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Article ; Online: Authors' Reply to: Methodological Clarifications and Generalizing From Weibo Data. Comment on "Nature and Diffusion of COVID-19-related Oral Health Information on Chinese Social Media: Analysis of Tweets on Weibo".

Tao, Zhuo-Ying / Su, Yu-Xiong

2021 Volume 23, Issue 5, Page(s) e29145

MeSH term(s)	COVID-19 ; China ; Humans ; Oral Health ; SARS-CoV-2 ; Social Media
Language	English
Publishing date	2021-05-21
Publishing country	Canada
Document type	Letter ; Comment
ZDB-ID	2028830-X
ISSN	1438-8871 ; 1439-4456
ISSN (online)	1438-8871
ISSN	1439-4456
DOI	10.2196/29145
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Lingual Denervation Improves the Efficacy of Anti-PD-1 Immunotherapy in Oral Squamous Cell Carcinomas by Downregulating TGFβ Signaling.

Tao, Zhuo-Ying / Wang, Leilei / Zhu, Wang-Yong / Zhang, Gao / Su, Yu-Xiong

Cancer research communications

2024 Volume 4, Issue 2, Page(s) 418–430

Abstract: Purpose: Intratumoral nerve infiltration relates to tumor progression and poor survival in oral squamous cell carcinoma (OSCC). How neural involvement regulates antitumor immunity has not been well characterized. This study aims to investigate molecular ...

Abstract	Purpose: Intratumoral nerve infiltration relates to tumor progression and poor survival in oral squamous cell carcinoma (OSCC). How neural involvement regulates antitumor immunity has not been well characterized. This study aims to investigate molecular mechanisms of regulating tumor aggressiveness and impairing antitumor immunity by nerve-derived factors. Experimental design: We performed the surgical lingual denervation in an immunocompetent mouse OSCC model to investigate its effect on tumor growth and the efficacy of anti-PD-1 immunotherapy. A trigeminal ganglion neuron and OSCC cell coculture system was established to investigate the proliferation, migration, and invasion of tumor cells and the PD-L1 expression. Both the neuron-tumor cell coculture in vitro model and the OSCC animal model were explored. Results: Lingual denervation slowed down tumor growth and improved the efficacy of anti-PD-1 treatment in the OSCC model. Coculturing with neurons not only enhanced the proliferation, migration, and invasion but also upregulated TGFβ-SMAD2 signaling and PD-L1 expression of tumor cells. Treatment with the TGFβ signaling inhibitor galunisertib reversed nerve-derived tumor aggressiveness and downregulated PD-L1 on tumor cells. Similarly, lingual denervation in vivo decreased TGFβ and PD-L1 expression and increased CD8+ T-cell infiltration and the expression of IFNγ and TNFα within tumor. Conclusions: Neural involvement enhanced tumor aggressiveness through upregulating TGFβ signaling and PD-L1 expression in OSCC, while denervation of OSCC inhibited tumor growth, downregulated TGFβ signaling, enhanced activities of CD8+ T cells, and improved the efficacy of anti-PD-1 immunotherapy. This study will encourage further research focusing on denervation as a potential adjuvant therapeutic approach in OSCC. Significance: This study revealed the specific mechanisms for nerve-derived cancer progression and impaired antitumor immunity in OSCC, providing a novel insight into the cancer-neuron-immune network as well as pointing the way for new strategies targeting nerve-cancer cross-talk as a potential adjuvant therapeutic approach for OSCC.
MeSH term(s)	Animals ; Mice ; B7-H1 Antigen/metabolism ; Carcinoma, Squamous Cell/immunology ; Carcinoma, Squamous Cell/therapy ; Denervation ; Immunotherapy ; Mouth Neoplasms/immunology ; Mouth Neoplasms/therapy ; Transforming Growth Factor beta/metabolism ; Signal Transduction
Chemical Substances	B7-H1 Antigen ; Transforming Growth Factor beta
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2767-9764
ISSN (online)	2767-9764
DOI	10.1158/2767-9764.CRC-23-0192
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Authors’ Reply to

