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  1. Book ; Conference proceedings: Hepatocellular carcinoma

    Seeff, Leonard B.

    screening, diagnosis and management ; proceedings of workshop, April 1 - 3, 2004, National Institute of Health, Bethesda, Maryland

    (Gastroenterology ; 127,5, Suppl. 1)

    2004  

    Institution National Institute of Health
    Event/congress Workshop Entitled Hepatocellular Carcinoma: Screening, Diagnosis, and Management (2004, BethesdaMd.)
    Author's details [Workshop Entitled Hepatocellular Carcinoma: Screening, Diagnosis, and Management]. Ed.: Leonard B. Seeff
    Series title Gastroenterology ; 127,5, Suppl. 1
    Collection
    Language English
    Size S323 S. : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT014195299
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ui V Zs 44 -127,5,Suppl.1- verfügbar in Königswinter Königswinter

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  2. Article: The Origins of the Modern-Day Study of Drug Hepatotoxicity: Focus on Hyman J. Zimmerman.

    Lewis, James H / Seeff, Leonard B

    Clinical liver disease

    2020  Volume 15, Issue Suppl 1, Page(s) S25–S36

    Language English
    Publishing date 2020-03-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2657644-2
    ISSN 2046-2484
    ISSN 2046-2484
    DOI 10.1002/cld.856
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Drug-Induced Liver Injury Is a Major Risk for New Drugs.

    Seeff, Leonard B

    Digestive diseases (Basel, Switzerland)

    2015  Volume 33, Issue 4, Page(s) 458–463

    Abstract: Drug-induced liver injury (DILI), a relatively rare condition, is nevertheless a major reason for not approving a drug in development or for removing one already marketed. With a specific diagnostic biomarker lacking, finding elevated serum enzyme [ ... ...

    Abstract Drug-induced liver injury (DILI), a relatively rare condition, is nevertheless a major reason for not approving a drug in development or for removing one already marketed. With a specific diagnostic biomarker lacking, finding elevated serum enzyme [alanine aminotransferase (ALT), aspartate aminotransferase and alkaline phosphatase] activities remains an initial signal for incipient liver injury. Enzyme elevations alone may not be harmful, but if caused by a drug and followed by jaundice (called 'Hy's law') there is a high possibility of serious DILI. In 1997 several drugs were approved by the Food and Drug Administration (FDA) of the USA that were later withdrawn from the market for serious liver toxicity. New drugs in development are now required to be monitored for liver injury, and the data is to be considered in the approval decision. A program called e-DISH (evaluation of drug-induced serious hepatotoxicity) was introduced in 2004 to aid medical reviewers to select from all subjects studied those few who show nontrivial liver injury and estimate the most likely cause. The threshold of enzyme elevation comprising a warning for possibly serious DILI is uncertain, although generally accepted as 3-5 times the 'upper limit of normal'. The new direct-acting antiviral agents for treating chronic hepatitis C virus, which often lead to a reduction of elevated ALTs, mandate that a later increase without viral breakthrough be compared to the new on-treatment level of values. The drug may be discontinued or interrupted for evaluation to exclude other possible causes of liver injury. The FDA has approved no drug since 1997 that has been withdrawn later because of serious hepatotoxicity.
    MeSH term(s) Alanine Transaminase/blood ; Alkaline Phosphatase/blood ; Aspartate Aminotransferases/blood ; Chemical and Drug Induced Liver Injury/blood ; Chemical and Drug Induced Liver Injury/diagnosis ; Drug Approval/methods ; Drug Evaluation/methods ; Humans ; Liver Function Tests ; United States
    Chemical Substances Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2) ; Alkaline Phosphatase (EC 3.1.3.1)
    Language English
    Publishing date 2015
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 632798-9
    ISSN 1421-9875 ; 0257-2753
    ISSN (online) 1421-9875
    ISSN 0257-2753
    DOI 10.1159/000374089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1853: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Sustained virologic response: is this equivalent to cure of chronic hepatitis C?

    Seeff, Leonard B

    Hepatology (Baltimore, Md.)

    2013  Volume 57, Issue 2, Page(s) 438–440

    MeSH term(s) Animals ; Female ; Hepacivirus/genetics ; Hepatitis C, Chronic/virology ; Humans ; Leukocytes, Mononuclear/virology ; Male ; RNA, Viral/blood
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2013-02
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.25964
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1660: Show issues Location:
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  5. Article: Complementary and alternative medicines for hepatic disease.

    Seeff, Leonard B

    Gastroenterology & hepatology

    2012  Volume 4, Issue 1, Page(s) 33–35

    Language English
    Publishing date 2012-06-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2386402-3
    ISSN 1554-7914
    ISSN 1554-7914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 517: Show issues

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  6. Article: Drug-Induced Liver Injury Is a Major Risk for New Drugs

    Seeff, Leonard B.

    Digestive Diseases

    2015  Volume 33, Issue 4, Page(s) 458–463

    Abstract: Drug-induced liver injury (DILI), a relatively rare condition, is nevertheless a major reason for not approving a drug in development or for removing one already marketed. With a specific diagnostic biomarker lacking, finding elevated serum enzyme [ ... ...

