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  1. Article ; Online: Evaluating the effectiveness of a laboratory-based professional development program for science educators.

    Amolins, Michael W / Ezrailson, Cathy M / Pearce, David A / Elliott, Amy J / Vitiello, Peter F

    Advances in physiology education

    2015  Volume 39, Issue 4, Page(s) 341–351

    Abstract: The process of developing effective science educators has been a long-standing objective of the broader education community. Numerous studies have recommended not only depth in a teacher's subject area but also a breadth of professional development ... ...

    Abstract The process of developing effective science educators has been a long-standing objective of the broader education community. Numerous studies have recommended not only depth in a teacher's subject area but also a breadth of professional development grounded in constructivist principles, allowing for successful student-centered and inquiry-based instruction. Few programs, however, have addressed the integration of the scientific research laboratory into the science classroom as a viable approach to professional development. Additionally, while occasional laboratory training programs have emerged in recent years, many lack a component for translating acquired skills into reformed classroom instruction. Given the rapid development and demand for knowledgeable employees and an informed population from the biotech and medical industries in recent years, it would appear to be particularly advantageous for the physiology and broader science education communities to consider this issue. The goal of this study was to examine the effectiveness of a laboratory-based professional development program focused on the integration of reformed teaching principles into the classrooms of secondary teachers. This was measured through the program's ability to instill in its participants elevated academic success while gaining fulfillment in the classroom. The findings demonstrated a significant improvement in the use of student-centered instruction and other reformed methods by program participants as well as improved self-efficacy, confidence, and job satisfaction. Also revealed was a reluctance to refashion established classroom protocols. The combination of these outcomes allowed for construction of an experiential framework for professional development in applied science education that supports an atmosphere of reformed teaching in the classroom.
    MeSH term(s) Biomedical Research/education ; Education, Professional/methods ; Educational Status ; Faculty ; Humans ; Laboratories ; Program Evaluation ; Staff Development/methods ; Teaching/methods
    Language English
    Publishing date 2015-12
    Publishing country United States
    Document type Evaluation Studies ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1024917-5
    ISSN 1522-1229 ; 1043-4046
    ISSN (online) 1522-1229
    ISSN 1043-4046
    DOI 10.1152/advan.00088.2015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Natural product inhibitors of Hsp90: potential leads for drug discovery.

    Amolins, M W / Blagg, B S J

    Mini reviews in medicinal chemistry

    2009  Volume 9, Issue 2, Page(s) 140–152

    Abstract: Heat shock protein 90 has emerged as a promising target for the treatment of cancer and neurodegenerative diseases. This review summarizes recent advancements towards the development of natural products as they pertain to the biological and chemical ... ...

    Abstract Heat shock protein 90 has emerged as a promising target for the treatment of cancer and neurodegenerative diseases. This review summarizes recent advancements towards the development of natural products as they pertain to the biological and chemical understanding of this molecular chaperone.
    MeSH term(s) Animals ; Antineoplastic Agents/pharmacology ; Biological Products/pharmacology ; Drug Design ; HSP90 Heat-Shock Proteins/antagonists & inhibitors ; Humans ; Protein Folding ; Structure-Activity Relationship
    Chemical Substances Antineoplastic Agents ; Biological Products ; HSP90 Heat-Shock Proteins
    Language English
    Publishing date 2009-02-04
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2104081-3
    ISSN 1875-5607 ; 1389-5575
    ISSN (online) 1875-5607
    ISSN 1389-5575
    DOI 10.2174/138955709787316056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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