Tao, Zhuo-Ying / Su, Yu-Xiong

Journal of Medical Internet Research, Vol 23, Iss 5, p e

Methodological Clarifications and Generalizing From Weibo Data. Comment on “Nature and Diffusion of COVID-19–related Oral Health Information on Chinese Social Media: Analysis of Tweets on Weibo”

2021 Volume 29145

Keywords	Computer applications to medicine. Medical informatics ; R858-859.7 ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	JMIR Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Photodynamic Therapy of LD4-Photosensitizer Attenuates the Acute Pneumonia Induced by

Tao, Zhuo / Li, Xin / Yu, Hongzhi / Wu, Junping / Wen, Ying / Liu, Tianjun

ACS pharmacology & translational science

2024 Volume 7, Issue 4, Page(s) 1101–1113

Abstract: Klebsiella ... ...

Abstract	Klebsiella pneumoniae
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Journal Article
ISSN	2575-9108
ISSN (online)	2575-9108
DOI	10.1021/acsptsci.3c00392
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Article: The effect of drug holiday on preventing medication-related osteonecrosis of the jaw in osteoporotic rat model.

Zhu, Wang-Yong / Yang, Wei-Fa / Wang, Leilei / Lan, Xinmiao / Tao, Zhuo-Ying / Guo, Jiaxin / Xu, Jiankun / Qin, Ling / Su, Yu-Xiong

Journal of orthopaedic translation

2023 Volume 39, Page(s) 55–62

Abstract: Background: Medication-related osteonecrosis of the jaw (MRONJ) is a severe complication associated with antiresorptive medications managing osteoporosis, such as bisphosphonates (BPs). To date, there is very limited evidence from prospective, ... ...

Abstract	Background: Medication-related osteonecrosis of the jaw (MRONJ) is a severe complication associated with antiresorptive medications managing osteoporosis, such as bisphosphonates (BPs). To date, there is very limited evidence from prospective, controlled studies to support or refute the controversial prevention regimen that if a discontinuation of BPs before dentoalveolar surgery, so called "drug holiday", is effective in reducing the risk of MRONJ development in patients with osteoporosis. We proposed an experimental animal study, aiming to investigate the prevention of MRONJ following tooth extractions in osteoporotic condition, with the implementation of a BP drug holiday. Methods: Twenty rats were subjected to bilateral ovariectomy. After establishing the osteoporotic condition, all rats were exposed to weekly injections of zoledronate acid (ZA) for 8 weeks. After ZA treatment, 10 rats were subjected to dental extraction and defined as control group, and the rest 10 rats assigned to the DH group had a drug holiday of 8 weeks prior to dental extraction. Eight weeks after the dentoalveolar surgery, bone turnover biomarker in serum, occurrence of MRONJ-like lesion and histomorphometric assessment of osteonecrosis in mandible, and bone microarchitecture indices in femur, were examined. Results: Eight weeks after dental extraction, the DH group showed a recovered osteoclastic activity, indicated by significantly increased number of osteoclasts in the mandibles and serum level of C-terminal telopeptides of type I collagen, as compared to the control group. No significant differences were observed in the gross-view and histological occurrences of MRONJ-like lesions between the two groups.There was no significant difference in bone microarchitecture in the femur between the control and DH groups before ZA therapy and 8 weeks after dental extraction. Conclusion: Our data provided the first experimental evidence in the osteoporotic animal model that the implementation of a BP holiday in prior to dental extractions could partially recover osteoclastic activity, but could not alleviate the development of MRONJ-like lesion or exacerbate the osteoporotic condition in the femur. Longer-term drug holiday, or combination of drug holiday and other prophylaxes to prevent MRONJ in patients with osteoporosis could be worth exploring in future studies, to pave the way for clinical managements. The translational potential of this article: This
Language	English
Publishing date	2023-01-10
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2747531-1
ISSN	2214-031X
ISSN	2214-031X
DOI	10.1016/j.jot.2022.12.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Animal Models of Temporomandibular Disorder.

