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Article: Contribution of Native Plasmids of

Klein-Gordon, Jeannie M / Johnson, Kenneth B / Loper, Joyce E / Stockwell, Virginia O

2023 Volume 113, Issue 12, Page(s) 2187–2196

Abstract: ... Pantoea ... ...

Abstract	Pantoea vagans
MeSH term(s)	Malus/microbiology ; Fruit ; Pantoea/genetics ; Pyrus/microbiology ; Plant Diseases/prevention & control ; Plant Diseases/microbiology ; Plasmids ; Erwinia amylovora/genetics ; Flowers/microbiology
Language	English
Publishing date	2023-12-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	208889-7
ISSN	1943-7684 ; 0031-949X
ISSN (online)	1943-7684
ISSN	0031-949X
DOI	10.1094/PHYTO-04-23-0144-SA
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Article ; Online: Contribution of Native Plasmids of Pantoea vagans C9-1 to Epiphytic Fitness and Fire Blight Management on Apple and Pear Flowers and Fruits

Klein-Gordon, Jeannie M. / Johnson, Kenneth B. / Loper, Joyce E. / Stockwell, Virginia O.

Phytopathology®. 2023 Dec., v. 113, no. 12 p.2187-2196

2023

Abstract: Pantoea vagans C9-1 (C9-1) is a biological control bacterium that is applied to apple and pear trees during bloom for suppression of fire blight, caused by Erwinia amylovora. Strain C9-1 has three megaplasmids: pPag1, pPag2, and pPag3. Prior ... ...

Abstract	Pantoea vagans C9-1 (C9-1) is a biological control bacterium that is applied to apple and pear trees during bloom for suppression of fire blight, caused by Erwinia amylovora. Strain C9-1 has three megaplasmids: pPag1, pPag2, and pPag3. Prior bioinformatic studies predicted these megaplasmids have a role in environmental fitness and/or biocontrol efficacy. Plasmid pPag3 is part of the large Pantoea plasmid (LPP-1) group that is present in all Pantoea spp. and has been hypothesized to contribute to environmental colonization and persistence, while pPag2 is less common. We assessed fitness of C9-1 derivatives cured of pPag2 and/or pPag3 on pear and apple flowers and fruit in experimental orchards. We also assessed the ability of a C9-1 derivative lacking pPag3 to reduce populations of E. amylovora on flowers and disease incidence. Previously, we determined that tolerance to stresses imposed in vitro was compromised in derivatives of C9-1 lacking pPag2 and/or pPag3; however, in this study, the loss of pPag2 and/or pPag3 did not consistently reduce the fitness of C9-1 on flowers in orchards. Over the summer, pPag3 contributed to survival of C9-1 on developing apple and pear fruit in two of five trials, whereas loss of pPag2 did not significantly affect survival of C9-1. We also found that loss of pPag3 did not affect C9-1’s ability to reduce E. amylovora populations or fire blight incidence on apple flowers. Our findings partially support prior hypotheses that LPP-1 in Pantoea species contributes to persistence on plant surfaces but questions whether LPP-1 facilitates host colonization.
Keywords	Erwinia amylovora ; Pantoea ; apples ; bacteria ; bioinformatics ; biological control ; disease incidence ; epiphytes ; fire blight ; fruits ; pears ; plasmids ; summer ; Erwinia herbicola ; Malus ; microbial ecology ; Pantoea agglomerans ; pome fruit ; Pyrus ; stigma
Language	English
Dates of publication	2023-12
Size	p. 2187-2196.
Publishing place	The American Phytopathological Society
Document type	Article ; Online
ZDB-ID	208889-7
ISSN	1943-7684 ; 0031-949X
ISSN (online)	1943-7684
ISSN	0031-949X
DOI	10.1094/PHYTO-04-23-0144-SA
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Article ; Online: Need for Speed: From Human SARS-CoV-2 Samples to Protective and Efficacious Antibodies in Weeks.

Joyce, M Gordon / Wheatley, Adam K / Modjarrad, Kayvon

Cell

2020 Volume 182, Issue 1, Page(s) 7–9

Abstract: The emergence of SARS-CoV-2 has driven a global research effort to identify medical countermeasures at an unprecedented pace. In this issue of Cell, Cao et al. identify thousands of SARS-CoV-2 neutralizing antibodies from convalescent donors. The authors ...

