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Article ; Online: Inhaled pulmonary vasodilators in severe COVID-19: Don't hold your breath.

Pawar, Swapnil S / Wilcox, M Elizabeth / van Haren, Frank M P

2022 Volume 69, Page(s) 153988

MeSH term(s)	Body Fluids ; COVID-19 ; Humans ; Lung ; Vasodilator Agents/therapeutic use
Chemical Substances	Vasodilator Agents
Language	English
Publishing date	2022-01-28
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	632818-0
ISSN	1557-8615 ; 0883-9441
ISSN (online)	1557-8615
ISSN	0883-9441
DOI	10.1016/j.jcrc.2022.153988
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Article ; Online: Immunocompromised Patients with Acute Respiratory Failure: "Don't Wait to Intubate"?

Pickkers, Peter / van Haren, Frank M P

American journal of respiratory and critical care medicine

2021 Volume 204, Issue 2, Page(s) 121–123

MeSH term(s)	Humans ; Immunocompromised Host ; Respiratory Distress Syndrome ; Respiratory Insufficiency/therapy
Language	English
Publishing date	2021-05-04
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202103-0813ED
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Article ; Online: A Chamber With a View: The Size of the Right Ventricle During Cardiopulmonary Resuscitation.

van Haren, Frank M P

Critical care medicine

2017 Volume 45, Issue 7, Page(s) 1258–1260

MeSH term(s)	Cardiopulmonary Resuscitation ; Heart Arrest ; Heart Ventricles ; Humans ; Pulmonary Embolism
Language	English
Publishing date	2017-06-16
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	197890-1
ISSN	1530-0293 ; 0090-3493
ISSN (online)	1530-0293
ISSN	0090-3493
DOI	10.1097/CCM.0000000000002357
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Article ; Online: Respiratory Muscle Rehabilitation in Patients with Prolonged Mechanical Ventilation: A Targeted Approach.

Bissett, Bernie / Gosselink, Rik / van Haren, Frank M P

Critical care (London, England)

2020 Volume 24, Issue 1, Page(s) 103

Abstract: This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2020. Further information about the ... ...

Abstract	This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2020. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901.
MeSH term(s)	Breathing Exercises/methods ; Breathing Exercises/trends ; Humans ; Intensive Care Units/organization & administration ; Intensive Care Units/statistics & numerical data ; Respiration, Artificial/adverse effects ; Respiration, Artificial/methods ; Respiratory Muscles/physiopathology
Keywords	covid19
Language	English
Publishing date	2020-03-24
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2041406-7
ISSN	1466-609X ; 1364-8535
ISSN (online)	1466-609X
ISSN	1364-8535
DOI	10.1186/s13054-020-2783-0
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Article ; Online: The bereavement experiences of families of potential organ donors: a qualitative longitudinal case study illuminating opportunities for family care.

Dicks, Sean G / Northam, Holly L / van Haren, Frank M P / Boer, Douglas P

International journal of qualitative studies on health and well-being

2022 Volume 18, Issue 1, Page(s) 2149100

Abstract: Objectives: To illuminate opportunities for care in the context of deceased organ donation by exploring pre-existing family and healthcare professional characteristics, in-hospital experiences, and ongoing adjustment through the lenses of grief theory, ... ...

Abstract	Objectives: To illuminate opportunities for care in the context of deceased organ donation by exploring pre-existing family and healthcare professional characteristics, in-hospital experiences, and ongoing adjustment through the lenses of grief theory, systems theory, meaning-making, narrative, and organ donation literature. Method: Qualitative longitudinal case studies explored individual and family change in five Australian families who had consented to Donation after Circulatory Determination of Death at a single centre. Participants attended semi-structured interviews at four, eight, and twelve months after the death. Findings: Family values, pre-existing relationships, and in-hospital experiences influenced first responses to their changed lives, understanding of the patient's death, and ongoing family adjustment. Novel behaviour that was conguent with family values was required at the hospital, especially if the patient had previously played a key role in family decision-making. This behaviour and emerging interactional patterns were drawn into family life over the first year of their bereavement. Recommendations: Training that includes lenses introduced in this study will enable healthcare professionals to confidently respond to individual and family psychosocial needs. Conclusion: The lenses of grief theory and systems thinking highlight opportunities for care tailored to the unique in-hospital context and needs that emerge in the months that follow.
MeSH term(s)	Humans ; Family/psychology ; Decision Making ; Australia ; Bereavement ; Grief ; Tissue Donors/psychology
Language	English
Publishing date	2022-12-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2232726-5
ISSN	1748-2631 ; 1748-2623
ISSN (online)	1748-2631
ISSN	1748-2623
DOI	10.1080/17482631.2022.2149100
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Article ; Online: The bereavement experiences of families of potential organ donors

Sean G. Dicks / Holly L. Northam / Frank M.P. van Haren / Douglas P. Boer

International Journal of Qualitative Studies on Health & Well-Being, Vol 18, Iss

a qualitative longitudinal case study illuminating opportunities for family care

2023 Volume 1

Abstract: Objectives To illuminate opportunities for care in the context of deceased organ donation by exploring pre-existing family and healthcare professional characteristics, in-hospital experiences, and ongoing adjustment through the lenses of grief theory, ... ...