Xiang, Ting / Tao, Zhuo-Ying / Liao, Li-Fan / Wang, Shuang / Cao, Dong-Yuan

Journal of pain research

2021 Volume 14, Page(s) 1415–1430

Abstract: Temporomandibular disorders (TMD) are a group of diseases in the oral and maxillofacial region that can manifest as acute or chronic persistent pain, affecting millions of people worldwide. Although hundreds of studies have explored mechanisms and ... ...

Abstract	Temporomandibular disorders (TMD) are a group of diseases in the oral and maxillofacial region that can manifest as acute or chronic persistent pain, affecting millions of people worldwide. Although hundreds of studies have explored mechanisms and treatments underlying TMD, multiple pathogenic factors and diverse clinical manifestations make it still poorly managed. Appropriate animal models are helpful to study the pathogenesis of TMD and explore effective treatment measures. At present, due to the high cost of obtaining large animals, rodents and rabbits are often used to prepare TMD animal models. Over the past decade, various animal models have been intensively developed to understand neurobiological and molecular mechanisms of TMD, and seek effective treatments. Although these models cannot carry out all clinical features, they are valuable in revealing the mechanisms of TMD and creating curative access. Currently, there are multitudinous animal models of TMD research. They can be constructed in different means and summarized into four ways according to the various causes and symptoms, including chemical induction (intra-articular injection of ovalbumin, collagenase, formalin, vascular endothelial growth factor, intramuscular injection of complete Freund's adjuvant, etc.), mechanical stress stimulation (passive mouth opening, change of chewing load), surgical operation (partial disc resection, joint disc perforation) and psychological stress induction. Here, we summarize and discuss different approaches of animal models for determining neurophysiological and mechanical mechanisms of TMD and assess their advantages and limitations, respectively.
Language	English
Publishing date	2021-05-26
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2495284-9
ISSN	1178-7090
ISSN	1178-7090
DOI	10.2147/JPR.S303536
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Article ; Online: SAHA Inhibits Somatic Hyperalgesia Induced by Stress Combined with Orofacial Inflammation Through Targeting Different Spinal 5-HT Receptor Subtypes.

Tao, Zhuo-Ying / Qiu, Xin-Yi / Wei, Si-Qi / Bai, Guang / Li, Jin-Feng / Cao, Dong-Yuan

Neurochemical research

2022 Volume 47, Issue 5, Page(s) 1405–1418

Abstract: Epigenetic regulation of gene expression has been implicated in the development of chronic pain. However, little is known about whether this regulation is involved in the development and treatment of chronic pain comorbidities such as fibromyalgia ... ...

Abstract	Epigenetic regulation of gene expression has been implicated in the development of chronic pain. However, little is known about whether this regulation is involved in the development and treatment of chronic pain comorbidities such as fibromyalgia syndrome (FMS) and temporomandibular disorder (TMD), a comorbidity predominantly occurring among women. Here we explored the impact of the histone deacetylase (HDAC) inhibitor suberoylanilide hydroxamic acid (SAHA) on somatic hyperalgesia induced by stress or stress combined with orofacial inflammation, which mimicked the comorbidity of FMS and TMD in rats. Our data showed that somatic thermal hyperalgesia and mechanical allodynia induced by both conditions were completely prevented by intrathecal injection of SAHA, which upregulated 5-HT
MeSH term(s)	Animals ; Epigenesis, Genetic ; Female ; Hyperalgesia/chemically induced ; Hyperalgesia/drug therapy ; Inflammation/drug therapy ; Rats ; Rats, Sprague-Dawley ; Receptors, Serotonin ; Spinal Cord ; Vorinostat/pharmacology ; Vorinostat/therapeutic use
Chemical Substances	Receptors, Serotonin ; Vorinostat (58IFB293JI)
Language	English
Publishing date	2022-01-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	199335-5
ISSN	1573-6903 ; 0364-3190
ISSN (online)	1573-6903
ISSN	0364-3190
DOI	10.1007/s11064-022-03540-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1368: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Oxytocin inhibits hindpaw hyperalgesia induced by orofacial inflammation combined with stress.

