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  1. Book ; Online: Role of CD1- and MR1-restricted T cells in Immunity and Disease

    Iwabuchi, Kazuya / Van Kaer, Luc

    2019  

    Keywords Medicine ; Immunology ; CD1 ; MR1 ; natural killer T cells ; Mucosal-associated invariant T cells ; Unconventional T cells ; non-peptide antigens ; Immunity ; Immune-mediated disease
    Size 1 electronic resource (429 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021229877
    ISBN 9782889631223 ; 2889631222
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Preface: Unconventional T Cells in Health and Disease.

    Van Kaer, Luc

    Critical reviews in immunology

    2022  Volume 41, Issue 4, Page(s) v–ix

    Language English
    Publishing date 2022-08-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1353116-5
    ISSN 1040-8401
    ISSN 1040-8401
    DOI 10.1615/CritRevImmunol.2021041608
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: LEF1 Creates Memories in iNKT Cells That Potentiate Antitumor Immunity.

    Van Kaer, Luc

    Cancer immunology research

    2023  Volume 11, Issue 2, Page(s) 144

    Abstract: Invariant natural killer T (iNKT) cells are a subset of innate-like T cells with great potential for developing cancer immunotherapies, including approaches based on chimeric antigen receptors (CAR). In this issue, Ngai and colleagues report that the ... ...

    Abstract Invariant natural killer T (iNKT) cells are a subset of innate-like T cells with great potential for developing cancer immunotherapies, including approaches based on chimeric antigen receptors (CAR). In this issue, Ngai and colleagues report that the transcription factor lymphoid enhancer-binding factor 1 (LEF1) optimizes functional properties of iNKT cells that promote antitumor immunity, raising enthusiasm for the development of robust cancer immunotherapies based on CAR-modified iNKT cells. See related article by Ngai et al., p. 171 (2).
    MeSH term(s) Humans ; Natural Killer T-Cells/immunology ; Lymphoid Enhancer-Binding Factor 1/immunology ; Immunotherapy ; Neoplasms/therapy ; Neoplasms/immunology
    Chemical Substances Lymphoid Enhancer-Binding Factor 1 ; LEF1 protein, human
    Language English
    Publishing date 2023-01-11
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2732489-8
    ISSN 2326-6074 ; 2326-6066
    ISSN (online) 2326-6074
    ISSN 2326-6066
    DOI 10.1158/2326-6066.CIR-22-0902
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Editorial: Therapeutic potential of innate and innate-like effector lymphocytes in autoimmune and inflammatory diseases.

    Wu, Lan / Shi, Fu-Dong / Van Kaer, Luc

    Frontiers in immunology

    2023  Volume 14, Page(s) 1323486

    MeSH term(s) Lymphocytes ; Mucosal-Associated Invariant T Cells
    Language English
    Publishing date 2023-10-31
    Publishing country Switzerland
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1323486
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Role of CD1d and iNKT cells in regulating intestinal inflammation.

    Lee, Sung Won / Park, Hyun Jung / Van Kaer, Luc / Hong, Seokmann

    Frontiers in immunology

    2024  Volume 14, Page(s) 1343718

    Abstract: Invariant natural killer T (iNKT) cells, a subset of unconventional T cells that recognize glycolipid antigens in a CD1d-dependent manner, are crucial in regulating diverse immune responses such as autoimmunity. By engaging with CD1d-expressing non- ... ...

    Abstract Invariant natural killer T (iNKT) cells, a subset of unconventional T cells that recognize glycolipid antigens in a CD1d-dependent manner, are crucial in regulating diverse immune responses such as autoimmunity. By engaging with CD1d-expressing non-immune cells (such as intestinal epithelial cells and enterochromaffin cells) and immune cells (such as type 3 innate lymphoid cells, B cells, monocytes and macrophages), iNKT cells contribute to the maintenance of immune homeostasis in the intestine. In this review, we discuss the impact of iNKT cells and CD1d in the regulation of intestinal inflammation, examining both cellular and molecular factors with the potential to influence the functions of iNKT cells in inflammatory bowel diseases such as Crohn's disease and ulcerative colitis.
    MeSH term(s) Humans ; Natural Killer T-Cells ; Immunity, Innate ; Lymphocytes ; Macrophages ; Inflammation
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1343718
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Therapeutic Targeting of Immune Cell Autophagy in Multiple Sclerosis: Russian Roulette or Silver Bullet?

    Yang, Guan / Van Kaer, Luc

    Frontiers in immunology

    2021  Volume 12, Page(s) 724108

    Abstract: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) in which the immune system damages the protective insulation surrounding nerve fibers that project from neurons. The pathological hallmark of MS is multiple ... ...

    Abstract Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) in which the immune system damages the protective insulation surrounding nerve fibers that project from neurons. The pathological hallmark of MS is multiple areas of myelin loss accompanied by inflammation within the CNS, resulting in loss of cognitive function that ultimately leads to paralysis. Recent studies in MS have focused on autophagy, a cellular self-eating process, as a potential target for MS treatment. Here, we review the contribution of immune cell autophagy to the pathogenesis of experimental autoimmune encephalomyelitis (EAE), the prototypic animal model of MS. A better understanding of the role of autophagy in different immune cells to EAE might inform the development of novel therapeutic approaches in MS and other autoimmune and inflammatory diseases.
    MeSH term(s) Adaptive Immunity ; Animals ; Autophagy ; Disease Models, Animal ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Humans ; Immunity, Innate ; Multiple Sclerosis/immunology ; T-Lymphocytes/immunology
    Language English
    Publishing date 2021-08-31
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.724108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: PIK3C3/VPS34 keeps body fats healthy.

