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  1. Article ; Online: Study of the K_{L}→π^{0}νν[over ¯] Decay at the J-PARC KOTO Experiment.

    Ahn, J K / Beckford, B / Campbell, M / Chen, S H / Comfort, J / Dona, K / Farrington, M S / Hanai, K / Hara, N / Haraguchi, H / Hsiung, Y B / Hutcheson, M / Inagaki, T / Isoe, M / Kamiji, I / Kato, T / Kim, E J / Kim, J L / Kim, H M /
    Komatsubara, T K / Kotera, K / Lee, S K / Lee, J W / Lim, G Y / Lin, Q S / Lin, C / Luo, Y / Mari, T / Masuda, T / Matsumura, T / Mcfarland, D / McNeal, N / Miyazaki, K / Murayama, R / Nakagiri, K / Nanjo, H / Nishimiya, H / Noichi, Y / Nomura, T / Nunes, T / Ohsugi, M / Okuno, H / Redeker, J C / Sanchez, J / Sasaki, M / Sasao, N / Sato, T / Sato, K / Sato, Y / Shimizu, N / Shimogawa, T / Shinkawa, T / Shinohara, S / Shiomi, K / Shiraishi, R / Su, S / Sugiyama, Y / Suzuki, S / Tajima, Y / Taylor, M / Tecchio, M / Togawa, M / Toyoda, T / Tung, Y-C / Vuong, Q H / Wah, Y W / Watanabe, H / Yamanaka, T / Yoshida, H Y / Zaidenberg, L

    Physical review letters

    2021  Volume 126, Issue 12, Page(s) 121801

    Abstract: The rare decay K_{L}→π^{0}νν[over ¯] was studied with the dataset taken at the J-PARC KOTO ... and scattered K_{L} decays were studied, and the total number of background events was estimated to be ... with the background expectation. For this dataset, we set an upper limit of 4.9×10^{-9} on the branching fraction of K ...

    Abstract The rare decay K_{L}→π^{0}νν[over ¯] was studied with the dataset taken at the J-PARC KOTO experiment in 2016, 2017, and 2018. With a single event sensitivity of (7.20±0.05_{stat}±0.66_{syst})×10^{-10}, three candidate events were observed in the signal region. After unveiling them, contaminations from K^{±} and scattered K_{L} decays were studied, and the total number of background events was estimated to be 1.22±0.26. We conclude that the number of observed events is statistically consistent with the background expectation. For this dataset, we set an upper limit of 4.9×10^{-9} on the branching fraction of K_{L}→π^{0}νν[over ¯] at the 90% confidence level.
    Language English
    Publishing date 2021-03-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.126.121801
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  2. Article ; Online: Search for K_{L}→π^{0}νν[over ¯] and K_{L}→π^{0}X^{0} Decays at the J-PARC KOTO Experiment.

    Ahn, J K / Beckford, B / Beechert, J / Bryant, K / Campbell, M / Chen, S H / Comfort, J / Dona, K / Hara, N / Haraguchi, H / Hsiung, Y B / Hutcheson, M / Inagaki, T / Kamiji, I / Kawasaki, N / Kim, E J / Kim, J L / Kim, Y J / Ko, J W /
    Komatsubara, T K / Kotera, K / Kurilin, A S / Lee, J W / Lim, G Y / Lin, C / Lin, Q / Luo, Y / Ma, J / Maeda, Y / Mari, T / Masuda, T / Matsumura, T / Mcfarland, D / McNeal, N / Micallef, J / Miyazaki, K / Murayama, R / Naito, D / Nakagiri, K / Nanjo, H / Nishimiya, H / Nomura, T / Ohsugi, M / Okuno, H / Sasaki, M / Sasao, N / Sato, K / Sato, T / Sato, Y / Schamis, H / Seki, S / Shimizu, N / Shimogawa, T / Shinkawa, T / Shinohara, S / Shiomi, K / Su, S / Sugiyama, Y / Suzuki, S / Tajima, Y / Taylor, M / Tecchio, M / Togawa, M / Tung, Y C / Wah, Y W / Watanabe, H / Woo, J K / Yamanaka, T / Yoshida, H Y

    Physical review letters

    2019  Volume 122, Issue 2, Page(s) 21802

    Abstract: A search for the rare decay K_{L}→π^{0}νν[over ¯] was performed. With the data collected in 2015 ... for the branching fraction of K_{L}→π^{0}νν[over ¯] at the 90% confidence level (C.L.), which improved the previous ... limit by almost an order of magnitude. An upper limit for K_{L}→π^{0}X^{0} was also set as 2.4×10^{-9 ...

