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Article ; Online: Letter: fulminant-onset complicated inflammatory bowel disease (IBD)-a unique subtype?

Szigeti, Reka / Krishna, Mahesh / Kellermayer, Richard

2023 Volume 57, Issue 10, Page(s) 1192–1193

MeSH term(s)	Humans ; Inflammatory Bowel Diseases/complications ; Phenotype ; Age of Onset
Language	English
Publishing date	2023-04-22
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	639012-2
ISSN	1365-2036 ; 0269-2813 ; 0953-0673
ISSN (online)	1365-2036
ISSN	0269-2813 ; 0953-0673
DOI	10.1111/apt.17418
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Article ; Online: Antecedents and components of burnout among Hungarian teachers in a cross-sectional study: Development of the Burnout Antecedents and Components Questionnaire.

Szigeti, Réka / Balázs, Noémi / Urbán, Róbert

Acta psychologica

2023 Volume 241, Page(s) 104080

Abstract: Background: Studies have focused more on the outcome than on the antecedents of burnout. We aimed to develop a new measurement tool for burnout, including the antecedents and different components drawing from theories of the developmental aspect of ... ...

Abstract	Background: Studies have focused more on the outcome than on the antecedents of burnout. We aimed to develop a new measurement tool for burnout, including the antecedents and different components drawing from theories of the developmental aspect of burnout. Methods: In this cross-sectional study we tested the Burnout Antecedents and Components Questionnaire on a convenience sample of teachers (n = 618, 83.9 % women; mean age 44.52 years). We used confirmatory factor analyses to test our measurement model. We examined the concurrent validity with the Maslach Burnout Inventory. We also tested construct validity with depression, overcommitment, demographic characteristics and work-related factors. Results: The confirmatory factor analyses supported our measurement model with seven primary factors (need to prove oneself, overload of tasks, neglecting one's needs, conflict between values, interpersonal conflicts, passivity, and emotional drain) and three second-order factors (excessive effort, conflict, and total depletion). The covariates in the Maslach Burnout Inventory showed that emotional exhaustion had a strong relationship with the first- and second-order factors. Overcommitment showed a stronger relationship with factors at the beginning whereas depression showed a stronger relationship with factors at the end of the process. Demographic characteristics and work-related factors did not show strong associations. Conclusions: The Burnout Antecedents and Components Questionnaire is a promising measurement tool with good convergent validity. Future research should further validate our questionnaire for burnout research, prevention, and screening. It adds a new dimension to the measurement of burnout. The approach involving the antecedents in measuring burnout among teachers can guide future research and tailored prevention programs.
MeSH term(s)	Humans ; Female ; Adult ; Male ; Cross-Sectional Studies ; Hungary/epidemiology ; Burnout, Professional/epidemiology ; Burnout, Professional/diagnosis ; Burnout, Professional/psychology ; Burnout, Psychological/epidemiology ; Surveys and Questionnaires
Language	English
Publishing date	2023-11-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1480049-4
ISSN	1873-6297 ; 0001-6918
ISSN (online)	1873-6297
ISSN	0001-6918
DOI	10.1016/j.actpsy.2023.104080
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Tying the past to the present: time tested knowledge with state-of-the-art technology in the fight against emerging and drug resistant microbes.

Szigeti, Reka / Kellermayer, Richard

Therapeutic advances in infectious disease

2021 Volume 8, Page(s) 2049936121989552

Language	English
Publishing date	2021-02-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2728410-4
ISSN	2049-937X ; 2049-9361
ISSN (online)	2049-937X
ISSN	2049-9361
DOI	10.1177/2049936121989552
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Article ; Online: Natural unblinding of BCG vaccination trials.

Szigeti, Reka / Kellermayer, Richard

Vaccine

2021 Volume 39, Issue 15, Page(s) 2017–2019

Abstract: There is significant public and clinical interest in the potential for Bacillus Calmette-Guérin (BCG) vaccination to protect against type 2 Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) induced COVID-19. This question could be best answered ... ...

