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  1. Article ; Online: Why are women with polycystic ovary syndrome obese?

    Barber, T M

    British medical bulletin

    2022  Volume 143, Issue 1, Page(s) 4–15

    Abstract: Introduction: Polycystic ovary syndrome (PCOS) is a common condition characterized by reproductive, hyperandrogenic and dysmetabolic features, and often becomes clinically manifest during adolescence, particularly with weight-gain.: Sources of data: ... ...

    Abstract Introduction: Polycystic ovary syndrome (PCOS) is a common condition characterized by reproductive, hyperandrogenic and dysmetabolic features, and often becomes clinically manifest during adolescence, particularly with weight-gain.
    Sources of data: Pubmed search.
    Areas of agreement: PCOS is heritable and closely associates with obesity (based on data from both epidemiological and genetic studies). Furthermore, insulin resistance forms a central cornerstone of the pathogenesis of PCOS and mediates a close association between obesity and the severity of the phenotypic features of PCOS.
    Areas of controversy: Our understanding of the pathogenesis of PCOS remains incomplete, especially regarding its missing heritability (with only a small fraction having been identified from the genome-wide association studies reported to date), and its developmental origins.
    Growing points: A challenge for the future is to explore a role for epigenetic modifications in the development of PCOS, and implications for the in utero environment and novel therapeutic opportunities.
    MeSH term(s) Adolescent ; Epigenesis, Genetic ; Female ; Genome-Wide Association Study ; Humans ; Insulin Resistance/genetics ; Male ; Obesity/complications ; Obesity/epidemiology ; Obesity/genetics ; Polycystic Ovary Syndrome/complications ; Polycystic Ovary Syndrome/epidemiology ; Polycystic Ovary Syndrome/genetics
    Language English
    Publishing date 2022-03-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 213294-1
    ISSN 1471-8391 ; 0007-1420
    ISSN (online) 1471-8391
    ISSN 0007-1420
    DOI 10.1093/bmb/ldac007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Re: A multi-institutional evaluation of active surveillance for low risk prostate cancer. S. E. Eggener, A. Mueller, R. K. Berglund, R. Ayyathurai, C. Soloway, M. S. Soloway, R. Abouassaly, E. A. Klein, S. J. Jones, C. Zappavigna, L. Goldenberg, P. T. Scardino, J. A. Eastham and B. Guillonneau J Urol 2009; 181: 1635-1641.

    Ayres, B E / Bott, S R J / Barber, N J / Langley, S E M / Montgomery, B S I

    The Journal of urology

    2010  Volume 184, Issue 3, Page(s) 1223–4; author reply 1224

    MeSH term(s) Humans ; Male ; Multicenter Studies as Topic ; Population Surveillance ; Prostatic Neoplasms/epidemiology ; Risk Factors
    Language English
    Publishing date 2010-09
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1016/j.juro.2010.05.001
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  3. Article ; Online: Pediatric Pulmonology 2022 year in review: Rare and diffuse lung disease.

    Barber, Andrew T / Liptzin, Deborah R / Gower, William A / Hinds, Daniel M

    Pediatric pulmonology

    2023  Volume 58, Issue 10, Page(s) 2719–2724

    Abstract: The field of rare and diffuse pediatric lung disease continues to evolve and expand rapidly as clinicians and researchers make advancements in the diagnosis and treatment of children's interstitial and diffuse lung disease, non-cystic fibrosis ... ...

    Abstract The field of rare and diffuse pediatric lung disease continues to evolve and expand rapidly as clinicians and researchers make advancements in the diagnosis and treatment of children's interstitial and diffuse lung disease, non-cystic fibrosis bronchiectasis, and primary ciliary dyskinesia. Papers published on these topics in Pediatric Pulmonology and other journals in 2022 describe newly recognized disorders, elucidate disease mechanisms and courses, explore potential biomarkers, and assess novel treatments. In this review, we will discuss these important advancements and place them in the context of existing literature.
    MeSH term(s) Child ; Humans ; Pulmonary Medicine ; Lung Diseases/diagnosis ; Lung Diseases/therapy ; Bronchiectasis/diagnosis ; Bronchiectasis/therapy ; Lung ; Thorax
    Language English
    Publishing date 2023-07-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.26603
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  4. Article ; Online: Mirizzi syndrome: The Trojan horse of gallbladder disease.

    Froehlich, Mary / Sodomin, Elizabeth M / Fontenot, Taylor / Iftekhar, Noama / Chan, Christian N / Barber, Annabel

    Surgery open science

    2024  Volume 18, Page(s) 103–106

    Abstract: Background: The incidence of Mirizzi Syndrome ranges from 0.05 to 5.7 % of patients who undergo cholecystectomy. The purpose of this study is to examine the preoperative workup and postoperative outcomes for patients diagnosed with Mirizzi Syndrome.: ... ...