    Abstract A search for the rare decay K_{L}→π^{0}νν[over ¯] was performed. With the data collected in 2015, corresponding to 2.2×10^{19} protons on target, a single event sensitivity of (1.30±0.01_{stat}±0.14_{syst})×10^{-9} was achieved and no candidate events were observed. We set an upper limit of 3.0×10^{-9} for the branching fraction of K_{L}→π^{0}νν[over ¯] at the 90% confidence level (C.L.), which improved the previous limit by almost an order of magnitude. An upper limit for K_{L}→π^{0}X^{0} was also set as 2.4×10^{-9} at the 90% C.L., where X^{0} is an invisible boson with a mass of 135  MeV/c^{2}.
    Language English
    Publishing date 2019-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.122.021802
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  3. Article: Reproducibility in Preclinical

    Lim, Charmaine J M / Janhunen, Sanna K / Riedel, Gernot

    Journal of integrative neuroscience

    2024  Volume 23, Issue 2, Page(s) 30

    Language English
    Publishing date 2024-03-01
    Publishing country Singapore
    Document type Editorial
    ZDB-ID 2136427-8
    ISSN 0219-6352
    ISSN 0219-6352
    DOI 10.31083/j.jin2302030
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  4. Article ; Online: The role of Manganese in tree defenses against pests and pathogens.

    Lim-Hing, Simone / Gandhi, Kamal J K / Villari, Caterina

    Plant physiology and biochemistry : PPB

    2024  Volume 210, Page(s) 108641

    Abstract: Manganese (Mn) deficiency is a widespread occurrence across different landscapes, including agricultural systems and managed forests, and causes interruptions in the normal metabolic functioning of plants. The microelement is well-characterized for its ... ...

    Abstract Manganese (Mn) deficiency is a widespread occurrence across different landscapes, including agricultural systems and managed forests, and causes interruptions in the normal metabolic functioning of plants. The microelement is well-characterized for its role in the oxygen-evolving complex in photosystem II and maintenance of photosynthetic structures. Mn is also required for a variety of enzymatic reactions in secondary metabolism, which play a crucial role in defense strategies for trees. Despite the strong relationship between Mn availability and the biosynthesis of defense-related compounds, there are few studies addressing how Mn deficiency can impact tree defense mechanisms and the ensuing ecological patterns and processes. Understanding this relationship and highlighting the potentially deleterious effects of Mn deficiency in trees can also inform silvicultural and management decisions to build more robust forests. In this review, we address this relationship, focusing on forest trees. We describe Mn availability in forest soils, characterize the known impacts of Mn deficiency in plant susceptibility, and discuss the relationship between Mn and defense-related compounds by secondary metabolite class. In our review, we find several lines of evidence that low Mn availability is linked with lowered or altered secondary metabolite activity. Additionally, we compile documented instances where Mn limitation has altered the defense capabilities of the host plant and propose potential ecological repercussions when studies are not available. Ultimately, this review aims to highlight the importance of untangling the effects of Mn limitation on the ecophysiology of plants, with a focus on forest trees in both managed and natural stands.
    Language English
    Publishing date 2024-04-18
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 742978-2
    ISSN 1873-2690 ; 0981-9428
    ISSN (online) 1873-2690
    ISSN 0981-9428
    DOI 10.1016/j.plaphy.2024.108641
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  5. Article: NASH and the Gut Microbiome: Implications for New Therapies.

    Tsay, Cynthia J / Lim, Joseph K

    Clinical liver disease

    2022  Volume 19, Issue 3, Page(s) 97–100

    Abstract: Content available: Author Audio Recording. ...

    Abstract Content available: Author Audio Recording.
    Language English
    Publishing date 2022-01-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2657644-2
    ISSN 2046-2484
    ISSN 2046-2484
    DOI 10.1002/cld.1170
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  6. Article ; Online: Reclassification of a spindle cell sarcoma after identification of a TFG-ROS1 fusion: A case demonstrating the clinical benefit of next-generation sequencing in sarcoma.

    Lim, John J / Chen, Eleanor Y / Schaub, Stephanie K / Wagner, Michael J

    Molecular genetics & genomic medicine

    2024  Volume 12, Issue 4, Page(s) e2423

    Abstract: Background: Inflammatory myofibroblastic tumors (IMTs) are rare mesenchymal soft tissue sarcomas that often present diagnostic challenges due to their wide and varied morphology. A subset of IMTs have fusions involving ALK or ROS1. The role of next- ... ...

