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  1. Article ; Online: The COVID-19 vaccine ChAdOx1-S is not contaminated with sulfated glycosaminoglycans.

    Alban, Susanne / Neupane, Sandesh / Girreser, Ulrich / Sönnichsen, Frank D / Greinacher, Andreas

    Journal of thrombosis and haemostasis : JTH

    2022  Volume 20, Issue 3, Page(s) 777–780

    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines ; Glycosaminoglycans ; Humans ; SARS-CoV-2
    Chemical Substances COVID-19 Vaccines ; Glycosaminoglycans ; A73025 (268AW7000T)
    Language English
    Publishing date 2022-01-14
    Publishing country England
    Document type Letter
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.15633
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5805: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 295: Show issues

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  2. Article: Dépistage du cancer du poumon : que dire à nos patient·e·s en attendant un programme organisé ?

    Selby, Kevin / Gubelmann, Rosanne / Lovis, Alban / Bulliard, Jean-Luc / Beigelman-Aubry, Catherine / Casutt, Alessio / Peters, Solange / Krueger, Thorsten / Von Garnier, Christophe / Cornuz, Jacques

    Revue medicale suisse

    2020  Volume 16, Issue 713, Page(s) 2086–2091

    Abstract: The NLST study in the United States showed, in 2011, that low-dose lung CT scans can reduce lung cancer mortality but was limited in its routine recommendation by 96% of false positive screening results. The European NELSON trial, published in 2020, ... ...

    Title translation Lung cancer screening: what can we tell our patients while we await a screening program ?
    Abstract The NLST study in the United States showed, in 2011, that low-dose lung CT scans can reduce lung cancer mortality but was limited in its routine recommendation by 96% of false positive screening results. The European NELSON trial, published in 2020, confirmed a 24% decrease in lung cancer mortality and, by using lung nodule volume and volume doubling time, decreased false positive results to 56% of positive tests. The implementation of screening programs is now expected in Europe, including Switzerland. In anticipation, we have developed a decision aid to present patients with the benefits (decreased lung cancer mortality), risks (false positives and indeterminate results), and uncertainties (incidental findings) of lung cancer screening.
    MeSH term(s) Early Detection of Cancer ; Europe ; Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/epidemiology ; Mass Screening ; Switzerland/epidemiology ; United States
    Language French
    Publishing date 2020-11-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Building London’s Food Democracy

    Alban Hasson

    Politics and Governance, Vol 7, Iss 4, Pp 154-

    Assessing the Contributions of Urban Agriculture to Local Food Decision-Making

    2019  Volume 164

    Abstract: ... through specific social and political practices. Webster and Engberg-Pedersen’s political space framework (2002 ...

    Abstract This article presents the contributions of Urban Agriculture practitioners in establishing the local food movement and the foundations of an active food democracy in London. It argues that food democracy is emerging from a set of contestations within institutional channels, but also through the historical struggle of formulating the dominating political discourses, both of which are co-constituted through specific social and political practices. Webster and Engberg-Pedersen’s political space framework (2002) breaks up this article in order to describe: 1) How specific institutional channels form different strategies of collaboration and contestation; 2) how these are reflected in political discourses evolution; and 3) what dilemmas and opportunities this evolution in practice entails in relation to responsibilisation and its influence on the possibility of establishing true active food democracy in London.
    Keywords allotments ; community food projects ; food democracy ; political space ; responsibilisation ; urban agriculture ; Political science (General) ; JA1-92
    Language English
    Publishing date 2019-10-01T00:00:00Z
    Publisher Cogitatio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson’s disease model

    Gustavo Morrone Parfitt / Elena Coccia / Camille Goldman / Kristen Whitney / Ricardo Reyes / Lily Sarrafha / Ki Hong Nam / Soha Sohail / Drew R. Jones / John F. Crary / Alban Ordureau / Joel Blanchard / Tim Ahfeldt

    Nature Communications, Vol 15, Iss 1, Pp 1-

    2024  Volume 17

    Abstract: ... to development of early onset Parkinson’s Disease (PD) caused by loss-of-function of DJ1, a protein deglycase ...

    Abstract Abstract Accumulation of advanced glycation end products (AGEs) on biopolymers accompanies cellular aging and drives poorly understood disease processes. Here, we studied how AGEs contribute to development of early onset Parkinson’s Disease (PD) caused by loss-of-function of DJ1, a protein deglycase. In induced pluripotent stem cell (iPSC)-derived midbrain organoid models deficient for DJ1 activity, we find that lysosomal proteolysis is impaired, causing AGEs to accumulate, α-synuclein (α-syn) phosphorylation to increase, and proteins to aggregate. We demonstrated these processes are at least partly driven by astrocytes, as DJ1 loss reduces their capacity to provide metabolic support and triggers acquisition of a pro-inflammatory phenotype. Consistently, in co-cultures, we find that DJ1-expressing astrocytes are able to reverse the proteolysis deficits of DJ1 knockout midbrain neurons. In conclusion, astrocytes’ capacity to clear toxic damaged proteins is critical to preserve neuronal function and their dysfunction contributes to the neurodegeneration observed in a DJ1 loss-of-function PD model.
    Keywords Science ; Q
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: French recommendations for the management of Takayasu’s arteritis

    David Saadoun / Alessandra Bura-Riviere / Chloé Comarmond / Marc Lambert / Alban Redheuil / Tristan Mirault / Collaborators

    Orphanet Journal of Rare Diseases, Vol 16, Iss S3, Pp 1-

    2021  Volume 23

    Abstract: ... with Takayasu’s arteritis. Its purpose is to optimize and harmonize the management and follow-up of this rare disease ...

