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  1. Article: Variable Phenotypes in Alternating Hemiplegia of Childhood: A Genetically Proven Case Series.

    Mohanlal, Smilu / Babu, Sachin Suresh / Pachat, Divya

    Annals of Indian Academy of Neurology

    2021  Volume 24, Issue 3, Page(s) 449–450

    Language English
    Publishing date 2021-01-25
    Publishing country India
    Document type Journal Article
    ZDB-ID 2240174-X
    ISSN 1998-3549 ; 0972-2327
    ISSN (online) 1998-3549
    ISSN 0972-2327
    DOI 10.4103/aian.AIAN_495_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Genome-Based Therapeutics: Era of Precision Medicine in Genetic Epilepsies and Epileptic Encephalopathies.

    Balaji, Aarthi / Mohanlal, Smilu / Pachat, Divya / Babu, Sachin Suresh / Kumar, Ek Suresh / Mamukoya, Najiya / Das, Syama

    Annals of Indian Academy of Neurology

    2023  Volume 26, Issue 5, Page(s) 723–727

    Abstract: Introduction: The recent evolution of genomics has led to the development of targeted therapeutics, revolutionizing medical approaches. This study aimed to assess the impact of genetic testing on the current epilepsy management paradigm with a specific ... ...

    Abstract Introduction: The recent evolution of genomics has led to the development of targeted therapeutics, revolutionizing medical approaches. This study aimed to assess the impact of genetic testing on the current epilepsy management paradigm with a specific focus on the variability of outcomes subsequent to genetic diagnoses.
    Methodology: Data were collected retrospectively from a cohort of children aged 1-18 years, diagnosed with refractory epilepsy of confirmed genetic origin. The participants received care at a quaternary care center's pediatric neurology clinic from August 2019 to June 2021. The collected information included demographic characteristics, seizure types, EEG findings, imaging abnormalities, genetic diagnoses, attempted treatments, and seizure outcomes.
    Results: Among the 210 children with confirmed genetic diagnoses, 74 were included in the study. The gender distribution comprised 45 males and 29 females. Within the cohort, 68/74 exhibited single gene variations, with 23 cases associated with sodium/potassium/calcium channelopathies. Precision medicine could be applied to 25/74 cases. 17/74 children (22.97%) experienced a reduction of up to 50% in seizure frequency due to precision medicine implementation.
    Conclusion: While our study indicates the significance of genetic insights in adapting treatment approaches for pediatric epilepsy, it is important to temper our conclusions. The retrospective nature of our study confines our ability to definitively gauge the extent of precision medicine's utility. Our findings suggest the potential of genetic information to enhance epilepsy management, but the true impact of precision medicine can only be established through prospective investigations.
    Language English
    Publishing date 2023-10-26
    Publishing country India
    Document type Journal Article
    ZDB-ID 2240174-X
    ISSN 1998-3549 ; 0972-2327
    ISSN (online) 1998-3549
    ISSN 0972-2327
    DOI 10.4103/aian.aian_314_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Genome-based therapeutics

    Aarthi Balaji / Smilu Mohanlal / Divya Pachat / Sachin Suresh Babu / E K Suresh Kumar / Najiya Mamukoya / Syama Das

    Annals of Indian Academy of Neurology, Vol 26, Iss 5, Pp 723-

    Era of precision medicine in genetic epilepsies and epileptic encephalopathies

    2023  Volume 727

    Abstract: Introduction: The recent evolution of genomics has led to the development of targeted therapeutics, revolutionizing medical approaches. This study aimed to assess the impact of genetic testing on the current epilepsy management paradigm with a specific ... ...

    Abstract Introduction: The recent evolution of genomics has led to the development of targeted therapeutics, revolutionizing medical approaches. This study aimed to assess the impact of genetic testing on the current epilepsy management paradigm with a specific focus on the variability of outcomes subsequent to genetic diagnoses. Methodology: Data were collected retrospectively from a cohort of children aged 1–18 years, diagnosed with refractory epilepsy of confirmed genetic origin. The participants received care at a quaternary care center's pediatric neurology clinic from August 2019 to June 2021. The collected information included demographic characteristics, seizure types, EEG findings, imaging abnormalities, genetic diagnoses, attempted treatments, and seizure outcomes. Results: Among the 210 children with confirmed genetic diagnoses, 74 were included in the study. The gender distribution comprised 45 males and 29 females. Within the cohort, 68/74 exhibited single gene variations, with 23 cases associated with sodium/potassium/calcium channelopathies. Precision medicine could be applied to 25/74 cases. 17/74 children (22.97%) experienced a reduction of up to 50% in seizure frequency due to precision medicine implementation. Conclusion: While our study indicates the significance of genetic insights in adapting treatment approaches for pediatric epilepsy, it is important to temper our conclusions. The retrospective nature of our study confines our ability to definitively gauge the extent of precision medicine's utility. Our findings suggest the potential of genetic information to enhance epilepsy management, but the true impact of precision medicine can only be established through prospective investigations.
    Keywords developmental and epileptic encephalopathies ; genetic epilepsies ; precision medicine ; Neurology. Diseases of the nervous system ; RC346-429
    Subject code 616
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Andersen-Tawil syndrome: A review of literature.

    Babu, Sachin Suresh / Nigam, Gaurav Bhaskar / Peter, C Sudhir / Peter, C Shobhna

    Neurology India

    2015  Volume 63, Issue 5, Page(s) 772–774

    Language English
    Publishing date 2015-09
    Publishing country India
    Document type Letter
    ZDB-ID 415522-1
    ISSN 1998-4022 ; 0028-3886
    ISSN (online) 1998-4022
    ISSN 0028-3886
    DOI 10.4103/0028-3886.166530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article: Thalamus and vertical gaze: Arguing for an independent association.

