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  1. Article ; Online: Trends in Incidence of Conjunctival Melanoma in the US.

    Weppelmann, Thomas A / Zimmerman, Keith T / Rashidi, Vania

    JAMA network open

    2022  Volume 5, Issue 10, Page(s) e2237229

    MeSH term(s) Humans ; Incidence ; Conjunctival Neoplasms/epidemiology ; Melanoma/epidemiology
    Language English
    Publishing date 2022-10-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2022.37229
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  2. Article ; Online: Weight changes in patients with sustained viral suppression switching tenofovir disoproxil fumarate to tenofovir alafenamide.

    Schafer, Jason J / Zimmerman, Matty / Walshe, Ciara / Cerankowski, Jesse / Shimada, Ayako / Keith, Scott W

    Obesity (Silver Spring, Md.)

    2022  Volume 30, Issue 6, Page(s) 1197–1204

    Abstract: Objective: Switching from tenofovir disoproxil fumarate (TDF)- to tenofovir alafenamide (TAF)-containing antiretroviral therapy may negatively influence weight, cholesterol, and atherosclerotic cardiovascular disease risk. The extent of these changes ... ...

    Abstract Objective: Switching from tenofovir disoproxil fumarate (TDF)- to tenofovir alafenamide (TAF)-containing antiretroviral therapy may negatively influence weight, cholesterol, and atherosclerotic cardiovascular disease risk. The extent of these changes and their association with TAF remain unclear.
    Methods: This retrospective cohort evaluated metabolic changes in virologically suppressed patients with HIV infection who switched from TDF to TAF without switching other antiretroviral therapy medications. Adult patients on TDF and with no HIV viral load values >200 copies/mL for ≥2 years prior to and following a TAF switch were included. Weight and other variables were collected for 2 years before and after the switch. Longitudinal linear mixed-effects models evaluated changes at 1 and 2 years after the switch.
    Results: In the unadjusted analysis, there were increases in weight, BMI, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, systolic blood pressure, fasting glucose, and atherosclerotic cardiovascular disease risk scores 2 years after switching to TAF (each p ≤ 0.03). However, only increases in total and low-density lipoprotein cholesterol were associated with TAF and were significantly different from expected changes predicted in the adjusted longitudinal models.
    Conclusions: Despite observing significant unadjusted metabolic changes after switching to TAF, only changes in cholesterol were associated with TAF and were different from changes expected in time-trend adjusted models.
    MeSH term(s) Adenine/therapeutic use ; Adult ; Alanine/therapeutic use ; Anti-HIV Agents/therapeutic use ; Cardiovascular Diseases/epidemiology ; Cholesterol/blood ; Drug Substitution ; Fumarates/therapeutic use ; HIV Infections/drug therapy ; Humans ; Retrospective Studies ; Sustained Virologic Response ; Tenofovir/analogs & derivatives ; Tenofovir/therapeutic use ; Weight Gain
    Chemical Substances Anti-HIV Agents ; Fumarates ; Cholesterol (97C5T2UQ7J) ; Tenofovir (99YXE507IL) ; tenofovir alafenamide (EL9943AG5J) ; Adenine (JAC85A2161) ; Alanine (OF5P57N2ZX)
    Language English
    Publishing date 2022-06-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2230457-5
    ISSN 1930-739X ; 1071-7323 ; 1930-7381
    ISSN (online) 1930-739X
    ISSN 1071-7323 ; 1930-7381
    DOI 10.1002/oby.23443
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4061: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 87: Show issues

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  3. Article ; Online: Extraintestinal Pathogenic

    Coe, Sarah E / Magagna, Michelle A / Zimmerman, Annie / George, April / Carter, Caitlyn / Dean, Charissa / Nelson, Keith

    Toxicologic pathology

    2022  , Page(s) 1926233221129233

    Abstract: Extraintestinal ... ...

    Abstract Extraintestinal pathogenic
    Language English
    Publishing date 2022-10-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 841009-4
    ISSN 1533-1601 ; 0192-6233
    ISSN (online) 1533-1601
    ISSN 0192-6233
    DOI 10.1177/01926233221129233
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    Zs.A 1975: Show issues Location:
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    Zs.MO 473: Show issues

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  4. Article ; Online: Natural protection of ocular surface from viral infections - A hypothesis.

    Zimmerman, Keith / Kearns, Fiona / Tzekov, Radouil

    Medical hypotheses

    2020  Volume 143, Page(s) 110082

    Abstract: A pandemic outbreak of a viral respiratory infection (COVID-19) caused by a coronavirus (SARS-CoV-2) prompted a multitude of research focused on various aspects of this disease. One of the interesting aspects of the clinical manifestation of the ... ...

