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  1. Article: The Application of Membrane Separation Technology in the Pharmaceutical Industry.

    Ma, Ruirui / Li, Juan / Zeng, Ping / Duan, Liang / Dong, Jimin / Ma, Yunxia / Yang, Lingkong

    Membranes

    2024  Volume 14, Issue 1

    Abstract: With the advancement in membrane technology, membrane separation technology has been found increasingly widespread applications in the pharmaceutical industry. It is utilized in drug separation and purification, wastewater treatment, and the recycling of ...

    Abstract With the advancement in membrane technology, membrane separation technology has been found increasingly widespread applications in the pharmaceutical industry. It is utilized in drug separation and purification, wastewater treatment, and the recycling of wastewater resources. This study summarizes the application history of membrane technology in the pharmaceutical industry, presents practical engineering examples of its applications, analyzes the various types of membrane technologies employed in the pharmaceutical sector, and finally, highlights the application cases of renowned international and Chinese membrane technology companies in the pharmaceutical field.
    Language English
    Publishing date 2024-01-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2614641-1
    ISSN 2077-0375
    ISSN 2077-0375
    DOI 10.3390/membranes14010024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Diaphragmatic paralysis in a neonate with circumferential skin creases Kunze type.

    Chun Fang, Gao / Kaiwei, Ding / Lingkong, Zeng / Xuwei, Tao

    Molecular genetics & genomic medicine

    2022  Volume 10, Issue 9, Page(s) e2003

    Abstract: Background: A range of clinical features have been confirmed with heterozygous mutations in Beta Tubulin (TUBB), including skin creases, facial deformities, abnormal cerebral structures, and intellectual disability, and were defined as Circumferential ... ...

    Abstract Background: A range of clinical features have been confirmed with heterozygous mutations in Beta Tubulin (TUBB), including skin creases, facial deformities, abnormal cerebral structures, and intellectual disability, and were defined as Circumferential Skin Creases Kunze type (CSC-KT).
    Methods: Clinical information was obtained retrospectively on a neonate hospitalized in the Neonatal Intensive Care Unit, Wuhan Children's Hospital. Genomic DNA was extracted from circulating leukocytes of the proband according to standard procedures.
    Results: The neonate presented dyspnea resulting from diaphragmatic paralysis, accompanied by other typical features of CSC-KT. Additionally, exome sequencing confirmed a new variant (NM_178,014. 4: c. 1114 A > G) in TUBB. We also summarized features described in previous cases, thus representing phenotype extension of CSC-KT.
    Conclusion: Our report is the youngest confirmed case, which could extend the current phenotype of CSC-KT as well as the clinical diagnostic approach.
    MeSH term(s) Heterozygote ; Humans ; Infant, Newborn ; Respiratory Paralysis/genetics ; Retrospective Studies ; Skin ; Tubulin/chemistry ; Tubulin/genetics
    Chemical Substances Tubulin
    Language English
    Publishing date 2022-06-23
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2734884-2
    ISSN 2324-9269 ; 2324-9269
    ISSN (online) 2324-9269
    ISSN 2324-9269
    DOI 10.1002/mgg3.2003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [An infant with premature closure of cranial sutures due to variant of ERF gene and a literature review].

    Wang, Jin / Wang, Dan / Zeng, Lingkong / Wang, Shi

    Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

    2023  Volume 40, Issue 8, Page(s) 1009–1014

    Abstract: Objective: To analyze the clinical and genetic characteristics of an infant with craniosynostosis.: Methods: An infant who was admitted to Wuhan Children's Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology ...

