Article ; Online: Need for a comprehensive medical approach to the neuro-immuno-gastroenterology of irritable bowel syndrome.
World journal of gastroenterology
2011 Volume 17, Issue 23, Page(s) 2791–2800
Abstract: Irritable bowel syndrome (IBS) is defined by the Rome III criteria as symptoms of recurrent abdominal pain or discomfort with the onset of a marked change in bowel habits with no evidence of an inflammatory, anatomic, metabolic, or neoplastic process. As ...
| Abstract | Irritable bowel syndrome (IBS) is defined by the Rome III criteria as symptoms of recurrent abdominal pain or discomfort with the onset of a marked change in bowel habits with no evidence of an inflammatory, anatomic, metabolic, or neoplastic process. As such, many clinicians regard IBS as a central nervous system problem of altered pain perception. Here, we review the recent literature and discuss the evidence that supports an organic based model, which views IBS as a complex, heterogeneous, inter-dependent, and multi-variable inflammatory process along the neuronal-gut axis. We delineate the organic pathophysiology of IBS, demonstrate the role of inflammation in IBS, review the possible differences between adult and pediatric IBS, discuss the merits of a comprehensive treatment model as taught by the Institute of Functional Medicine, and describe the potential for future research for this syndrome. |
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| MeSH term(s) | Abdominal Pain/etiology ; Abdominal Pain/physiopathology ; Antigens/immunology ; Gastroenterology ; Gastrointestinal Tract/microbiology ; Gastrointestinal Tract/physiology ; Gastrointestinal Tract/physiopathology ; Humans ; Inflammation/physiopathology ; Irritable Bowel Syndrome/pathology ; Irritable Bowel Syndrome/physiopathology ; Neuroimmunomodulation ; Serotonin/metabolism ; Stress, Physiological |
| Chemical Substances | Antigens ; Serotonin (333DO1RDJY) |
| Language | English |
| Publishing date | 2011-05-20 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
| ZDB-ID | 2185929-2 |
| ISSN | 2219-2840 ; 1007-9327 |
| ISSN (online) | 2219-2840 |
| ISSN | 1007-9327 |
| DOI | 10.3748/wjg.v17.i23.2791 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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