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Article ; Online: New Paradigm in Cell Therapy Using Sperm Head to Restore Brain Function and Structure in Animal Model of Alzheimer's Disease: Support for Boosting Constructive Inflammation

Pakravan, Nafiseh / Abbasi, Ardeshir / Hassan, Zuhair Mohammad

2022 Volume 2022, Page(s) 8343763

Abstract: Alzheimer's is characterized by accumulation of amyloid- ...

Abstract	Alzheimer's is characterized by accumulation of amyloid-
MeSH term(s)	Alzheimer Disease/metabolism ; Alzheimer Disease/therapy ; Amyloid beta-Peptides ; Animals ; Anti-Inflammatory Agents/therapeutic use ; Brain ; Cell- and Tissue-Based Therapy ; Disease Models, Animal ; Female ; Inflammation/metabolism ; Male ; Rats ; Rats, Sprague-Dawley ; Rats, Wistar ; Sperm Head/metabolism ; Sperm Head/pathology
Chemical Substances	Amyloid beta-Peptides ; Anti-Inflammatory Agents
Language	English
Publishing date	2022-04-07
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2817541-4
ISSN	2314-7156 ; 2314-7156
ISSN (online)	2314-7156
ISSN	2314-7156
DOI	10.1155/2022/8343763
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Article ; Online: Modulatory effects of R10 fraction of garlic (Allium sativum L.) on hormonal levels, T cell polarization, and fertility-related genes in mice model of polycystic ovarian syndrome.

Falahatian, Somaye / Haddad, Raheem / Pakravan, Nafiseh

Journal of ovarian research

2022 Volume 15, Issue 1, Page(s) 4

Abstract: Polycystic ovary syndrome (PCOS) is an inflammatory endocrine-metabolic disorder related to reproductive system characterized by polycystic ovarian morphology, androgen excess, and chronic anovulation. Current treatments haven't been very successful in ... ...

Abstract	Polycystic ovary syndrome (PCOS) is an inflammatory endocrine-metabolic disorder related to reproductive system characterized by polycystic ovarian morphology, androgen excess, and chronic anovulation. Current treatments haven't been very successful in PCOS treatment and the problem still remains as a challenge. Therefore, new approaches should be applied to overcome the disease. Previous studies demonstrated immunomodulatory effects of R10 fraction of garlic in the treatment of inflammatory conditions such as cancer. Considering previous studies suggesting immunomodulatory therapy for PCOS, therapeutic effects of R10 fraction was evaluated in a mouse model of PCOS. To do so, PCOS was developed by intramuscular injection of estradiol valerate. Treatment with R10 fraction, isolated from garlic, was performed and the alterations in hormonal levels (estradiol, progesterone, and testosterone), T cell polarization markers (IFN-γ, IL-4, and IL-17), and expression of fertility-related genes (Gpx3 and Ptx3) were evaluated. The results showed that hormonal levels were elevated in PCOS model comparing to normal animals but were markedly modulated after treatment with R10 fraction. Moreover, a severe disturbance in T cell polarization with a significant reduction of fertility-related genes expression were detected in PCOS-induced ovaries. Treatment with R10 fraction also represented modulatory effects on T cell polarization by increasing IL-4 and decreasing IL-17 and IFN-γ levels. Accordingly, fertility-related genes were also modulated following treatment with R10 fraction in PCOS. Our study elucidated that R10 fraction of garlic possess immunomodulatory effects alleviating PCOS symptoms. This approach could be adjusted to give rise the optimum therapeutic results and considered as a candidate therapeutic approach for PCOS.
MeSH term(s)	Animals ; Cytokines/metabolism ; Disease Models, Animal ; Estradiol/toxicity ; Female ; Fertilization/drug effects ; Fertilization/genetics ; Garlic/chemistry ; Gonadal Steroid Hormones/blood ; Immunomodulating Agents/chemistry ; Immunomodulating Agents/therapeutic use ; Mice ; Ovary/drug effects ; Ovary/metabolism ; Ovulation/drug effects ; Ovulation/genetics ; Plant Extracts/chemistry ; Plant Extracts/therapeutic use ; Polycystic Ovary Syndrome/chemically induced ; Polycystic Ovary Syndrome/drug therapy ; T-Lymphocytes/drug effects ; T-Lymphocytes/metabolism
Chemical Substances	Cytokines ; Gonadal Steroid Hormones ; Immunomodulating Agents ; Plant Extracts ; Estradiol (4TI98Z838E)
Language	English
Publishing date	2022-01-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2455679-8
ISSN	1757-2215 ; 1757-2215
ISSN (online)	1757-2215
ISSN	1757-2215
DOI	10.1186/s13048-021-00926-6
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Article ; Online: In vitro and in vivo Evidence on Intra-tumor Injection of Allogeneic Serum for Immunotherapy in a Mouse Model of Colon Cancer.

