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  1. Article ; Online: Natural Products as Enzyme Inhibitors in Drug Design and Discovery.

    Orhan, Ilkay Erdogan

    Current topics in medicinal chemistry

    2022  Volume 22, Issue 3, Page(s) 188

    MeSH term(s) Biological Products/pharmacology ; Drug Design ; Enzyme Inhibitors/pharmacology
    Chemical Substances Biological Products ; Enzyme Inhibitors
    Language English
    Publishing date 2022-03-15
    Publishing country United Arab Emirates
    Document type Editorial
    ZDB-ID 2064823-6
    ISSN 1873-4294 ; 1568-0266
    ISSN (online) 1873-4294
    ISSN 1568-0266
    DOI 10.2174/156802662203220209154741
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5572: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Deciphering Neuroprotective Effect of Rosmarinus officinalis L. (syn. Salvia rosmarinus Spenn.) through Preclinical and Clinical Studies.

    Oresanya, Ibukun O / Orhan, Ilkay Erdogan

    Current drug targets

    2024  

    Abstract: Rosmarinus officinalis L. (RO, rosemary) is a well-known medicinal, aromatic, and culinary herb with traditional use in European folk medicine against memory deficits and neurodegenerative disorders. This review highlights the different neuroprotective ... ...

    Abstract Rosmarinus officinalis L. (RO, rosemary) is a well-known medicinal, aromatic, and culinary herb with traditional use in European folk medicine against memory deficits and neurodegenerative disorders. This review highlights the different neuroprotective activities of RO investigated in both preclinical and clinical studies, as well as in silico molecular docking of bioactive compounds found in RO. The neuroprotective effect of RO was searched through databases including PubMed, Web of Science (WoS), Scopus, and Clinical Trials using the keywords "Rosmarinus officinalis, rosemary, neuroprotective effect, memory, cognitive dysfunction, Alzheimer's disease." RO, which is rich in secondary metabolites that have memory-enhancing potential, has displayed neuroprotection through different molecular mechanisms such as inhibition of cholinesterase, modulation of dopaminergic and oxytocinergic systems, mediation of oxidative and inflammatory proteins, involved in neuropathic pain, among others. RO extracts exhibited antidepressant and anxiolytic activities. Also, the plant has shown efficacy in scopolamine-, lipopolysaccharide-, AlCl3 -, and H2O2 -induced amnesia as well as amyloid-beta- and ibotenic acid-induced neurotoxicity and chronic constriction injury-related oxidative stress memory and cognitive impairments in animal models. A few clinical studies available supported the neuroprotective effects of RO and its constituents. However, more clinical studies are needed to confirm results from preclinical studies further and should include not only placebo-controlled studies but also studies including positive controls using approved drugs. Many studies underlined that constituents of RO may have the potential for developing drug candidates against Alzheimer's disease that possess high bioavailability, low toxicity, and enhanced penetration to CNS, as revealed from the experimental and molecular docking analysis.
    Language English
    Publishing date 2024-01-22
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2064859-5
    ISSN 1873-5592 ; 1389-4501
    ISSN (online) 1873-5592
    ISSN 1389-4501
    DOI 10.2174/0113894501255093240117092328
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5578: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article: A Focused Review on Cognitive Improvement by the Genus

    Ertas, Abdulselam / Yigitkan, Serkan / Orhan, Ilkay Erdogan

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 2

    Abstract: Ethnopharmacology has been an important starting point in medical and pharmaceutical sciences for discovering drug candidates from natural sources. In this regard, the ... ...

    Abstract Ethnopharmacology has been an important starting point in medical and pharmaceutical sciences for discovering drug candidates from natural sources. In this regard, the genus
    Language English
    Publishing date 2023-01-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16020171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: African Under-Utilized Medicinal Leafy Vegetables Studied by Microtiter Plate Assays and High-Performance Thin-Layer Chromatography-Planar Assays.

    Oresanya, Ibukun O / Orhan, Ilkay Erdogan / Heil, Julia / Morlock, Gertrud E

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 3

    Abstract: Biological activities of six under-utilized medicinal leafy vegetable plants indigenous to Africa, ...

    Abstract Biological activities of six under-utilized medicinal leafy vegetable plants indigenous to Africa,
    MeSH term(s) Antioxidants/chemistry ; Butyrylcholinesterase ; Vegetables ; Chromatography, Thin Layer ; Acetylcholinesterase ; Monophenol Monooxygenase ; Plants, Medicinal/chemistry ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Anti-Infective Agents/analysis
    Chemical Substances Antioxidants ; Butyrylcholinesterase (EC 3.1.1.8) ; Acetylcholinesterase (EC 3.1.1.7) ; Monophenol Monooxygenase (EC 1.14.18.1) ; Plant Extracts ; Anti-Infective Agents
    Language English
    Publishing date 2024-02-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29030733
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Show issues

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  5. Article ; Online: Enzyme Inhibitors as the Attractive Targets for the Treatment of Various Diseases.

    Orhan, Ilkay Erdogan

    Current medicinal chemistry

    2019  Volume 26, Issue 18, Page(s) 3206–3207

    MeSH term(s) Disease ; Drug Discovery ; Drug Therapy ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/therapeutic use ; Humans
    Chemical Substances Enzyme Inhibitors
    Language English
    Publishing date 2019-09-13
    Publishing country United Arab Emirates
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/092986732618190821115641
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4432: Show issues Location:
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  6. Article ; Online: Cholinesterase Inhibitory Potential of Quercetin towards Alzheimer's Disease - A Promising Natural Molecule or Fashion of the Day? - A Narrowed Review.