Li, Yue-Xin / Li, Jia-Heng / Guo, Yi / Tao, Zhuo-Ying / Qin, Shi-Hao / Traub, Richard J / An, Hong / Cao, Dong-Yuan

Molecular pain

2022 Volume 18, Page(s) 17448069221089591

Abstract: Oxytocin (OT) is recognized as a critical neuropeptide in pain-related disorders. Chronic pain caused by the comorbidity of temporomandibular disorder (TMD) and fibromyalgia syndrome (FMS) is common, but whether OT plays an analgesic role in the ... ...

Abstract	Oxytocin (OT) is recognized as a critical neuropeptide in pain-related disorders. Chronic pain caused by the comorbidity of temporomandibular disorder (TMD) and fibromyalgia syndrome (FMS) is common, but whether OT plays an analgesic role in the comorbidity of TMD and FMS is unknown. Female rats with masseter muscle inflammation combined with 3-day forced swim (FS) stress developed somatic hypersensitivity, which modeled the comorbidity of TMD and FMS. Using this model, the effects of spinal OT administration on mechanical allodynia and thermal hyperalgesia in hindpaws were examined. Furthermore, the protein levels of OT receptors and 5-HT
MeSH term(s)	Analgesics/therapeutic use ; Animals ; Female ; Humans ; Hyperalgesia/chemically induced ; Hyperalgesia/complications ; Hyperalgesia/drug therapy ; Inflammation/chemically induced ; Inflammation/complications ; Inflammation/drug therapy ; Oxytocin/pharmacology ; Oxytocin/therapeutic use ; Rats ; Rats, Sprague-Dawley ; Receptor, Serotonin, 5-HT2A ; Ritanserin/adverse effects ; Serotonin ; Spinal Cord/metabolism
Chemical Substances	Analgesics ; Receptor, Serotonin, 5-HT2A ; Ritanserin (145TFV465S) ; Serotonin (333DO1RDJY) ; Oxytocin (50-56-6)
Language	English
Publishing date	2022-03-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2174252-2
ISSN	1744-8069 ; 1744-8069
ISSN (online)	1744-8069
ISSN	1744-8069
DOI	10.1177/17448069221089591
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A neural-related gene risk score for head and neck squamous cell carcinoma.

Tao, Zhuo-Ying / Yang, Wei-Fa / Zhu, Wang-Yong / Wang, Lei-Lei / Li, Kar Yan / Guan, Xin-Yuan / Su, Yu-Xiong

Oral diseases

2022 Volume 30, Issue 2, Page(s) 477–491

Abstract: Objectives: This study aimed to establish a neural-related gene risk score (NRGRS) for the prediction of head and neck squamous cell carcinoma prognosis and explore its predictive value on the benefit of immune checkpoint inhibitor therapy.: Methods: ...