Basirat, Erfan / Dehghan, Danial / Abbasi, Ardeshir / Pakravan, Nafiseh

Iranian journal of allergy, asthma, and immunology

2022 Volume 21, Issue 5, Page(s) 549–560

Abstract: It is believed that preformed antibodies are responsible for blood transfusion reactions and transplant rejections. In order to remove a tumor, the tissue must be rejected. On the basis of transfusion reaction and transplantation immunology, we ... ...

Abstract	It is believed that preformed antibodies are responsible for blood transfusion reactions and transplant rejections. In order to remove a tumor, the tissue must be rejected. On the basis of transfusion reaction and transplantation immunology, we hypothesized that allogeneic serum can inhibit tumor growth when injected intra-tumor. Initially, an in vitro cytotoxicity test was conducted using the C57BL/6 serum (intact or decomplemented) in combination with the BALB/c-originating CT26 cell line. The CT26 cell line was used to establish a mouse model of colon cancer. When the tumor was palpable, C57BL/6 serum was injected intra-tumor. In addition to tumor size, hypoxia, metastatic capacity, angiogenesis, and metabolic and inflammatory status, we evaluated matrix metalloproteinase-2 (MMP)-2 and 9, vascular endothelial growth factor (VEGF)-A, Cluster of Designation (CD) 31, CD38 and interleukine (IL)-10. An in vitro experiment showed that heat-inactivated C57BL/6 serum had significantly lower cytotoxic effects on BALB/c-derived CT26 cells than intact C57BL/6 serum or BALB/c serum. In vivo experiments revealed that tumor size, HIF-1α, MMP-2, and MMP-9 levels were significantly lower in the experimental group than in the control group. In contrast to control animals, allogeneic serum treatment led to marked reductions in CD31, VEGF-1, CD38, and IL-10 levels. A new approach to serum or plasma therapy and allogeneic vaccines for cancer is intra-tumor injection of allogeneic serum. In light of the ease and availability of allogeneic immunotherapies, allogeneic serum and plasma therapy could potentially be used as an alternative monotherapy or in combination with other therapies.
MeSH term(s)	Mice ; Animals ; Vascular Endothelial Growth Factor A/metabolism ; Matrix Metalloproteinase 2/metabolism ; Cell Line, Tumor ; Mice, Inbred C57BL ; Colonic Neoplasms/therapy ; Neovascularization, Pathologic/therapy ; Mice, Inbred BALB C ; Disease Models, Animal ; Hematopoietic Stem Cell Transplantation ; Immunotherapy
Chemical Substances	Vascular Endothelial Growth Factor A ; Matrix Metalloproteinase 2 (EC 3.4.24.24)
Language	English
Publishing date	2022-10-26
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2488724-9
ISSN	1735-5249 ; 1735-1502
ISSN (online)	1735-5249
ISSN	1735-1502
DOI	10.18502/ijaai.v21i5.11042
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Article ; Online: Corrigendum to "Intra-nasal administration of sperm head turns neutrophil into reparative mode after PGE1- and/or Ang II receptor-mediated phagocytosis followed by expression of sperm head's coding RNA" [Int. Immunopharmacol. 2021 (98) 107696].

Pakravan, Nafiseh / Hassan, Zuhair Mohammad / Abbasi, Ardeshir

International immunopharmacology

2021 Volume 104, Page(s) 108458

Language	English
Publishing date	2021-12-16
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2021.108458
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Article ; Online: Immunotherapy Using Oxygenated Water and Tumor-Derived Exosomes Potentiates Antitumor Immune Response and Attenuates Malignancy Tendency in Mice Model of Breast Cancer.