    Abstract Background: The incidence of Mirizzi Syndrome ranges from 0.05 to 5.7 % of patients who undergo cholecystectomy. The purpose of this study is to examine the preoperative workup and postoperative outcomes for patients diagnosed with Mirizzi Syndrome.
    Methods: Retrospective chart review was conducted between January 2018 and January 2022 at a single institution. All adult patients who underwent cholecystectomy were included.
    Results: 1628 patients underwent cholecystectomy of which 47 were diagnosed with Mirizzi Syndrome. The majority of patients had type 1 Mirizzi Syndrome. Preoperative studies were often nondiagnostic and 81 % of cases were diagnosed intraoperatively. 66 % of cases were performed laparoscopically, an open approach was required for type V Mirizzi Syndrome. The complication rate was 25 %; most commonly a bile leak requiring ERCP.
    Conclusion: Mirizzi syndrome is more common than previously expected and related to patient's ability to seek timely medical care. Most cases can be completed laparoscopically however there is a high rate of complications.
    Key message: This study presents an additional cohort of patients found to have Mirizzi syndrome and supports the hypothesis that it is difficult to diagnose preoperatively. Cases should be attempted laparoscopically but there remains a high complication rate.
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Journal Article
    ISSN 2589-8450
    ISSN (online) 2589-8450
    DOI 10.1016/j.sopen.2024.02.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: EUPRO - A reference database on project-based R&D collaboration networks.

    Scherngell, Thomas / Barber, Michael / Zahradnik, Georg / Wolfmayr, Anna / Bilalli Shkodra, Xheneta

    Scientific data

    2024  Volume 11, Issue 1, Page(s) 291

    Abstract: The EUPRO database enables the analysis of participation patterns of organisations in and across different European R&D funding initiatives and the investigation of resulting collaborative R&D network structures and dynamics. The perimeter of EUPRO is ... ...

    Abstract The EUPRO database enables the analysis of participation patterns of organisations in and across different European R&D funding initiatives and the investigation of resulting collaborative R&D network structures and dynamics. The perimeter of EUPRO is currently more than 600,000 R&D projects funded by European (EU, transnational or national) research funding organisations, comprising systematic information about contents of the R&D projects, their participating organizations (including organisation type and location), and a number of additional characteristics (e.g. underlying policy instrument and programme). This scientific data descriptor serves as illustrative information source for users, both from science as well as from policy. It discusses the conceptual background and derives respective analytical opportunities for different actual, highly relevant debates in innovation studies and related fields. Moreover, the data collection process is described in a compact manner, as well as how the collected data are harmonized and aggregated into a suitable data model for analytical purposes. Finally, we put forward issues of technical validation, data quality and enrichment, and usage notes on how to access EUPRO.
    Language English
    Publishing date 2024-03-12
    Publishing country England
    Document type Dataset ; Journal Article
    ZDB-ID 2775191-0
    ISSN 2052-4463 ; 2052-4463
    ISSN (online) 2052-4463
    ISSN 2052-4463
    DOI 10.1038/s41597-024-03129-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Self-spinning filaments for autonomously linked microfibers.

    Barber, Dylan M / Emrick, Todd / Grason, Gregory M / Crosby, Alfred J

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 625

    Abstract: Filamentous bundles are ubiquitous in Nature, achieving highly adaptive functions and structural integrity from assembly of diverse mesoscale supramolecular elements. Engineering routes to synthetic, topologically integrated analogs demands precisely ... ...

    Abstract Filamentous bundles are ubiquitous in Nature, achieving highly adaptive functions and structural integrity from assembly of diverse mesoscale supramolecular elements. Engineering routes to synthetic, topologically integrated analogs demands precisely coordinated control of multiple filaments' shapes and positions, a major challenge when performed without complex machinery or labor-intensive processing. Here, we demonstrate a photocreasing design that encodes local curvature and twist into mesoscale polymer filaments, enabling their programmed transformation into target 3-dimensional geometries. Importantly, patterned photocreasing of filament arrays drives autonomous spinning to form linked filament bundles that are highly entangled and structurally robust. In individual filaments, photocreases unlock paths to arbitrary, 3-dimensional curves in space. Collectively, photocrease-mediated bundling establishes a transformative paradigm enabling smart, self-assembled mesostructures that mimic performance-differentiating structures in Nature (e.g., tendon and muscle fiber) and the macro-engineered world (e.g., rope).
    Language English
    Publishing date 2023-02-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-36355-w
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  7. Article ; Online: Acute Traumatic Subdural Hematoma in the Elderly and Associated Factors that May Influence Chronicity.

    Wasfie, T / Young, C / Naisan, M / Senger, B / Brimmeier, A / Sobell, A / Stanbaugh, S / Hille, J / Hella, J / Barber, K

    The American surgeon

    2023  Volume 89, Issue 12, Page(s) 6312–6314

    MeSH term(s) Humans ; Aged ; Hematoma, Subdural ; Hematoma, Subdural, Acute
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 202465-2
    ISSN 1555-9823 ; 0003-1348
    ISSN (online) 1555-9823
    ISSN 0003-1348
    DOI 10.1177/00031348231157814
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  8. Article ; Online: Genetic basis of polycystic ovary syndrome.

