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Article ; Online: Machine Perfusion-Leaving Its Mark on Liver Transplantation.

Richards, James A / Gaurav, Rohit / Upponi, Sara S / Watson, Christopher J E / Butler, Andrew J

2020 Volume 105, Issue 2, Page(s) e28–e29

MeSH term(s)	Donor Selection ; Hepatectomy/adverse effects ; Humans ; Liver/diagnostic imaging ; Liver/pathology ; Liver/surgery ; Liver Transplantation/adverse effects ; Liver Transplantation/instrumentation ; Perfusion/adverse effects ; Perfusion/instrumentation ; Tissue Donors/supply & distribution ; Treatment Outcome ; Waiting Lists
Language	English
Publishing date	2020-12-24
Publishing country	United States
Document type	Letter
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000003462
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Zs.A 488: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 509: Show issues

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Article ; Online: Asparagine Synthetase Marks a Distinct Dependency Threshold for Cardiomyocyte Dedifferentiation.

Circulation

2024

Abstract: Background: Adult mammalian cardiomyocytes have limited proliferative capacity, but in specifically induced contexts they traverse through cell-cycle reentry, offering the potential for heart regeneration. Endogenous cardiomyocyte proliferation is ... ...

Abstract	Background: Adult mammalian cardiomyocytes have limited proliferative capacity, but in specifically induced contexts they traverse through cell-cycle reentry, offering the potential for heart regeneration. Endogenous cardiomyocyte proliferation is preceded by cardiomyocyte dedifferentiation (CMDD), wherein adult cardiomyocytes revert to a less matured state that is distinct from the classical myocardial fetal stress gene response associated with heart failure. However, very little is known about CMDD as a defined cardiomyocyte cell state in transition. Methods: Here, we leveraged 2 models of in vitro cultured adult mouse cardiomyocytes and in vivo adeno-associated virus serotype 9 cardiomyocyte-targeted delivery of reprogramming factors ( Results: RNA sequencing and integrated analysis identified Conclusions: We discovered a novel gene
Language	English
Publishing date	2024-04-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	80099-5
ISSN	1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
ISSN (online)	1524-4539
ISSN	0009-7322 ; 0069-4193 ; 0065-8499
DOI	10.1161/CIRCULATIONAHA.123.063965
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Ui IV Zs.60: Show issues

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Article ; Online: Mitogenomes from two uncommon haplogroups mark late glacial/postglacial expansions from the near east and neolithic dispersals within Europe.

Olivieri, Anna / Pala, Maria / Gandini, Francesca / Hooshiar Kashani, Baharak / Perego, Ugo A / Woodward, Scott R / Grugni, Viola / Battaglia, Vincenza / Semino, Ornella / Achilli, Alessandro / Richards, Martin B / Torroni, Antonio

PloS one

2013 Volume 8, Issue 7, Page(s) e70492

Abstract: The current human mitochondrial (mtDNA) phylogeny does not equally represent all human populations but is biased in favour of representatives originally from north and central Europe. This especially affects the phylogeny of some uncommon West Eurasian ... ...

Abstract	The current human mitochondrial (mtDNA) phylogeny does not equally represent all human populations but is biased in favour of representatives originally from north and central Europe. This especially affects the phylogeny of some uncommon West Eurasian haplogroups, including I and W, whose southern European and Near Eastern components are very poorly represented, suggesting that extensive hidden phylogenetic substructure remains to be uncovered. This study expanded and re-analysed the available datasets of I and W complete mtDNA genomes, reaching a comprehensive 419 mitogenomes, and searched for precise correlations between the ages and geographical distributions of their numerous newly identified subclades with events of human dispersal which contributed to the genetic formation of modern Europeans. Our results showed that haplogroups I (within N1a1b) and W originated in the Near East during the Last Glacial Maximum or pre-warming period (the period of gradual warming between the end of the LGM, ∼19 ky ago, and the beginning of the first main warming phase, ∼15 ky ago) and, like the much more common haplogroups J and T, may have been involved in Late Glacial expansions starting from the Near East. Thus our data contribute to a better definition of the Late and postglacial re-peopling of Europe, providing further evidence for the scenario that major population expansions started after the Last Glacial Maximum but before Neolithic times, but also evidencing traces of diffusion events in several I and W subclades dating to the European Neolithic and restricted to Europe.
MeSH term(s)	Bayes Theorem ; DNA, Mitochondrial/chemistry ; DNA, Mitochondrial/classification ; DNA, Mitochondrial/genetics ; Europe ; Genetic Variation ; Genetics, Population ; Genome, Mitochondrial/genetics ; Geography ; Haplotypes ; Humans ; Middle East ; Molecular Sequence Data ; Phylogeny ; Sequence Analysis, DNA ; Time Factors
Chemical Substances	DNA, Mitochondrial
Language	English
Publishing date	2013-07-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0070492
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Article ; Online: Mitogenomes from two uncommon haplogroups mark late glacial/postglacial expansions from the near east and neolithic dispersals within Europe.