Pakravan, Nafiseh / Abbasi, Ardeshir / Hassan, Zuhair Mohammad

Oxidative medicine and cellular longevity

2021 Volume 2021, Page(s) 5529484

Abstract: Breast cancer is one of the most common type of tumor and the leading cause of death in the world's female population. Various therapeutic approaches have been used to treat tumors but have not led to complete recovery and have even damaged normal cells ... ...

Abstract	Breast cancer is one of the most common type of tumor and the leading cause of death in the world's female population. Various therapeutic approaches have been used to treat tumors but have not led to complete recovery and have even damaged normal cells in the body. Moreover, metastatic tumors such as breast cancer are much more resistant to treatment, and current treatments have not been very successful in treating them and remain a challenge. Therefore, new approaches should be applied to overcome this problem. Given the importance of hypoxia in tumor survival, we aimed to test the antitumor effects of oxygenated water to decrease hypoxia along with tumor-derived exosomes to target tumor. The purpose of administering oxygenated water and tumor exosomes was to reduce hypoxia and establish an effective immune response against tumor antigens, respectively. For this purpose, the breast cancer mice model was induced using the 4T1 cell line in Balb/c mice and treated with oxygenated water via an intratumoral (IT) and/or intraperitoneal (IP) route and/or exosome (TEX). Oxygenation via the IT+IP route was more efficient than oxygenation via the IT or IP route. The efficiency of oxygenation via the two routes along with TEX led to the best therapeutic outcome. Antitumor immune responses directed by TEX became optimized when systemic (IP) and local (IT) oxygenation was applied compared to administration of TEX alone. Results demonstrated a significant reduction in tumor size and the highest levels of IFN-
MeSH term(s)	Animals ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Cell Line, Tumor ; Disease Models, Animal ; Exosomes/metabolism ; Female ; Humans ; Immunity/immunology ; Immunotherapy/methods ; Mice ; Mice, Inbred BALB C ; Tumor Microenvironment ; Water/chemistry
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2021-05-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2455981-7
ISSN	1942-0994 ; 1942-0994
ISSN (online)	1942-0994
ISSN	1942-0994
DOI	10.1155/2021/5529484
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Article ; Online: Intra-nasal administration of sperm head turns neutrophil into reparative mode after PGE1- and/or Ang II receptor-mediated phagocytosis followed by expression of sperm head's coding RNA.

Pakravan, Nafiseh / Hassan, Zuhair Mohammad / Abbasi, Ardeshir

International immunopharmacology

2021 Volume 98, Page(s) 107696

Abstract: Having played homeostatic role, the immune system maintains the integrity of the body. Such a characteristic makes immune system as an attractive candidate for resolution of inflammatory disease followed by tissue repair. As first responder cells, ... ...

Abstract	Having played homeostatic role, the immune system maintains the integrity of the body. Such a characteristic makes immune system as an attractive candidate for resolution of inflammatory disease followed by tissue repair. As first responder cells, neutrophils direct immune response playing key role in tissue remodeling. Previous studies revealed that sperm attracts neutrophils and promotes uterine remodeling suitable for fetus growth. Accordingly, sperm and more efficiently sperm head had remodeling effects on damaged brain in Alzheimer's disease (AD) model. To further reveal the mechanism, two kinds of in vivo study, including kinetic study and inhibition of neutrophil phagocytosis on AD model, as well as in vitro study using co-culture of neutrophil and sperm head were performed. Kinetic study revealed that sperm head recruited neutrophil to nasal mucosa similar to that of uterus and sperm head-phagocytizing neutrophils acquired new activation status comparing to control. In vitro study also demonstrated that sperm head-phagocytizing neutrophils acquire new activation status and express coding RNAs of sperm head. Accordingly, inhibition of neutrophil phagocytic activity abrogated therapeutic effects of sperm head. Neutrophils activation status is important in the fate of inflammatory process. Modulation but not suppression of neutrophils helps remodeling and repair of damaged tissue. Sperm head is an intelligent cell and not just a simple particle to remove by phagocytosis but instead can program neutrophils and consequently immune response into reparative mode after phagocytosis.
MeSH term(s)	Administration, Intranasal ; Alprostadil/metabolism ; Alzheimer Disease/immunology ; Alzheimer Disease/pathology ; Alzheimer Disease/therapy ; Amyloid beta-Peptides/administration & dosage ; Amyloid beta-Peptides/toxicity ; Animals ; Cells, Cultured ; Coculture Techniques ; Disease Models, Animal ; Humans ; Male ; Nasal Mucosa ; Neutrophil Activation ; Neutrophils/immunology ; Neutrophils/metabolism ; Peptide Fragments/administration & dosage ; Peptide Fragments/toxicity ; Phagocytosis/immunology ; Primary Cell Culture ; RNA/metabolism ; Rats ; Receptor, Angiotensin, Type 1/metabolism ; Sperm Head/transplantation
Chemical Substances	Amyloid beta-Peptides ; Peptide Fragments ; Receptor, Angiotensin, Type 1 ; amyloid beta-protein (1-42) ; RNA (63231-63-0) ; Alprostadil (F5TD010360)
Language	English
Publishing date	2021-06-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2021.107696
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Article: Tumorigenesis: cell defense against hypoxia?