    Babu, Sachin Suresh / Khanna, Laxmi / Peter, Sudhir / Chindrippu, Sobhana / Patras, Elisheba

    Annals of Indian Academy of Neurology

    2016  Volume 19, Issue 3, Page(s) 426–428

    Language English
    Publishing date 2016-08-11
    Publishing country India
    Document type Journal Article
    ZDB-ID 2240174-X
    ISSN 1998-3549 ; 0972-2327
    ISSN (online) 1998-3549
    ISSN 0972-2327
    DOI 10.4103/0972-2327.179981
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Association of BMI and HDL Cholesterol in Relation to Glycated Albumin in Type 2 Diabetes Mellitus

    Suresh Babu Kondaveeti / Santosh Jagtap / Shilpa Kumar / Ankit Kumar Tiwari / Dipali khopade / Anita Kadam / Priyanka Ladi / Sachin Rathod

    Journal of Clinical and Diagnostic Research, Vol 14, Iss 7, Pp 07-

    2020  Volume 10

    Abstract: Introduction: The main issue with the morbidity and mortality of type 2 diabetes is its associated health complications. In the last decade Glycated Albumin (GA) emerged as an extinguished marker for short-term glycaemic control. Aim: To Quadrate the ... ...

    Abstract Introduction: The main issue with the morbidity and mortality of type 2 diabetes is its associated health complications. In the last decade Glycated Albumin (GA) emerged as an extinguished marker for short-term glycaemic control. Aim: To Quadrate the association of Body Mass Index (BMI) along with HDL-cholesterol to GA in Type 2 diabetic cases. Materials and Methods: Total of 50 diabetic cases (Group 1) and 50 healthy non-diabetic control subjects (Group 2) recruited for the study between November 2017 to December 2018, which includes both males and females. Serum samples of both the groups were analysed to assess the lipid profile to GA levels along with BMI. Variations among groups was compared using student t-test by calculating r-values of the parametres and the pearson coefficient was calculated with significant p value at <0.05. Results: The levels of High-Density Lipoprotein (HDL) cholesterol in group 1 when compared with group 2 were significantly lower. Both BMI and GA showed negative correlation with HDL-C levels in both the groups. (p values 0.051 and 0.331 respectively). To boot, there was a statistically undeviating reciprocity of Low Density Lipoprotein (LDL) cholesterol to GA levels, BMI to LDL-cholesterol and BMI to Triglycerides (TG). There was a statistically significant correlation between GA and BMI (r=0.240, p<0.0001) and there was a statistically significant negative correlation between GA and HDL-cholesterol (r=-0.286, p<0.051) in diabetic patients (group 1). The association between GA and LDL-cholesterol (r=0.271, p<0.0001) was also been found statistically significant in group 1. Conclusion: The present study suggests that GA can be adapted as a reliable prospective biomarker that endures the potentiality in prognostication of serum lipid levels in diabetic patients and also BMI is the key formidable feature of dyslipidemia in type 2 diabetic cases.
    Keywords biomarkers ; body mass index ; high-density lipoprotein ; lipid profile ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Lance-Adams syndrome: A special case of a mother.

    Nigam, Gaurav Bhaskar / Babu, Sachin Suresh / Peter, C Sudhir / Peter, C Shobhna

    Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

    2016  Volume 20, Issue 9, Page(s) 548–550

    Abstract: Predicting the neurological outcome in survivors of cardiorespiratory arrest is difficult. A distinction has been made between acute and chronic posthypoxic myoclonus, called myoclonic status epilepticus and Lance-Adams syndrome (LAS), respectively, with ...

    Abstract Predicting the neurological outcome in survivors of cardiorespiratory arrest is difficult. A distinction has been made between acute and chronic posthypoxic myoclonus, called myoclonic status epilepticus and Lance-Adams syndrome (LAS), respectively, with the acute condition carrying a bad prognosis. Here, we report a case of a 37-year-old female who developed seizures after a successful cardiopulmonary resuscitation. The available literature on such cases is very rare and has generally mentioned a poor outcome. However, our patient was successfully managed and showed clinical features of LAS. Thus, making an early diagnosis and proper management of hypoxic brain insults is positively related to improving the patient's functional outcome.
    Language English
    Publishing date 2016-02-18
    Publishing country India
    Document type Case Reports
    ZDB-ID 2121263-6
    ISSN 1998-359X ; 0972-5229
    ISSN (online) 1998-359X
    ISSN 0972-5229
    DOI 10.4103/0972-5229.190372
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Necrotizing autoimmune myopathy

    Sachin Suresh Babu / Laxmi Khanna / Ravindra Kumar Saran / Gaurav Mittal / Sudhir Peter / Ivy Sebastian

    Annals of Indian Academy of Neurology, Vol 19, Iss 2, Pp 288-

    2016  Volume 290

    Keywords Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Thalamus and vertical gaze

    Sachin Suresh Babu / Laxmi Khanna / Sudhir Peter / Sobhana Chindrippu / Elisheba Patras

    Annals of Indian Academy of Neurology, Vol 19, Iss 3, Pp 426-

    Arguing for an independent association

    2016  Volume 428

    Keywords Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  10. Article ; Online: Andersen-Tawil syndrome

    Sachin Suresh Babu / Gaurav Bhaskar Nigam / C Sudhir Peter / C Shobhna Peter

    Neurology India, Vol 63, Iss 5, Pp 772-

    A review of literature

    2015  Volume 774

    Keywords Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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