    Abstract Abstract The aim of this National Diagnostic and Care Protocol (PNDS) is to explain to the professionals involved the current optimal diagnosis and therapeutic management and care approach for a patient with Takayasu’s arteritis. Its purpose is to optimize and harmonize the management and follow-up of this rare disease throughout the country. It also identifies pharmaceutical specialties used in an indication not provided for in the Marketing Authorization, as well as the specialties, products or services necessary for the care of patients but not usually paid for or reimbursed.
    Keywords Medicine ; R
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Investigating the biological and technical origins of unknown bases in the S region of the SARS-CoV-2 Delta variant genome sequences

    Borcard, Loïc / Gempeler, Sonja / Terrazos Miani, Miguel A / Baumann, Christian / Grädel, Carole / Dijkman, Ronald / Suter-Riniker, Franziska / Leib, Stephen L / Bittel, Pascal / Neuenschwander, Stefan / Ramette, Alban

    medRxiv

    Abstract: We are reporting on the observation of a large, under-sequenced region of the S gene of the SARS ...

    Abstract We are reporting on the observation of a large, under-sequenced region of the S gene of the SARS-CoV2 Delta variant genomes, identified in sequences originating from various sequencing centres worldwide (e.g. USA, India, England, Switzerland, France, Germany). This poorly sequenced region was identified from the early phases of the Delta variant spread and the phenomenon is still ongoing. As many commonly-used protocols rely on amplicon-based sequencing procedures, we investigated the likely origin of the issue. We established its biological origin as resulting from mutations in the viral genomes at primer binding sites. We designed and evaluated new PCR primers to circumvent this issue in order to complement the ARTIC v3 set, and validated their performance for the sequencing of circulating Delta variants.
    Keywords covid19
    Language English
    Publishing date 2021-09-13
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2021.09.09.21262951
    Database COVID19

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  7. Article ; Online: Red-capped mangabeys (Cercocebus torquatus) adapt their interspecific gestural communication to the recipient’s behaviour

    Juliette Aychet / Pablo Pezzino / Arnaud Rossard / Philippe Bec / Catherine Blois-Heulin / Alban Lemasson

    Scientific Reports, Vol 10, Iss 1, Pp 1-

    2020  Volume 12

    Abstract: Abstract Sensitivity to recipient’s attention and responsiveness are critical markers ... have yet addressed this question concerning monkeys. Here, we characterise the effect of a recipient’s ...

    Abstract Abstract Sensitivity to recipient’s attention and responsiveness are critical markers of intentional communication. Although previous research showed that ape gestures can be intentional, few studies have yet addressed this question concerning monkeys. Here, we characterise the effect of a recipient’s presence, attentional state and responsiveness on the interspecific gestural communication of captive red-capped mangabeys (Cercocebus torquatus). Previous reports showed that they produced learnt begging gestures towards a human recipient preferentially when the latter was facing them. We used here a novel setup that allows subjects to move around an experimenter and to use different modalities (visual and acoustic) to communicate. We found that when the recipient was not facing them, mangabeys moved to a position in the visual field of their recipient rather than using attention-getters. Interestingly, unlike apes, they did not elaborate their communication visually or acoustically when the experimenter did not respond favourably to their begging. However, our results may suggest that begging gestures were goal-directed, since mangabeys inhibited them when the experimenter was not available to answer immediately (i.e. give a reward). Overall, red-capped mangabeys’ interspecific visual communication presented intentionality features, but their use of begging gestures was less flexible than that of great apes in similar situations.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Are Keggin’s POMs Charged Nanocolloids or Multicharged Anions?

    Malinenko, Alla / Alban Jonchère / Luc Girard / Olivier Diat / Pierre Bauduin / Sandra Parrès-Maynadié

    Langmuir. 2018 Feb. 06, v. 34, no. 5

    2018  

    Abstract: ... diffusion coefficients of two Keggin’s POMs [silicotungstate (SiW12O404–) and phosphotungstate (PW12O403 ... to the Debye length. As for classical charged colloids, we show that the POM’s counterions should not be ... on the micelle polar surface from static and dynamic points of view. We concluded that Keggin’s POMs behave ...