Anna Olivieri / Maria Pala / Francesca Gandini / Baharak Hooshiar Kashani / Ugo A Perego / Scott R Woodward / Viola Grugni / Vincenza Battaglia / Ornella Semino / Alessandro Achilli / Martin B Richards / Antonio Torroni

PLoS ONE, Vol 8, Iss 7, p e

2013 Volume 70492

Abstract	The current human mitochondrial (mtDNA) phylogeny does not equally represent all human populations but is biased in favour of representatives originally from north and central Europe. This especially affects the phylogeny of some uncommon West Eurasian haplogroups, including I and W, whose southern European and Near Eastern components are very poorly represented, suggesting that extensive hidden phylogenetic substructure remains to be uncovered. This study expanded and re-analysed the available datasets of I and W complete mtDNA genomes, reaching a comprehensive 419 mitogenomes, and searched for precise correlations between the ages and geographical distributions of their numerous newly identified subclades with events of human dispersal which contributed to the genetic formation of modern Europeans. Our results showed that haplogroups I (within N1a1b) and W originated in the Near East during the Last Glacial Maximum or pre-warming period (the period of gradual warming between the end of the LGM, ∼19 ky ago, and the beginning of the first main warming phase, ∼15 ky ago) and, like the much more common haplogroups J and T, may have been involved in Late Glacial expansions starting from the Near East. Thus our data contribute to a better definition of the Late and postglacial re-peopling of Europe, providing further evidence for the scenario that major population expansions started after the Last Glacial Maximum but before Neolithic times, but also evidencing traces of diffusion events in several I and W subclades dating to the European Neolithic and restricted to Europe.
Keywords	Medicine ; R ; Science ; Q
Subject code	930
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Author Correction: Macular retinal thickness differs markedly in age-related macular degeneration driven by risk polymorphisms on chromosomes 1 and 10.

Zouache, Moussa A / Bennion, Alex / Hageman, Jill L / Pappas, Christian / Richards, Burt T / Hageman, Gregory S

Scientific reports

2021 Volume 11, Issue 1, Page(s) 11164

Language	English
Publishing date	2021-05-21
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-90883-3
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Article ; Online: Macular retinal thickness differs markedly in age-related macular degeneration driven by risk polymorphisms on chromosomes 1 and 10.

Zouache, Moussa A / Bennion, Alex / Hageman, Jill L / Pappas, Christian / Richards, Burt T / Hageman, Gregory S

Scientific reports

2020 Volume 10, Issue 1, Page(s) 21093

Abstract: The two most common genetic contributors to age-related macular degeneration (AMD), a leading cause of irreversible vision loss worldwide, are variants associated with CFH-CFHR5 on chromosome 1 (Chr1) and ARMS2/HTRA1 on chromosome 10 (Chr10). We sought ... ...