Pakravan, Nafiseh

Oncology reviews

2013 Volume 7, Issue 1, Page(s) e1

Abstract: Microenvironmental elements can directly contribute to the induction and the maintenance of tumor. Oxygen is the main element in the cell microenvironment and hypoxia can affect the process of tumorigenesis. In response to hypoxia, cells change their ... ...

Abstract	Microenvironmental elements can directly contribute to the induction and the maintenance of tumor. Oxygen is the main element in the cell microenvironment and hypoxia can affect the process of tumorigenesis. In response to hypoxia, cells change their pattern and characteristics. These changes suggest that it is not just adaptation, but some sort of cell defense against hypoxia. If hypoxia is corrected, then cell defense mechanisms are interrupted. An examination of the process of tumorigenesis helps to design better therapeutic strategies. A systematic review of the English literature was conducted by searching PubMed, Google Scholar, and ISI Web databases for studies on changes that defend and help cells to live in a hypoxic microenvironment. Cells respond to hypoxia by de-differentiation and an increase in heat shock proteins. Angiogenesis and deviation of inflammatory response in favor of hypoxic cell survival also defend and save the oxygen-starved cells from death. Finally, anti-angiogenic therapies and more hypoxia enhance metastasis, as tumors with low oxygen concentration are more malignant than tumors with high oxygen concentration. All these enable cells to migrate away from low oxygen areas and seek a more conducive microenvironment. Therapies that make the microenvironment more hypoxic need to be revised. This has been done for anti-angiogenic therapies, previously considered to be anti-tumor approaches. Effective therapies may be correcting therapies which direct the tumor microenvironment towards natural physical/chemical condition. Correcting therapies either bring back tumor cells to a normal form (correct tumor cells) or help the immune system to eradicate tumor cells which can not be corrected.
Language	English
Publishing date	2013-04-22
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	2390302-8
ISSN	1970-5565 ; 1970-5565 ; 1970-5557
ISSN (online)	1970-5565
ISSN	1970-5565 ; 1970-5557
DOI	10.4081/oncol.2013.e1
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Article ; Online: The Role and Influence of the Mother in the Development of the Fetus: Comparative Study of Qur'an, Hadiths, and Modern Medical Perspectives.

Pakravan, Nafiseh / Motaharipour, Morteza

Journal of religion and health

2018 Volume 58, Issue 1, Page(s) 195–205

Abstract: The creation and development of the fetus is one of the wonders of nature and still has many unknowns. It was previously believed that the mother has no role in fetus formation/development and only acts as a chamber. Today, we know that the mother is ... ...

Abstract	The creation and development of the fetus is one of the wonders of nature and still has many unknowns. It was previously believed that the mother has no role in fetus formation/development and only acts as a chamber. Today, we know that the mother is involved in both formation and development of the fetus and even in the future of the baby's life. In this article, the relationship between some Qur'anic verses, Hadiths, and the results of new medical research on the importance of mother's role in the development of the fetus and future of the newborn life is discussed. It can be concluded that Qur'an and Hadiths are consistent with modern science in the issue discussed.
MeSH term(s)	Books ; Female ; Fetal Development ; Humans ; Infant, Newborn ; Islam ; Knowledge ; Mothers
Language	English
Publishing date	2018-06-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2017250-3
ISSN	1573-6571 ; 0022-4197
ISSN (online)	1573-6571
ISSN	0022-4197
DOI	10.1007/s10943-018-0655-6
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Article ; Online: Tumorigenesis

Nafiseh Pakravan

Oncology Reviews, Vol 7, Iss

cell defense against hypoxia?

