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Article ; Online: Cervicofacial Emphysema, Pneumomediastinum and Pneumothorax Caused by a Dental Procedure.

Paschos, Konstantinos A / Chatzigeorgiadis, Anestis

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

2019 Volume 29, Issue 2, Page(s) 191–192

MeSH term(s)	Adolescent ; Emergency Service, Hospital ; Female ; Follow-Up Studies ; Head/diagnostic imaging ; Humans ; Mediastinal Emphysema/diagnostic imaging ; Mediastinal Emphysema/etiology ; Mediastinal Emphysema/physiopathology ; Multidetector Computed Tomography/methods ; Neck/diagnostic imaging ; Pakistan ; Pneumothorax/diagnostic imaging ; Pneumothorax/etiology ; Pneumothorax/physiopathology ; Remission, Spontaneous ; Subcutaneous Emphysema/diagnostic imaging ; Subcutaneous Emphysema/etiology ; Subcutaneous Emphysema/physiopathology ; Tooth Extraction/adverse effects ; Tooth Extraction/methods
Language	English
Publishing date	2019-01-30
Publishing country	Pakistan
Document type	Case Reports ; Journal Article
ZDB-ID	2276646-7
ISSN	1681-7168 ; 1022-386X
ISSN (online)	1681-7168
ISSN	1022-386X
DOI	10.29271/jcpsp.2019.02.191
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Zs.A 6532: Show issues

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Article: Pathophysiological and clinical aspects of the diagnosis and treatment of bezoars.

Paschos, Konstantinos A / Chatzigeorgiadis, Anestis

Annals of gastroenterology

2019 Volume 32, Issue 3, Page(s) 224–232

Abstract: Bezoars are intraluminal conglomerates of indigestible foreign materials that accumulate in the gastrointestinal (GI) tract. They consist of vegetable or fruit fibers, hairs or other substances; accordingly, bezoars are classified as phytobezoars, ... ...

Abstract	Bezoars are intraluminal conglomerates of indigestible foreign materials that accumulate in the gastrointestinal (GI) tract. They consist of vegetable or fruit fibers, hairs or other substances; accordingly, bezoars are classified as phytobezoars, trichobezoars, pharmacobezoars, etc. Although sometimes asymptomatic, bezoars may cause serious symptoms, such as abdominal discomfort or pain, dysphagia, hematemesis, or even life-threatening entities (GI bleeding, obstruction or perforation). Current technological applications have contributed to the diagnostic and therapeutic approach to these masses, mainly through endoscopic techniques able to diagnose, fragment and extract bezoars, as well as laparoscopic and other surgical modalities that may be used to treat serious complications. Although bezoars were described centuries ago and the term was officially introduced in the mid nineties by Quain, they are still a demanding pathological entity. Their pathophysiology, accurate and prompt diagnosis, as well as successful and minimally invasive treatment, remain under investigation and see continuous progress. Current advances in these challenging areas are discussed in this review, which attempts to present an in-depth study of bezoars along with the well-established modalities and techniques.
Language	English
Publishing date	2019-03-15
Publishing country	Greece
Document type	Journal Article ; Review
ZDB-ID	2032850-3
ISSN	1108-7471
ISSN	1108-7471
DOI	10.20524/aog.2019.0370
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Zs.A 2455: Show issues

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Article: Surgical and Endoscopic Treatment of a Double Phytobezoar Causing Ileus and Jaundice: A Case Report.

Paschos, Konstantinos A / Chatzigeorgiadis, Anestis

Iranian journal of medical sciences

2019 Volume 44, Issue 1, Page(s) 70–73

Abstract: Bezoars are rare conditions of mechanical intestinal occlusion. Among the various types of bezoars, phytobezoars and trichobezoars are the most common types. Symptoms are usually indistinguishable from other more common entities; therefore, it may be ... ...