Abstract	Objectives To illuminate opportunities for care in the context of deceased organ donation by exploring pre-existing family and healthcare professional characteristics, in-hospital experiences, and ongoing adjustment through the lenses of grief theory, systems theory, meaning-making, narrative, and organ donation literature. Method Qualitative longitudinal case studies explored individual and family change in five Australian families who had consented to Donation after Circulatory Determination of Death at a single centre. Participants attended semi-structured interviews at four, eight, and twelve months after the death. Findings Family values, pre-existing relationships, and in-hospital experiences influenced first responses to their changed lives, understanding of the patient’s death, and ongoing family adjustment. Novel behaviour that was conguent with family values was required at the hospital, especially if the patient had previously played a key role in family decision-making. This behaviour and emerging interactional patterns were drawn into family life over the first year of their bereavement. Recommendations Training that includes lenses introduced in this study will enable healthcare professionals to confidently respond to individual and family psychosocial needs. Conclusion The lenses of grief theory and systems thinking highlight opportunities for care tailored to the unique in-hospital context and needs that emerge in the months that follow.
Keywords	“patient and public involvement” ; bereavement ; family bereavement ; organ donation ; posttraumatic growth ; family resilience ; icu ; dcdd ; end-of-life-care ; Medicine (General) ; R5-920
Subject code	360
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Intensive care unit interventions to promote sleep and circadian biology in reducing incident delirium: a scoping review.

Wilcox, M Elizabeth / Burry, Lisa / Englesakis, Marina / Coman, Briar / Daou, Marietou / van Haren, Frank Mp / Ely, E Wes / Bosma, Karen J / Knauert, Melissa P

Thorax

2024

Abstract: Rationale/objectives: Despite plausible pathophysiological mechanisms, research is needed to confirm the relationship between sleep, circadian rhythm and delirium in patients admitted to the intensive care unit (ICU). The objective of this review is to ... ...

Abstract	Rationale/objectives: Despite plausible pathophysiological mechanisms, research is needed to confirm the relationship between sleep, circadian rhythm and delirium in patients admitted to the intensive care unit (ICU). The objective of this review is to summarise existing studies promoting, in whole or in part, the normalisation of sleep and circadian biology and their impact on the incidence, prevalence, duration and/or severity of delirium in ICU. Methods: A sensitive search of electronic databases and conference proceedings was completed in March 2023. Inclusion criteria were English-language studies of any design that evaluated in-ICU non-pharmacological, pharmacological or mixed intervention strategies for promoting sleep or circadian biology and their association with delirium, as assessed at least daily. Data were extracted and independently verified. Results: Of 7886 citations, we included 50 articles. Commonly evaluated interventions include care bundles (n=20), regulation or administration of light therapy (n=5), eye masks and/or earplugs (n=5), one nursing care-focused intervention and pharmacological intervention (eg, melatonin and ramelteon; n=19). The association between these interventions and incident delirium or severity of delirium was mixed. As multiple interventions were incorporated in included studies of care bundles and given that there was variable reporting of compliance with individual elements, identifying which components might have an impact on delirium is challenging. Conclusions: This scoping review summarises the existing literature as it relates to ICU sleep and circadian disruption (SCD) and delirium in ICU. Further studies are needed to better understand the role of ICU SCD promotion interventions in delirium mitigation.
Language	English
Publishing date	2024-02-13
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	204353-1
ISSN	1468-3296 ; 0040-6376
ISSN (online)	1468-3296
ISSN	0040-6376
DOI	10.1136/thorax-2023-220036
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Article: Feasibility, safety, and patient acceptability of electronic inspiratory muscle training in patients who require prolonged mechanical ventilation in the intensive care unit: A dual-centre observational study.

Nickels, Marc / Erwin, Katie / McMurray, Grant / Talbot, Richie / Strong, Mark / Krishnan, Anand / van Haren, Frank M P / Bissett, Bernie

Australian critical care : official journal of the Confederation of Australian Critical Care Nurses

2023 Volume 37, Issue 3, Page(s) 448–454

Abstract: Background: Inspiratory muscle training (IMT) is an intervention that can be used to rehabilitate the respiratory muscle deconditioning experienced by patients with critical illness, requiring prolonged mechanical ventilation. Clinicians are currently ... ...