    Abstract Objective: To analyze the clinical and genetic characteristics of an infant with craniosynostosis.
    Methods: An infant who was admitted to Wuhan Children's Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology in April 2021 due to widening of the lateral ventricles for over a month was selected as the study subject. Clinical data of the patient was collected. Peripheral blood samples were collected from the infant and her parents for chromosomal karyotyping and whole exome sequencing. Candidate variant was verified by Sanger sequencing and bioinformatic analysis. Relevant literature was retrieved from the PubMed, Wanfang and CNKI databases (up to December 2021) by using key words including ERF gene, craniosynostosis, ERF mutation, craniosynostosis and ERF-related craniosynostosis.
    Results: The infant, a 1-month-and-16-day-old female, was found to have sagittal synostosis by cranial X-ray radiography. Genetic testing revealed that she has harbored a heterozygous c.787C>T (p.Q263*) variant of the ERF gene, which was not found in either parent. Based on the guidelines from the American College of Medical Genetics and Genomics (ACMG), the variant was predicted as pathogenic (PVS1+PS2+PM2_Supporting). In total 63 relevant cases were retrieved from the database, and a total of 64 individuals were analyzed by genetic testing. Most of the cases were sporadic and males. Multiple cranial sutures (including at least two of the sagittal suture, coronal suture, lambdoid suture, and frontal suture) were involved in 45.45% of the cases, and those with sagittal suture closure only have accounted for 20.00%. The main clinical manifestations have included hypertelorism, exophthalmos, development delay, malar dysplasia, etc. Chiari type 1 malformation may present in some patients. Variants of the ERF gene have mainly included splicing and deletional variants, and there was a strong genetic heterogeneity among the infants and their pedigrees.
    Conclusion: The c.787C>T (p.Q263*) variant of the ERF gene probably underlay the craniosynostosis of this infant. Above finding has enriched the phenotype ~ genotype spectrum of the ERF gene.
    MeSH term(s) Female ; Humans ; Cranial Sutures/pathology ; Cranial Sutures/surgery ; Craniosynostoses/genetics ; Genetic Testing ; Mutation ; Repressor Proteins/genetics ; Infant
    Chemical Substances ERF protein, human ; Repressor Proteins
    Language Chinese
    Publishing date 2023-08-02
    Publishing country China
    Document type Case Reports ; English Abstract ; Journal Article ; Review
    ISSN 1003-9406
    ISSN 1003-9406
    DOI 10.3760/cma.j.cn511374-20220815-00548
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Hyperoxia Induced Bronchopulmonary Dysplasia-Like Inflammation

    Tao, Xuwei / Mo, Luxia / Zeng, Lingkong

    Frontiers in pediatrics

    2022  Volume 10, Page(s) 805860

    Abstract: Lung injury induced by oxygen is a key contributor to the pathogenesis of preterm infant bronchopulmonary dysplasia (BPD). To date, there are comprehensive therapeutic strategy for this disease, but the underlying mechanism is still in progress. By using ...

    Abstract Lung injury induced by oxygen is a key contributor to the pathogenesis of preterm infant bronchopulmonary dysplasia (BPD). To date, there are comprehensive therapeutic strategy for this disease, but the underlying mechanism is still in progress. By using lentivirus, we constructed microRNA34a (miR34a)-overexpressing or knockdown A549 cell lines, and exposure to hyperoxia to mimic oxygen induce lung injury. In this study, we investigated 4 proinflammatory cytokines, interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), angiopoietin-1 (Ang-1), and Cyclooxygenase-2 (COX-2) in the secreted sputum of infants who received mechanical ventilation, and found that IL-1β was substantially elevated in the first week after oxygen therapy and with no significant decrease until the fourth week, while TNF-α, Ang-1, and COX-2 were increased in the first week but decreased quickly in the following weeks. In addition,
    Language English
    Publishing date 2022-03-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2022.805860
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 From the Mother to the Infant-Reply.

    Zeng, Lingkong / Xiao, Tiantian / Zhou, Wenhao

    JAMA pediatrics

    2020  Volume 174, Issue 10, Page(s) 1008–1009

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Female ; Humans ; Infant ; Infectious Disease Transmission, Vertical ; Mothers ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome
    Keywords covid19
    Language English
    Publishing date 2020-07-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2701223-2
    ISSN 2168-6211 ; 2168-6203
    ISSN (online) 2168-6211
    ISSN 2168-6203
    DOI 10.1001/jamapediatrics.2020.2156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Neonatal Early-Onset Infection With SARS-CoV-2 in 33 Neonates Born to Mothers With COVID-19 in Wuhan, China.