Abstract	Bezoars are rare conditions of mechanical intestinal occlusion. Among the various types of bezoars, phytobezoars and trichobezoars are the most common types. Symptoms are usually indistinguishable from other more common entities; therefore, it may be difficult to reach a correct diagnosis. Computed tomography (CT) scan is the preferred diagnostic method. Treatment may include surgery, lavage with Coca-Cola or hydrolytic solutions, and endoscopic mechanical or electrical disintegration. The present case report aimed to describe an uncommon symptomatic double phytobezoar (ileal and gastric), which was successfully treated surgically and endoscopically. The patient, an 83-year-old woman, was admitted to the General Hospital of Drama (Drama, Greece) after suffering from abdominal pain for 3 days. Physical examination revealed abdominal distention and pain mainly in the right quadrants. The CT scan revealed an intestinal phytobezoar which was subsequently removed surgically with a longitudinal enterotomy. On the third postoperative day, the patient presented jaundice and a new CT scan showed a second phytobezoar impacted into the duodenal bulb, which was missed during the initial diagnosis. The gastric phytobezoar was fragmented endoscopically using a polypectomy snare with high flow electric current (70-80 Watts) and its pieces were removed orally. The patient had no complications during the hospital stay and was discharged on the eighth postoperative day. Three months later, the follow-up gastroduodenoscopy and CT scan revealed no signs or symptoms of any gastrointestinal mass. The present case report is the first presentation of a double gastrointestinal phytobezoar that caused ileus and temporary jaundice. Moreover, a successful single-session mechanical-electrical fragmentation of a large gastric phytobezoar is described for the first time.
Language	English
Publishing date	2019-01-21
Publishing country	Iran
Document type	Case Reports
ZDB-ID	603872-4
ISSN	1735-3688 ; 0253-0716
ISSN (online)	1735-3688
ISSN	0253-0716
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Article ; Online: Surgical and Endoscopic Treatment of a Double Phytobezoar Causing Ileus and Jaundice

Konstantinos A Paschos / Anestis Chatzigeorgiadis

Iranian Journal of Medical Sciences, Vol 44, Iss 1, Pp 70-

A Case Report

2019 Volume 73

Abstract	Bezoars are rare conditions of mechanical intestinal occlusion. Among the various types of bezoars, phytobezoars and trichobezoars are the most common types. Symptoms are usually indistinguishable from other more common entities; therefore, it may be difficult to reach a correct diagnosis. Computed tomography (CT) scan is the preferred diagnostic method. Treatment may include surgery, lavage with Coca-Cola or hydrolytic solutions, and endoscopic mechanical or electrical disintegration.The present case report aimed to describe an uncommon symptomatic double phytobezoar (ileal and gastric), which was successfully treated surgically and endoscopically. The patient, an 83-year-old woman, was admitted to the General Hospital of Drama (Drama, Greece) after suffering from abdominal pain for 3 days. Physical examination revealed abdominal distention and pain mainly in the right quadrants. The CT scan revealed an intestinal phytobezoar which was subsequently removed surgically with a longitudinal enterotomy. On the third postoperative day, the patient presented jaundice and a new CT scan showed a second phytobezoar impacted into the duodenal bulb, which was missed during the initial diagnosis. The gastric phytobezoar was fragmented endoscopically using a polypectomy snare with high flow electric current (70-80 Watts) and its pieces were removed orally. The patient had no complications during the hospital stay and was discharged on the eighth postoperative day. Three months later, the follow-up gastroduodenoscopy and CT scan revealed no signs or symptoms of any gastrointestinal mass.The present case report is the first presentation of a double gastrointestinal phytobezoar that caused ileus and temporary jaundice. Moreover, a successful single-session mechanical-electrical fragmentation of a large gastric phytobezoar is described for the first time.
Keywords	Bezoar ; Gastroscopy ; Ileus ; Jaundice ; Small Bowel Obstruction ; Medicine (General) ; R5-920
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Shiraz University of Medical Sciences
Document type	Article ; Online
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Article ; Online: Comparative efficacy of glucose-lowering drugs on liver steatosis as assessed by means of magnetic resonance imaging in patients with type 2 diabetes mellitus: systematic review and network meta-analysis.