Abstract	Background: Inspiratory muscle training (IMT) is an intervention that can be used to rehabilitate the respiratory muscle deconditioning experienced by patients with critical illness, requiring prolonged mechanical ventilation. Clinicians are currently using mechanical threshold IMT devices that have limited resistance ranges. Objectives: The objective of this study was to evaluate the safety, feasibility, and acceptability of using an electronic device to facilitate IMT with participants requiring prolonged mechanical ventilation. Method: A dual-centre observational cohort study, with convenience sampling, was conducted at two tertiary intensive care units. Daily training supervised by intensive care unit physiotherapists was completed with the electronic IMT device. A priori definitions for feasibility, safety, and acceptability were determined. Feasibility was defined as more than 80% of planned sessions completed. Safety was defined as no major adverse events and less than 3% minor adverse event rate, and acceptability was evaluated following the acceptability of intervention framework principles. Results: Forty participants completed 197 electronic IMT treatment sessions. Electronic IMT was feasible, with 81% of planned sessions completed. There were 10% minor adverse events and no major adverse events. All the minor adverse events were transient without clinical consequences. All the participants who recalled completing electronic IMT sessions reported that the training was acceptable. Acceptability was demonstrated; over 85% of participants reported that electronic IMT was either helpful or beneficial and that electronic IMT assisted their recovery. Conclusion: Electronic IMT is feasible and acceptable to complete with critically ill participants who require prolonged mechanical ventilation. As all minor adverse events were transient without clinical consequences, electronic IMT can be considered a relatively safe intervention with patients who require prolonged mechanical ventilation.
MeSH term(s)	Humans ; Respiration, Artificial ; Breathing Exercises ; Feasibility Studies ; Intensive Care Units ; Muscles
Language	English
Publishing date	2023-06-14
Publishing country	Australia
Document type	Observational Study ; Journal Article
ZDB-ID	1159493-7
ISSN	1878-1721 ; 1036-7314
ISSN (online)	1878-1721
ISSN	1036-7314
DOI	10.1016/j.aucc.2023.04.008
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Article ; Online: Compliance Phenotypes in Early Acute Respiratory Distress Syndrome before the COVID-19 Pandemic.

Panwar, Rakshit / Madotto, Fabiana / Laffey, John G / van Haren, Frank M P

American journal of respiratory and critical care medicine

2020 Volume 202, Issue 9, Page(s) 1244–1252

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Female ; Follow-Up Studies ; Humans ; Intensive Care Units ; Lung Compliance/physiology ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/epidemiology ; Prospective Studies ; Respiratory Distress Syndrome/physiopathology ; Respiratory Function Tests ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-09-03
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202005-2046OC
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Article ; Online: Inhaled nebulised unfractionated heparin (UFH) for the treatment of hospitalised patients with COVID-19: A randomised controlled pilot study.

DeNucci, Gilberto / Wilkinson, Tom / Sverdloff, Carlos / Babadopulos, Tainah / Woodcock, Ashley / Shute, Jan / Renato Guazelli, Pedro / Gerbase, Luis Frederico / Mourão, Paulo A S / Singh, Dave / van Haren, Frank M P / Page, Clive

Pulmonary pharmacology & therapeutics

2023 Volume 80, Page(s) 102212

Abstract: ... versus SOC (10 out of 37 patients; 27.0%), but not statistically significant; odds ratio (OR) 0.51, p = 0 ... 24. However, in the mITT population, nebulised UFH reduced mortality (OR 0.2, p = 0.035). Length ... following treatment with UFH in the ITT and mITT populations (p = 0.076 and p = 0.012 respectively ...

Abstract	There is a strong scientific rationale to use nebulised unfractionated heparin (UFH) in treating patients with COVID-19. This pilot study investigated whether nebulised UFH was safe and had any impact on mortality, length of hospitalisation and clinical progression, in the treatment of hospitalised patients with COVID-19. This parallel group, open label, randomised trial included adult patients with confirmed SARS-CoV-2 infection admitted to two hospitals in Brazil. One hundred patients were planned to be randomised to either "standard of care" (SOC) or SOC plus nebulized UFH. The trial was stopped after randomisation of 75 patients due to falling COVID-19 hospitalisation rates. Significance tests were 1-sided test (10% significance level). The key analysis populations were intention to treat (ITT) and modified ITT (mITT) which excluded (from both arms) subjects admitted to ITU or who died within 24 h of randomisation. In the ITT population (n = 75), mortality was numerically lower for nebulised UFH (6 out of 38 patients; 15.8%) versus SOC (10 out of 37 patients; 27.0%), but not statistically significant; odds ratio (OR) 0.51, p = 0.24. However, in the mITT population, nebulised UFH reduced mortality (OR 0.2, p = 0.035). Length of hospital stay was similar between groups, but at day 29, there was a greater improvement in ordinal score following treatment with UFH in the ITT and mITT populations (p = 0.076 and p = 0.012 respectively), while mechanical ventilation rates were lower with UFH in the mITT population (OR 0.31; p = 0.08). Nebulised UFH did not cause any significant adverse events. In conclusion, nebulised UFH added to SOC in hospitalised patients with COVID-19 was well tolerated and showed clinical benefit, particularly in patients who received at least 6 doses of heparin. This trial was funded by The J.R. Moulton Charity Trust and registered under REBEC RBR-8r9hy8f (UTN code: U1111-1263-3136).
MeSH term(s)	Adult ; Humans ; COVID-19 ; Heparin/adverse effects ; Pilot Projects ; SARS-CoV-2 ; Hospitalization ; Treatment Outcome
Chemical Substances	Heparin (9005-49-6)
Language	English
Publishing date	2023-03-27
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1399707-5
ISSN	1522-9629 ; 1094-5539
ISSN (online)	1522-9629
ISSN	1094-5539
DOI	10.1016/j.pupt.2023.102212
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