    Abstract Owing to their multiple charges and their nanometric size, polyoxometalates (POMs) are at the frontier between ions and charged colloids. We investigated here the effect of POM–POM electrostatics repulsions on their self-diffusion in water by varying POM and supporting salt concentrations. The self-diffusion coefficients of two Keggin’s POMs [silicotungstate (SiW12O404–) and phosphotungstate (PW12O403–)] were determined by dynamic light scattering (DLS) and 1H/31P DOSY NMR, whereas POM–POM electrostatic repulsions were investigated by the determination of the static structure factors using small-angle X-ray scattering (SAXS). The self-diffusion coefficients for the two POMs and for different POM/background salt concentrations were collected in a master curve by comparing the averaged POM–POM distance in solution to the Debye length. As for classical charged colloids, we show that the POM’s counterions should not be considered in the calculation of the ionic strength that governs POM–POM electrostatic repulsions. This result was confirmed by fitting the POM–POM structure factor by considering a pair potential of spherical charged particles using the well-known Hayter mean spherical approximation (MSA). These Keggin POMs also behave as (super)chaotropic anions (i.e., they have a strong propensity to adsorb on (neutral polar) surfaces, which was also investigated) here on the surface of octyl-β-glucoside (C8G1) micelles. The variations of (i) the chemical shift of 1H/31P NMR signals and (ii) the self-diffusion coefficients obtained by DOSY 1H/31P NMR of PW3– and of C8G1 were in good agreement, confirming the strong adsorption of POMs on the micelle polar surface from static and dynamic points of view. We concluded that Keggin’s POMs behave (i) as anions because they adsorb on surfaces as chaotropic anions and (ii) as colloids because they can be described by a classical colloidal approach by dynamic and static scattering techniques (i.e., by the investigation of their interparticle electrostatic structure factor and self-diffusion without considering the POM’s counterions in the ionic strength calculation). This work highlights the dynamic properties of POMs at soft interfaces compared to bulk aqueous solution, which is essential in the understanding of functional properties of POMs, such as (photo)catalysis and the rational design of POM-based hybrid nanomaterials from soft templating routes (i.e., in aqueous solutions at room temperature).
    Keywords adsorption ; ambient temperature ; anions ; aqueous solutions ; catalytic activity ; colloids ; electrostatic interactions ; functional properties ; ionic strength ; light scattering ; micelles ; nanomaterials ; nuclear magnetic resonance spectroscopy ; small-angle X-ray scattering
    Language English
    Dates of publication 2018-0206
    Size p. 2026-2038.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.7b03640
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Incidence of EMILY’S multimedia software and its impact on early childhood education

    Nelson Eduardo Mariscal Huacon / Gladys Patricia Guevara Albán / Cristian Salomón Guevara Albán

    Journal of Science and Research, Vol 1, Iss CITT 2016, Pp 7-

    2016  Volume 9

    Abstract: ... of early childhood education, where the use of multimedia software Emily’s are considered feasible. ...

    Abstract The multimedia software for teaching logical-mathematical relationships in early childhood education today has achieved significant changes in teaching, leaving using traditional methods and teaching techniques to apply information technology and communications - ICT within the teaching-learning process, and that is where the imperative of using a multimedia software using it as a central focus for early childhood education arises. The main objective of this research was to apply a multimedia software to improve the teaching-learning process in logical relationships - math children early education Early Education Center .El Mamey”. It is noted that the factors influencing the teaching of children aged between 3 and 5 years are: habits, motivation, methodology, family and emotional intelligence, all this leading to use of a multimedia software to improve cognitive, psychomotor and even more so when you learn playing skills. The above is based on surveys of parents i / or legal representatives of children of early childhood education, where the use of multimedia software Emily’s are considered feasible.
    Keywords Software multimedia ; relaciones lógico-matemáticas ; educación inicial. ; Technology ; T ; Science ; Q
    Subject code 028
    Language Spanish
    Publishing date 2016-08-01T00:00:00Z
    Publisher Universidad Técnica de Babahoyo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Incidence of EMILY’S multimedia software and its impact on early childhood education

    Nelson Eduardo Mariscal Huacon / Gladys Patricia Guevara Albán / Cristian Salomón Guevara Albán

    Journal of Science and Research, Vol 1, Iss CITT2016, Pp 7-

    2016  Volume 9

    Abstract: ... of early childhood education, where the use of multimedia software Emily’s are considered feasible. ...

    Abstract The multimedia software for teaching logical-mathematical relationships in early childhood education today has achieved significant changes in teaching, leaving using traditional methods and teaching techniques to apply information technology and communications - ICT within the teaching-learning process, and that is where the imperative of using a multimedia software using it as a central focus for early childhood education arises. The main objective of this research was to apply a multimedia software to improve the teaching-learning process in logical relationships - math children early education Early Education Center .El Mamey”. It is noted that the factors influencing the teaching of children aged between 3 and 5 years are: habits, motivation, methodology, family and emotional intelligence, all this leading to use of a multimedia software to improve cognitive, psychomotor and even more so when you learn playing skills. The above is based on surveys of parents i / or legal representatives of children of early childhood education, where the use of multimedia software Emily’s are considered feasible.
    Keywords Software multimedia ; relaciones lógico-matemáticas ; educación inicial ; Technology ; T ; Science ; Q
    Subject code 028
    Language Spanish
    Publishing date 2016-08-01T00:00:00Z
    Publisher Universidad Técnica de Babahoyo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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