Abstract	There is significant public and clinical interest in the potential for Bacillus Calmette-Guérin (BCG) vaccination to protect against type 2 Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) induced COVID-19. This question could be best answered by blinded and placebo controlled clinical trials. However, a skin reaction occurs within days at the site of BCG injection, making it rather challenging to blind this vaccination. Here, we examined registered clinical trials in ClinicalTrials.gov on BCG against COVID-19 by October 9th 2020, and found that 94.7% of such trials were listed as placebo controlled (all with normal saline as placebo), and single to quadruple blinded. The mode of overcoming the natural unblinding by the BCG induced skin reaction was not clarified on the website in either of the trials. We conclude that detailed description of the strategy towards overcoming the BCG vaccination induced skin reaction associated unblinding hurdle will be important for the interpretation of the theoretically blinded COVID-19 directed clinical trials.
MeSH term(s)	BCG Vaccine/administration & dosage ; COVID-19/prevention & control ; Clinical Trials as Topic ; Double-Blind Method ; Humans ; Research Design ; Single-Blind Method ; Vaccination
Chemical Substances	BCG Vaccine
Language	English
Publishing date	2021-03-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2021.03.039
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Article: Natural unblinding of BCG vaccination trials

Szigeti, Reka / Kellermayer, Richard

Vaccine. 2021 Apr. 08, v. 39, no. 15

2021

Abstract	There is significant public and clinical interest in the potential for Bacillus Calmette-Guérin (BCG) vaccination to protect against type 2 Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) induced COVID-19. This question could be best answered by blinded and placebo controlled clinical trials. However, a skin reaction occurs within days at the site of BCG injection, making it rather challenging to blind this vaccination. Here, we examined registered clinical trials in ClinicalTrials.gov on BCG against COVID-19 by October 9th 2020, and found that 94.7% of such trials were listed as placebo controlled (all with normal saline as placebo), and single to quadruple blinded. The mode of overcoming the natural unblinding by the BCG induced skin reaction was not clarified on the website in either of the trials. We conclude that detailed description of the strategy towards overcoming the BCG vaccination induced skin reaction associated unblinding hurdle will be important for the interpretation of the theoretically blinded COVID-19 directed clinical trials.
Keywords	COVID-19 infection ; Internet ; Mycobacterium bovis BCG ; Severe acute respiratory syndrome coronavirus ; Severe acute respiratory syndrome coronavirus 2 ; placebos ; vaccination ; vaccines
Language	English
Dates of publication	2021-0408
Size	p. 2017-2019.
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-light
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2021.03.039
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Genetic Variation Between Small Bowel and Colon-Predominant Crohn Disease.

Patel, Halee / Harris, R Alan / Qian, Justin H / Oezguen, Numan / Watson, Ashleigh / Szigeti, Reka G / Cho, Stanley / Ruan, Wenly / Britto, Savini / Opekun, Antone / Preidis, Geoffrey / Kellermayer, Richard

Cellular and molecular gastroenterology and hepatology

2024

Language	English
Publishing date	2024-02-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2819778-1
ISSN	2352-345X ; 2352-345X
ISSN (online)	2352-345X
ISSN	2352-345X
DOI	10.1016/j.jcmgh.2024.02.010
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Article ; Online: Wood Pastures

László Somay / Viktor Szigeti / Gergely Boros / Réka Ádám / András Báldi

Forests, Vol 12, Iss 25, p

A Transitional Habitat between Forests and Pastures for Dung Beetle Assemblages

2021 Volume 25

Abstract: Wood pastures are home to a variety of species, including the dung beetle. Dung beetles are an important functional group in decomposition. Specifically, in terms of livestock manure, they not only contribute to nutrient cycling but are key players in ... ...