Malandris, Konstantinos / Papandreou, Stylianos / Avgerinos, Ioannis / Karagiannis, Thomas / Paschos, Paschalis / Michailidis, Theodoros / Liakos, Aris / Bekiari, Eleni / Sinakos, Emmanouil / Tsapas, Apostolos

Hormones (Athens, Greece)

2023 Volume 22, Issue 4, Page(s) 655–664

Abstract: Purpose: To assess the comparative efficacy of glucose-lowering drugs on liver steatosis as assessed by means of magnetic resonance imaging (MRI) in patients with T2D.: Methods: We searched several databases and grey literature sources. Eligible ... ...

Abstract	Purpose: To assess the comparative efficacy of glucose-lowering drugs on liver steatosis as assessed by means of magnetic resonance imaging (MRI) in patients with T2D. Methods: We searched several databases and grey literature sources. Eligible trials had at least 12 weeks of intervention, included patients with T2D, and assessed the efficacy of glucose-lowering drugs as monotherapies. The primary outcome of interest was absolute reduction in liver fat content (LFC), assessed by means of MRI. Secondary efficacy outcomes were reduction in visceral and subcutaneous adipose tissue. We performed random effects frequentist network meta-analyses to estimate mean differences (MDs) with 95% confidence intervals (CIs). We ranked treatments based on P-scores. Results: We included 29 trials with 1906 patients. Sodium-glucose cotransporter-2 (SGLT-2) inhibitors (P-score 0.84) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) (0.71) were the most efficacious in terms of liver fat content reduction. Among individual agents, empagliflozin was the most efficacious (0.86) and superior to pioglitazone (MD -5.7, 95% CI -11.2 to -0.3) (very low confidence). GLP-1 RAs had also the most favorable effects on visceral and subcutaneous adipose tissue. Conclusions: GLP-1 RAs and SGLT-2 inhibitors seem to be the most efficacious glucose-lowering drugs for liver steatosis in patients with T2D. Assessment of their efficacy on NAFLD in patients irrespective of presence of T2D is encouraged.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/complications ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Network Meta-Analysis ; Glucose ; Non-alcoholic Fatty Liver Disease/drug therapy ; Glucagon-Like Peptide 1/agonists ; Glucagon-Like Peptide 1/therapeutic use
Chemical Substances	Hypoglycemic Agents ; Glucose (IY9XDZ35W2) ; Glucagon-Like Peptide 1 (89750-14-1)
Language	English
Publishing date	2023-09-28
Publishing country	Switzerland
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2075912-5
ISSN	2520-8721 ; 1109-3099
ISSN (online)	2520-8721
ISSN	1109-3099
DOI	10.1007/s42000-023-00493-z
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Article ; Online: Efficacy of pharmacologic interventions on magnetic resonance imaging biomarkers in patients with nonalcoholic fatty liver disease: systematic review and network meta-analysis.

Malandris, Konstantinos / Papandreou, Stylianos / Vasilakou, Despoina / Kakotrichi, Panagiota / Sarakapina, Anna / Kalopitas, Georgios / Karagiannis, Thomas / Giouleme, Olga / Bekiari, Eleni / Liakos, Aris / Iatridi, Fotini / Paschos, Paschalis / Sinakos, Emmanouil / Tsapas, Apostolos

Journal of gastroenterology and hepatology

2024

Abstract: Background and aim: Several agents are under investigation for nonalcoholic fatty liver disease (NAFLD). We assessed the comparative efficacy of pharmacologic interventions for patients with NAFLD focusing on magnetic resonance imaging (MRI) biomarkers.! ...