Abstract	The two most common genetic contributors to age-related macular degeneration (AMD), a leading cause of irreversible vision loss worldwide, are variants associated with CFH-CFHR5 on chromosome 1 (Chr1) and ARMS2/HTRA1 on chromosome 10 (Chr10). We sought to determine if risk and protective variants associated with these two loci drive differences in macular retinal thickness prior and subsequent to the onset of clinically observable signs of AMD. We considered 299 individuals (547 eyes) homozygous for risk variants or haplotypes on Chr1 or Chr10 exclusively (Chr1-risk and Chr10-risk, respectively) or homozygous for a neutral haplotype (Chr1-neu), for the protective I62 tagged haplotype (Chr1-prot-I62) or for the protection conferring CFHR1/3 deletion haplotype (Chr1-prot-del) on Chr1 without any risk alleles on Chr10. Among eyes with no clinically observable signs of AMD, the deletion of CFHR1/3, which is strongly protective against this disease, is associated with significantly thicker retinas in the perifovea. When controlling for age, Chr10-risk eyes with early or intermediate AMD have thinner retinas as compared to eyes from the Chr1-risk group with similar disease severity. Our analysis indicates that this difference likely results from distinct biological and disease initiation and progression events associated with Chr1- and Chr10-directed AMD.
MeSH term(s)	Aged ; Aged, 80 and over ; Chromosomes, Human, Pair 1/genetics ; Chromosomes, Human, Pair 10/genetics ; Complement Factor H/genetics ; Complement System Proteins/genetics ; Female ; High-Temperature Requirement A Serine Peptidase 1/genetics ; Humans ; Macular Degeneration/diagnostic imaging ; Macular Degeneration/genetics ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Proteins/genetics ; Retina/diagnostic imaging
Chemical Substances	ARMS2 protein, human ; CFHR5 protein, human ; Proteins ; Complement Factor H (80295-65-4) ; Complement System Proteins (9007-36-7) ; High-Temperature Requirement A Serine Peptidase 1 (EC 3.4.21.-) ; HTRA1 protein, human (EC 3.4.21.-)
Language	English
Publishing date	2020-12-03
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-78059-x
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Article: Not all who wander are lost: nest fidelity in Xylocopa virginica examined by mark recapture

Peso, M / Richards, M. H

Insectes sociaux. 2011 Feb., v. 58, no. 1

2011

Abstract: ... and male bees were trapped at nest entrances, individually paint marked, and then released. Subsequent ...

Abstract	Relocation to novel nests (sometimes called drifting) in flying Hymenoptera is often interpreted as the result of navigation error and guard bees erroneously admitting foreign individuals into the nest. We studied nest fidelity and nest relocation of both females and males in a nesting aggregation of Xylocopa virginica in southern Ontario, Canada, where females can nest either solitarily or socially. Adult female and male bees were trapped at nest entrances, individually paint marked, and then released. Subsequent recapture patterns were used to assess nest fidelity: that is, how faithful individuals were to their home nest and how often they moved to another nest. Bees were considered to have relocated if they were recaptured in a nest different from the one in which they were initially trapped, indicating that they had spent at least one night in a new nest. Some females were only captured in one nest, some occasionally moved to new nests, temporarily or permanently, and a few were never caught in the same nest twice. In addition, females relocated to nests that were further away in 2007 when population density was low, suggesting that they seek out and claim nesting spaces when they are available. Males relocated more frequently than females, with most drifting from nest to nest in no obvious pattern. This indicates that males spend the night wherever space is available or in nests nearest to their territories. This study reveals that for both female and male X. virginica, nest membership is not as stable as once thought.
Keywords	nests
Language	English
Dates of publication	2011-02
Size	p. 127-133.
Publisher	SP Birkhäuser Verlag Basel
Publishing place	Basel
Document type	Article
ZDB-ID	218790-5
ISSN	1420-9098 ; 0020-1812
ISSN (online)	1420-9098
ISSN	0020-1812
DOI	10.1007/s00040-010-0125-y
Database	NAL-Catalogue (AGRICOLA)

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INRES, Ökologie der Kulturlandschaft und Naturschutz, Tierökologie, Melbweg 42: Show issues

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Article ; Online: Plasma markers to risk stratify for heart failure in atrial fibrillation.

Richards, A Mark

European journal of heart failure

2023 Volume 25, Issue 6, Page(s) 842–844

MeSH term(s)	Humans ; Atrial Fibrillation/complications ; Heart Failure ; Risk Factors
Language	English
Publishing date	2023-06-04
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	1483672-5
ISSN	1879-0844 ; 1388-9842
ISSN (online)	1879-0844
ISSN	1388-9842
DOI	10.1002/ejhf.2885
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Zs.A 5299: Show issues

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Article: Epigenetic marks in melanoma.

Richards, Hunter W / Medrano, Estela E

Pigment cell & melanoma research

2009 Volume 22, Issue 1, Page(s) 14–29

Abstract: ... in the current decade. In prostate and other cancers, some histone marks have clinical diagnostic and/or ...