2013 Volume 1

Abstract	Microenvironmental elements can directly contribute to the induction and the maintenance of tumor. Oxygen is the main element in the cell microenvironment and hypoxia can affect the process of tumorigenesis. In response to hypoxia, cells change their pattern and characteristics. These changes suggest that it is not just adaptation, but some sort of cell defense against hypoxia. If hypoxia is corrected, then cell defense mechanisms are interrupted. An examination of the process of tumorigenesis helps to design better therapeutic strategies.A systematic review of the English literature was conducted by searching PubMed, Google Scholar, and ISI Web databases for studies on changes that defend and help cells to live in a hypoxic microenvironment. Cells respond to hypoxia by de-differentiation and an increase in heat shock proteins. Angiogenesis and deviation of inflammatory response in favor of hypoxic cell survival also defend and save the oxygen-starved cells from death. Finally, anti-angiogenic therapies and more hypoxia enhance metastasis, as tumors with low oxygen concentration are more malignant than tumors with high oxygen concentration. All these enable cells to migrate away from low oxygen areas and seek a more conducive microenvironment. Therapies that make the microenvironment more hypoxic need to be revised. This has been done for antiangiogenic therapies, previously considered to be anti-tumor approaches. Effective therapies may be correcting therapies which direct the tumor microenvironment towards natural physical/chemical condition. Correcting therapies either bring back tumor cells to a normal form (correct tumor cells) or help the immune system to eradicate tumor cells which can not be corrected.
Keywords	tumorigenesis/metastasis ; differentiation ; heat shock proteins ; hypoxia ; inflammation ; Other systems of medicine ; RZ201-999 ; Internal medicine ; RC31-1245
Subject code	610
Language	English
Publishing date	2013-04-01T00:00:00Z
Publisher	PAGEPress Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Immunotherapy using regulatory T cells in cancer suggests more flavors of hypersensitivity type IV.

Pakravan, Nafiseh / Hassan, Zuhair Mohammad

Immunotherapy

2018 Volume 10, Issue 3, Page(s) 213–219

Abstract: Regulatory T cells (Tregs) profoundly affect tumor microenvironment and exert dominant suppression over antitumor immunity in response to self-antigen expressed by tumor. Immunotherapy targeting Tregs lead to a significant improvement in antitumor ... ...

Abstract	Regulatory T cells (Tregs) profoundly affect tumor microenvironment and exert dominant suppression over antitumor immunity in response to self-antigen expressed by tumor. Immunotherapy targeting Tregs lead to a significant improvement in antitumor immunity. Intradermal injection of tumor antigen results in negative delayed-type hypersensitivity (DTH) type IV. However, anti-Tregs treatment/use of adjuvant along with tumor antigens turns DTH to positive. Considering Tregs as the earliest tumor sensor/responders, tumor can be regarded as Treg-mediated type IV hypersensitivity and negative DTH to tumor antigen is due to anti-inflammatory action of Tregs to tumor antigens at the injection site. Such a view would help us in basic and clinical situations to testify a candidate vaccine via dermal administration and evaluation of Treg proportion at injection site.
MeSH term(s)	Animals ; Antigens, Neoplasm/administration & dosage ; Antigens, Neoplasm/immunology ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/immunology ; Cancer Vaccines/administration & dosage ; Cancer Vaccines/immunology ; Humans ; Hypersensitivity, Delayed/immunology ; Immunotherapy/methods ; Injections, Intradermal ; Lymphocyte Depletion ; Neoplasms/immunology ; Neoplasms/therapy ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/immunology ; Tumor Microenvironment/immunology
Chemical Substances	Antigens, Neoplasm ; Antineoplastic Agents ; Cancer Vaccines
Language	English
Publishing date	2018-01-25
Publishing country	England
Document type	Journal Article
ISSN	1750-7448
ISSN (online)	1750-7448
DOI	10.2217/imt-2017-0129
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