Abstract	Background and aim: Several agents are under investigation for nonalcoholic fatty liver disease (NAFLD). We assessed the comparative efficacy of pharmacologic interventions for patients with NAFLD focusing on magnetic resonance imaging (MRI) biomarkers. Methods: We searched Medline, Embase, and CENTRAL. We included randomized controlled trials of more than 12 weeks of intervention that recruited patients with biopsy-confirmed or MRI-confirmed NAFLD and assessed the efficacy of interventions on liver fat content (LFC) and fibrosis by means of MRI. We performed random-effects frequentist network meta-analyses and assessed confidence in our estimates using the CINeMA (Confidence in Network Meta-Analysis) approach. Results: We included 47 trials (8583 patients). Versus placebo, thiazolidinediones were the most efficacious for the absolute change in LFC, followed by vitamin E, fibroblast growth factor (FGF) analogs, and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) with mean differences ranging from -7.46% (95% confidence interval [-11.0, -3.9]) to -4.36% (-7.2, -1.5). No differences between drug classes were evident. Patients receiving GLP-1 RAs or glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 RAs were more likely to achieve ≥30% relative reduction in LFC. Among agents, efruxifermin produced the largest reduction in LFC compared to placebo [-13.5% (-18.5, -8.5)], followed by pioglitazone, while being superior to most interventions. The effect of interventions on magnetic resonance elastography assessed fibrosis was small and insignificant. The confidence in our estimates was low to very low. Conclusions: Several drug classes may reduce LFC in patients with NAFLD without a significant effect on fibrosis; nevertheless, trial duration was small, and confidence in the effect estimates was low.
Language	English
Publishing date	2024-04-16
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	632882-9
ISSN	1440-1746 ; 0815-9319
ISSN (online)	1440-1746
ISSN	0815-9319
DOI	10.1111/jgh.16559
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Zs.A 2180: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Add-on interventions for the prevention of recurrent Clostridioides Difficile infection: A systematic review and network meta-analysis.

Paschos, Paschalis / Ioakim, Konstantinos / Malandris, Konstantinos / Koukoufiki, Argyro / Nayfeh, Tarek / Akriviadis, Evangelos / Tsapas, Apostolos / Bekiari, Eleni

Anaerobe

2021 Volume 71, Page(s) 102441

Abstract: Objectives: We aimed to assess the comparative efficacy and safety of adjunctive interventions for the prevention of Clostridioides difficile recurrence.: Methods: We searched Medline, Embase, CENTRAL, and clinicaltrials.gov up to May 2021. We ... ...

Abstract	Objectives: We aimed to assess the comparative efficacy and safety of adjunctive interventions for the prevention of Clostridioides difficile recurrence. Methods: We searched Medline, Embase, CENTRAL, and clinicaltrials.gov up to May 2021. We included randomized controlled trials comparing interventions added to antibiotic therapy for prevention of CDI recurrence, to placebo or each other. Efficacy outcomes were CDI and diarrhea recurrence. Safety outcomes included the incidence of any adverse event (AE), serious AEs, and discontinuation due to AEs. We performed random-effects network meta-analysis. We ranked interventions based on SUCRA (surface under the cumulative ranking curve) probabilities. We assessed confidence in estimates utilizing the CINeMA (Confidence in Network Meta-Analysis) framework. Results: Fifteen trials (3909 patients) assessed 9 interventions. Oligofructose (OR 0.17; 95% CI, 0.07 to 0.46), NTCD-M3 (OR 0.29; 95% CI, 0.12 to 0.68), rifaximin (OR 0.47; 95% CI, 0.24 to 0.93), RBX2660 (OR 0.47; 95% CI, 0.22 to 0.99), the combination bezlotoxumab/actoxumab (OR 0.47; 95% CI, 0.37 to 0.60), and bezlotoxumab (OR, 0.53; 95% CI, 0.42 to 0.68) were associated with lower incidence of CDI recurrence than placebo (moderate confidence). Oligofructose was ranked highest, however data for oligofructose were derived solely from one small trial. Probiotics, actoxumab and SER-109 were not superior to placebo (low confidence). Probiotics were not well tolerated (low confidence) and actoxumab showed high rates of serious AEs (moderate confidence). Conclusion: Add-on treatment with oligofructose, NTCD-M3 spores, rifaximin, RBX2660, and bezlotoxumab likely reduces the risk of CDI. Evidence on probiotics and SER-109 are uncertain, thus adequately powered trials are warranted.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents/administration & dosage ; Antibodies, Monoclonal/therapeutic use ; Broadly Neutralizing Antibodies/therapeutic use ; Clostridioides difficile/drug effects ; Clostridioides difficile/genetics ; Clostridioides difficile/physiology ; Clostridium Infections/microbiology ; Clostridium Infections/prevention & control ; Female ; Humans ; Male ; Middle Aged ; Network Meta-Analysis ; Probiotics/administration & dosage ; Randomized Controlled Trials as Topic
Chemical Substances	Anti-Bacterial Agents ; Antibodies, Monoclonal ; Broadly Neutralizing Antibodies ; bezlotoxumab (4H5YMK1H2E) ; actoxumab (G3LU5LC5SX)
Language	English
Publishing date	2021-08-25
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	1237621-8
ISSN	1095-8274 ; 1075-9964
ISSN (online)	1095-8274
ISSN	1075-9964
DOI	10.1016/j.anaerobe.2021.102441
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Zs.A 4318: Show issues