    Abstract A pandemic outbreak of a viral respiratory infection (COVID-19) caused by a coronavirus (SARS-CoV-2) prompted a multitude of research focused on various aspects of this disease. One of the interesting aspects of the clinical manifestation of the infection is an accompanying ocular surface viral infection, viral conjunctivitis. Although occasional reports of viral conjunctivitis caused by this and the related SARS-CoV virus (causing the SARS outbreak in the early 2000s) are available, the prevalence of this complication among infected people appears low (~1%). This is surprising, considering the recent discovery of the presence of viral receptors (ACE2 and TMPRSS2) in ocular surface tissue. The discrepancy between the theoretically expected high rate of concurrence of viral ocular surface inflammation and the observed relatively low occurrence can be explained by several factors. In this work, we discuss the significance of natural protective factors related to anatomical and physiological properties of the eyes and preventing the deposition of large number of virus-loaded particles on the ocular surface. Specifically, we advance the hypothesis that the standing potential of the eye plays an important role in repelling aerosol particles (microdroplets) from the surface of the eye and discuss factors associated with this hypothesis, possible ways to test it and its implications in terms of prevention of ocular infections.
    MeSH term(s) Aerosols ; Air Microbiology ; Betacoronavirus/pathogenicity ; COVID-19 ; Conjunctivitis, Viral/prevention & control ; Conjunctivitis, Viral/virology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Eye/virology ; Humans ; Membrane Potentials ; Models, Biological ; Ocular Physiological Phenomena ; Pandemics/prevention & control ; Particle Size ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Static Electricity
    Chemical Substances Aerosols
    Keywords covid19
    Language English
    Publishing date 2020-07-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.110082
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1132: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article ; Online: Endoscopic Evaluation of Inflammatory Bowel Disease With High-Grade Dysplasia Should Not Be Delayed During the COVID-19 Pandemic: A Case Report.

    Raphael, Kara L / Trindade, Arvind J / Zimmerman, Howard M / Sultan, Keith S

    The American journal of gastroenterology

    2020  Volume 115, Issue 10, Page(s) 1727–1728

    MeSH term(s) Betacoronavirus/pathogenicity ; COVID-19 ; Colectomy/standards ; Colon/diagnostic imaging ; Colon/pathology ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Disease Progression ; Endoscopy/standards ; Female ; Humans ; Infection Control/standards ; Inflammatory Bowel Diseases/diagnosis ; Inflammatory Bowel Diseases/pathology ; Inflammatory Bowel Diseases/surgery ; Intestinal Mucosa/diagnostic imaging ; Intestinal Mucosa/pathology ; Middle Aged ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Time-to-Treatment/standards
    Keywords covid19
    Language English
    Publishing date 2020-08-21
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000000813
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    Ui V Zs.36: Show issues Location:
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  6. Article ; Online: Providing a framework for seagrass mapping in United States coastal ecosystems using high spatial resolution satellite imagery.

    Coffer, Megan M / Graybill, David D / Whitman, Peter J / Schaeffer, Blake A / Salls, Wilson B / Zimmerman, Richard C / Hill, Victoria / Lebrasse, Marie Cindy / Li, Jiang / Keith, Darryl J / Kaldy, James / Colarusso, Phil / Raulerson, Gary / Ward, David / Kenworthy, W Judson

    Journal of environmental management

    2023  Volume 337, Page(s) 117669

    Abstract: Seagrasses have been widely recognized for their ecosystem services, but traditional seagrass monitoring approaches emphasizing ground and aerial observations are costly, time-consuming, and lack standardization across datasets. This study leveraged ... ...

    Abstract Seagrasses have been widely recognized for their ecosystem services, but traditional seagrass monitoring approaches emphasizing ground and aerial observations are costly, time-consuming, and lack standardization across datasets. This study leveraged satellite imagery from Maxar's WorldView-2 and WorldView-3 high spatial resolution, commercial satellite platforms to provide a consistent classification approach for monitoring seagrass at eleven study areas across the continental United States, representing geographically, ecologically, and climatically diverse regions. A single satellite image was selected at each of the eleven study areas to correspond temporally to reference data representing seagrass coverage and was classified into four general classes: land, seagrass, no seagrass, and no data. Satellite-derived seagrass coverage was then compared to reference data using either balanced agreement, the Mann-Whitney U test, or the Kruskal-Wallis test, depending on the format of the reference data used for comparison. Balanced agreement ranged from 58% to 86%, with better agreement between reference- and satellite-indicated seagrass absence (specificity ranged from 88% to 100%) than between reference- and satellite-indicated seagrass presence (sensitivity ranged from 17% to 73%). Results of the Mann-Whitney U and Kruskal-Wallis tests demonstrated that satellite-indicated seagrass percentage cover had moderate to large correlations with reference-indicated seagrass percentage cover, indicative of moderate to strong agreement between datasets. Satellite classification performed best in areas of dense, continuous seagrass compared to areas of sparse, discontinuous seagrass and provided a suitable spatial representation of seagrass distribution within each study area. This study demonstrates that the same methods can be applied across scenes spanning varying seagrass bioregions, atmospheric conditions, and optical water types, which is a significant step toward developing a consistent, operational approach for mapping seagrass coverage at the national and global scales. Accompanying this manuscript are instructional videos describing the processing workflow, including data acquisition, data processing, and satellite image classification. These instructional videos may serve as a management tool to complement field- and aerial-based mapping efforts for monitoring seagrass ecosystems.
    MeSH term(s) United States ; Ecosystem ; Satellite Imagery ; Environmental Monitoring/methods
    Language English
    Publishing date 2023-03-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2023.117669
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    In stock of ZB MED Bonn / Germany

    Z 7556: Show issues

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  7. Article ; Online: Nonionic Surfactant Properties of Amphiphilic Hyperbranched Polyglycerols.

