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  1. Book ; Online ; Thesis: Natural Killer Cell-Mediated Target Cell Killing in the Context of Viral Infections

    Hagemann, Kerri [Verfasser] / Altfeld, Marcus [Akademischer Betreuer]

    2022  

    Author's details Kerri Hagemann ; Betreuer: Marcus Altfeld
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky
    Publishing place Hamburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Article ; Online: HIV-1 Nef-mediated downregulation of CD155 results in viral restriction by KIR2DL5+ NK cells.

    Fittje, Pia / Hœlzemer, Angelique / Garcia-Beltran, Wilfredo F / Vollmers, Sarah / Niehrs, Annika / Hagemann, Kerri / Martrus, Glòria / Körner, Christian / Kirchhoff, Frank / Sauter, Daniel / Altfeld, Marcus

    PLoS pathogens

    2022  Volume 18, Issue 6, Page(s) e1010572

    Abstract: Antiviral NK cell activity is regulated through the interaction of activating and inhibitory NK cell receptors with their ligands on infected cells. HLA class I molecules serve as ligands for most killer cell immunoglobulin-like receptors (KIRs), but no ... ...

    Abstract Antiviral NK cell activity is regulated through the interaction of activating and inhibitory NK cell receptors with their ligands on infected cells. HLA class I molecules serve as ligands for most killer cell immunoglobulin-like receptors (KIRs), but no HLA class I ligands for the inhibitory NK cell receptor KIR2DL5 have been identified to date. Using a NK cell receptor/ligand screening approach, we observed no strong binding of KIR2DL5 to HLA class I or class II molecules, but confirmed that KIR2DL5 binds to the poliovirus receptor (PVR, CD155). Functional studies using primary human NK cells revealed a significantly decreased degranulation of KIR2DL5+ NK cells in response to CD155-expressing target cells. We subsequently investigated the role of KIR2DL5/CD155 interactions in HIV-1 infection, and showed that multiple HIV-1 strains significantly decreased CD155 expression levels on HIV-1-infected primary human CD4+ T cells via a Nef-dependent mechanism. Co-culture of NK cells with HIV-1-infected CD4+ T cells revealed enhanced anti-viral activity of KIR2DL5+ NK cells against wild-type versus Nef-deficient viruses, indicating that HIV-1-mediated downregulation of CD155 renders infected cells more susceptible to recognition by KIR2DL5+ NK cells. These data show that CD155 suppresses the antiviral activity of KIR2DL5+ NK cells and is downmodulated by HIV-1 Nef protein as potential trade-off counteracting activating NK cell ligands, demonstrating the ability of NK cells to counteract immune escape mechanisms employed by HIV-1.
    MeSH term(s) Antiviral Agents/metabolism ; Down-Regulation ; HIV Infections ; HIV Seropositivity ; HIV-1 ; Humans ; Killer Cells, Natural ; Ligands ; Receptors, Natural Killer Cell/metabolism ; Receptors, Virus ; nef Gene Products, Human Immunodeficiency Virus/genetics ; nef Gene Products, Human Immunodeficiency Virus/metabolism
    Chemical Substances Antiviral Agents ; Ligands ; Receptors, Natural Killer Cell ; Receptors, Virus ; nef Gene Products, Human Immunodeficiency Virus ; nef protein, Human immunodeficiency virus 1 ; nef protein, Human immunodeficiency virus 2 ; poliovirus receptor
    Language English
    Publishing date 2022-06-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1010572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The co-inhibitory receptor TIGIT regulates NK cell function and is upregulated in human intrahepatic CD56

    Ziegler, Annerose E / Fittje, Pia / Müller, Luisa M / Ahrenstorf, Annika E / Hagemann, Kerri / Hagen, Sven H / Hess, Leonard U / Niehrs, Annika / Poch, Tobias / Ravichandran, Gevitha / Löbl, Sebastian M / Padoan, Benedetta / Brias, Sébastien / Hennesen, Jana / Richard, Myrtille / Richert, Laura / Peine, Sven / Oldhafer, Karl J / Fischer, Lutz /
    Schramm, Christoph / Martrus, Glòria / Bunders, Madeleine J / Altfeld, Marcus / Lunemann, Sebastian

    Frontiers in immunology

    2023  Volume 14, Page(s) 1117320

    Abstract: The crosstalk between NK cells and their surrounding environment is enabled through activating and inhibitory receptors, which tightly control NK cell activity. The co-inhibitory receptor TIGIT decreases NK cell cytotoxicity and is involved in NK cell ... ...

