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  1. Article: A Journey into Atopic Dermatitis: 5 Experts' Reviews Appearing in DPCJ Next Issues.

    Balato, Anna

    Dermatology practical & conceptual

    2021  Volume 11, Issue 4, Page(s) e2021147

    Language English
    Publishing date 2021-10-01
    Publishing country Austria
    Document type Editorial
    ZDB-ID 2685397-8
    ISSN 2160-9381
    ISSN 2160-9381
    DOI 10.5826/dpc.1104a147
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Palmoplantar psoriasis or palmoplantar keratoderma? Successful treatment with brodalumab.

    Buononato, Dario / Giorgio, Caterina M R / Carraturo, Emma / Pagliuca, Francesca / Argenziano, Giuseppe / Balato, Anna

    International journal of dermatology

    2024  

    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Letter
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.17159
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  3. Article ; Online: A Familial Novel Putative-Pathogenic Mutation Identified in Plaque-Psoriasis by a Multigene Panel Analysis.

    Nunziato, Marcella / Balato, Anna / Ruocco, Anna / D'Argenio, Valeria / Di Caprio, Roberta / Balato, Nicola / Ayala, Fabio / Salvatore, Francesco

    International journal of molecular sciences

    2023  Volume 24, Issue 5

    Abstract: Psoriasis is a chronic multifactorial skin disorder with an immune basis. It is characterized by patches of skin that are usually red, flaky and crusty, and that often release silvery scales. The patches appear predominantly on the elbows, knees, scalp ... ...

    Abstract Psoriasis is a chronic multifactorial skin disorder with an immune basis. It is characterized by patches of skin that are usually red, flaky and crusty, and that often release silvery scales. The patches appear predominantly on the elbows, knees, scalp and lower back, although they may also appear on other body areas and severity may be variable. The majority of patients (about 90%) present small patches known as "plaque psoriasis". The roles of environmental triggers such as stress, mechanical trauma and streptococcal infections are well described in psoriasis onset, but much effort is still needed to unravel the genetic component. The principal aim of this study was to use a next-generation sequencing technologies-based approach together with a 96 customized multigene panel in the attempt to determine if there are germline alterations that can explain the onset of the disease, and thus to find associations between genotypes and phenotypes. To this aim, we analyzed a family in which the mother showed mild psoriasis, and her 31-year-old daughter had suffered from psoriasis for several years, whereas an unaffected sister served as a negative control. We found variants already associated directly to psoriasis in the
    MeSH term(s) Adult ; Female ; Humans ; Genetic Predisposition to Disease ; Mutation ; Phenotype ; Psoriasis/etiology ; Psoriasis/genetics ; Streptococcal Infections/complications
    Chemical Substances TRAF3IP2 protein, human
    Language English
    Publishing date 2023-03-01
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24054743
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  4. Article: Impact in Contact Dermatitis during and after SARS-CoV2 Pandemic.

    Babino, Graziella / Argenziano, Giuseppe / Balato, Anna

    Current treatment options in allergy

    2022  Volume 9, Issue 1, Page(s) 19–26

    Abstract: Purpose of the review: Due to the recent COVID-19 pandemic, several skin conditions have emerged due to the preventive measures adopted by both health care workers and the general population against SARS-CoV-2. Above all, wearing of personal protective ... ...

