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  1. Article: Emerging Role of Mechanical Forces in Cell Fate Acquisition.

    Alvarez, Yanina / Smutny, Michael

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 864522

    Abstract: Mechanical forces are now recognized as key cellular effectors that together with genetic and cellular signals physically shape and pattern tissues and organs during development. Increasing efforts are aimed toward understanding the less explored role of ...

    Abstract Mechanical forces are now recognized as key cellular effectors that together with genetic and cellular signals physically shape and pattern tissues and organs during development. Increasing efforts are aimed toward understanding the less explored role of mechanical forces in controlling cell fate decisions in embryonic development. Here we discuss recent examples of how differential forces feedback into cell fate specification and tissue patterning. In particular, we focus on the role of actomyosin-contractile force generation and transduction in affecting tissue morphogenesis and cell fate regulation in the embryo.
    Language English
    Publishing date 2022-05-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.864522
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Feeling the force: Multiscale force sensing and transduction at the cell-cell interface.

    Inman, Angus / Smutny, Michael

    Seminars in cell & developmental biology

    2021  Volume 120, Page(s) 53–65

    Abstract: A universal principle of all living cells is the ability to sense and respond to mechanical stimuli which is essential for many biological processes. Recent efforts have identified critical mechanosensitive molecules and response pathways involved in ... ...

    Abstract A universal principle of all living cells is the ability to sense and respond to mechanical stimuli which is essential for many biological processes. Recent efforts have identified critical mechanosensitive molecules and response pathways involved in mechanotransduction during development and tissue homeostasis. Tissue-wide force transmission and local force sensing need to be spatiotemporally coordinated to precisely regulate essential processes during development such as tissue morphogenesis, patterning, cell migration and organogenesis. Understanding how cells identify and interpret extrinsic forces and integrate a specific response on cell and tissue level remains a major challenge. In this review we consider important cellular and physical factors in control of cell-cell mechanotransduction and discuss their significance for cell and developmental processes. We further highlight mechanosensitive macromolecules that are known to respond to external forces and present examples of how force responses can be integrated into cell and developmental programs.
    MeSH term(s) Cadherins/metabolism ; Cell Adhesion/physiology ; Humans ; Mechanotransduction, Cellular/physiology ; Signal Transduction
    Chemical Substances Cadherins
    Language English
    Publishing date 2021-07-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2021.06.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2918: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Emerging Role of Mechanical Forces in Cell Fate Acquisition

    Yanina Alvarez / Michael Smutny

    Frontiers in Cell and Developmental Biology, Vol

    2022  Volume 10

    Abstract: Mechanical forces are now recognized as key cellular effectors that together with genetic and cellular signals physically shape and pattern tissues and organs during development. Increasing efforts are aimed toward understanding the less explored role of ...

    Abstract Mechanical forces are now recognized as key cellular effectors that together with genetic and cellular signals physically shape and pattern tissues and organs during development. Increasing efforts are aimed toward understanding the less explored role of mechanical forces in controlling cell fate decisions in embryonic development. Here we discuss recent examples of how differential forces feedback into cell fate specification and tissue patterning. In particular, we focus on the role of actomyosin-contractile force generation and transduction in affecting tissue morphogenesis and cell fate regulation in the embryo.
    Keywords mechanical forces ; cell fate acquisition ; morphogenesis ; embryonic development ; patterning ; actomyosin ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Translational control of furina by an RNA regulon is important for left-right patterning, heart morphogenesis and cardiac valve function.

    Nagorska, Agnieszka / Zaucker, Andreas / Lambert, Finnlay / Inman, Angus / Toral-Perez, Sara / Gorodkin, Jan / Wan, Yue / Smutny, Michael / Sampath, Karuna

    Development (Cambridge, England)

    2023  Volume 150, Issue 23

    Abstract: Heart development is a complex process that requires asymmetric positioning of the heart, cardiac growth and valve morphogenesis. The mechanisms controlling heart morphogenesis and valve formation are not fully understood. The pro-convertase FurinA ... ...