    Song, Wenqiang / Postoak, J Luke / Wu, Lan / Van Kaer, Luc

    Autophagy

    2023  Volume 19, Issue 8, Page(s) 2398–2400

    Abstract: Adipose tissue, or body fat, plays a critical role in the maintenance of health and the development of metabolic diseases. The pathological expansion of adipose tissue during obesity and the pathological reduction of adipose tissue during lipodystrophy ... ...

    Abstract Adipose tissue, or body fat, plays a critical role in the maintenance of health and the development of metabolic diseases. The pathological expansion of adipose tissue during obesity and the pathological reduction of adipose tissue during lipodystrophy can lead to a similar array of metabolic diseases that include diabetes, but mechanisms remain to be fully defined. In our recent studies, we explored the contribution of the lipid kinase PIK3C3/VPS34 to adipose tissue health and metabolic disease. We found that adipocyte-specific PIK3C3/VPS34 deficiency causes defects in the differentiation, survival and functional properties of adipocytes, resulting in reduced adipose tissue mass, altered blood lipid levels, fatty liver disease, diabetes, and defective body temperature control. These abnormalities mirror those observed in patients with lipodystrophy. These findings identify adipocyte PIK3C3/VPS34 as a potential target for therapeutic intervention in metabolic diseases.
    MeSH term(s) Humans ; Autophagy ; Adipocytes/metabolism ; Adipose Tissue, Brown/metabolism ; Lipodystrophy/metabolism ; Obesity/metabolism ; Class III Phosphatidylinositol 3-Kinases/metabolism
    Chemical Substances Class III Phosphatidylinositol 3-Kinases (EC 2.7.1.137)
    Language English
    Publishing date 2023-01-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2023.2166275
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The Role of Myeloid-Derived Suppressor Cells in Multiple Sclerosis and Its Animal Model.

    Jiang, Qianling / Duan, Jielin / Kaer, Luc Van / Yang, Guan

    Aging and disease

    2023  

    Abstract: Myeloid-derived suppressor cells (MDSCs), a heterogeneous cell population that consists of mostly immature myeloid cells, are immunoregulatory cells mainly characterized by their suppressive functions. Emerging findings have revealed the involvement of ... ...

    Abstract Myeloid-derived suppressor cells (MDSCs), a heterogeneous cell population that consists of mostly immature myeloid cells, are immunoregulatory cells mainly characterized by their suppressive functions. Emerging findings have revealed the involvement of MDSCs in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). MS is an autoimmune and degenerative disease of the central nervous system characterized by demyelination, axon loss, and inflammation. Studies have reported accumulation of MDSCs in inflamed tissues and lymphoid organs of MS patients and EAE mice, and these cells display dual functions in EAE. However, the contribution of MDSCs to MS/EAE pathogenesis remains unclear. This review aims to summarize our current understanding of MDSC subsets and their possible roles in MS/EAE pathogenesis. We also discuss the potential utility and associated obstacles in employing MDSCs as biomarkers and cell-based therapies for MS.
    Language English
    Publishing date 2023-05-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2625789-0
    ISSN 2152-5250
    ISSN 2152-5250
    DOI 10.14336/AD.2023.0323-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: PIK3C3/VPS34 links T-cell autophagy to autoimmunity.

    Yang, Guan / Van Kaer, Luc

    Cell death & disease

    2020  Volume 11, Issue 5, Page(s) 334

    MeSH term(s) Animals ; Autoimmunity ; Autophagy ; Beclin-1/metabolism ; Class III Phosphatidylinositol 3-Kinases/metabolism ; Humans ; Mice ; Phagocytosis ; Signal Transduction ; T-Lymphocytes/immunology
    Chemical Substances Beclin-1 ; Class III Phosphatidylinositol 3-Kinases (EC 2.7.1.137)
    Language English
    Publishing date 2020-05-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2541626-1
    ISSN 2041-4889 ; 2041-4889
    ISSN (online) 2041-4889
    ISSN 2041-4889
    DOI 10.1038/s41419-020-2568-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Survivre et vivre: When iNKT cells met a Hippo.

    Van Kaer, Luc / Joyce, Sebastian

    The Journal of experimental medicine

    2020  Volume 217, Issue 6

    Abstract: Invariant natural killer T (iNKT) cells are innate-like lymphocytes with unique signaling requirements for their development and differentiation. In this issue of JEM, Raynor et al. (https://doi.org/10.1084/jem.20191157) report that the Hippo signaling ... ...

    Abstract Invariant natural killer T (iNKT) cells are innate-like lymphocytes with unique signaling requirements for their development and differentiation. In this issue of JEM, Raynor et al. (https://doi.org/10.1084/jem.20191157) report that the Hippo signaling pathway controls the maturation and effector differentiation of iNKT cells by modulating cellular metabolism.
    MeSH term(s) Cell Differentiation ; Cell Division ; Natural Killer T-Cells ; Signal Transduction
    Language English
    Publishing date 2020-05-07
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20200343
    Database MEDical Literature Analysis and Retrieval System OnLINE

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