    Abstract Purpose of the review: Due to the recent COVID-19 pandemic, several skin conditions have emerged due to the preventive measures adopted by both health care workers and the general population against SARS-CoV-2. Above all, wearing of personal protective equipment, frequent hand-washing and disinfecting of surfaces have resulted in an increased risk of irritant or allergic contact dermatitis. The aim of this review is to investigate contact dermatitis associated with COVID-19 pandemic period.
    Recent findings: There is a real evidence of the rising prevalence of irritant and allergic contact dermatitis in response to the COVID-19 pandemic. The most commonly recorded symptoms are dryness, itch and redness of the skin. Nasal bridge, cheeks, forehead and hands represent the mainly affected skin sites.
    Summary: Contact dermatitis lesions may appear as a result of various recommendations to prevent transmission of COVID-19. Procedures to alleviate pressure and friction, gentle skin care and adequate moisturizing, have been identified as important preventive strategies for contact dermatitis related to personal protective equipment and personal hygiene measures.
    Language English
    Publishing date 2022-02-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2196-3053
    ISSN 2196-3053
    DOI 10.1007/s40521-022-00298-2
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  5. Article ; Online: Sociodemographic, clinical and therapeutic factors as predictors of life quality impairment in psoriasis: A cross-sectional study in Italy.

    Scala, Emanuele / Kaczmarczyk, Robert / Zink, Alexander / Balato, Anna

    Dermatologic therapy

    2022  Volume 35, Issue 8, Page(s) e15622

    Abstract: Psoriasis is a chronic inflammatory skin disease showing a high burden due to its aesthetic, social, psychological, and quality of life (QoL) implications which also affect patient-physician relationship and, consequently, the adherence to treatments. ... ...

    Abstract Psoriasis is a chronic inflammatory skin disease showing a high burden due to its aesthetic, social, psychological, and quality of life (QoL) implications which also affect patient-physician relationship and, consequently, the adherence to treatments. Limited data on the natural history of psoriasis and factors predicting its prognosis are available. The aim of this study was to investigate patients' global characteristics, including treatments, associated with QoL impairment in psoriasis. Questionnaires evaluating sociodemographic features and Dermatology Life Quality Index (DLQI) were administered to patients. Multiple regression analysis was performed to evaluate factors associated with a large effect on patient's life (DLQI > 10), moderate effect on patient's life (DLQI ≥ 6 ≤ 10), small effect on patient's life (DLQI ≥ 2 < 6), and no effect on patient's life (DLQI < 2). Overall, 1052 consecutive patients affected by mild-to-severe psoriasis were recruited. Our logistic regression analysis showed that the influencing factors for a large effect on QoL were living in Southern Italy, depression, psoriatic arthritis, and psoriasis localization on facial, intertriginous, palmoplantar, trunk and scalp regions. For a moderate effect on patient's life, phototherapy and non-biological systemic therapies resulted to be the predictive factors. Mild psoriasis, living in social housing and the isolated involvement of scalp psoriasis had a small effect on QoL. Lastly, mild psoriasis and current biological therapies including anti-IL-12/23, anti-IL-17, and anti-TNF-α were positively associated with no life quality impairment. Perceived quality of life impairment in psoriasis not only depends on the skin disease but rather on patients' global characteristics. Therefore, the individual background of these patients should be respected in the selection of treatment options.
    MeSH term(s) Arthritis, Psoriatic ; Cross-Sectional Studies ; Humans ; Psoriasis/drug therapy ; Quality of Life ; Severity of Illness Index ; Tumor Necrosis Factor Inhibitors
    Chemical Substances Tumor Necrosis Factor Inhibitors
    Language English
    Publishing date 2022-06-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.15622
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  6. Article ; Online: A case of erythrodermic psoriasis successfully treated with ixekizumab.

    Megna, Matteo / Gallo, Lucia / Balato, Nicola / Balato, Anna

    Dermatologic therapy

    2019  Volume 32, Issue 2, Page(s) e12825

    Abstract: Erythrodermic psoriasis (EP) is the most severe form of psoriasis, resulting in significant morbidity and mortality. International guidelines on EP treatment are lacking, with most of the biologic drugs being used basing on case reports or small case ... ...