    Barber, T M / Franks, S

    Expert review of endocrinology & metabolism

    2019  Volume 5, Issue 4, Page(s) 549–561

    Abstract: Polycystic ovary syndrome (PCOS) is associated with obesity and manifests with reproductive, hyperandrogenic and metabolic features. Although the etiology of PCOS is complex and incompletely understood, genetics plays an important role (heritability: ∼70% ...

    Abstract Polycystic ovary syndrome (PCOS) is associated with obesity and manifests with reproductive, hyperandrogenic and metabolic features. Although the etiology of PCOS is complex and incompletely understood, genetics plays an important role (heritability: ∼70%). Potential problems with studying the genetics of PCOS include the heterogeneity of the condition and associated sub-fertility. A candidate gene approach has been used in over 70 published studies on PCOS, most of which have been inadequately powered to detect a statistically meaningful association. Furthermore, these studies often fail to replicate prior published studies on the same candidate gene in different populations. The first genome-sequence variant (identified from a genome-wide association study in subjects with Type 2 diabetes mellitus) to be studied in PCOS (FTO gene) has been shown by our group to associate with susceptibility for the development of PCOS. This is the first genetic corroboration of a link between PCOS and obesity. Future directions include a genome-wide association study in PCOS.
    Language English
    Publishing date 2019-02-19
    Publishing country England
    Document type Journal Article
    ISSN 1744-8417
    ISSN (online) 1744-8417
    DOI 10.1586/eem.10.32
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  9. Article ; Online: Obesity Stigma: Causes, Consequences, and Potential Solutions.

    Westbury, Susannah / Oyebode, Oyinlola / van Rens, Thijs / Barber, Thomas M

    Current obesity reports

    2023  Volume 12, Issue 1, Page(s) 10–23

    Abstract: Purpose of review: This review aims to examine (i) the aetiology of obesity; (ii) how and why a perception of personal responsibility for obesity so dominantly frames this condition and how this mindset leads to stigma; (iii) the consequences of obesity ...

    Abstract Purpose of review: This review aims to examine (i) the aetiology of obesity; (ii) how and why a perception of personal responsibility for obesity so dominantly frames this condition and how this mindset leads to stigma; (iii) the consequences of obesity stigma for people living with obesity, and for the public support for interventions to prevent and manage this condition; and (iv) potential strategies to diminish our focus on personal responsibility for the development of obesity, to enable a reduction of obesity stigma, and to move towards effective interventions to prevent and manage obesity within the population.
    Recent findings: We summarise literature which shows that obesity stems from a complex interplay of genetic and environment factors most of which are outside an individual's control. Despite this, evidence of obesity stigmatisation remains abundant throughout areas of media, entertainment, social media and the internet, advertising, news outlets, and the political and public health landscape. This has damaging consequences including psychological, physical, and socioeconomic harm. Obesity stigma does not prevent obesity. A combined, concerted, and sustained effort from multiple stakeholders and key decision-makers within society is required to dispel myths around personal responsibility for body weight, and to foster more empathy for people living in larger bodies. This also sets the scene for more effective policies and interventions, targeting the social and environmental drivers of health, to ultimately improve population health.
    MeSH term(s) Humans ; Social Stigma ; Obesity/epidemiology ; Body Weight ; Social Behavior ; Stereotyping
    Language English
    Publishing date 2023-02-14
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2162-4968
    ISSN (online) 2162-4968
    DOI 10.1007/s13679-023-00495-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Direct or indirect post crowns to restore compromised teeth: a review of the literature.

    Owen, T A / Barber, M

    British dental journal

    2018  Volume 224, Issue 6, Page(s) 413–418

    Abstract: Post crowns are restorations which utilise the root canal space to improve the retention and resistance form of teeth which lack coronal tooth structure. In recent years there have been significant developments in the materials, systems and evidence-base ...

    Abstract Post crowns are restorations which utilise the root canal space to improve the retention and resistance form of teeth which lack coronal tooth structure. In recent years there have been significant developments in the materials, systems and evidence-base surrounding the provision of post crowns. This review aims to refresh the general dental practitioner's (GDPs) knowledge of the different factors that must be considered when placing a post crown, and how these factors can help guide the dentist in their decision to provide either a direct or indirect post and core.
    MeSH term(s) Dental Materials ; Dental Prosthesis Design ; Humans ; Post and Core Technique/instrumentation ; Tooth Root/pathology ; Tooth, Nonvital/pathology ; Tooth, Nonvital/therapy
    Chemical Substances Dental Materials
    Language English
    Publishing date 2018-03-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/sj.bdj.2018.218
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    Zs.MO 447: Show issues

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