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Article ; Online: Primary Renal Vein Aneurysm Rupture: Case Report of a Catastrophic Entity.

Paschos, Konstantinos A / Kirmanidis, Michalis / Boulas, Konstantinos / Spanoudaki, Athina / Chatzigeorgiadis, Anestis

Annals of vascular surgery

2019 Volume 63, Page(s) 459.e1–459.e4

Abstract: Background: Renal vein aneurysms (RVAs) are uncommon entities, which are usually incidental findings or may cause mild nonspecific symptoms. Modern radiological imaging, mainly multislice computed tomography (CT), has substantially contributed to a ... ...

Abstract	Background: Renal vein aneurysms (RVAs) are uncommon entities, which are usually incidental findings or may cause mild nonspecific symptoms. Modern radiological imaging, mainly multislice computed tomography (CT), has substantially contributed to a prompt and accurate diagnosis. Treatment may range from watchful waiting to aneurysmorraphy, aneurysmectomy, and nephrectomy. Potential complications include thrombosis, pulmonary embolism, pressure to other structures, and rupture. Case: A 58-year-old male patient was admitted at the emergency department with abdominal pain. He underwent an emergency CT scan which showed a huge retroperitoneal hematoma around the right kidney, while soon afterward he had a hypovolemic shock, less than an hour after a temporary loss of consciousness after an acute emotional distress episode. He underwent an emergency laparotomy and a right nephrectomy because of an RVA. Interestingly, his postoperative course was uneventful and his six-month follow-up was normal. Discussion: This report presents the rupture of an RVA for the first time, which was successfully treated through nephrectomy by general surgeons in a secondary hospital. This is a catastrophic event which may be lethal, in case prompt diagnosis and surgical intervention delay. Due to the rarity of the disease, its etiology and optimal treatment remain to be clarified.
MeSH term(s)	Aneurysm, Ruptured/diagnostic imaging ; Aneurysm, Ruptured/surgery ; Computed Tomography Angiography ; Humans ; Male ; Middle Aged ; Multidetector Computed Tomography ; Nephrectomy ; Phlebography ; Renal Veins/diagnostic imaging ; Renal Veins/surgery ; Treatment Outcome
Language	English
Publishing date	2019-10-14
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	1027366-9
ISSN	1615-5947 ; 0890-5096
ISSN (online)	1615-5947
ISSN	0890-5096
DOI	10.1016/j.avsg.2019.08.075
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Book ; Online: Middle-mile optimization for next-day delivery

Benidis, Konstantinos / Paschos, Georgios / Gross, Martin / Iosifidis, George

2023

Abstract: We consider an e-commerce retailer operating a supply chain that consists of middle- and last-mile transportation, and study its ability to deliver products stored in warehouses within a day from customer's order time. Successful next-day delivery ... ...