    Abstract Erythrodermic psoriasis (EP) is the most severe form of psoriasis, resulting in significant morbidity and mortality. International guidelines on EP treatment are lacking, with most of the biologic drugs being used basing on case reports or small case series. Ixekizumab, a fully human anti-interleukin (IL)-17A monoclonal antibody, is approved for moderate to severe plaque psoriasis while its use in EP is off label. However, two studies conducted on eight Japanese EP patients have showed ixekizumab as an efficacious and well tolerated therapy up to 24 and 52 weeks, respectively. To date, no case reports on Caucasian patients have been described. We report the case of a 66-year-old Caucasian female with EP successfully treated with ixekizumab, reaching PASI 100 after only 6 weeks of therapy and still maintaining this response at week 24. Our case report suggests ixekizumab as a highly efficacious treatment in EP, presenting also a very rapid action which leads to complete resolution of the disease after 6 weeks. Further studies are warrant to confirm our data, with controlled trials specifically dedicated to EP being strictly needed in order to verify the role and efficacy of the new biologics in EP.
    MeSH term(s) Aged ; Antibodies, Monoclonal, Humanized/therapeutic use ; Dermatitis, Exfoliative/drug therapy ; Dermatitis, Exfoliative/pathology ; Dermatologic Agents/therapeutic use ; Female ; Humans ; Interleukin-17/immunology ; Psoriasis/drug therapy ; Psoriasis/pathology ; Treatment Outcome
    Chemical Substances Antibodies, Monoclonal, Humanized ; Dermatologic Agents ; IL17A protein, human ; Interleukin-17 ; ixekizumab (BTY153760O)
    Language English
    Publishing date 2019-01-31
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.12825
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  7. Article ; Online: A Familial Novel Putative-Pathogenic Mutation Identified in Plaque-Psoriasis by a Multigene Panel Analysis

    Marcella Nunziato / Anna Balato / Anna Ruocco / Valeria D’Argenio / Roberta Di Caprio / Nicola Balato / Fabio Ayala / Francesco Salvatore

    International Journal of Molecular Sciences, Vol 24, Iss 4743, p

    2023  Volume 4743

    Abstract: Psoriasis is a chronic multifactorial skin disorder with an immune basis. It is characterized by patches of skin that are usually red, flaky and crusty, and that often release silvery scales. The patches appear predominantly on the elbows, knees, scalp ... ...

    Abstract Psoriasis is a chronic multifactorial skin disorder with an immune basis. It is characterized by patches of skin that are usually red, flaky and crusty, and that often release silvery scales. The patches appear predominantly on the elbows, knees, scalp and lower back, although they may also appear on other body areas and severity may be variable. The majority of patients (about 90%) present small patches known as “plaque psoriasis”. The roles of environmental triggers such as stress, mechanical trauma and streptococcal infections are well described in psoriasis onset, but much effort is still needed to unravel the genetic component. The principal aim of this study was to use a next-generation sequencing technologies-based approach together with a 96 customized multigene panel in the attempt to determine if there are germline alterations that can explain the onset of the disease, and thus to find associations between genotypes and phenotypes. To this aim, we analyzed a family in which the mother showed mild psoriasis, and her 31-year-old daughter had suffered from psoriasis for several years, whereas an unaffected sister served as a negative control. We found variants already associated directly to psoriasis in the TRAF3IP2 gene, and interestingly we found a missense variant in the NAT9 gene. The use of multigene panels in such a complex pathology such as psoriasis can be of great help in identifying new susceptibility genes, and in being able to make early diagnoses especially in families with affected subjects.
    Keywords multigene panel ; plaque-psoriasis ; predictive medicine ; psoriasis familial mutations ; predisposing genes ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 616
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Artificial Intelligence in Skin Cancer Diagnosis: A Reality Check.

    Brancaccio, Gabriella / Balato, Anna / Malvehy, Josep / Puig, Susana / Argenziano, Giuseppe / Kittler, Harald

    The Journal of investigative dermatology

    2023  Volume 144, Issue 3, Page(s) 492–499

    Abstract: The field of skin cancer detection offers a compelling use case for the application of artificial intelligence (AI) within the realm of image-based diagnostic medicine. Through the analysis of large datasets, AI algorithms have the capacity to classify ... ...