    Abstract Heart development is a complex process that requires asymmetric positioning of the heart, cardiac growth and valve morphogenesis. The mechanisms controlling heart morphogenesis and valve formation are not fully understood. The pro-convertase FurinA functions in heart development across vertebrates. How FurinA activity is regulated during heart development is unknown. Through computational analysis of the zebrafish transcriptome, we identified an RNA motif in a variant FurinA transcript harbouring a long 3' untranslated region (3'UTR). The alternative 3'UTR furina isoform is expressed prior to organ positioning. Somatic deletions in the furina 3'UTR lead to embryonic left-right patterning defects. Reporter localisation and RNA-binding assays show that the furina 3'UTR forms complexes with the conserved RNA-binding translational repressor, Ybx1. Conditional ybx1 mutant embryos show premature and increased Furin reporter expression, abnormal cardiac morphogenesis and looping defects. Mutant ybx1 hearts have an expanded atrioventricular canal, abnormal sino-atrial valves and retrograde blood flow from the ventricle to the atrium. This is similar to observations in humans with heart valve regurgitation. Thus, the furina 3'UTR element/Ybx1 regulon is important for translational repression of FurinA and regulation of heart development.
    MeSH term(s) Animals ; Humans ; Zebrafish ; 3' Untranslated Regions ; Regulon/genetics ; Morphogenesis/genetics ; Heart Valves ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism ; Proprotein Convertases/genetics ; Proprotein Convertases/metabolism
    Chemical Substances 3' Untranslated Regions ; FurinA protein, zebrafish (EC 3.4.-) ; Zebrafish Proteins ; Proprotein Convertases (EC 3.4.21.-)
    Language English
    Publishing date 2023-11-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.201657
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.183: Show issues Location:
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    Zs.MG 91: Show issues

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  5. Article: Editorial: Forces in Biology - Cell and Developmental Mechanobiology and Its Implications in Disease.

    Wu, Selwin K / Gomez, Guillermo A / Stehbens, Samantha J / Smutny, Michael

    Frontiers in cell and developmental biology

    2020  Volume 8, Page(s) 598179

    Language English
    Publishing date 2020-09-30
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2020.598179
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Light-activated Frizzled7 reveals a permissive role of non-canonical wnt signaling in mesendoderm cell migration.

    Čapek, Daniel / Smutny, Michael / Tichy, Alexandra-Madelaine / Morri, Maurizio / Janovjak, Harald / Heisenberg, Carl-Philipp

    eLife

    2019  Volume 8

    Abstract: Non-canonical Wnt signaling plays a central role for coordinated cell polarization and directed migration in metazoan development. While spatiotemporally restricted activation of non-canonical Wnt-signaling drives cell polarization in epithelial tissues, ...

    Abstract Non-canonical Wnt signaling plays a central role for coordinated cell polarization and directed migration in metazoan development. While spatiotemporally restricted activation of non-canonical Wnt-signaling drives cell polarization in epithelial tissues, it remains unclear whether such instructive activity is also critical for directed mesenchymal cell migration. Here, we developed a light-activated version of the non-canonical Wnt receptor Frizzled 7 (Fz7) to analyze how restricted activation of non-canonical Wnt signaling affects directed anterior axial mesendoderm (prechordal plate, ppl) cell migration within the zebrafish gastrula. We found that Fz7 signaling is required for ppl cell protrusion formation and migration and that spatiotemporally restricted ectopic activation is capable of redirecting their migration. Finally, we show that uniform activation of Fz7 signaling in ppl cells fully rescues defective directed cell migration in
    MeSH term(s) Animals ; Animals, Genetically Modified ; Cell Movement/radiation effects ; Embryo, Nonmammalian/cytology ; Embryo, Nonmammalian/radiation effects ; Endoderm/cytology ; Light ; Mesoderm/cytology ; Mutation/genetics ; Phenotype ; Receptors, Cell Surface/metabolism ; Stem Cells/cytology ; Stem Cells/radiation effects ; Wnt Signaling Pathway/radiation effects ; Zebrafish/embryology ; Zebrafish/genetics ; Zebrafish Proteins/metabolism
    Chemical Substances Receptors, Cell Surface ; Zebrafish Proteins ; fzd7a protein, zebrafish
    Language English
    Publishing date 2019-01-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.42093
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Editorial

    Selwin K. Wu / Guillermo A. Gomez / Samantha J. Stehbens / Michael Smutny

    Frontiers in Cell and Developmental Biology, Vol

    Forces in Biology - Cell and Developmental Mechanobiology and Its Implications in Disease

    2020  Volume 8

    Keywords mechanobiology ; cell biology ; developmental biology ; cardiovascular ; signaling ; stem cells ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Article ; Online: Neighborly relations: cadherins and mechanotransduction.