    Institution Einstein Healthcare Network, Philadelphia, Pa., USA
    Abstract Drug-induced liver injury (DILI), a relatively rare condition, is nevertheless a major reason for not approving a drug in development or for removing one already marketed. With a specific diagnostic biomarker lacking, finding elevated serum enzyme [alanine aminotransferase (ALT), aspartate aminotransferase and alkaline phosphatase] activities remains an initial signal for incipient liver injury. Enzyme elevations alone may not be harmful, but if caused by a drug and followed by jaundice (called ‘Hy's law') there is a high possibility of serious DILI. In 1997 several drugs were approved by the Food and Drug Administration (FDA) of the USA that were later withdrawn from the market for serious liver toxicity. New drugs in development are now required to be monitored for liver injury, and the data is to be considered in the approval decision. A program called e-DISH (evaluation of drug-induced serious hepatotoxicity) was introduced in 2004 to aid medical reviewers to select from all subjects studied those few who show nontrivial liver injury and estimate the most likely cause. The threshold of enzyme elevation comprising a warning for possibly serious DILI is uncertain, although generally accepted as 3-5 times the ‘upper limit of normal'. The new direct-acting antiviral agents for treating chronic hepatitis C virus, which often lead to a reduction of elevated ALTs, mandate that a later increase without viral breakthrough be compared to the new on-treatment level of values. The drug may be discontinued or interrupted for evaluation to exclude other possible causes of liver injury. The FDA has approved no drug since 1997 that has been withdrawn later because of serious hepatotoxicity.
    Keywords Causality assessment ; e-DISH ; Drug-induced liver injury ; Food and Drug Administration ; Hyߣs law
    Language English
    Publishing date 2015-07-06
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Understanding the Problem of DILI
    ZDB-ID 632798-9
    ISBN 978-3-318-05446-0 ; 978-3-318-05447-7 ; 3-318-05446-1 ; 3-318-05447-X
    ISSN 1421-9875 ; 0257-2753
    ISSN (online) 1421-9875
    ISSN 0257-2753
    DOI 10.1159/000374089
    Database Karger publisher's database

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  7. Article: Are herbals as safe as their advocates believe?

    Seeff, Leonard B

    Journal of hepatology

    2009  Volume 50, Issue 1, Page(s) 13–16

    MeSH term(s) Chronic Disease ; Complementary Therapies/adverse effects ; Hepatitis/etiology ; Herbal Medicine ; Humans ; Liver Cirrhosis/etiology ; Liver Diseases/therapy ; Nutrition Surveys ; United States ; United States Food and Drug Administration
    Language English
    Publishing date 2009-01
    Publishing country Netherlands
    Document type Comment ; Editorial
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2008.10.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: A brief history of the treatment of viral hepatitis C.

    Strader, Doris B / Seeff, Leonard B

    Clinical liver disease

    2012  Volume 1, Issue 1, Page(s) 6–11

    Language English
    Publishing date 2012-03-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2657644-2
    ISSN 2046-2484
    ISSN 2046-2484
    DOI 10.1002/cld.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The history of the "natural history" of hepatitis C (1968-2009).

    Seeff, Leonard B

    Liver international : official journal of the International Association for the Study of the Liver

    2008  Volume 29 Suppl 1, Page(s) 89–99

    Abstract: In the late 1960's, only types A and B hepatitis were believed to exist, distinguished ... begun with the belief that hepatitis B would be responsible should transfusion-associated hepatitis ... develop. After discovery of the viruses of hepatitis A and B, neither agent was found responsible ...

    Abstract In the late 1960's, only types A and B hepatitis were believed to exist, distinguished by circumstances of exposure and incubation periods. In the early 1970's, studies of transfusion recipients were begun with the belief that hepatitis B would be responsible should transfusion-associated hepatitis develop. After discovery of the viruses of hepatitis A and B, neither agent was found responsible, hence non-A, non-B (NANB) hepatitis. Initial follow-up of these cases showed that approximately 50% developed chronic hepatitis based on persistence of serum enzymes for at least 6 months. Approximately 15 years later, after the hepatitis C virus had been identified as the cause for NANB hepatitis, chronic hepatitis was found to develop more frequently as indicated by persistent viral infection in over 80% of infected adults but in only about 50% of infected children or young women. Follow-up over 2 to 4 decades indicated that many infected persons developed progressive hepatic fibrosis, sometimes culminating in cirrhosis and/or liver cancer. Long-term natural history studies have proved to be challenging because disease onset is often silent and progression extremely slow. Differing strategies have been used to determine the natural history, the descriptions and results of which are presented in this review.
    MeSH term(s) Disease Progression ; Genotype ; Hepacivirus/genetics ; Hepatitis C/history ; Hepatitis C/physiopathology ; History, 20th Century ; History, 21st Century ; Humans ; Risk Factors
    Language English
    Publishing date 2008-12-10
    Publishing country United States
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/j.1478-3231.2008.01927.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Liver injury induced by herbal complementary and alternative medicine.

    Navarro, Victor J / Seeff, Leonard B

    Clinics in liver disease

    2013  Volume 17, Issue 4, Page(s) 715–35, x

    Abstract: Herbal and dietary supplement use is common. Most marketed products consist of complex mixtures. Although they are perceived as safe, instances of hepatotoxicity attributable to these products underscore their potential for injury, but the exact ... ...

    Abstract Herbal and dietary supplement use is common. Most marketed products consist of complex mixtures. Although they are perceived as safe, instances of hepatotoxicity attributable to these products underscore their potential for injury, but the exact component that is responsible for injury is difficult to discern. The lenient regulatory environment in the United States, which opens the possibility of adulteration and contamination, adds to the challenge of disease attribution. Although many different herbal and dietary supplements have been reported to cause liver injury, in the United States, products used for bodybuilding and weight loss are the most commonly implicated.
    MeSH term(s) Chemical and Drug Induced Liver Injury/etiology ; Complementary Therapies/adverse effects ; Dietary Supplements/adverse effects ; Humans ; Plant Preparations/adverse effects ; United States
    Chemical Substances Plant Preparations
    Language English
    Publishing date 2013-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1472315-3
    ISSN 1557-8224 ; 1089-3261
    ISSN (online) 1557-8224
    ISSN 1089-3261
    DOI 10.1016/j.cld.2013.07.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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