    Andrade, Brenda / Knewstub, Samuel N / Harris, Keith / Tucker, Christopher J / Katz, Joshua S / Zimmerman, Steven C

    Langmuir : the ACS journal of surfaces and colloids

    2020  Volume 36, Issue 34, Page(s) 10103–10109

    Abstract: The surfactant properties of amphiphilic hyperbranched polyglycerols (HPGs) were investigated. The HPGs were prepared by ring-opening multibranching polymerization of glycidol using hydrophobic initiators of varying size and structure. The cloud points ... ...

    Abstract The surfactant properties of amphiphilic hyperbranched polyglycerols (HPGs) were investigated. The HPGs were prepared by ring-opening multibranching polymerization of glycidol using hydrophobic initiators of varying size and structure. The cloud points for all HPG surfactants were found to be >80 °C in deionized water with >1 wt % NaCl. The HPG surfactants with hydrophilic-lipophilic balance values between 16 and 18 were found to form stable octanol/water (o/w) emulsions within a 24 h period. Several surface properties, including critical micelle concentration (CMC), efficiency of surface tension reduction (p
    Language English
    Publishing date 2020-08-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.0c01349
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  8. Article ; Online: Protective role of Bruton tyrosine kinase inhibitors in patients with chronic lymphocytic leukaemia and COVID-19.

    Thibaud, Santiago / Tremblay, Douglas / Bhalla, Sheena / Zimmerman, Brittney / Sigel, Keith / Gabrilove, Janice

    British journal of haematology

    2020  Volume 190, Issue 2, Page(s) e73–e76

    MeSH term(s) Agammaglobulinaemia Tyrosine Kinase/antagonists & inhibitors ; Aged ; Aged, 80 and over ; Benzamides/therapeutic use ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Female ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Protein Kinase Inhibitors/therapeutic use ; Pyrazines/therapeutic use ; Pyrazoles/therapeutic use ; Pyrimidines/therapeutic use ; SARS-CoV-2
    Chemical Substances Benzamides ; Protein Kinase Inhibitors ; Pyrazines ; Pyrazoles ; Pyrimidines ; ibrutinib (1X70OSD4VX) ; Agammaglobulinaemia Tyrosine Kinase (EC 2.7.10.2) ; acalabrutinib (I42748ELQW)
    Keywords covid19
    Language English
    Publishing date 2020-06-04
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16863
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    Uh III Zs.182: Show issues Location:
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  9. Article: Natural protection of ocular surface from viral infections - A hypothesis

    Zimmerman, Keith / Kearns, Fiona / Tzekov, Radouil

    Med Hypotheses

    Abstract: A pandemic outbreak of a viral respiratory infection (COVID-19) caused by a coronavirus (SARS-CoV-2) prompted a multitude of research focused on various aspects of this disease. One of the interesting aspects of the clinical manifestation of the ... ...

    Abstract A pandemic outbreak of a viral respiratory infection (COVID-19) caused by a coronavirus (SARS-CoV-2) prompted a multitude of research focused on various aspects of this disease. One of the interesting aspects of the clinical manifestation of the infection is an accompanying ocular surface viral infection, viral conjunctivitis. Although occasional reports of viral conjunctivitis caused by this and the related SARS-CoV virus (causing the SARS outbreak in the early 2000s) are available, the prevalence of this complication among infected people appears low (~1%). This is surprising, considering the recent discovery of the presence of viral receptors (ACE2 and TMPRSS2) in ocular surface tissue. The discrepancy between the theoretically expected high rate of concurrence of viral ocular surface inflammation and the observed relatively low occurrence can be explained by several factors. In this work, we discuss the significance of natural protective factors related to anatomical and physiological properties of the eyes and preventing the deposition of large number of virus-loaded particles on the ocular surface. Specifically, we advance the hypothesis that the standing potential of the eye plays an important role in repelling aerosol particles (microdroplets) from the surface of the eye and discuss factors associated with this hypothesis, possible ways to test it and its implications in terms of prevention of ocular infections.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #643405
    Database COVID19

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  10. Article: Endoscopic Evaluation of Inflammatory Bowel Disease With High-Grade Dysplasia Should Not Be Delayed During the COVID-19 Pandemic: A Case Report

    Raphael, Kara L / Trindade, Arvind J / Zimmerman, Howard M / Sultan, Keith S

    Am J Gastroenterol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #725384
    Database COVID19

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