    Smutny, Michael / Yap, Alpha S

    The Journal of cell biology

    2010  Volume 189, Issue 7, Page(s) 1075–1077

    Abstract: Cell-cell adhesions are sites where cells experience and resist tugging forces. It has long been postulated, but not directly tested, that cadherin adhesion molecules may serve in mechanotransduction at cell-cell contacts. In this issue, Le Duc et al. ( ... ...

    Abstract Cell-cell adhesions are sites where cells experience and resist tugging forces. It has long been postulated, but not directly tested, that cadherin adhesion molecules may serve in mechanotransduction at cell-cell contacts. In this issue, Le Duc et al. (2010. J. Cell Biol. doi: 10.1083/jcb.201001149) provide direct evidence that E-cadherin participates in a mechanosensing pathway that regulates the actomyosin cytoskeleton to modulate cell stiffness in response to pulling force.
    MeSH term(s) Biomechanical Phenomena ; Cadherins/physiology ; Cytoskeleton/physiology ; Mechanotransduction, Cellular
    Chemical Substances Cadherins
    Language English
    Publishing date 2010-06-28
    Publishing country United States
    Document type Comment ; Journal Article ; Review
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.201005151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.190: Show issues Location:
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  9. Article ; Online: Light-activated Frizzled7 reveals a permissive role of non-canonical wnt signaling in mesendoderm cell migration

    Daniel Čapek / Michael Smutny / Alexandra-Madelaine Tichy / Maurizio Morri / Harald Janovjak / Carl-Philipp Heisenberg

    eLife, Vol

    2019  Volume 8

    Abstract: Non-canonical Wnt signaling plays a central role for coordinated cell polarization and directed migration in metazoan development. While spatiotemporally restricted activation of non-canonical Wnt-signaling drives cell polarization in epithelial tissues, ...

    Abstract Non-canonical Wnt signaling plays a central role for coordinated cell polarization and directed migration in metazoan development. While spatiotemporally restricted activation of non-canonical Wnt-signaling drives cell polarization in epithelial tissues, it remains unclear whether such instructive activity is also critical for directed mesenchymal cell migration. Here, we developed a light-activated version of the non-canonical Wnt receptor Frizzled 7 (Fz7) to analyze how restricted activation of non-canonical Wnt signaling affects directed anterior axial mesendoderm (prechordal plate, ppl) cell migration within the zebrafish gastrula. We found that Fz7 signaling is required for ppl cell protrusion formation and migration and that spatiotemporally restricted ectopic activation is capable of redirecting their migration. Finally, we show that uniform activation of Fz7 signaling in ppl cells fully rescues defective directed cell migration in fz7 mutant embryos. Together, our findings reveal that in contrast to the situation in epithelial cells, non-canonical Wnt signaling functions permissively rather than instructively in directed mesenchymal cell migration during gastrulation.
    Keywords Wnt ; planar cell polarity ; cell migration ; polarity ; protrusion formation ; optogenetics ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Neighborly relations: cadherins and mechanotransduction

    Smutny, Michael / Yap, Alpha S

    Journal of cell biology. 2010, v. 189, no. 7

    2010  

    Abstract: Cell-cell adhesions are sites where cells experience and resist tugging forces. It has long been postulated, but not directly tested, that cadherin adhesion molecules may serve in mechanotransduction at cell-cell contacts. In this issue, Le Duc et al. ( ... ...

    Abstract Cell-cell adhesions are sites where cells experience and resist tugging forces. It has long been postulated, but not directly tested, that cadherin adhesion molecules may serve in mechanotransduction at cell-cell contacts. In this issue, Le Duc et al. (2010. J. Cell Biol. doi: 10.1083/jcb.201001149) provide direct evidence that E-cadherin participates in a mechanosensing pathway that regulates the actomyosin cytoskeleton to modulate cell stiffness in response to pulling force.
    Language English
    Size p. 1075-1077.
    Publishing place The Rockefeller University Press
    Document type Article
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 56/32: Show issues

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