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  1. Article ; Online: Reply to letter to the editor "antibody responses to second doses of COVID-19 vaccination in lung cancer patients: Comment".

    Narita, Daisuke / Ebina-Shibuya, Risa

    Respiratory investigation

    2023  Volume 61, Issue 3, Page(s) 347–348

    MeSH term(s) Humans ; COVID-19 Vaccines ; Antibody Formation ; COVID-19/prevention & control ; Lung Neoplasms ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-03-07
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2660821-2
    ISSN 2212-5353 ; 2212-5345
    ISSN (online) 2212-5353
    ISSN 2212-5345
    DOI 10.1016/j.resinv.2023.02.004
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  2. Article ; Online: TSLP-targeting therapy: Beyond allergy?

    Ebina-Shibuya, Risa / Leonard, Warren J

    Clinical and translational medicine

    2023  Volume 13, Issue 5, Page(s) e1241

    MeSH term(s) Humans ; Hypersensitivity/drug therapy ; Cytokines
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-05-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.1241
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  3. Article ; Online: TSLP‐targeting therapy

    Risa Ebina‐Shibuya / Warren J. Leonard

    Clinical and Translational Medicine, Vol 13, Iss 5, Pp n/a-n/a (2023)

    Beyond allergy?

    2023  

    Keywords tezepelumab ; thymic stromal lymphopoietin ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Role of thymic stromal lymphopoietin in allergy and beyond.

    Ebina-Shibuya, Risa / Leonard, Warren J

    Nature reviews. Immunology

    2022  Volume 23, Issue 1, Page(s) 24–37

    Abstract: Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine that acts on multiple cell lineages, including dendritic cells, T cells, B cells, neutrophils, mast cells, eosinophils and innate lymphoid cells, affecting their maturation, survival and ... ...

    Abstract Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine that acts on multiple cell lineages, including dendritic cells, T cells, B cells, neutrophils, mast cells, eosinophils and innate lymphoid cells, affecting their maturation, survival and recruitment. It is best known for its role in promoting type 2 immune responses such as in allergic diseases and, in 2021, a monoclonal antibody targeting TSLP was approved for the treatment of severe asthma. However, it is now clear that TSLP has many other important roles in a variety of settings. Indeed, several genetic variants for TSLP are linked to disease severity, and chromosomal alterations in TSLP are common in certain cancers, indicating important roles of TSLP in disease. In this Review, we discuss recent advances in TSLP biology, highlighting how it regulates the tissue environment not only in allergic disease but also in infectious diseases, inflammatory diseases and cancer. Encouragingly, therapies targeting the TSLP pathway are being actively pursued for several diseases.
    MeSH term(s) Humans ; Thymic Stromal Lymphopoietin ; Immunity, Innate ; Lymphocytes/metabolism ; Cytokines ; Hypersensitivity ; Neoplasms
    Chemical Substances Thymic Stromal Lymphopoietin (GT0IL38SP4) ; Cytokines
    Language English
    Publishing date 2022-06-01
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Intramural
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-022-00735-y
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    Zs.A 5565: Show issues Location:
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  5. Article ; Online: National policies for paediatric universal BCG vaccination were associated with decreased mortality due to COVID-19.

    Ebina-Shibuya, Risa / Horita, Nobuyuki / Namkoong, Ho / Kaneko, Takeshi

    Respirology (Carlton, Vic.)

    2020  Volume 25, Issue 8, Page(s) 898–899

    Keywords covid19
    Language English
    Publishing date 2020-06-18
    Publishing country Australia
    Document type Letter ; Comment
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.13885
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    Zs.A 4957: Show issues Location:
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  6. Article ; Online: Peripheral blood biomarkers associated with combination of immune checkpoint blockade plus chemotherapy in NSCLC.

    Kimura, Nozomu / Tsukita, Yoko / Ebina-Shibuya, Risa / Miyauchi, Eisaku / Yamada, Mitsuhiro / Narita, Daisuke / Saito, Ryota / Inoue, Chihiro / Fujino, Naoya / Ichikawa, Tomohiro / Tamada, Tsutomu / Sugiura, Hisatoshi

    Cancer biomarkers : section A of Disease markers

    2024  

    Abstract: Background: Biomarkers predicting clinical outcomes of treating non-small cell lung cancer (NSCLC) with combination of immune checkpoint inhibitors (ICIs) and chemotherapy would be valuable.: Objective: This study aims to seek predictors of ... ...

    Abstract Background: Biomarkers predicting clinical outcomes of treating non-small cell lung cancer (NSCLC) with combination of immune checkpoint inhibitors (ICIs) and chemotherapy would be valuable.
    Objective: This study aims to seek predictors of combination of ICI/chemotherapy response in NSCLC patients using peripheral blood samples.
    Methods: Patients diagnosed with advanced NSCLC between July 2019 and May 2021 receiving combination of ICI/chemotherapy were included and assessed for partial responses (PR), stable disease (SD) or progressive disease (PD). We measured circulating immune cells, plasma cytokines and chemokines.
    Results: Nineteen patients were enrolled. The proportions of circulating natural killer (NK) cells within CD45 + cells, programmed death 1 (PD-1) + Tim-3 + T cells within CD4 + cells, and the amount of chemokine C-X-C ligand (CXCL10) in the plasma were significantly elevated in PR relative to SD/PD patients (median 8.1%-vs-2.1%, P= 0.0032; median 1.2%-vs-0.3%, P= 0.0050; and median 122.6 pg/ml-vs-76.0 pg/ml, P= 0.0125, respectively). Patients with 2 or 3 elevated factors had longer progression-free survival than patients with 0 or only one (not reached-vs-5.6 months, P= 0.0002).
    Conclusions: We conclude that NK cells, CD4 + PD-1 + Tim-3 + T cells, and CXCL10 levels in pre-treatment peripheral blood may predict the efficacy of combination of ICI/chemotherapy in NSCLC.
    Language English
    Publishing date 2024-03-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2203517-5
    ISSN 1875-8592 ; 1574-0153 ; 1875-8592
    ISSN (online) 1875-8592 ; 1574-0153
    ISSN 1875-8592
    DOI 10.3233/CBM-230301
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    Zs.A 6127: Show issues Location:
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  7. Article: Current national policies for infant universal bacille Calmette-Guérin vaccination were associated with lower mortality from coronavirus disease 2019.