Abstract	The emergence of SARS-CoV-2 has driven a global research effort to identify medical countermeasures at an unprecedented pace. In this issue of Cell, Cao et al. identify thousands of SARS-CoV-2 neutralizing antibodies from convalescent donors. The authors improve our understanding of immunity against the coronavirus spike glycoprotein and detail novel pathways to rapidly identify and characterize protective monoclonal antibodies.
MeSH term(s)	Antibodies, Viral ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS Virus/immunology ; SARS-CoV-2
Chemical Substances	Antibodies, Viral
Keywords	covid19
Language	English
Publishing date	2020-07-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2020.06.017
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Article ; Online: Inequalities in urban greenness and epigenetic aging: Different associations by race and neighborhood socioeconomic status.

Kim, Kyeezu / Joyce, Brian T / Nannini, Drew R / Zheng, Yinan / Gordon-Larsen, Penny / Shikany, James M / Lloyd-Jones, Donald M / Hu, Ming / Nieuwenhuijsen, Mark J / Vaughan, Douglas E / Zhang, Kai / Hou, Lifang

Science advances

2023 Volume 9, Issue 26, Page(s) eadf8140

Abstract: Slower epigenetic aging is associated with exposure to green space (greenness); however, the longitudinal relationship has not been well studied, particularly in minority groups. We investigated the association between 20-year exposure to greenness [ ... ...

Abstract	Slower epigenetic aging is associated with exposure to green space (greenness); however, the longitudinal relationship has not been well studied, particularly in minority groups. We investigated the association between 20-year exposure to greenness [Normalized Difference Vegetation Index (NDVI)] and epigenetic aging in a large, biracial (Black/white), U.S. urban cohort. Using generalized estimating equations adjusted for individual and neighborhood socioeconomic characteristics, greater greenness was associated with slower epigenetic aging. Black participants had less surrounding greenness and an attenuated association between greenness and epigenetic aging [β
MeSH term(s)	Humans ; Social Class ; Socioeconomic Factors ; Residence Characteristics ; Aging/genetics ; Epigenesis, Genetic
Language	English
Publishing date	2023-06-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adf8140
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Determination of Binding Affinity of Antibodies to HIV-1 Recombinant Envelope Glycoproteins, Pseudoviruses, Infectious Molecular Clones, and Cell-Expressed Trimeric gp160 Using Microscale Thermophoresis.

Basu, Shraddha / Gohain, Neelakshi / Kim, Jiae / Trinh, Hung V / Choe, Misook / Joyce, M Gordon / Rao, Mangala

Cells

2023 Volume 13, Issue 1

Abstract: Developing a preventative vaccine for HIV-1 has been a global priority. The elicitation of broadly neutralizing antibodies (bNAbs) against a broad range of HIV-1 envelopes (Envs) from various strains appears to be a critical requirement for an ... ...

Abstract	Developing a preventative vaccine for HIV-1 has been a global priority. The elicitation of broadly neutralizing antibodies (bNAbs) against a broad range of HIV-1 envelopes (Envs) from various strains appears to be a critical requirement for an efficacious HIV-1 vaccine. To understand their ability to neutralize HIV-1, it is important to characterize the binding characteristics of bNAbs. Our work is the first to utilize microscale thermophoresis (MST), a rapid, economical, and flexible in-solution temperature gradient method to quantitatively determine the binding affinities of bNAbs and non-neutralizing monoclonal antibodies (mAbs) to HIV-1 recombinant envelope monomer and trimer proteins of different subtypes, pseudoviruses (PVs), infectious molecular clones (IMCs), and cells expressing the trimer. Our results demonstrate that the binding affinities were subtype-dependent. The bNAbs exhibited a higher affinity to IMCs compared to PVs and recombinant proteins. The bNAbs and mAbs bound with high affinity to native-like gp160 trimers expressed on the surface of CEM cells compared to soluble recombinant proteins. Interesting differences were seen with V2-specific mAbs. Although they recognize linear epitopes, one of the antibodies also bound to the Envs on PVs, IMCs, and a recombinant trimer protein, suggesting that the epitope was not occluded. The identification of epitopes on the envelope surface that can bind to high affinity mAbs could be useful for designing HIV-1 vaccines and for down-selecting vaccine candidates that can induce high affinity antibodies to the HIV-1 envelope in their native conformation.
MeSH term(s)	Humans ; HIV-1 ; Broadly Neutralizing Antibodies ; Antibodies, Monoclonal ; Communicable Diseases ; AIDS Vaccines ; Clone Cells ; Epitopes ; HIV Seropositivity ; Recombinant Proteins ; Glycoproteins ; HIV Envelope Protein gp160
Chemical Substances	Broadly Neutralizing Antibodies ; Antibodies, Monoclonal ; AIDS Vaccines ; Epitopes ; Recombinant Proteins ; Glycoproteins ; gp160 protein, Human immunodeficiency virus 2 ; HIV Envelope Protein gp160 ; gp160 protein, Human immunodeficiency virus 1
Language	English
Publishing date	2023-12-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells13010033
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Article: Need for Speed: From Human SARS-CoV-2 Samples to Protective and Efficacious Antibodies in Weeks

