LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 92

Search options

  1. Article ; Online: Teclistamab in relapsed or refractory AL amyloidosis: a multinational retrospective case series.

    Forgeard, Nathalie / Elessa, Dikélélé / Carpinteiro, Alexander / Belhadj, Karim / Minnema, Monique / Roussel, Murielle / Huart, Antoine / Javaugue, Vincent / Pascal, Laurent / Royer, Bruno / Talbot, Alexis / Gounot, Romain / Hegenbart, Ute / Schonland, Stefan / Karlin, Lionel / Harel, Stéphanie / Kastritis, Efstathios / Bridoux, Frank / Jaccard, Arnaud /
    Arnulf, Bertrand

    Blood

    2023  Volume 143, Issue 8, Page(s) 734–737

    MeSH term(s) Humans ; Immunoglobulin Light-chain Amyloidosis/drug therapy ; Retrospective Studies ; Amyloidosis/drug therapy ; Antineoplastic Agents/therapeutic use ; Immunoglobulin Light Chains
    Chemical Substances Antineoplastic Agents ; Immunoglobulin Light Chains
    Language English
    Publishing date 2023-12-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2023022937
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article: High power 2.5D integrated thermoelectric generators combined with microchannels technology

    Savelli, Guillaume / Colonna, Jean-Philippe / Coudrain, Perceval / Faucherand, Pascal / Royer, Agnès / Collin, Louis-Michel / Amnache, Amrid / Fréchette, Luc

    Energy. 2022 Aug. 01, v. 252

    2022  

    Abstract: We have developed high power integrated thermoelectric generators (μTEGs). These μTEGs are CMOS compatible, i.e. based on polycristalline SiGe materials. These μTEGs have been processed directly on a silicon interposer. Even if poly-SiGe exhibits low ... ...

    Abstract We have developed high power integrated thermoelectric generators (μTEGs). These μTEGs are CMOS compatible, i.e. based on polycristalline SiGe materials. These μTEGs have been processed directly on a silicon interposer. Even if poly-SiGe exhibits low thermoelectric performances at room temperature, the specific design and proposed architecture enable μTEGs to deliver up to 680 μW for a temperature difference at 15.5 K. To reach such high power, an original 2.5D structure has been developed and μchannels technology has been associated, below the μTEG, to dissipate heat coming from the hot side. μTEGs have been tested in real environment, located below a hot test chip. Such μTEG performances overtake those from similar state-of-the-art CMOS compatible devices, and pave the way for a potential use in different applications such as sensors power supply or battery charger.
    Keywords ambient temperature ; batteries ; energy ; heat ; silicon
    Language English
    Dates of publication 2022-0801
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2019804-8
    ISSN 0360-5442 ; 0360-5442
    ISSN (online) 0360-5442
    ISSN 0360-5442
    DOI 10.1016/j.energy.2022.123984
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  3. Article ; Online: Automatic aortic root segmentation and anatomical landmarks detection for TAVI procedure planning.

    Lalys, Florent / Esneault, Simon / Castro, Miguel / Royer, Lucas / Haigron, Pascal / Auffret, Vincent / Tomasi, Jacques

    Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy

    2018  Volume 28, Issue 3, Page(s) 157–164

    Abstract: Purpose: Minimally invasive trans-catheter aortic valve implantation (TAVI) has emerged as a treatment of choice for high-risk patients with severe aortic stenosis. However, the planning of TAVI procedures would greatly benefit from automation to speed ... ...