    Abstract Background: Inflammatory myofibroblastic tumors (IMTs) are rare mesenchymal soft tissue sarcomas that often present diagnostic challenges due to their wide and varied morphology. A subset of IMTs have fusions involving ALK or ROS1. The role of next-generation sequencing (NGS) for classification of unselected sarcomas remains controversial.
    Methods and results: We report a case of a metastatic sarcoma in a 34-year-old female originally diagnosed as an unclassified spindle cell sarcoma with myofibroblastic differentiation and later reclassified as IMT after NGS revealed a TFG-ROS1 rearrangement. Histologically, the neoplasm had spindle cell morphology with a lobulated to focally infiltrative growth pattern with scant inflammatory cell infiltrate. Immunohistochemistry demonstrated focal desmin and variable smooth muscle actin staining but was negative for SOX10, S100, and CD34. Fluorescence in situ hybridization was negative for USP6 or ALK gene rearrangements. NGS revealed a TFG-ROS1 rearrangement and the patient was treated with crizotinib with clinical benefit.
    Conclusions: We discuss the role of NGS as well as its potential benefit in patients with unresectable, ALK-negative metastatic disease. Considering this case and previous literature, we support the use of NGS for patients requiring systemic treatment.
    MeSH term(s) Female ; Humans ; Adult ; Protein-Tyrosine Kinases/genetics ; Anaplastic Lymphoma Kinase/genetics ; In Situ Hybridization, Fluorescence ; Proto-Oncogene Proteins/genetics ; Sarcoma/drug therapy ; Sarcoma/genetics ; Sarcoma/pathology ; High-Throughput Nucleotide Sequencing ; Ubiquitin Thiolesterase/genetics ; Vesicular Transport Proteins/genetics
    Chemical Substances Protein-Tyrosine Kinases (EC 2.7.10.1) ; Anaplastic Lymphoma Kinase (EC 2.7.10.1) ; Proto-Oncogene Proteins ; USP6 protein, human (EC 3.4.19.12) ; Ubiquitin Thiolesterase (EC 3.4.19.12) ; ROS1 protein, human (EC 2.7.10.1) ; TFG protein, human ; Vesicular Transport Proteins
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2734884-2
    ISSN 2324-9269 ; 2324-9269
    ISSN (online) 2324-9269
    ISSN 2324-9269
    DOI 10.1002/mgg3.2423
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  7. Article ; Conference proceedings: Differential Diagnosis between Crohn's Disease and Intestinal Tuberculosis Using an Artificial Intelligence Algorithm

    Byeon, J. S. / Park, K. / Lim, J. / Kim, N.

    Endoscopy

    2024  Volume 56, Issue S 02

    Event/congress ESGE Days 2024, Berlin, Germany, 2024-04-25
    Language English
    Publishing date 2024-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/s-0044-1782938
    Database Thieme publisher's database

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  8. Article ; Online: Simultaneous bilateral anterior shoulder fracture dislocations in the elderly: case report and focused clinical treatment algorithm.

    Bohlen, Hunter L / Wright, David J / Lim, Philip K

    JSES reviews, reports, and techniques

    2023  Volume 3, Issue 3, Page(s) 382–387

    Language English
    Publishing date 2023-06-01
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2666-6391
    ISSN (online) 2666-6391
    DOI 10.1016/j.xrrt.2023.05.001
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  9. Article ; Online: National Institute for Health and Care Excellence and Royal College of Radiologists' Fractionation Guideline for Metastatic Spinal Cord Compression.

    Lim, J S / Boon, C S / Oguejiofor, K / Ramkumar, S / Boon, I S

    Clinical oncology (Royal College of Radiologists (Great Britain))

    2024  Volume 36, Issue 5, Page(s) e114

    MeSH term(s) Humans ; Spinal Cord Compression/etiology ; Dose Fractionation, Radiation
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1036844-9
    ISSN 1433-2981 ; 0936-6555
    ISSN (online) 1433-2981
    ISSN 0936-6555
    DOI 10.1016/j.clon.2024.02.006
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  10. Article ; Online: Impact of the COVID-19 pandemic on the epidemiology of TB in a low-incidence setting.

    Mah, J K / Lieu, A / Fisher, D / Lim, R K

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

    2023  Volume 27, Issue 1, Page(s) 69–71

    MeSH term(s) Humans ; COVID-19 ; Incidence ; Pandemics ; Tuberculosis/epidemiology
    Language English
    Publishing date 2023-03-30
    Publishing country France
    Document type Letter
    ZDB-ID 1385624-8
    ISSN 1815-7920 ; 1027-3719
    ISSN (online) 1815-7920
    ISSN 1027-3719
    DOI 10.5588/ijtld.22.0378
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