    Abstract The crosstalk between NK cells and their surrounding environment is enabled through activating and inhibitory receptors, which tightly control NK cell activity. The co-inhibitory receptor TIGIT decreases NK cell cytotoxicity and is involved in NK cell exhaustion, but has also been associated with liver regeneration, highlighting that the contribution of human intrahepatic CD56
    MeSH term(s) Humans ; CD56 Antigen/metabolism ; Killer Cells, Natural/metabolism ; Liver/metabolism ; Receptors, Immunologic/genetics ; Receptors, Immunologic/metabolism ; Flow Cytometry
    Chemical Substances CD56 Antigen ; Receptors, Immunologic ; TIGIT protein, human
    Language English
    Publishing date 2023-02-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1117320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Natural killer cell-mediated ADCC in SARS-CoV-2-infected individuals and vaccine recipients.

    Hagemann, Kerri / Riecken, Kristoffer / Jung, Johannes M / Hildebrandt, Heike / Menzel, Stephan / Bunders, Madeleine J / Fehse, Boris / Koch-Nolte, Friedrich / Heinrich, Fabian / Peine, Sven / Schulze Zur Wiesch, Julian / Brehm, Thomas T / Addo, Marylyn M / Lütgehetmann, Marc / Altfeld, Marcus

    European journal of immunology

    2022  Volume 52, Issue 8, Page(s) 1297–1307

    Abstract: COVID-19, caused by SARS-CoV-2, has emerged as a global pandemic. While immune responses of the adaptive immune system have been in the focus of research, the role of NK cells in COVID-19 remains less well understood. Here, we characterized NK cell- ... ...

    Abstract COVID-19, caused by SARS-CoV-2, has emerged as a global pandemic. While immune responses of the adaptive immune system have been in the focus of research, the role of NK cells in COVID-19 remains less well understood. Here, we characterized NK cell-mediated SARS-CoV-2 antibody-dependent cellular cytotoxicity (ADCC) against SARS-CoV-2 spike-1 (S1) and nucleocapsid (NC) protein. Serum samples from SARS-CoV-2 resolvers induced significant CD107a-expression by NK cells in response to S1 and NC, while serum samples from SARS-CoV-2-negative individuals did not. Furthermore, serum samples from individuals that received the BNT162b2 vaccine induced strong CD107a expression by NK cells that increased with the second vaccination and was significantly higher than observed in infected individuals. As expected, vaccine-induced responses were only directed against S1 and not against NC protein. S1-specific CD107a responses by NK cells were significantly correlated to NK cell-mediated killing of S1-expressing cells. Interestingly, screening of serum samples collected prior to the COVID-19 pandemic identified two individuals with cross-reactive antibodies against SARS-CoV-2 S1, which also induced degranulation of NK cells. Taken together, these data demonstrate that antibodies induced by SARS-CoV-2 infection and anti-SARS-CoV-2 vaccines can trigger significant NK cell-mediated ADCC activity, and identify some cross-reactive ADCC-activity against SARS-CoV-2 by endemic coronavirus-specific antibodies.
    MeSH term(s) Antibodies, Viral/metabolism ; Antibody-Dependent Cell Cytotoxicity ; BNT162 Vaccine ; COVID-19 ; Humans ; Killer Cells, Natural ; Pandemics ; SARS-CoV-2
    Chemical Substances Antibodies, Viral ; BNT162 Vaccine (N38TVC63NU)
    Language English
    Publishing date 2022-04-22
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202149470
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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Healthcare Complaints Analysis Tool: reliability testing on a sample of Danish patient compensation claims.

    Bogh, Soren Bie / Kerring, Jonas Harder / Jakobsen, Katrine Prisak / Hilsøe, Camilla Hagemann / Mikkelsen, Kim / Birkeland, Søren Fryd

    BMJ open

    2019  Volume 9, Issue 11, Page(s) e033638

    Abstract: Objective: The study aim was to test the intra-assessor and interassessor reliability of the Healthcare Complaints Analysis Tool (HCAT) for categorising the information in the claim letters in a sample of Danish patient compensation claims.: Design, ... ...