    Abstract Purpose: Minimally invasive trans-catheter aortic valve implantation (TAVI) has emerged as a treatment of choice for high-risk patients with severe aortic stenosis. However, the planning of TAVI procedures would greatly benefit from automation to speed up, secure and guide the deployment of the prosthetic valve. We propose a hybrid approach allowing the computation of relevant anatomical measurements along with an enhanced visualization.
    Material and methods: After an initial step of centerline detection and aorta segmentation, model-based and statistical-based methods are used in combination with 3 D active contour models to exploit the complementary aspects of these methods and automatically detect aortic leaflets and coronary ostia locations. Important anatomical measurements are then derived from these landmarks.
    Results: A validation on 50 patients showed good precision with respect to expert sizing for the ascending aorta diameter calculation (2.2 ± 2.1 mm), the annulus diameter (1.31 ± 0.75 mm), and both the right and left coronary ostia detection (1.96 ± 0.87 mm and 1.80 ± 0.74 mm, respectively). The visualization is enhanced thanks to the aorta and aortic root segmentation, the latter showing good agreement with manual expert delineation (Jaccard index: 0.96 ± 0.03).
    Conclusion: This pipeline is promising and could greatly facilitate TAVI planning.
    MeSH term(s) Aged ; Aged, 80 and over ; Aorta/surgery ; Aortic Valve/surgery ; Aortic Valve Stenosis/surgery ; Automation ; Female ; Heart Valve Prosthesis ; Humans ; Male ; Transcatheter Aortic Valve Replacement/methods
    Language English
    Publishing date 2018-07-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1317160-4
    ISSN 1365-2931 ; 1364-5706
    ISSN (online) 1365-2931
    ISSN 1364-5706
    DOI 10.1080/13645706.2018.1488734
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Pomalidomide and dexamethasone until progression after first salvage therapy in multiple myeloma.

    Garderet, Laurent / Kuhnowski, Frederique / Berge, Benoit / Roussel, Murielle / Devlamynck, Laure / Petillon, Marie Odile / Escoffre-Barbe, Martine / Lafon, Ingrid / Facon, Thierry / Leleu, Xavier / Karlin, Lionel / Perrot, Aurore / Stoppa, Anne-Marie / Royer, Bruno / Chaleteix, Carine / Tiab, Mourad / Araujo, Carla / Lenain, Pascal / Macro, Margaret /
    Belhadj, Karim / Ikhlef, Souhila / Hulin, Cyrille / Loiseau, Herve Avet / Attal, Michel / Moreau, Philippe

    British journal of haematology

    2023  Volume 201, Issue 6, Page(s) 1103–1115

    Abstract: Lenalidomide maintenance in myeloma is well established. Nevertheless, pomalidomide could provide an alternative. Myeloma patients in first relapse, initially treated in the Intergroupe Francophone du Myélome (IFM) 2009 trial, and subsequently in the IFM ...

    Abstract Lenalidomide maintenance in myeloma is well established. Nevertheless, pomalidomide could provide an alternative. Myeloma patients in first relapse, initially treated in the Intergroupe Francophone du Myélome (IFM) 2009 trial, and subsequently in the IFM 2013-01 phase 2 trial, received four cycles of salvage therapy with pomalidomide plus cyclophosphamide plus dexamethasone (PCD) with transplantation plus 2 PCD consolidation or without transplantation but with 5 PCD and for all patients pomalidomide plus dexamethasone maintenance therapy. This consisted of 28-day cycles of pomalidomide 4 mg daily on days 1-21 and dexamethasone 20 mg weekly until progression. The primary endpoint was an improved response to treatment. A total of 75/100 patients reached therapy. The median follow-up time was 73 months. The median duration of treatment was 23.7 months. One third of patients improved their response from the initiation of treatment: 11%, 19% and 4% to a very good partial response, complete response or stringent complete response respectively. The median progression-free survival time was 33.2 months and the median overall survival time was not reached. Among the 75 patients, the reasons for pomalidomide discontinuation were progressive disease (54%), adverse events (AEs) (30%), investigator discretion (11%) and consent withdrawal (5%). Grade (G) 3/4 haematological AEs included neutropenia (51%) and lymphopenia (35%); G3/4 drug-related non-haematological AEs (>5%) comprised 13% infections. Long-term administration of pomalidomide and dexamethasone is feasible and one third of the patients improved their response.
    MeSH term(s) Humans ; Multiple Myeloma ; Salvage Therapy ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Dexamethasone
    Chemical Substances pomalidomide (D2UX06XLB5) ; Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2023-03-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18772
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Complex deformation of cartilage micropellets following mechanical stimulation promotes chondrocyte gene expression.

    Petitjean, Noémie / Canadas, Patrick / Jorgensen, Christian / Royer, Pascale / Le Floc'h, Simon / Noël, Danièle

    Stem cell research & therapy

    2023  Volume 14, Issue 1, Page(s) 226

    Abstract: Background: Articular cartilage (AC)'s main function is to resist to a stressful mechanical environment, and chondrocytes are responding to mechanical stress for the development and homeostasis of this tissue. However, current knowledge on processes ... ...