Abstract	Objectives: This study aimed to establish a neural-related gene risk score (NRGRS) for the prediction of head and neck squamous cell carcinoma prognosis and explore its predictive value on the benefit of immune checkpoint inhibitor therapy. Methods: Based on the transcriptome data of HNSCC patients (n = 546) from The Cancer Genome Atlas database, 37 neural-related hub genes were identified by weighted gene co-expression network analysis. Four genes (ITGA5, PYGM, GNG7 and ATP2A3) were identified to construct NRGRS using Lasso-Cox regression method based on the derivation cohort and validated in the Gene Expression Omnibus cohort (n = 109). The survival analysis was performed to validate the prognostic value of NRGRS and immune characteristics in NRGRS-defined subgroups were analyzed. Results: NRGRS-high patients had a worse overall survival than NRGRS-low patients. Tumors with high NRGRS were more likely to have high infiltration of naive CD4 Conclusion: NRGRS strongly correlates with survival and is a promising biomarker to predict immunotherapy benefits for head and neck cancer patients. This study provides evidence for the potential correlation between neural-related transcriptome alteration and immune activity.
MeSH term(s)	Humans ; Squamous Cell Carcinoma of Head and Neck/genetics ; Gene Expression Profiling ; Genetic Risk Score ; Macrophages ; Head and Neck Neoplasms/genetics ; Prognosis
Language	English
Publishing date	2022-11-21
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1290529-x
ISSN	1601-0825 ; 1354-523X
ISSN (online)	1601-0825
ISSN	1354-523X
DOI	10.1111/odi.14434
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Zs.A 4427: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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Article: Biodegradable magnesium implant enhances angiogenesis and alleviates medication-related osteonecrosis of the jaw in rats.

Zhu, Wang-Yong / Guo, Jiaxin / Yang, Wei-Fa / Tao, Zhuo-Ying / Lan, Xinmiao / Wang, Leilei / Xu, Jiankun / Qin, Ling / Su, Yu-Xiong

Journal of orthopaedic translation

2022 Volume 33, Page(s) 153–161

Abstract: Background: Medication-related osteonecrosis of the jaw (MRONJ) is a serious complication associated with antiresorptive and antiangiogenic medications, of which impaired angiogenesis is a key pathological alteration. Since Magnesium (Mg)-based implants ...

Abstract	Background: Medication-related osteonecrosis of the jaw (MRONJ) is a serious complication associated with antiresorptive and antiangiogenic medications, of which impaired angiogenesis is a key pathological alteration. Since Magnesium (Mg)-based implants possess proangiogenic effects, we hypothesized that the biodegradable Mg implant could alleviate the development of MRONJ via enhancing angiogenesis. Methods: MRONJ model was established and divided into the Veh + Ti group (Vehicle-treated rat, with Titanium (Ti) implant), BP + Ti group (Bisphosphonate (BP)-treated rat, with Ti implant), BP + Mg group (BP-treated rat, with Mg implant), BP + Mg + SU5416 group (BP-treated rat, with Mg implant and vascular endothelial growth factor (VEGF) receptor-2 inhibitor), BP + Mg + BIBN group (BP-treated rat, with Mg implant and calcitonin gene-related peptide (CGRP) receptor antagonist), and BP + Mg + SU5416+BIBN group (BP-treated rat, with Mg implant and VEGF receptor-2 inhibitor and CGRP receptor antagonist). The occurrence of MRONJ, alveolar bone necrosis, new bone formation and vessel formation were assessed by histomorphometry, immunohistochemistry, and micro-CT analysis. Results: Eight weeks after surgery, the BP + Mg group had significantly reduced occurrence of MRONJ-like lesion and histological osteonecrosis, increased bone microstructural parameters, and increased expressions of VEGFA and CGRP, than the BP + Ti group. By simultaneously blocking VEGF receptor-2 and CGRP receptor, the vessel volume and new bone formation in the BP + Mg group were significantly decreased, meanwhile the occurrence of MRONJ-like lesion and histological bone necrosis were significantly increased. Conclusion: Biodegradable Mg implant could alleviate the development of MRONJ-like lesion, possibly via upregulating VEGF- and CGRP-mediated angiogenesis. Mg-based implants have the translational potential to be developed as a novel internal fixation device for patients with the risk of MRONJ. The translational potential of this article: This work reports a biodegradable Mg implant which ameliorates the development of MRONJ-like lesions possibly due to its angiogenic property. Mg-based implants have the potential to be developed as a novel internal fixation device for patients at the risk of MRONJ.
Language	English
Publishing date	2022-03-28
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2747531-1
ISSN	2214-031X
ISSN	2214-031X
DOI	10.1016/j.jot.2022.03.004
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