Joyce, M. Gordon / Wheatley, Adam K / Modjarrad, Kayvon

Cell. 2020 July 09, v. 182, no. 1

2020

Abstract	The emergence of SARS-CoV-2 has driven a global research effort to identify medical countermeasures at an unprecedented pace. In this issue of Cell, Cao et al. identify thousands of SARS-CoV-2 neutralizing antibodies from convalescent donors. The authors improve our understanding of immunity against the coronavirus spike glycoprotein and detail novel pathways to rapidly identify and characterize protective monoclonal antibodies.
Keywords	Severe acute respiratory syndrome coronavirus 2 ; glycoproteins ; humans ; immunity ; monoclonal antibodies ; neutralization ; neutralizing antibodies
Language	English
Dates of publication	2020-0709
Size	p. 7-9.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2020.06.017
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Article ; Online: Aquatic connectivity: challenges and solutions in a changing climate.

Franklin, Paul A / Bašić, Tea / Davison, Phil I / Dunkley, Katie / Ellis, Jonathan / Gangal, Mayuresh / González-Ferreras, Alexia M / Gutmann Roberts, Catherine / Hunt, Georgina / Joyce, Domino / Klöcker, C Antonia / Mawer, Rachel / Rittweg, Timo / Stoilova, Velizara / Gutowsky, Lee Frank Gordon

Journal of fish biology

2024

Abstract: The challenge of managing aquatic connectivity in a changing climate is exacerbated in the presence of additional anthropogenic stressors, social factors, and economic drivers. Here we discuss these issues in the context of structural and functional ... ...

Abstract	The challenge of managing aquatic connectivity in a changing climate is exacerbated in the presence of additional anthropogenic stressors, social factors, and economic drivers. Here we discuss these issues in the context of structural and functional connectivity for aquatic biodiversity, specifically fish, in both the freshwater and marine realms. We posit that adaptive management strategies that consider shifting baselines and the socio-ecological implications of climate change will be required to achieve management objectives. The role of renewable energy expansion, particularly hydropower, is critically examined for its impact on connectivity. We advocate for strategic spatial planning that incorporates nature-positive solutions, ensuring climate mitigation efforts are harmonized with biodiversity conservation. We underscore the urgency of integrating robust scientific modelling with stakeholder values to define clear, adaptive management objectives. Finally, we call for innovative monitoring and predictive decision-making tools to navigate the uncertainties inherent in a changing climate, with the goal of ensuring the resilience and sustainability of aquatic ecosystems.
Language	English
Publishing date	2024-04-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	410564-3
ISSN	1095-8649 ; 0022-1112
ISSN (online)	1095-8649
ISSN	0022-1112
DOI	10.1111/jfb.15727
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Article ; Online: Nurturing Diverse Generations of the Medical Workforce for Success With Authenticity: An Association of Black Cardiologists' Roundtable.