    Ebina-Shibuya, Risa / Horita, Nobuyuki / Namkoong, Ho / Kaneko, Takeshi

    Clinical and experimental vaccine research

    2020  Volume 9, Issue 2, Page(s) 179–182

    Abstract: An exciting debate has emerged whether bacille Calmette-Guérin (BCG) vaccination is effective for the coronavirus disease 2019 (COVID-19) pandemic. Some advocated that BCG-vaccinated people are less suffered from the virus because BCG vaccination is ... ...

    Abstract An exciting debate has emerged whether bacille Calmette-Guérin (BCG) vaccination is effective for the coronavirus disease 2019 (COVID-19) pandemic. Some advocated that BCG-vaccinated people are less suffered from the virus because BCG vaccination is recommendedin COVID-19 high burden countries. However, the others objected because this seemingly attractive relationship is explainable with confounding factors. In a multiple regression with 171 countries adjusting socioeconomical and climatic covariates, countries with current universal pediatric BCG policy were associated with 30-fold (95% confidence interval, 17-52) decrease of COVID-19 mortality per population compared to countries without the policy.
    Keywords covid19
    Language English
    Publishing date 2020-07-31
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2684652-4
    ISSN 2287-366X ; 2287-3651
    ISSN (online) 2287-366X
    ISSN 2287-3651
    DOI 10.7774/cevr.2020.9.2.179
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  8. Article ; Online: Antibody responses to second doses of COVID-19 vaccination in lung cancer patients undergoing treatment.

    Narita, Daisuke / Ebina-Shibuya, Risa / Miyauchi, Eisaku / Tsukita, Yoko / Saito, Ryota / Murakami, Koji / Kimura, Nozomu / Sugiura, Hisatoshi

    Respiratory investigation

    2022  Volume 61, Issue 2, Page(s) 247–253

    Abstract: Background: Several reports have revealed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection tends to have more severe outcomes in cancer patients. Although vaccination reduces the risk of severe disease, data on antibody titers ...

    Abstract Background: Several reports have revealed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection tends to have more severe outcomes in cancer patients. Although vaccination reduces the risk of severe disease, data on antibody titers achieved by vaccination is scarce in cancer patients.
    Methods: We collected 79 blood samples (69 lung cancer patients and 10 control individuals) and conducted an anti-SARS-CoV-2 antibody assay to compare the antibody titer achieved with current treatment. Sixty-eight patients (86%) received the BNT162 mRNA vaccine and 11 (14%) received the mRNA-1273 vaccine. They were categorized according to the current treatment: control individuals without cancer (cohort A), lung cancer patients who were treated with cytotoxic chemotherapy (cohort B), immunotherapy (cohort C), combination of cytotoxic chemotherapy and immunotherapy (cohort D), tyrosine kinase inhibitors (cohort E), and radiation therapy (cohort F).
    Results: Among 69 lung cancer patients (cohort B-F), 57 (83%) had adenocarcinoma, and 66 (96%) had advanced-stage cancer. In the anti-SARS-CoV-2 antibody assay, the antibody titer was significantly lower in lung cancer patients than in control individuals (p = 0.01). The median antibody titers were 161 AU/ml in control individuals and 59.9 AU/ml in lung cancer patients.
    Conclusions: Antibody titers after the second vaccination were lower in cancer patients than those in healthy individuals. Our findings provide essential information for understanding the benefits and necessity of additional vaccination to prevent SARS-CoV-2 infection in lung cancer patients.
    MeSH term(s) Humans ; COVID-19 Vaccines ; Antibody Formation ; 2019-nCoV Vaccine mRNA-1273 ; COVID-19 ; SARS-CoV-2 ; Lung Neoplasms ; Vaccination ; BNT162 Vaccine
    Chemical Substances COVID-19 Vaccines ; 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4) ; BNT162 Vaccine
    Language English
    Publishing date 2022-12-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2660821-2
    ISSN 2212-5353 ; 2212-5345
    ISSN (online) 2212-5353
    ISSN 2212-5345
    DOI 10.1016/j.resinv.2022.11.005
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  9. Article: National policies for paediatric universal BCG vaccination were associated with decreased mortality due to COVID-19

    Ebina-Shibuya, Risa / Horita, Nobuyuki / Namkoong, Ho / Kaneko, Takeshi

    Respirology

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #603888
    Database COVID19

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  10. Article ; Online: National policies for paediatric universal BCG vaccination were associated with decreased mortality due to COVID ‐19

    Ebina‐Shibuya, Risa / Horita, Nobuyuki / Namkoong, Ho / Kaneko, Takeshi

    Respirology

    2020  Volume 25, Issue 8, Page(s) 898–899

    Keywords Pulmonary and Respiratory Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.13885
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

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