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  1. Article ; Online: Emicizumab for acquired hemophilia A: Report of two cases and dosing strategies.

    Ahmed, Faiza / Kasianchyk, Mariia / Moreno, Alejandro / Chang, Simone / Maharaj, Satish

    EJHaem

    2024  Volume 5, Issue 2, Page(s) 387–391

    Abstract: Acquired hemophilia A (AHA) is a rare autoimmune bleeding disorder caused by autoantibodies against FVIII. Severe AHA is life-threatening. Currently, licensed hemostatic agents for the treatment of severe AHA have short half-lives and require intravenous ...

    Abstract Acquired hemophilia A (AHA) is a rare autoimmune bleeding disorder caused by autoantibodies against FVIII. Severe AHA is life-threatening. Currently, licensed hemostatic agents for the treatment of severe AHA have short half-lives and require intravenous administration, leading to a need for hospitalization, higher costs, and negative effects on quality of life. We present two cases of severe AHA with high inhibitor titers where emicizumab was safely and effectively used with intensive immunosuppression. These reports suggest in vivo efficacy even in high inhibitor environments. The optimal dosing regimen (accelerated vs. standard loading, maintenance frequency) is unknown and we discuss the current approaches.
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Case Reports
    ISSN 2688-6146
    ISSN (online) 2688-6146
    DOI 10.1002/jha2.878
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  2. Article ; Online: Procalcitonin as a diagnostic marker for infection in sickle cell disease.

    Maharaj, Satish / Chang, Simone

    Expert review of hematology

    2022  Volume 15, Issue 6, Page(s) 559–564

    Abstract: Background: Patients with sickle cell disease (SCD) are at increased risks of infection. Fever often occurs with vaso-occlusive crisis (VOC), posing a diagnostic challenge in SCD. Procalcitonin (PCT) is an infectious biomarker validated in the general ... ...

    Abstract Background: Patients with sickle cell disease (SCD) are at increased risks of infection. Fever often occurs with vaso-occlusive crisis (VOC), posing a diagnostic challenge in SCD. Procalcitonin (PCT) is an infectious biomarker validated in the general population but with limited data on use in SCD.
    Methods: We performed a retrospective single-center study (n = 145) with primary objective of assessing ability of PCT to differentiate infection from VOC in SCD presenting with fever. Subgroups included confirmed bacterial infection (CBI), suspected bacterial infection, viral infection, and VOC. A secondary objective examined the association of PCT with acute chest syndrome. Clinical characteristics and data were collected and analyzed to assess the diagnostic performance of PCT and associated variables.
    Results: Of the cohort, 16% had CBI and 8% had viral infection. PCT was able to discriminate CBI from viral infection [AUC = 0.89 (95%CI, 0.78-0.99)] and VOC [AUC = 0.87 (95%CI, 0.78-0.97)]. PCT had an association with ACS but poor diagnostic performance [AUC = 0.69 (95% CI, 0.54-0.84)].
    Conclusion: PCT has utility in distinguishing confirmed bacterial infection from VOC or viral infection and is a promising biomarker when investigating fever in SCD.
    MeSH term(s) Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/diagnosis ; Bacterial Infections/complications ; Bacterial Infections/diagnosis ; Biomarkers ; Hemoglobinopathies ; Humans ; Procalcitonin ; Retrospective Studies ; Volatile Organic Compounds
    Chemical Substances Biomarkers ; Procalcitonin ; Volatile Organic Compounds
    Language English
    Publishing date 2022-05-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2516804-6
    ISSN 1747-4094 ; 1747-4086
    ISSN (online) 1747-4094
    ISSN 1747-4086
    DOI 10.1080/17474086.2022.2079490
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    Zs.A 6943: Show issues Location:
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  3. Article ; Online: Left ventricular thrombi in malignancy: A therapeutic dilemma.