Abstract	We consider an e-commerce retailer operating a supply chain that consists of middle- and last-mile transportation, and study its ability to deliver products stored in warehouses within a day from customer's order time. Successful next-day delivery requires inventory availability and timely truck schedules in the middle-mile and in this paper we assume a fixed inventory position and focus on optimizing the middle-mile. We formulate a novel optimization problem which decides the departure of the last middle-mile truck at each (potential) network connection in order to maximize the number of next-day deliveries. We show that the respective \emph{next-day delivery optimization} is a combinatorial problem that is $NP$-hard to approximate within $(1-1/e)\cdot\texttt{opt}\approx 0.632\cdot\texttt{opt}$, hence every retailer that offers one-day deliveries has to deal with this complexity barrier. We study three variants of the problem motivated by operational constraints that different retailers encounter, and propose solutions schemes tailored to each problem's properties. To that end, we rely on greedy submodular maximization, pipage rounding techniques, and Lagrangian heuristics. The algorithms are scalable, offer optimality gap guarantees, and evaluated in realistic datasets and network scenarios were found to achieve near-optimal results.
Keywords	Computer Science - Data Structures and Algorithms
Publishing date	2023-10-27
Publishing country	us
Document type	Book ; Online
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Article ; Online: Performance of Baveno VI and Expanded Baveno VI Criteria for Excluding High-Risk Varices in Patients With Chronic Liver Diseases: A Systematic Review and Meta-analysis.

Stafylidou, Maria / Paschos, Paschalis / Katsoula, Anastasia / Malandris, Konstantinos / Ioakim, Konstantinos / Bekiari, Eleni / Haidich, Anna-Bettina / Akriviadis, Evangelos / Tsapas, Apostolos

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

2019 Volume 17, Issue 9, Page(s) 1744–1755.e11

Abstract: Background & aims: We aimed to assess the accuracy of Baveno VI criteria for identification of high-risk varices (HRVs) and varices of any size in patients with compensated advanced chronic liver disease (cACLD).: Methods: We performed a systematic ... ...

Abstract	Background & aims: We aimed to assess the accuracy of Baveno VI criteria for identification of high-risk varices (HRVs) and varices of any size in patients with compensated advanced chronic liver disease (cACLD). Methods: We performed a systematic search of publications through December 2018 for studies that assessed the accuracy of Baveno VI criteria for screening for varices in patients with cACLD. We used hierarchical models to synthesize evidence. We also conducted a post hoc analysis to assess the accuracy of Εxpanded Baveno VI criteria. We appraised the confidence in estimates using the Grading of Recommendations Assessment, Development and Evaluation approach. Results: We identified 30 studies (8469 participants). Pooled values of Baveno VI criteria for HRVs (26 studies) were a sensitivity of 0.97 (95% CI, 0.95-0.98) and a specificity of 0.32 (95% CI, 0.26-0.39). Pooled sensitivity of Εxpanded Baveno VI criteria for HRVs (12 studies) was 0.90 (95% CI, 0.85-0.93) and specificity was 0.51 (95% CI, 0.45-0.57). In 1000 patients with cACLD, with a prevalence of HRVs of 20%, Baveno VI criteria would prevent endoscopy in 262 patients, but 6 patients with HRVs would be missed. Instead, use of the Εxpanded Baveno VI criteria would result in 428 patients avoiding endoscopy, but 20 patients with HRVs would be missed. The credibility of our findings is moderate or low, mainly owing to the retrospective design of most studies. Conclusions: Baveno VI criteria have high diagnostic accuracy as a triage test for screening for HRVs in patients with cACLD. Expanded Baveno VI criteria could reduce the proportion of unnecessary endoscopies further, nevertheless with a higher rate of missed HRVs.
MeSH term(s)	Elasticity Imaging Techniques ; Endoscopy, Digestive System ; Esophageal and Gastric Varices/epidemiology ; Esophageal and Gastric Varices/etiology ; Gastrointestinal Hemorrhage/epidemiology ; Gastrointestinal Hemorrhage/etiology ; Humans ; Liver/diagnostic imaging ; Liver Cirrhosis/blood ; Liver Cirrhosis/complications ; Liver Cirrhosis/diagnostic imaging ; Liver Diseases/blood ; Liver Diseases/complications ; Liver Diseases/diagnostic imaging ; Platelet Count ; Risk Assessment ; Severity of Illness Index ; Thrombocytopenia/blood ; Thrombocytopenia/etiology
Language	English
Publishing date	2019-05-08
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2119789-1
ISSN	1542-7714 ; 1542-3565
ISSN (online)	1542-7714
ISSN	1542-3565
DOI	10.1016/j.cgh.2019.04.062
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