Haynes, Norrisa A / Johnson, Michelle / Lewsey, Sabra C / Alexander, Kevin M / Anstey, D Edmund / Dillenburg, Tierra / Njoroge, Joyce N / Gordon, Debra / Ofili, Elizabeth O / Yancy, Clyde W / Albert, Michelle A

Circulation. Cardiovascular quality and outcomes

2023 Volume 16, Issue 1, Page(s) e009032

Abstract: The COVID-19 pandemic exposed the consequences of systemic racism in the United States with Black, Hispanic, and other racial and ethnic diverse populations dying at disproportionately higher rates than White Americans. Addressing the social and health ... ...

Abstract	The COVID-19 pandemic exposed the consequences of systemic racism in the United States with Black, Hispanic, and other racial and ethnic diverse populations dying at disproportionately higher rates than White Americans. Addressing the social and health disparities amplified by COVID-19 requires in part restructuring of the healthcare system, particularly the diversity of the healthcare workforce to better reflect that of the US population. In January 2021, the Association of Black Cardiologists hosted a virtual roundtable designed to discuss key issues pertaining to medical workforce diversity and to identify strategies aimed at improving racial and ethnic diversity in medical school, graduate medical education, faculty, and leadership positions. The Nurturing Diverse Generations of the Medical Workforce for Success with Authenticity roundtable brought together diverse stakeholders and champions of diversity and inclusion to discuss innovative ideas, solutions, and opportunities to address workforce diversification.
MeSH term(s)	Humans ; United States/epidemiology ; Cardiologists ; Pandemics ; COVID-19 ; Ethnicity ; Workforce
Language	English
Publishing date	2023-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2483197-9
ISSN	1941-7705 ; 1941-7713
ISSN (online)	1941-7705
ISSN	1941-7713
DOI	10.1161/CIRCOUTCOMES.122.009032
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Article ; Online: Need for Speed

Joyce, M. Gordon / Wheatley, Adam K. / Modjarrad, Kayvon

Cell

From Human SARS-CoV-2 Samples to Protective and Efficacious Antibodies in Weeks

2020 Volume 182, Issue 1, Page(s) 7–9

Keywords	General Biochemistry, Genetics and Molecular Biology ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2020.06.017
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Article ; Online: Discovery of Potent and Selective Quinoxaline-Based Protease-Activated Receptor 4 (PAR4) Antagonists for the Prevention of Arterial Thrombosis.

Zhang, Xiaojun / Jiang, Wen / Richter, Jeremy M / Bates, J Alex / Reznik, Samuel K / Stachura, Sylwia / Rampulla, Richard / Doddalingappa, Dyamanna / Ulaganathan, Sankar / Hua, Ji / Bostwick, Jeffrey S / Sum, Chi / Posy, Shana / Malmstrom, Sarah / Dickey, Joyce / Harden, David / Lawrence, R Michael / Guarino, Victor R / Schumacher, William A /

Wong, Pancras / Yang, Jing / Gordon, David A / Wexler, Ruth R / Priestley, E Scott

Journal of medicinal chemistry

2024 Volume 67, Issue 5, Page(s) 3571–3589

Abstract: PAR4 is a promising antithrombotic target with potential for separation of efficacy from bleeding risk relative to current antiplatelet therapies. In an effort to discover a novel PAR4 antagonist chemotype, a quinoxaline-based HTS ... ...

Abstract	PAR4 is a promising antithrombotic target with potential for separation of efficacy from bleeding risk relative to current antiplatelet therapies. In an effort to discover a novel PAR4 antagonist chemotype, a quinoxaline-based HTS hit
MeSH term(s)	Animals ; Fibrinolytic Agents/pharmacology ; Fibrinolytic Agents/therapeutic use ; Macaca fascicularis ; Quinoxalines/pharmacology ; Quinoxalines/therapeutic use ; Receptors, Thrombin ; Thrombin ; Hemorrhage ; Thrombosis/drug therapy ; Thrombosis/prevention & control ; Receptor, PAR-1 ; Blood Platelets ; Platelet Aggregation
Chemical Substances	protease-activated receptor 4 (JWE1M73YZN) ; Fibrinolytic Agents ; Quinoxalines ; Receptors, Thrombin ; Thrombin (EC 3.4.21.5) ; Receptor, PAR-1
Language	English
Publishing date	2024-02-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.3c01986
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