LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 138

Search options

  1. Article ; Online: Understanding microorganisms in the prevention of allergy.

    Umetsu, Dale T

    Nature immunology

    2022  

    Language English
    Publishing date 2022-11-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-022-01356-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5294: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 42: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Mechanisms by which obesity impacts upon asthma.

    Umetsu, Dale T

    Thorax

    2017  Volume 72, Issue 2, Page(s) 174–177

    Abstract: Asthma, an inflammatory disease of the airways, is a common condition, currently affecting about 9% of adults. Obesity is another disease with high prevalence in adults, and asthma that develops in obese individuals appears to be distinct from other ... ...

    Abstract Asthma, an inflammatory disease of the airways, is a common condition, currently affecting about 9% of adults. Obesity is another disease with high prevalence in adults, and asthma that develops in obese individuals appears to be distinct from other forms of asthma, in being particularly severe and difficult to control even with oral corticosteroids. Moreover, recent studies suggest that obesity may have a causal relationship with asthma. In this review, we discuss possible obesity-driven metabolic and immunological pathways that might lead to asthma that is associated with obesity. Our understanding of the mechanisms that underlie this association will likely lead in the future to improved treatments for this significant unmet medical need.
    MeSH term(s) Asthma/etiology ; Asthma/prevention & control ; Humans ; Obesity/complications ; Obesity/prevention & control ; Risk Factors ; Severity of Illness Index
    Language English
    Publishing date 2017-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thoraxjnl-2016-209130
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui III Zs.83: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Targeting IgE to facilitate oral immunotherapy for food allergy: a potential new role for anti-IgE therapy?

    Umetsu, Dale T

    Expert review of clinical immunology

    2014  Volume 10, Issue 9, Page(s) 1125–1128

    Abstract: Food allergy is a major public health problem without satisfactory treatment options. Of several new treatments being studied, oral immunotherapy (OIT) appears to be the most promising. Unfortunately, OIT is associated with an unacceptably high frequency ...

    Abstract Food allergy is a major public health problem without satisfactory treatment options. Of several new treatments being studied, oral immunotherapy (OIT) appears to be the most promising. Unfortunately, OIT is associated with an unacceptably high frequency of allergic reactions. However, recent studies suggest that OIT might be made safer and faster when performed in conjunction with anti-IgE monoclonal antibody as an adjunctive treatment.
    MeSH term(s) Administration, Oral ; Allergens/adverse effects ; Allergens/immunology ; Allergens/therapeutic use ; Anaphylaxis/etiology ; Anaphylaxis/prevention & control ; Animals ; Antibodies, Monoclonal/therapeutic use ; Antigens, Plant/administration & dosage ; Antigens, Plant/adverse effects ; Arachis/immunology ; Desensitization, Immunologic/methods ; Desensitization, Immunologic/trends ; Drug Therapy, Combination ; Food Hypersensitivity/immunology ; Food Hypersensitivity/therapy ; Humans ; Immunoglobulin E/immunology ; Milk/immunology ; Milk Proteins/administration & dosage ; Milk Proteins/adverse effects
    Chemical Substances Allergens ; Antibodies, Monoclonal ; Antigens, Plant ; Milk Proteins ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2014-09
    Publishing country England
    Document type Editorial
    ZDB-ID 2274260-8
    ISSN 1744-8409 ; 1744-666X
    ISSN (online) 1744-8409
    ISSN 1744-666X
    DOI 10.1586/1744666X.2014.948849
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6661: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Early exposure to germs and the Hygiene Hypothesis.

    Umetsu, Dale T

    Cell research

    2012  Volume 22, Issue 8, Page(s) 1210–1211

    Abstract: ... called natural killer T cells, which predisposes to colitis and asthma. Such a scenario could explain ...

    Abstract A recent paper suggests that reduced exposure to germs results in the expansion of a cell type called natural killer T cells, which predisposes to colitis and asthma. Such a scenario could explain the Hygiene Hypothesis, which has been a puzzle for decades.
    MeSH term(s) Animals ; Asthma/immunology ; Asthma/pathology ; Cell Proliferation ; Colitis/chemically induced ; Colitis/immunology ; Colitis/pathology ; Environmental Exposure ; Humans ; Hygiene Hypothesis ; Hypersensitivity/immunology ; Hypersensitivity/pathology ; Interleukins/immunology ; Metagenome/immunology ; Mice ; Natural Killer T-Cells/immunology ; Natural Killer T-Cells/metabolism ; Natural Killer T-Cells/pathology ; Oxazolone/adverse effects ; Specific Pathogen-Free Organisms/immunology
    Chemical Substances Interleukins ; Oxazolone (15646-46-5)
    Language English
    Publishing date 2012-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/cr.2012.65
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5283: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Reply.