    Abstract Background: Articular cartilage (AC)'s main function is to resist to a stressful mechanical environment, and chondrocytes are responding to mechanical stress for the development and homeostasis of this tissue. However, current knowledge on processes involved in response to mechanical stimulation is still limited. These mechanisms are commonly investigated in engineered cartilage models where the chondrocytes are included in an exogeneous biomaterial different from their natural extracellular matrix. The aim of the present study is to better understand the impact of mechanical stimulation on mesenchymal stromal cells (MSCs)-derived chondrocytes generated in their own extracellular matrix.
    Methods: A fluidic custom-made device was used for the mechanical stimulation of cartilage micropellets obtained from human MSCs by culture in a chondrogenic medium for 21 days. Six micropellets were positioned into the conical wells of the device chamber and stimulated with different signals of positive pressure (amplitude, frequency and duration). A camera was used to record the sinking of each micropellet into their cone, and micropellet deformation was analyzed using a finite element model. Micropellets were harvested at different time points after stimulation for RT-qPCR and histology analysis.
    Results: Moderate micropellet deformation was observed during stimulation with square pressure signals as mean von Mises strains between 6.39 and 14.35% were estimated for amplitudes of 1.75-14 kPa superimposed on a base pressure of 50% of the amplitude. The compression, tension and shear observed during deformation did not alter micropellet microstructure as shown by histological staining. A rapid and transient increase in the expression of chondrocyte markers (SOX9, AGG and COL2B) was measured after a single 30-min stimulation with a square pressure signal of 3.5 kPa amplitude superimposed on a minimum pressure of 1.75 kPa, at 1 Hz. A small change of 1% of cyclical deformations when using a square pressure signal instead of a constant pressure signal induced a fold change of 2 to 3 of chondrogenic gene expression. Moreover, the expression of fibrocartilage (COL I) or hypertrophic cartilage (COL X, MMP13 and ADAMTS5) was not significantly regulated, except for COL X.
    Conclusions: Our data demonstrate that the dynamic deformation of cartilage micropellets by fluidic-based compression modulates the expression of chondrocyte genes responsible for the production of a cartilage-like extracellular matrix. This lays the foundations for further investigating the chondrocyte mechanobiology and the cartilage growth under mechanical stimulation.
    MeSH term(s) Humans ; Chondrocytes ; Cartilage ; Biocompatible Materials ; Chondrogenesis/genetics ; Gene Expression
    Chemical Substances Biocompatible Materials
    Language English
    Publishing date 2023-08-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2548671-8
    ISSN 1757-6512 ; 1757-6512
    ISSN (online) 1757-6512
    ISSN 1757-6512
    DOI 10.1186/s13287-023-03459-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Derivation of Predator Functional Responses Using a Mechanistic Approach in a Natural System

    Andréanne Beardsell / Dominique Gravel / Dominique Berteaux / Gilles Gauthier / Jeanne Clermont / Vincent Careau / Nicolas Lecomte / Claire-Cécile Juhasz / Pascal Royer-Boutin / Joël Bêty

    Frontiers in Ecology and Evolution, Vol

    2021  Volume 9

    Abstract: The functional response is at the core of any predator-prey interactions as it establishes the link between trophic levels. The use of inaccurate functional response can profoundly affect the outcomes of population and community models. Yet most ... ...

    Abstract The functional response is at the core of any predator-prey interactions as it establishes the link between trophic levels. The use of inaccurate functional response can profoundly affect the outcomes of population and community models. Yet most functional responses are evaluated using phenomenological models which often fail to discriminate among functional response shapes and cannot identify the proximate mechanisms regulating predator acquisition rates. Using a combination of behavioral, demographic, and experimental data collected over 20 years, we develop a mechanistic model based on species traits and behavior to assess the functional response of a generalist mammalian predator, the arctic fox (Vulpes lagopus), to various tundra prey species (lemmings and the nests of geese, passerines, and sandpipers). Predator acquisition rates derived from the mechanistic model were consistent with field observations. Although acquisition rates slightly decrease at high goose nest and lemming densities, none of our simulations resulted in a saturating response in all prey species. Our results highlight the importance of predator searching components in predator-prey interactions, especially predator speed, while predator acquisition rates were not limited by handling processes. By combining theory with field observations, our study provides support that the predator acquisition rate is not systematically limited at the highest prey densities observed in a natural system. Our study also illustrates how mechanistic models based on empirical estimates of the main components of predation can generate functional response shapes specific to the range of prey densities observed in the wild. Such models are needed to fully untangle proximate drivers of predator-prey population dynamics and to improve our understanding of predator-mediated interactions in natural communities.
    Keywords functional response ; predation ; trophic interactions ; tundra ; predator-prey interactions ; arctic fox (Vulpes lagopus) ; Evolution ; QH359-425 ; Ecology ; QH540-549.5
    Subject code 590
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  7. Article: Surface Phase Nucleation of Lead Monoatomic Layers on Si(111) Induced by Manganese Phthalocyanine Molecules