    Orhan, Ilkay Erdogan

    Current neuropharmacology

    2020  Volume 19, Issue 12, Page(s) 2205–2213

    Abstract: Natural substances are known to have strong protective effects against neurodegenerative diseases. Among them, phenolic compounds, especially flavonoids, come to the fore with their neuroprotective effects. Since quercetin, which is found in many ... ...

    Abstract Natural substances are known to have strong protective effects against neurodegenerative diseases. Among them, phenolic compounds, especially flavonoids, come to the fore with their neuroprotective effects. Since quercetin, which is found in many medicinal plants and foods, is also taken through diet, its physiological effects on humans are imperative. Many studies have been published up to date on the neuroprotective properties of quercetin, a flavanol derivative. However, there is no review published so far summarizing the effect of quercetin on the cholinesterase (ChE) enzymes related to the cholinergic hypothesis, which is one of the pathological mechanisms of Alzheimer's Disease (AD). However, ChE inhibitors, regardless of natural or synthetic, play a vital role in the treatment of AD. Although the number of studies on the ChE inhibitory effect of quercetin is limited, it deserves to be discussed in a review article. With this sensitivity, the neuroprotective effect of quercetin against AD through ChE inhibition was scrutinized in the current review study. In addition, studies on the bioavailability of quercetin and its capacity to cross the blood-brain barrier and how this capacity and bioavailability can be increased were given. Generally, studies containing data published in recent years were obtained from search engines such as PubMed, Scopus, and Medline and included herein. Consequently, quercetin should not be considered as a fashionable natural compound and should be identified as a promising compound, especially with increased bioavailability, for the treatment of AD.
    MeSH term(s) Alzheimer Disease/drug therapy ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/therapeutic use ; Cholinesterases/therapeutic use ; Humans ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Quercetin/pharmacology ; Quercetin/therapeutic use
    Chemical Substances Cholinesterase Inhibitors ; Neuroprotective Agents ; Quercetin (9IKM0I5T1E) ; Cholinesterases (EC 3.1.1.8)
    Language English
    Publishing date 2020-11-19
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2192352-8
    ISSN 1875-6190 ; 1570-159X
    ISSN (online) 1875-6190
    ISSN 1570-159X
    DOI 10.2174/1570159X18666201119153807
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6150: Show issues Location:
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  7. Article ; Online: Flavonoids as Sirtuin Modulators.

    Deniz, Fatma Sezer Şenol / Eren, Gökçen / Orhan, Ilkay Erdogan

    Current topics in medicinal chemistry

    2022  Volume 22, Issue 9, Page(s) 790–805

    Abstract: Sirtuins (SIRTs) are described as ... ...

    Abstract Sirtuins (SIRTs) are described as NAD
    MeSH term(s) Animals ; Apoptosis ; Flavonoids/pharmacology ; Humans ; Resveratrol ; Sirtuins/metabolism
    Chemical Substances Flavonoids ; Sirtuins (EC 3.5.1.-) ; Resveratrol (Q369O8926L)
    Language English
    Publishing date 2022-05-03
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2064823-6
    ISSN 1873-4294 ; 1568-0266
    ISSN (online) 1873-4294
    ISSN 1568-0266
    DOI 10.2174/1568026622666220422094744
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5572: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Kombucha - An ancient fermented beverage with desired bioactivities: A narrowed review.

    Abaci, Nurten / Senol Deniz, Fatma Sezer / Orhan, Ilkay Erdogan

    Food chemistry: X

    2022  Volume 14, Page(s) 100302

    Abstract: Kombucha, originated in China 2000  years ago, is a sour and sweet-tasted drink, prepared traditionally through fermentation of black tea. During the fermentation of kombucha, consisting of mainly acidic compounds, microorganisms, and a tiny amount of ... ...

    Abstract Kombucha, originated in China 2000  years ago, is a sour and sweet-tasted drink, prepared traditionally through fermentation of black tea. During the fermentation of kombucha, consisting of mainly acidic compounds, microorganisms, and a tiny amount of alcohol, a biofilm called SCOBY forms. The bacteria in kombucha has been generally identified as Acetobacteraceae. Kombucha is a noteworthy source of B complex vitamins, polyphenols, and organic acids (mainly acetic acid). Nowadays, kombucha is tended to be prepared with some other plant species, which, therefore, lead to variations in its composition. Pre-clinical studies conducted on kombucha revealed that it has desired bioactivities such as antimicrobial, antioxidant, hepatoprotective, anti-hypercholestorelomic, anticancer, anti-inflammatory, etc. Only a few clinical studies have been also reported. In the current review, we aimed to overhaul pre-clinical bioactivities reported on kombucha as well as its brief compositional chemistry. The literature data indicate that kombucha has valuable biological effects on human health.
    Language English
    Publishing date 2022-04-06
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2590-1575
    ISSN (online) 2590-1575
    DOI 10.1016/j.fochx.2022.100302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Bay Leaf (

    Brinza, Ion / Boiangiu, Razvan Stefan / Hancianu, Monica / Cioanca, Oana / Erdogan Orhan, Ilkay / Hritcu, Lucian

    Antioxidants (Basel, Switzerland)

    2021  Volume 10, Issue 2

    Abstract: Bay leaf ( ...

    Abstract Bay leaf (
    Language English
    Publishing date 2021-02-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10020259
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  10. Article: Chemical Composition, Antioxidant and Anti-Enzymatic Activity of Golden Root (

    Polumackanycz, Milena / Konieczynski, Pawel / Orhan, Ilkay Erdogan / Abaci, Nurten / Viapiana, Agnieszka

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 5

    Abstract: The aim of the study was to compare the chemical composition of the water and hydromethanolic extracts ... ...

    Abstract The aim of the study was to compare the chemical composition of the water and hydromethanolic extracts of
    Language English
    Publishing date 2022-05-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11050919
    Database MEDical Literature Analysis and Retrieval System OnLINE

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