Abstract	Melanoma is a highly heterogeneous cancer that comes in different flavors (lentigo maligna melanoma, superficial spreading melanoma, nodular melanoma, acral lentiginous/mucosal melanoma and other less common subtypes including malignant cellular blue nevus, desmoplastic melanoma, nevoid melanoma, and animal-type melanoma) and colors (black/bluish or unpigmented). Pathologists have known for many years that melanoma displays notable changes in the nuclear architecture including thick chromatic rims, presence of mitosis, nuclear grooves, and more. It is now evident from other cancers that such changes reflect not only genomic alterations but also non-genomic changes in both the structure of DNA and the structure of chromatin to which the DNA is bound (nucleosomes). Although aberrant gene expression resulting from DNA methylation has been known for many years, genome alterations resulting from histone modifications became evident in the current decade. In prostate and other cancers, some histone marks have clinical diagnostic and/or prognostic value. Here, we review the current data on epigenetic research in melanoma skin cancers, discuss ways to modify the epigenetic landscape of melanoma for inhibiting its growth, and propose strategies for identifying novel melanoma markers.
MeSH term(s)	Epigenesis, Genetic ; Humans ; Melanoma/genetics
Language	English
Publishing date	2009-02
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2409570-9
ISSN	1755-148X ; 1600-0749 ; 1755-1471 ; 0893-5785
ISSN (online)	1755-148X ; 1600-0749
ISSN	1755-1471 ; 0893-5785
DOI	10.1111/j.1755-148X.2008.00534.x
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Article ; Online: Enduring epigenetic landmarks define the cancer microenvironment.

Pidsley, Ruth / Lawrence, Mitchell G / Zotenko, Elena / Niranjan, Birunthi / Statham, Aaron / Song, Jenny / Chabanon, Roman M / Qu, Wenjia / Wang, Hong / Richards, Michelle / Nair, Shalima S / Armstrong, Nicola J / Nim, Hieu T / Papargiris, Melissa / Balanathan, Preetika / French, Hugh / Peters, Timothy / Norden, Sam / Ryan, Andrew /

Pedersen, John / Kench, James / Daly, Roger J / Horvath, Lisa G / Stricker, Phillip / Frydenberg, Mark / Taylor, Renea A / Stirzaker, Clare / Risbridger, Gail P / Clark, Susan J

Genome research

2018 Volume 28, Issue 5, Page(s) 625–638

Abstract: ... a novel epigenetic hallmark of the cancer microenvironment and promises new biomarkers to improve ...

Abstract	The growth and progression of solid tumors involves dynamic cross-talk between cancer epithelium and the surrounding microenvironment. To date, molecular profiling has largely been restricted to the epithelial component of tumors; therefore, features underpinning the persistent protumorigenic phenotype of the tumor microenvironment are unknown. Using whole-genome bisulfite sequencing, we show for the first time that cancer-associated fibroblasts (CAFs) from localized prostate cancer display remarkably distinct and enduring genome-wide changes in DNA methylation, significantly at enhancers and promoters, compared to nonmalignant prostate fibroblasts (NPFs). Differentially methylated regions associated with changes in gene expression have cancer-related functions and accurately distinguish CAFs from NPFs. Remarkably, a subset of changes is shared with prostate cancer epithelial cells, revealing the new concept of tumor-specific epigenome modifications in the tumor and its microenvironment. The distinct methylome of CAFs provides a novel epigenetic hallmark of the cancer microenvironment and promises new biomarkers to improve interpretation of diagnostic samples.
MeSH term(s)	Cancer-Associated Fibroblasts/metabolism ; Cells, Cultured ; DNA Methylation ; Epigenomics/methods ; Fibroblasts/metabolism ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Genome, Human/genetics ; Humans ; Male ; Promoter Regions, Genetic/genetics ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/pathology ; Tumor Microenvironment/genetics ; Whole Genome Sequencing/methods
Language	English
Publishing date	2018-04-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1284872-4
ISSN	1549-5469 ; 1088-9051 ; 1054-9803
ISSN (online)	1549-5469
ISSN	1088-9051 ; 1054-9803
DOI	10.1101/gr.229070.117
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Zs.A 3729: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 8: Show issues

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