    Longo, Danilo / Bocquet, Marie-Laure / Lorente, Nicolás / Cruguel, Hervé / Debontridder, François / Royer, Sébastien / David, Pascal / Palacio-Morales, Alexandra / Cren, Tristan / Witkowski, Nadine / Brun, Christophe

    Journal of physical chemistry. 2020 Aug. 26, v. 124, no. 36

    2020  

    Abstract: Hybrid interfaces where organic molecules are adsorbed on metallic substrates are very interesting to understand the fundamental interactions that might modify the chemical–physical properties of molecules or substrate. Here, we explore the adsorption of ...

    Abstract Hybrid interfaces where organic molecules are adsorbed on metallic substrates are very interesting to understand the fundamental interactions that might modify the chemical–physical properties of molecules or substrate. Here, we explore the adsorption of manganese phthalocyanines (MnPcs) on different structural phases of a Pb monatomic layer, namely, the √7 × √3-Pb and the striped incommensurate phase (SIC-Pb) phase, grown on Si(111). Surprisingly, the deposition of a minute amount of MnPc molecules (∼0.18 molecules/100 nm²) nucleates a macroscopic structural transition of the √7 × √3-Pb phase into the SIC-Pb phase. Our combined scanning tunneling microscopy, low-energy electron diffraction, and density functional theory study revealed that the mechanism behind this surface transformation is related to a strong and local molecule–substrate interaction. The structural phase transition is finally driven by the strained nature of the Pb phases and the energetic stability of the MnPc/SIC-Pb/Si(111) system with respect to the MnPc/√7 × √3-Pb/Si(111) one. The molecule–substrate interaction found in the present study is stronger than the one observed on Pb(111) bulk or thin films, highlighting the implication of the Pb/Si(111) interface in the interaction process. Hence, our results reveal that playing with the substrate dimensionality to tune the molecule–substrate coupling has strong impact on the electronic/magnetic properties of organic hybrid systems.
    Keywords adsorption ; density functional theory ; magnetism ; manganese ; phase transition
    Language English
    Dates of publication 2020-0826
    Size p. 19829-19840.
    Publishing place American Chemical Society
    Document type Article
    Note NAL-AP-2-clean
    ISSN 1932-7455
    DOI 10.1021/acs.jpcc.0c05278
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  8. Article ; Online: Cartilage biomechanics: From the basic facts to the challenges of tissue engineering.

    Petitjean, Noémie / Canadas, Patrick / Royer, Pascale / Noël, Danièle / Le Floc'h, Simon

    Journal of biomedical materials research. Part A

    2022  Volume 111, Issue 7, Page(s) 1067–1089

    Abstract: Articular cartilage (AC) is the thin tissue that covers the long bone ends in the joints and that ensures the transmission of forces between adjacent bones while allowing nearly frictionless movements between them. AC repair is a technologic and ... ...

    Abstract Articular cartilage (AC) is the thin tissue that covers the long bone ends in the joints and that ensures the transmission of forces between adjacent bones while allowing nearly frictionless movements between them. AC repair is a technologic and scientific challenge that has been addressed with numerous approaches. A major deadlock is the capacity to take in account its complex mechanical properties in repair strategies. In this review, we first describe the major mechanical behaviors of AC for the non-specialists. Then, we show how researchers have progressively identified specific mechanical parameters using mathematical models. There are still gaps in our understanding of some of the observations concerning AC biomechanical properties, particularly the differences in extracellular matrix stiffness measured at the microscale and at the millimetric scale. Nevertheless, for bioengineering applications, AC repair strategies must take into account what are commonly considered the main mechanical features of cartilage: its ability to withstand high stresses through three main behaviors (elasticity, poroelasticity and swelling). Finally, we emphasize that future studies need to investigate AC mechanical properties at different scales, particularly the gradient of mechanical properties around cells and across the cartilage depth, and the differences in mechanical properties at different scales. This multi-scale approach could greatly enhance the success of AC restorative approaches.
    MeSH term(s) Tissue Engineering ; Biomechanical Phenomena ; Cartilage, Articular ; Extracellular Matrix ; Elasticity ; Stress, Mechanical
    Language English
    Publishing date 2022-12-30
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2099989-6
    ISSN 1552-4965 ; 1549-3296 ; 0021-9304
    ISSN (online) 1552-4965
    ISSN 1549-3296 ; 0021-9304
    DOI 10.1002/jbm.a.37478
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Estimation of Muscle Mass by Ultrasonography Differs between Observers and Life States of Models in Small Birds.

