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  1. Article ; Online: Understanding how diagnostics influence antimicrobial decision-making is key to successful clinical trial design.

    Rawson, Timothy M / Moore, Luke S P

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2023  Volume 29, Issue 6, Page(s) 666–669

    MeSH term(s) Humans ; Clinical Trials as Topic ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/therapeutic use ; Multiplex Polymerase Chain Reaction ; Decision Making ; Clinical Decision-Making
    Chemical Substances Anti-Infective Agents
    Language English
    Publishing date 2023-03-12
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2023.03.010
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    Zs.A 4541: Show issues Location:
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  2. Article ; Online: Orthopaedic preparedness for disasters must extend to infection surveillance.

    Boyd, Sara E / Pallett, Scott J C / Moore, Luke S P

    Lancet (London, England)

    2023  Volume 402, Issue 10398, Page(s) 290

    MeSH term(s) Humans ; Orthopedics ; Disasters ; Infection Control
    Language English
    Publishing date 2023-06-08
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)01166-2
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  3. Article ; Online: Near-patient SARS-CoV-2 molecular platforms: new-old tools for new-old problems.

    Moore, Luke S P

    The Lancet. Respiratory medicine

    2020  Volume 8, Issue 12, Page(s) 1161–1163

    MeSH term(s) COVID-19 ; Hospitals ; Humans ; Pandemics ; Point-of-Care Testing ; Prospective Studies ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-10-08
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(20)30451-3
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  4. Article ; Online: Coronavirus disease 2019 (COVID-19) impact on central-line-associated bloodstream infections (CLABSI): a systematic review.

    Satta, Giovanni / Rawson, Timothy M / Moore, Luke S P

    Infection prevention in practice

    2023  Volume 5, Issue 4, Page(s) 100313

    Abstract: Introduction: Central line-associated bloodstream infections (CLABSI) are an important clinical and public health issue, impacted by the purported increase in healthcare-associated infections (including CLABSI) during the COVID-19 pandemic. This review ... ...

    Abstract Introduction: Central line-associated bloodstream infections (CLABSI) are an important clinical and public health issue, impacted by the purported increase in healthcare-associated infections (including CLABSI) during the COVID-19 pandemic. This review evaluates the impact of COVID-19 on CLABSI at a global level, to determine risk factors, effective preventive measures and microbiological epidemiology.
    Methods: A systematic literature review was performed using a PECO framework, with COVID-19 infection as the exposure measure and CLABSI rates as the main outcome of interest, pre- and during the pandemic.
    Results: Overall, most studies (17 of
    Conclusion: The COVID-19 pandemic significantly impacted CLABSI incidence/rates. Observations from the different studies highlight significant gaps in healthcare associated infections (HCAI) knowledge and practice during the pandemic, and the importance of identifying preventive measures effective in reducing CLABSI, essential to health system resilience for future pandemics. Central to this are changes to CLABSI surveillance, as reporting is not mandatory in many healthcare systems. An audit tool combined with regular assessments of the compliance with infection control measures and line care bundles also remains an essential step in the prevention of CLABSI.
    Language English
    Publishing date 2023-10-13
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2590-0889
    ISSN (online) 2590-0889
    DOI 10.1016/j.infpip.2023.100313
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  5. Article ; Online: Bacterial peritonitis in paediatric appendicitis; microbial epidemiology and antimicrobial management.

    Bhaskar, Keir / Clarke, Simon / Moore, Luke S P / Hughes, Stephen

    Annals of clinical microbiology and antimicrobials

    2023  Volume 22, Issue 1, Page(s) 45

    Abstract: ... with a greater LOS (7.0 vs. 5.0 days; p = 0.011) but nil effect on the incidence of postoperative collections ... Presence of milleri Streptococcus spp. was associated with longer LOS (7.0 vs. 5.0 day; p = 0.007), DOT (12 ... 0 vs. 8.5 day; p = 0.007) but had no observed outcome on postoperative collections (29.4% vs. 18.6 ...

    Abstract Background: Appendicitis remains a common surgical emergency in children. Empirical antibacterial treatment is indicated to reduce infective complications. We investigate the bacterial pathogens identified intra-operatively during appendectomies in children to guide empirical surgical antimicrobial prophylaxis options.
    Methods: A retrospective analysis of patients (< 18 years old) undergoing an appendectomy across a multisite London hospital (Nov 2019-March 2022) was undertaken. Patient-related outcomes including length of hospital stay (LOS), days of antibacterial therapy (DOT), intra-operative microbiology and post-operative radiology reports were interrogated.
    Results: 304 patients underwent an appendectomy during this period; 39.1% of patients had intraoperative samples cultured. Bacterial pathogens were found in 73/119 (61.3%) cases; the most common isolates being Escherichia coli (42.0%), Pseudomonas aeruginosa (21.0%), milleri Streptococcus spp. (14.3%) and Bacteroides fragilis (5.9%). Polymicrobial infection was common (32/73). Isolation of Pseudomonas spp. from intra-operative sampling was associated with a greater LOS (7.0 vs. 5.0 days; p = 0.011) but nil effect on the incidence of postoperative collections. Presence of milleri Streptococcus spp. was associated with longer LOS (7.0 vs. 5.0 day; p = 0.007), DOT (12.0 vs. 8.5 day; p = 0.007) but had no observed outcome on postoperative collections (29.4% vs. 18.6%; p = 0.330). 48% of E. coli positive cultures were co-amoxiclav resistant and prolonged LOS compared to the non-resistant group (7.0 vs. 5.0 days; p = 0.040) but had no difference in post-operative collections (29.2% vs. 17.9%; p = 0.260).
    Conclusion: A high proportion of children with appendicitis have Pseudomonas spp. isolated, leading to a prolonged LOS. Evolving Enterobacterales resistance and the presence of Pseudomonas spp. necessitate extended antibacterial coverage for paediatric appendectomies with evidence of peritonitis.
    MeSH term(s) Child ; Humans ; Adolescent ; Appendicitis/drug therapy ; Appendicitis/epidemiology ; Appendicitis/surgery ; Retrospective Studies ; Escherichia coli ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Peritonitis/drug therapy ; Peritonitis/epidemiology ; Peritonitis/microbiology ; Bacteria ; Length of Stay
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-06-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097873-X
    ISSN 1476-0711 ; 1476-0711
    ISSN (online) 1476-0711
    ISSN 1476-0711
    DOI 10.1186/s12941-023-00591-1
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  6. Article ; Online: Multidrug-resistant infections in war victims in Ukraine.