    Omar, Michael Brandon / Maharaj, Satish

    Heart & lung : the journal of critical care

    2020  Volume 50, Issue 1, Page(s) 231

    MeSH term(s) Heart Diseases/diagnosis ; Heart Ventricles/diagnostic imaging ; Humans ; Neoplasms/complications ; Thrombosis/etiology
    Language English
    Publishing date 2020-10-21
    Publishing country United States
    Document type Letter
    ZDB-ID 193129-5
    ISSN 1527-3288 ; 0147-9563
    ISSN (online) 1527-3288
    ISSN 0147-9563
    DOI 10.1016/j.hrtlng.2020.10.001
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    Zs.A 1035: Show issues Location:
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  4. Article ; Online: Coagulopathy following Crotaliπae snakebites in northeast Florida.

    Maharaj, Satish / Seegobin, Karan / Chang, Simone

    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis

    2022  Volume 33, Issue 4, Page(s) 220–223

    Abstract: Effects of Crotalinae envenomation vary by geographical areas and research into coagulopathy and effects of antivenom are needed to optimize management. This was a single-center retrospective review with testing on presentation and 4 h after; antivenom ... ...

    Abstract Effects of Crotalinae envenomation vary by geographical areas and research into coagulopathy and effects of antivenom are needed to optimize management. This was a single-center retrospective review with testing on presentation and 4 h after; antivenom administration was noted and data analyzed overall and comparing envenomations. One hundred and nineteen snakebites evaluated with 59 identified as Crotalinae and half receiving antivenom. PT/aPTT was elevated in 20% of water moccasin/copperhead and 21% of rattlesnake bites. DIC-like syndrome occurred in 8% water moccasin/copperhead and 6% rattlesnake bites. Antivenom did not seem to correct PT or aPTT at 4 h follow-up in most cases. Thrombotic microangiopathy was not seen. Coagulopathy was prevalent affecting one in five patients in this cohort and does seem to persist at short interval follow-up, even in those receiving antivenom. We support guidelines recommending clinical monitoring and serial coagulation profiles in such cases. Blood Coagul Fibrinolysis 30:000 - 000 Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.
    MeSH term(s) Agkistrodon ; Animals ; Antivenins/therapeutic use ; Blood Coagulation Disorders/etiology ; Crotalus ; Disseminated Intravascular Coagulation ; Florida ; Humans ; Snake Bites/complications ; Snake Bites/epidemiology
    Chemical Substances Antivenins
    Language English
    Publishing date 2022-01-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1033551-1
    ISSN 1473-5733 ; 0957-5235
    ISSN (online) 1473-5733
    ISSN 0957-5235
    DOI 10.1097/MBC.0000000000001123
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    Zs.A 2920: Show issues Location:
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  5. Article: A Case Report of Cytarabine-Induced Red Ear Syndrome.

    Botros, Monica / De La Rosa, Alan / Nadella, Sahithi / Chang, Aymara Y / Maharaj, Satish S

    Cureus

    2023  Volume 15, Issue 11, Page(s) e48707

    Abstract: Cytarabine is an antimetabolite used in the treatment of acute myeloid leukemia which acts by inhibiting DNA synthesis and subsequently cell division. It works on rapidly dividing cells, for that reason, it affects cancer cells, bone marrow and skin ... ...

    Abstract Cytarabine is an antimetabolite used in the treatment of acute myeloid leukemia which acts by inhibiting DNA synthesis and subsequently cell division. It works on rapidly dividing cells, for that reason, it affects cancer cells, bone marrow and skin cells. Cytarabine has variable cutaneous side effects, the most common one is palmar-plantar erythema which usually presents with a tingling sensation around 5-7 days after cytarabine initiation, followed by erythema and tenderness. Auricular erythema is a rare subtype involving bilateral ears which often presents as ear redness and tenderness as described in the presented case. It is unclear if the skin side effects are related to cytarabine dose or plasma concentration. Most cases of auricular erythema have a benign course and resolve spontaneously. Treatment is mainly conservative. Steroids and antihistamines can be used to speed up recovery given that the pathophysiology is thought to be immediate or due to a delayed hypersensitivity reaction to cytarabine.
    Language English
    Publishing date 2023-11-12
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.48707
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  6. Article ; Online: Breast Implant-Associated CD30 Negative Peripheral T-Cell Lymphoma, NOS.