    Lieberman, Phillip L / Umetsu, Dale T / Carrigan, Gillis J / Rahmaoui, Abdelkader

    The Journal of allergy and clinical immunology

    2017  Volume 139, Issue 5, Page(s) 1718–1719

    MeSH term(s) Anaphylaxis ; Humans ; Omalizumab
    Chemical Substances Omalizumab (2P471X1Z11)
    Language English
    Publishing date 2017-03-03
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2016.12.976
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.92: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: A new player on the psoriasis block: IL-17A- and IL-22-producing innate lymphoid cells.

    Ward, Nicole L / Umetsu, Dale T

    The Journal of investigative dermatology

    2014  Volume 134, Issue 9, Page(s) 2305–2307

    Abstract: Innate lymphoid cells (ILCs) are a recently discovered family of innate immune cells belonging to the lymphoid lineage, yet lacking antigen-specific receptors. ILCs were first identified in the intestinal tract, where they contribute to epithelial ... ...

    Abstract Innate lymphoid cells (ILCs) are a recently discovered family of innate immune cells belonging to the lymphoid lineage, yet lacking antigen-specific receptors. ILCs were first identified in the intestinal tract, where they contribute to epithelial barrier integrity and host responses to commensal microbes. Teunissen et al. (in the current issue) and Villanova et al. (2014) now suggest an important role for type 3 ILCs (ILC3s) in the skin, particularly in psoriasis. Both groups found an increased frequency of IL-22- and/or IL-17A-producing ILCs in psoriatic skin and blood. These cells are activated in response to IL-1β and IL-23, correlate with disease severity, and are decreased following antitumor necrosis factor-α (anti-TNFα) treatment. The presence of a novel ILC population in psoriatic skin, one that responds to biologic therapeutics, suggests that dysregulation of ILCs is a contributing factor to psoriasis pathogenesis.
    MeSH term(s) Dermis/immunology ; Epidermis/immunology ; Humans ; Lymphocytes/immunology ; Natural Cytotoxicity Triggering Receptor 2/immunology ; Psoriasis/immunology
    Chemical Substances NCR2 protein, human ; Natural Cytotoxicity Triggering Receptor 2
    Language English
    Publishing date 2014-08-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1038/jid.2014.216
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.124: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Innate lymphoid cells in asthma: Will they take your breath away?

    Kim, Hye Young / Umetsu, Dale T / Dekruyff, Rosemarie H

    European journal of immunology

    2016  Volume 46, Issue 4, Page(s) 795–806

    Abstract: Asthma is a complex and heterogeneous disease that is characterized by airway hyper-reactivity (AHR) and airway inflammation. Although asthma was long thought to be driven by allergen-reactive TH 2 cells, it has recently become clear that the ... ...

    Abstract Asthma is a complex and heterogeneous disease that is characterized by airway hyper-reactivity (AHR) and airway inflammation. Although asthma was long thought to be driven by allergen-reactive TH 2 cells, it has recently become clear that the pathogenesis of asthma is more complicated and associated with multiple pathways and cell types. A very exciting recent development was the discovery of innate lymphoid cells (ILCs) as key players in the pathogenesis of asthma. ILCs do not express antigen receptors but react promptly to "danger signals" from inflamed tissue and produce an array of cytokines that direct the ensuing immune response. The roles of ILCs may differ in distinct asthma phenotypes. ILC2s may be critical for initiation of adaptive immune responses in inhaled allergen-driven AHR, but may also function independently of adaptive immunity, mediating influenza-induced AHR. ILC2s also contribute to resolution of lung inflammation through their production of amphiregulin. Obesity-induced asthma is associated with expansion of IL-17A-producing ILC3s in the lungs. Furthermore, ILCs may also contribute to steroid-resistant asthma. Although the precise roles of ILCs in different types of asthma are still under investigation, it is clear that inhibition of ILC function represents a potential target that could provide novel treatments for asthma.
    MeSH term(s) Adaptive Immunity/immunology ; Allergens/immunology ; Amphiregulin ; Asthma/immunology ; Asthma/pathology ; EGF Family of Proteins/immunology ; Humans ; Immunity, Innate/immunology ; Influenza, Human/immunology ; Interleukin-17/immunology ; Interleukin-33/immunology ; Lung/cytology ; Lung/immunology ; Lung/pathology ; Lymphocytes/immunology ; Obesity/immunology ; Signal Transduction/immunology
    Chemical Substances AREG protein, human ; Allergens ; Amphiregulin ; EGF Family of Proteins ; IL17A protein, human ; IL25 protein, human ; IL33 protein, human ; Interleukin-17 ; Interleukin-33
    Language English
    Publishing date 2016-04
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.201444557
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 489: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 85: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Revising the immunological theories of asthma and allergy.