    Pallett, Scott J C / Trompeter, Alex / Basarab, Marina / Moore, Luke S P / Boyd, Sara E

    The Lancet. Infectious diseases

    2023  Volume 23, Issue 8, Page(s) e270–e271

    MeSH term(s) Humans ; Ukraine/epidemiology ; Warfare
    Language English
    Publishing date 2023-07-11
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(23)00391-2
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    Zs.A 5743: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Coronavirus disease 2019 (COVID-19) impact on central-line-associated bloodstream infections (CLABSI)

    Giovanni Satta / Timothy M. Rawson / Luke S.P. Moore

    Infection Prevention in Practice, Vol 5, Iss 4, Pp 100313- (2023)

    a systematic review

    2023  

    Abstract: Introduction: Central line-associated bloodstream infections (CLABSI) are an important clinical and public health issue, impacted by the purported increase in healthcare-associated infections (including CLABSI) during the COVID-19 pandemic. This review ... ...

    Abstract Introduction: Central line-associated bloodstream infections (CLABSI) are an important clinical and public health issue, impacted by the purported increase in healthcare-associated infections (including CLABSI) during the COVID-19 pandemic. This review evaluates the impact of COVID-19 on CLABSI at a global level, to determine risk factors, effective preventive measures and microbiological epidemiology. Methods: A systematic literature review was performed using a PECO framework, with COVID-19 infection as the exposure measure and CLABSI rates as the main outcome of interest, pre- and during the pandemic. Results: Overall, most studies (17 of N=21) found a significant increase in CLABSI incidence/rates during the pandemic. Four studies showed a reduction (N=1) or no increase (N=3). High workload, redeployment, and ‘overwhelmed’ healthcare staff were recurrent risk-factor themes, likely to have negatively influenced basic infection control practices, including compliance with hand hygiene and line care bundles. Microbiological epidemiology was also impacted, with an increase in enterococcal infections and other pathogens. Conclusion: The COVID-19 pandemic significantly impacted CLABSI incidence/rates. Observations from the different studies highlight significant gaps in healthcare associated infections (HCAI) knowledge and practice during the pandemic, and the importance of identifying preventive measures effective in reducing CLABSI, essential to health system resilience for future pandemics. Central to this are changes to CLABSI surveillance, as reporting is not mandatory in many healthcare systems. An audit tool combined with regular assessments of the compliance with infection control measures and line care bundles also remains an essential step in the prevention of CLABSI.
    Keywords Central line-associated bloodstream infections ; CLABSI ; COVID-19 infection ; Global epidemiology ; Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
    Subject code 610
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Novel use of oral chloramphenicol for treatment-resistant

    Goodfellow, Jonathan Joseph / Hughes, Stephen / Smith, Jo / Jones, Rachael / Moore, Luke S P / Rayment, Michael

    Sexually transmitted infections

    2023  Volume 99, Issue 3, Page(s) 208–210

    Abstract: We describe the novel use of oral chloramphenicol for treatment- ... ...

    Abstract We describe the novel use of oral chloramphenicol for treatment-resistant
    MeSH term(s) Humans ; Male ; Young Adult ; Adult ; Mycoplasma genitalium ; Urethritis/drug therapy ; Urethritis/microbiology ; Chloramphenicol/therapeutic use ; Mycoplasma Infections/drug therapy ; Mycoplasma Infections/microbiology ; Anti-Infective Agents/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Drug Resistance, Bacterial
    Chemical Substances Chloramphenicol (66974FR9Q1) ; Anti-Infective Agents ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-01-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 1420303-0
    ISSN 1472-3263 ; 1368-4973
    ISSN (online) 1472-3263
    ISSN 1368-4973
    DOI 10.1136/sextrans-2022-055621
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  10. Article ; Online: Near-patient SARS-CoV-2 molecular platforms

    Moore, Luke S P

    The Lancet Respiratory Medicine ; ISSN 2213-2600

    new-old tools for new-old problems

    2020  

    Keywords Pulmonary and Respiratory Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/s2213-2600(20)30451-3
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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