Abstract	Wood pastures are home to a variety of species, including the dung beetle. Dung beetles are an important functional group in decomposition. Specifically, in terms of livestock manure, they not only contribute to nutrient cycling but are key players in supporting human and animal health. Dung beetles, however, are declining in population, and urgent recommendations are needed to reverse this trend. Recommendations need to be based on solid evidence and specific habitats. Herein, we aimed to investigate the role of an intermediate habitat type between forests and pastures. Wood pastures are key areas for dung beetle conservation. For this reason, we compared dung beetle assemblages among forests, wood pastures, and grasslands. We complemented this with studies on the effects of dung type and season at three Hungarian locations. Pitfall traps baited with cattle, sheep, or horse dung were used in forests, wood pastures, and pasture habitats in spring, summer, and autumn. Dung beetle assemblages of wood pastures showed transient characteristics between forests and pastures regarding their abundance, species richness, Shannon diversity, assemblage composition, and indicator species. We identified a strong effect of season and a weak of dung type. Assemblage composition proved to be the most sensitive measure of differences among habitats. The conservation of dung beetles, and the decomposition services they provide, need continuous livestock grazing to provide fresh dung, as well as the maintenance of wood pastures where dung beetle assemblages typical of forests and pastures can both survive.
Keywords	abundance ; community composition ; decomposition ; Shannon diversity ; ecosystem service ; Geotrupidae ; Plant ecology ; QK900-989
Subject code	333
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Burnout and depressive symptoms in teachers: Factor structure and construct validity of the Maslach Burnout inventory-educators survey among elementary and secondary school teachers in Hungary.

Szigeti, Réka / Balázs, Noémi / Bikfalvi, Réka / Urbán, Róbert

Stress and health : journal of the International Society for the Investigation of Stress

2017 Volume 33, Issue 5, Page(s) 530–539

Abstract: This study validated the Hungarian version of the Maslach Burnout Inventory-Educators Survey on a sample of n = 211 elementary and secondary teachers. To test factorial validity, we ran a series of confirmatory analysis with eight models. The best ... ...

Abstract	This study validated the Hungarian version of the Maslach Burnout Inventory-Educators Survey on a sample of n = 211 elementary and secondary teachers. To test factorial validity, we ran a series of confirmatory analysis with eight models. The best fitting model was the bifactor model with general burnout and three specific factors: emotional exhaustion, depersonalization, and personal accomplishment. Analyzing the covariates revealed that gender and age were not associated with burnout, but depressive symptoms and overcommitment had a significant relationship with general burnout, and overcommitment was related to emotional exhaustion as well.
MeSH term(s)	Achievement ; Adult ; Burnout, Professional/epidemiology ; Burnout, Professional/psychology ; Depersonalization/epidemiology ; Depersonalization/psychology ; Depression/epidemiology ; Depression/psychology ; Female ; Humans ; Hungary/epidemiology ; Male ; Middle Aged ; Psychometrics/methods ; Reproducibility of Results ; School Teachers/psychology ; School Teachers/statistics & numerical data
Keywords	covid19
Language	English
Publishing date	2017-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2042041-9
ISSN	1532-2998 ; 1532-3005
ISSN (online)	1532-2998
ISSN	1532-3005
DOI	10.1002/smi.2737
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Article ; Online: Theta-burst rTMS in schizophrenia to ameliorate negative and cognitive symptoms: study protocol for a double-blind, sham-controlled, randomized clinical trial.

Csukly, Gábor / Orbán-Szigeti, Boglárka / Suri, Karolin / Zsigmond, Réka / Hermán, Levente / Simon, Viktória / Kabaji, Anita / Bata, Barnabás / Hársfalvi, Péter / Vass, Edit / Csibri, Éva / Farkas, Kinga / Réthelyi, János

Trials

2024 Volume 25, Issue 1, Page(s) 269

Abstract: Background: Treatment effects of conventional approaches with antipsychotics or psychosocial interventions are limited when it comes to reducing negative and cognitive symptoms in schizophrenia. While there is emerging clinical evidence that new, ... ...