    Royer-Boutin, Pascal / Cortés, Pablo A / Milbergue, Myriam / Petit, Magali / Vézina, François

    Physiological and biochemical zoology : PBZ

    2015  Volume 88, Issue 3, Page(s) 336–344

    Abstract: Ultrasonography has proven to be a valuable noninvasive method of measure of muscle size in birds, but validation of its use in birds as small as black-capped chickadees (Poecile atricapillus; 11 g) is scarce. The effect of observers and life state (dead ...

    Abstract Ultrasonography has proven to be a valuable noninvasive method of measure of muscle size in birds, but validation of its use in birds as small as black-capped chickadees (Poecile atricapillus; 11 g) is scarce. The effect of observers and life state (dead or alive) of models used for calibration on measurement quality is also poorly documented. Using 31 dead and 22 live chickadees, linear regressions between ultrasound and dissection measurements of pectoral and thigh muscles were fitted and compared between five different observers. R(2) values varied greatly between observers and were generally weaker in live birds, ranging between 0.02 and 0.59, despite high repeatability of measurement. Using equations calculated from dead birds to estimate muscle mass of live birds yielded much higher measurement errors (9%-18%) than when using equations calculated from live birds (5%-8%). Our results suggest that with careful training and using only calibration from live birds, ultrasonography can be a useful but limited tool to estimate muscle size of birds as small as the black-capped chickadee.
    MeSH term(s) Animals ; Calibration ; Muscle, Skeletal/anatomy & histology ; Muscle, Skeletal/diagnostic imaging ; Observer Variation ; Passeriformes/anatomy & histology ; Pectoralis Muscles/anatomy & histology ; Pectoralis Muscles/diagnostic imaging ; Reproducibility of Results ; Thigh/anatomy & histology ; Thigh/diagnostic imaging ; Ultrasonography
    Language English
    Publishing date 2015-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1473845-4
    ISSN 1537-5293 ; 1522-2152
    ISSN (online) 1537-5293
    ISSN 1522-2152
    DOI 10.1086/680016
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: SO

    Dyrek, Achrène / Min, Michiel / Decin, Leen / Bouwman, Jeroen / Crouzet, Nicolas / Mollière, Paul / Lagage, Pierre-Olivier / Konings, Thomas / Tremblin, Pascal / Güdel, Manuel / Pye, John / Waters, Rens / Henning, Thomas / Vandenbussche, Bart / Ardevol Martinez, Francisco / Argyriou, Ioannis / Ducrot, Elsa / Heinke, Linus / van Looveren, Gwenael /
    Absil, Olivier / Barrado, David / Baudoz, Pierre / Boccaletti, Anthony / Cossou, Christophe / Coulais, Alain / Edwards, Billy / Gastaud, René / Glasse, Alistair / Glauser, Adrian / Greene, Thomas P / Kendrew, Sarah / Krause, Oliver / Lahuis, Fred / Mueller, Michael / Olofsson, Goran / Patapis, Polychronis / Rouan, Daniel / Royer, Pierre / Scheithauer, Silvia / Waldmann, Ingo / Whiteford, Niall / Colina, Luis / van Dishoeck, Ewine F / Östlin, Göran / Ray, Tom P / Wright, Gillian

    Nature

    2023  Volume 625, Issue 7993, Page(s) 51–54

    Abstract: WASP-107b is a warm (approximately 740 K) transiting planet with a Neptune-like mass of roughly 30.5 ... ...

    Abstract WASP-107b is a warm (approximately 740 K) transiting planet with a Neptune-like mass of roughly 30.5 M
    Language English
    Publishing date 2023-11-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-023-06849-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top