Article ; Online: Negative SARS-CoV-2 antibody testing following COVID-19 infection in Two MS patients treated with ocrelizumab.
Multiple sclerosis and related disorders
2020 Volume 44, Page(s) 102341
Abstract: Background: It is unknown whether MS disease modifying therapies impact ability to mount an antibody response to SARS-CoV-2.: Methods: Case series and literature review. We report a series of two MS patients who developed COVID-19 while on ... ...
| Abstract | Background: It is unknown whether MS disease modifying therapies impact ability to mount an antibody response to SARS-CoV-2. Methods: Case series and literature review. We report a series of two MS patients who developed COVID-19 while on Ocrelizumab therapy and subsequently exhibited negative SARS-CoV-2 serology. Results: A 42-year-old man and 39-year-old woman with MS developed COVID-19 while on Ocrelizumab therapy. Neither patient required hospitalization. The man exhibited negative serology at 7- and 9-weeks post-infection. The woman exhibited negative serology at 6- and 12-weeks post-infection. Conclusions: Large studies are essential to determine whether certain DMTs may blunt SARS-CoV-2 antibody production. |
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| MeSH term(s) | Adult ; Antibodies, Monoclonal, Humanized/therapeutic use ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19 Serological Testing ; Female ; Humans ; Immunologic Factors/therapeutic use ; Male ; Multiple Sclerosis/complications ; Multiple Sclerosis/drug therapy |
| Chemical Substances | Antibodies, Monoclonal, Humanized ; Immunologic Factors ; ocrelizumab (A10SJL62JY) |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-06-26 |
| Publishing country | Netherlands |
| Document type | Case Reports ; Letter ; Review |
| ZDB-ID | 2645330-7 |
| ISSN | 2211-0356 ; 2211-0348 |
| ISSN (online) | 2211-0356 |
| ISSN | 2211-0348 |
| DOI | 10.1016/j.msard.2020.102341 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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