    Maharaj, Satish / Murray, Drew / Hegazi, Mohamed / Chang, Simone

    HemaSphere

    2020  Volume 5, Issue 1, Page(s) e507

    Language English
    Publishing date 2020-12-09
    Publishing country United States
    Document type Case Reports
    ISSN 2572-9241
    ISSN (online) 2572-9241
    DOI 10.1097/HS9.0000000000000507
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  7. Article ; Online: Trousseau syndrome.

    Maharaj, Satish / Omar, Michael / Seegobin, Karan / Chang, Simone

    Cleveland Clinic journal of medicine

    2020  Volume 87, Issue 4, Page(s) 199–200

    MeSH term(s) Aged ; Humans ; Leg/blood supply ; Male ; Thrombophlebitis/diagnosis ; Thrombophlebitis/etiology ; Thrombophlebitis/therapy
    Language English
    Publishing date 2020-03-29
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.87a.19086
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  8. Article ; Online: Pharmacist Rethink through a Planetary Health Lens.

    Maharaj, Sandeep / Moonilal, Mala / Jankie, Satish / Dookeram, Darren

    Inquiry : a journal of medical care organization, provision and financing

    2021  Volume 58, Page(s) 469580211020885

    Abstract: Planetary Health is a rapidly developing field that is gaining momentum and significance as the world grapples with the devastating effects of infectious diseases, climate change, biodiversity loss, complex food insecurities, and international ... ...

    Abstract Planetary Health is a rapidly developing field that is gaining momentum and significance as the world grapples with the devastating effects of infectious diseases, climate change, biodiversity loss, complex food insecurities, and international competition for resources. These challenges are often attributable to the financial activity made by nation states and increasing disposable individual wealth. The outcomes have created a perfect storm of events that, if not managed properly, threatens the health of current and future generations. Given the front-line role pharmacists play within health system in the community and institutional levels, the profession is uniquely positioned to make a meaningful impact to planetary health. This article aims to explore contributions pharmacists can make to secure planetary health.
    MeSH term(s) Humans ; Medical Assistance ; Pharmacists
    Language English
    Publishing date 2021-06-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 42153-4
    ISSN 1945-7243 ; 0046-9580
    ISSN (online) 1945-7243
    ISSN 0046-9580
    DOI 10.1177/00469580211020885
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  9. Article ; Online: Venous and arterial thromboembolism with immunotherapy compared to platinum-based therapy.

    Maharaj, Satish / Chang, Simone / Kloecker, Goetz / Chesney, Jason / Redman, Rebecca / Rojan, Adam

    Thrombosis research

    2022  Volume 217, Page(s) 48–51

    MeSH term(s) Humans ; Immunotherapy ; Platinum/therapeutic use ; Risk Factors ; Stroke ; Venous Thromboembolism/drug therapy
    Chemical Substances Platinum (49DFR088MY)
    Language English
    Publishing date 2022-07-14
    Publishing country United States
    Document type Letter
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2022.07.006
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    Zs.A 863: Show issues Location:
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  10. Article ; Online: Melanoma of unknown primary: favorable survival persists in the immunotherapy era.

    Maharaj, Satish / Jain, Nikita / Al Bawaliz, Anas / Miller, Donald / Chesney, Jason

    International journal of dermatology

    2022  Volume 62, Issue 4, Page(s) e236–e238

    MeSH term(s) Humans ; Neoplasms, Unknown Primary/therapy ; Melanoma/therapy ; Immunotherapy
    Language English
    Publishing date 2022-08-28
    Publishing country England
    Document type Letter
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.16419
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