / Ballen, Karen / Hashmi, Shahrukh K

    Bone marrow transplantation

    2021  Volume 56, Issue 6, Page(s) 1471–1473

    MeSH term(s) Graft vs Host Disease/etiology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans
    Language English
    Publishing date 2021-02-09
    Publishing country England
    Document type Letter
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-021-01216-x
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  9. Article ; Online: Thank You for Not Smoking.

    Hashmi, Shahrukh K / Hussain, Fazal / Hays, James Taylor

    Mayo Clinic proceedings

    2020  Volume 95, Issue 10, Page(s) 2062–2064

    MeSH term(s) Betacoronavirus ; COVID-19 ; China ; Coronavirus ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-10-04
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2020.08.012
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  10. Article ; Online: Machine learning applications and challenges in graft-versus-host disease: a scoping review.

    Mushtaq, Ali Hassan / Shafqat, Areez / Salah, Haneen T / Hashmi, Shahrukh K / Muhsen, Ibrahim N

    Current opinion in oncology

    2023  Volume 35, Issue 6, Page(s) 594–600

    Abstract: Purpose of review: This review delves into the potential of artificial intelligence (AI), particularly machine learning (ML), in enhancing graft-versus-host disease (GVHD) risk assessment, diagnosis, and personalized treatment.: Recent findings: ... ...

    Abstract Purpose of review: This review delves into the potential of artificial intelligence (AI), particularly machine learning (ML), in enhancing graft-versus-host disease (GVHD) risk assessment, diagnosis, and personalized treatment.
    Recent findings: Recent studies have demonstrated the superiority of ML algorithms over traditional multivariate statistical models in donor selection for allogeneic hematopoietic stem cell transplantation. ML has recently enabled dynamic risk assessment by modeling time-series data, an upgrade from the static, "snapshot" assessment of patients that conventional statistical models and older ML algorithms offer. Regarding diagnosis, a deep learning model, a subset of ML, can accurately identify skin segments affected with chronic GVHD with satisfactory results. ML methods such as Q-learning and deep reinforcement learning have been utilized to develop adaptive treatment strategies (ATS) for the personalized prevention and treatment of acute and chronic GVHD.
    Summary: To capitalize on these promising advancements, there is a need for large-scale, multicenter collaborations to develop generalizable ML models. Furthermore, addressing pertinent issues such as the implementation of stringent ethical guidelines is crucial before the widespread introduction of AI into GVHD care.
    MeSH term(s) Humans ; Artificial Intelligence ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Graft vs Host Disease/therapy ; Graft vs Host Disease/prevention & control ; Bronchiolitis Obliterans Syndrome ; Machine Learning ; Multicenter Studies as Topic
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1049384-0
    ISSN 1531-703X ; 1040-8746
    ISSN (online) 1531-703X
    ISSN 1040-8746
    DOI 10.1097/CCO.0000000000000996
    Database MEDical Literature Analysis and Retrieval System OnLINE

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