    Abstract Objective: The study aim was to test the intra-assessor and interassessor reliability of the Healthcare Complaints Analysis Tool (HCAT) for categorising the information in the claim letters in a sample of Danish patient compensation claims.
    Design, setting and participants: We used a random sample of 140 compensation cases completed by the Danish Patient Compensation Association that were filed in the field of acute medicine at Danish hospitals from 2007 to 2018. Four assessors were trained in using the HCAT manual before assessing the claim letters independently.
    Main outcome measures: Intra-assessor and interassessor reliability was tested at domain, problem category and subcategory levels of the HCAT. We also investigated the reliability of ratings on the level of harm and of the descriptive details contained in the claim letters.
    Results: The HCAT was reliable for identifying problem categories, with reliability scores ranging from 0.55 to 0.99. Reliability was lower when coding the 'severity' of the problem. Interassessor reliability was generally lower than intra-assessor reliability. The categories of 'quality' and 'safety' were the least reliable of the seven HCAT problem categories. Reliability at the subcategory level was generally satisfactory, with only a few subcategories having poor reliability. Reliability was at least moderate when coding the stage of care, the complainant and the staff group involved. However, the coding of 'level of harm' was found to be unreliable (intrareliability 0.06; inter-reliability 0.29).
    Conclusion: Overall, HCAT was found to be a reliable tool for categorising problem types in patient compensation claims.
    MeSH term(s) Compensation and Redress ; Denmark ; Female ; Health Services Research ; Humans ; Linear Models ; Male ; Patient Safety ; Reproducibility of Results ; Safety Management/methods ; Total Quality Management/methods
    Language English
    Publishing date 2019-11-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2019-033638
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A roadmap for high-resolution satellite soil moisture applications – confronting product characteristics with user requirements

    Peng, Jian / Albergel, Clement / Balenzano, Anna / Brocca, Luca / Cartus, Oliver / Cosh, Michael H / Crow, Wade T / Dabrowska-Zielinska, Katarzyna / Dadson, Simon / Davidson, Malcolm W.J / de Rosnay, Patricia / Dorigo, Wouter / Gruber, Alexander / Hagemann, Stefan / Hirschi, Martin / Kerr, Yann H / Lovergine, Francesco / Mahecha, Miguel D / Marzahn, Philip /
    Mattia, Francesco / Musial, Jan Pawel / Preuschmann, Swantje / Reichle, Rolf H / Satalino, Giuseppe / Silgram, Martyn / van Bodegom, Peter M / Verhoest, Niko E.C / Wagner, Wolfgang / Walker, Jeffrey P / Wegmüller, Urs / Loew, Alexander

    Remote sensing of environment. 2021 Jan., v. 252

    2021  

    Abstract: Soil moisture observations are of broad scientific interest and practical value for a wide range of applications. The scientific community has made significant progress in estimating soil moisture from satellite-based Earth observation data, particularly ...

    Abstract Soil moisture observations are of broad scientific interest and practical value for a wide range of applications. The scientific community has made significant progress in estimating soil moisture from satellite-based Earth observation data, particularly in operationalizing coarse-resolution (25-50 km) soil moisture products. This review summarizes existing applications of satellite-derived soil moisture products and identifies gaps between the characteristics of currently available soil moisture products and the application requirements from various disciplines. We discuss the efforts devoted to the generation of high-resolution soil moisture products from satellite Synthetic Aperture Radar (SAR) data such as Sentinel-1 C-band backscatter observations and/or through downscaling of existing coarse-resolution microwave soil moisture products. Open issues and future opportunities of satellite-derived soil moisture are discussed, providing guidance for further development of operational soil moisture products and bridging the gap between the soil moisture user and supplier communities.
    Keywords environment ; satellites ; soil water ; synthetic aperture radar
    Language English
    Dates of publication 2021-01
    Publishing place Elsevier Inc.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 431483-9
    ISSN 0034-4257
    ISSN 0034-4257
    DOI 10.1016/j.rse.2020.112162
    Database NAL-Catalogue (AGRICOLA)

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    984/1289: Show issues
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