    Abstract The field of skin cancer detection offers a compelling use case for the application of artificial intelligence (AI) within the realm of image-based diagnostic medicine. Through the analysis of large datasets, AI algorithms have the capacity to classify clinical or dermoscopic images with remarkable accuracy. Although these AI-based applications can operate both autonomously and under human supervision, the best results are achieved through a collaborative approach that leverages the expertise of both AI and human experts. However, it is important to note that most studies focus on assessing the diagnostic accuracy of AI in artificial settings rather than in real-world scenarios. Consequently, the practical utility of AI-assisted diagnosis in a clinical environment is still largely unknown. Furthermore, there exists a knowledge gap concerning the optimal use cases and deployment settings for these AI systems as well as the practical challenges that may arise from widespread implementation. This review explores the advantages and limitations of AI in a variety of real-world contexts, with a specific focus on its value to consumers, general practitioners, and dermatologists.
    MeSH term(s) Humans ; Artificial Intelligence ; Skin Neoplasms/diagnosis ; Algorithms ; Skin ; Image Interpretation, Computer-Assisted
    Language English
    Publishing date 2023-11-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2023.10.004
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  9. Article ; Online: Limitations of current monoclonal antibodies for plaque-type psoriasis and an outlook for the future.

    Raimondo, Annunziata / Balato, Anna / Megna, Matteo / Balato, Nicola

    Expert opinion on biological therapy

    2018  Volume 18, Issue 6, Page(s) 605–607

    Language English
    Publishing date 2018-05-30
    Publishing country England
    Document type Editorial
    ZDB-ID 2052501-1
    ISSN 1744-7682 ; 1471-2598
    ISSN (online) 1744-7682
    ISSN 1471-2598
    DOI 10.1080/14712598.2018.1479738
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  10. Article: CLINICAL RESULTS OF COLLAGENASE TREATMENT FOR DUPUYTREN'S DISEASE: A CASE SERIES STUDY WITH 2-YEARS FOLLOW-UP.

    Basso, Morena Anna / Bernasconi, Alessio / Balato, Giovanni / Cozzolino, Andrea / Famiglietti, Giulia / Smeraglia, Francesco

    Acta ortopedica brasileira

    2023  Volume 31, Issue spe1, Page(s) e259218

    Abstract: Objectives: This study aims to report our experience with Clostridium Histolyticum collagenase (CCH) to support the importance of its clinical use and assess its clinical efficacy, complications, and recurrences.: Methods: This prospective ... ...

    Abstract Objectives: This study aims to report our experience with Clostridium Histolyticum collagenase (CCH) to support the importance of its clinical use and assess its clinical efficacy, complications, and recurrences.
    Methods: This prospective observational study of 66 patients with a 2-year follow-up. Patients with an extension lag major of 20° at the metacarpophalangeal joint (MPJ) and/or proximal interphalangeal joint (PIPJ) were included. We collected data on demographic and anamnestic details, MPJ and PIPJ contracture degrees, DASH score, complications, and recurrences.
    Results: The mean pre-injection contracture was 34° for MPJ and 31° for PIPJ. At the 2-year follow-up, the mean contracture for the MPJ and PIPJ were respectively 3° and 14.5°. The mean DASH score decreased from 21.8 before injection to 10,4 after 2 years. The disease recurrence occurred in 34.8% of the patients, all with PIPJ contracture. The main complication was skin breakage (25.7%).
    Conclusion: The CCH injections remain a consistent option in treating DD; withdrawal from the European market deprives surgeons and patients of low invasiveness and safe tool for treating DD.
    Language English
    Publishing date 2023-04-17
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2105206-2
    ISSN 1809-4406 ; 1413-7852
    ISSN (online) 1809-4406
    ISSN 1413-7852
    DOI 10.1590/1413-785220233101e259218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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