Abstract	Background: Treatment effects of conventional approaches with antipsychotics or psychosocial interventions are limited when it comes to reducing negative and cognitive symptoms in schizophrenia. While there is emerging clinical evidence that new, augmented protocols based on theta-burst stimulation can increase rTMS efficacy dramatically in depression, data on similar augmented therapies are limited in schizophrenia. The different patterns of network impairments in subjects may underlie that some but not all patients responded to given stimulation locations. Methods: Therefore, we propose an augmented theta-burst stimulation protocol in schizophrenia by stimulating both locations connected to negative symptoms: (1) the left dorsolateral prefrontal cortex (DLPFC), and (2) the vermis of the cerebellum. Ninety subjects with schizophrenia presenting negative symptoms and aging between 18 and 55 years will be randomized to active and sham stimulation in a 1:1 ratio. The TBS parameters we adopted follow the standard TBS protocols, with 3-pulse 50-Hz bursts given every 200 ms (at 5 Hz) and an intensity of 100% active motor threshold. We plan to deliver 1800 stimuli to the left DLPFC and 1800 stimuli to the vermis daily in two 9.5-min blocks for 4 weeks. The primary endpoint is the change in negative symptom severity measured by the Positive and Negative Syndrome Scale (PANSS). Secondary efficacy endpoints are changes in cognitive flexibility, executive functioning, short-term memory, social cognition, and facial emotion recognition. The difference between study groups will be analyzed by a linear mixed model analysis with the difference relative to baseline in efficacy variables as the dependent variable and treatment group, visit, and treatment-by-visit interaction as independent variables. The safety outcome is the number of serious adverse events. Discussion: This is a double-blind, sham-controlled, randomized medical device study to assess the efficacy and safety of an augmented theta-burst rTMS treatment in schizophrenia. We hypothesize that social cognition and negative symptoms of patients on active therapy will improve significantly compared to patients on sham treatment. Trial registration: The study protocol is registered at "ClinicalTrials.gov" with the following ID: NCT05100888. All items from the World Health Organization Trial Registration Data Set are registered. Initial release: 10/19/2021.
MeSH term(s)	Adult ; Humans ; Middle Aged ; Cognition ; Double-Blind Method ; Prefrontal Cortex/physiology ; Psychiatric Status Rating Scales ; Randomized Controlled Trials as Topic ; Schizophrenia/diagnosis ; Transcranial Magnetic Stimulation/methods ; Treatment Outcome ; Adolescent ; Young Adult
Language	English
Publishing date	2024-04-17
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-024-08106-9
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Article ; Online: Utility of Flow Cytometry of Bronchoalveolar Lavage in the Diagnosis of T and NK Cell Malignancies in Critically Ill Patients.

Aqil, Barina / Xie, Wei / Elghetany, M Tarek / Szigeti, Reka

Annals of clinical and laboratory science

2021 Volume 51, Issue 1, Page(s) 120–123

Abstract: Objective: The value of bronchoalveolar lavage (BAL) in the diagnosis of pulmonary diseases of diverse etiologies is widely accepted. Cytospin and cell-block preparations for cytomorphological (CM) evaluation and for immunohistochemical studies are the ... ...

Abstract	Objective: The value of bronchoalveolar lavage (BAL) in the diagnosis of pulmonary diseases of diverse etiologies is widely accepted. Cytospin and cell-block preparations for cytomorphological (CM) evaluation and for immunohistochemical studies are the standard method to evaluate BAL, though it may be time-consuming. Flow cytometric (FC) evaluation, on the other hand, has a short turnaround time, and is a useful methodology to differentiate reactive processes from hematological neoplasms, or detect a small aberrant population in an inflammatory background. BAL specimens provide an excellent source for FC studies. Case reports: We describe two cases of critically ill patients with no history of hematolymphoid neoplasms, who presented with non-specific symptoms. Abnormal pulmonary imaging studies prompted bronchoscopic evaluation and collection of BAL during the initial evaluation. FC analysis of the BAL fluid aided to the early diagnosis of aggressive NK cell leukemia and adult T cell leukemia/lymphoma, respectively. Conclusions: Flow cytometric immunophenotyping in addition to the CM assessment increases the diagnostic value and provides timely diagnosis from BAL specimens, which is especially important for critically ill patients.
MeSH term(s)	Aged ; Bronchoalveolar Lavage/methods ; Bronchoalveolar Lavage Fluid/cytology ; Critical Illness ; Early Detection of Cancer/methods ; Female ; Flow Cytometry/methods ; Hematologic Neoplasms/pathology ; Humans ; Killer Cells, Natural/metabolism ; Leukemia/diagnosis ; Leukemia/pathology ; Leukemia-Lymphoma, Adult T-Cell/diagnosis ; Leukemia-Lymphoma, Adult T-Cell/pathology ; Lung/pathology ; Lung Diseases/diagnosis ; Male ; Middle Aged
Language	English
Publishing date	2021-03-02
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	193092-8
ISSN	1550-8080 ; 0091-7370 ; 0095-8905
ISSN (online)	1550-8080
ISSN	0091-7370 ; 0095-8905
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