    Umetsu, Dale T

    Lancet (London, England)

    2005  Volume 365, Issue 9454, Page(s) 98–100

    MeSH term(s) Asthma/immunology ; Child ; Humans ; Hypersensitivity/immunology ; Immunity, Cellular ; T-Lymphocytes, Helper-Inducer/immunology
    Language English
    Publishing date 2005-01
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(05)17714-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.5: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 94: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Understanding the immunological basis of asthma; immunotherapy and regulatory T cells.

    Umetsu, Dale T

    Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M

    2006  , Issue 95, Page(s) 211–4; discussion 215–6

    Abstract: ... producing IL-12 and IL-10, produce IFN-gamma and IL-10, and also express T-bet and Foxp3. These Th1Reg cells ... because it induces regulatory T cells. With HKL you get Th1Reg cells, and with other forms of immunotherapy ...

    Abstract We believe that immunotherapy with HKL as an adjuvant induces Thl-like TReg cells that can inhibit AHR and airway inflammation. These antigen-specific TReg cells are induced with CD8alpha+ DCs producing IL-12 and IL-10, produce IFN-gamma and IL-10, and also express T-bet and Foxp3. These Th1Reg cells are distinct from antigen-specific TReg cells induced with respiratory tolerance, which can also inhibit AHR and airway inflammation. These Th2-like TReg cells are induced with CD8alpha- DCs producing IL-10, they express IL-10, GATA3 and Foxp3. So allergen immunotherapy is effective in large part because it induces regulatory T cells. With HKL you get Th1Reg cells, and with other forms of immunotherapy you may get Th2Reg cells. We believe that with further refinements, allergen immunotherapy that rapidly induces allergen specific TReg cells will indeed be the magic bullets for allergy and asthma.
    MeSH term(s) Animals ; Asthma/immunology ; Asthma/therapy ; Desensitization, Immunologic ; GATA3 Transcription Factor/analysis ; Humans ; Mice ; Ovalbumin/immunology ; T-Box Domain Proteins/analysis ; T-Lymphocytes, Regulatory/immunology
    Chemical Substances GATA3 Transcription Factor ; T-Box Domain Proteins ; T-box transcription factor TBX21 ; Ovalbumin (9006-59-1)
    Language English
    Publishing date 2006
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 565509-2
    ISSN 0936-8671 ; 0172-9454
    ISSN 0936-8671 ; 0172-9454
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Se 1334: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: Oral immunotherapy for food allergy: towards a new horizon.

    Khoriaty, Evelyne / Umetsu, Dale T

    Allergy, asthma & immunology research

    2012  Volume 5, Issue 1, Page(s) 3–15

    Abstract: Food allergy has increased dramatically in prevalence over the past decade in westernized countries, and is now a major public health problem. Unfortunately for patients with food allergy, there is no effective therapy beyond food allergen avoidance, and ...

    Abstract Food allergy has increased dramatically in prevalence over the past decade in westernized countries, and is now a major public health problem. Unfortunately for patients with food allergy, there is no effective therapy beyond food allergen avoidance, and rapid medical treatment for accidental exposures. Recently, oral immunotherapy (OIT) has been investigated as a treatment for this problem. In this review, we will discuss the progress in developing OIT for food allergy, including a novel approach utilizing Xolair (anti-IgE monoclonal antibody, omalizumab) in combination with OIT. This combination may enhance both the safety and efficacy of oral immunotherapy, and could lead to a widely available and safe therapy for food allergy.
    Language English
    Publishing date 2012-11-28
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2545725-1
    ISSN 2092-7363 ; 2092-7355
    ISSN (online) 2092-7363
    ISSN 2092-7355
    DOI 10.4168/aair.2013.5.1.3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top