    Zeng, Lingkong / Xia, Shiwen / Yuan, Wenhao / Yan, Kai / Xiao, Feifan / Shao, Jianbo / Zhou, Wenhao

    JAMA pediatrics

    2020  Volume 174, Issue 7, Page(s) 722–725

    MeSH term(s) Betacoronavirus/genetics ; COVID-19 ; China/epidemiology ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Female ; Humans ; Incidence ; Infant, Newborn ; Male ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; Pregnancy ; Pregnancy Complications, Infectious/epidemiology ; Pregnancy Complications, Infectious/virology ; Prognosis ; RNA, Viral/analysis ; SARS-CoV-2
    Chemical Substances RNA, Viral
    Keywords covid19
    Language English
    Publishing date 2020-03-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701223-2
    ISSN 2168-6211 ; 2168-6203
    ISSN (online) 2168-6211
    ISSN 2168-6203
    DOI 10.1001/jamapediatrics.2020.0878
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Um IV Zs.74: Show issues Location:
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  8. Article ; Online: Infants Born to Mothers With a New Coronavirus (COVID-19)

    Chen, Yan / Peng, Hua / Wang, Lin / Zhao, Yin / Zeng, Lingkong / Gao, Hui / Liu, Yalan

    Frontiers in Pediatrics

    2020  Volume 8

    Keywords covid19
    Publisher Frontiers Media SA
    Publishing country ch
    Document type Article ; Online
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2020.00104
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Infants Born to Mothers With a New Coronavirus (COVID-19).

    Chen, Yan / Peng, Hua / Wang, Lin / Zhao, Yin / Zeng, Lingkong / Gao, Hui / Liu, Yalan

    Frontiers in pediatrics

    2020  Volume 8, Page(s) 104

    Abstract: A novel viral respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is responsible for an epidemic of the coronavirus disease 2019 (COVID-19) in cases in China and worldwide. Four full-term, singleton infants were ... ...

    Abstract A novel viral respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is responsible for an epidemic of the coronavirus disease 2019 (COVID-19) in cases in China and worldwide. Four full-term, singleton infants were born to pregnant women who tested positive for COVID-19 in the city of Wuhan, the capital of Hubei province, China, where the disease was first identified. Of the three infants, for who consent to be diagnostically tested was provided, none tested positive for the virus. None of the infants developed serious clinical symptoms such as fever, cough, diarrhea, or abnormal radiologic or hematologic evidence, and all four infants were alive at the time of hospital discharge. Two infants had rashes of unknown etiology at birth, and one had facial ulcerations. One infant had tachypnea and was supported by non-invasive mechanical ventilation for 3 days. One had rashes at birth but was discharged without parental consent for a diagnostic test. This case report describes the clinical course of four live born infants, born to pregnant women with the COVID-19 infection.
    Keywords covid19
    Language English
    Publishing date 2020-03-16
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2020.00104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Infants Born to Mothers With a New Coronavirus (COVID-19)

    Yan Chen / Hua Peng / Lin Wang / Yin Zhao / Lingkong Zeng / Hui Gao / Yalan Liu

    Frontiers in Pediatrics, Vol

    2020  Volume 8

    Abstract: A novel viral respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is responsible for an epidemic of the coronavirus disease 2019 (COVID-19) in cases in China and worldwide. Four full-term, singleton infants were ... ...

    Abstract A novel viral respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is responsible for an epidemic of the coronavirus disease 2019 (COVID-19) in cases in China and worldwide. Four full-term, singleton infants were born to pregnant women who tested positive for COVID-19 in the city of Wuhan, the capital of Hubei province, China, where the disease was first identified. Of the three infants, for who consent to be diagnostically tested was provided, none tested positive for the virus. None of the infants developed serious clinical symptoms such as fever, cough, diarrhea, or abnormal radiologic or hematologic evidence, and all four infants were alive at the time of hospital discharge. Two infants had rashes of unknown etiology at birth, and one had facial ulcerations. One infant had tachypnea and was supported by non-invasive mechanical ventilation for 3 days. One had rashes at birth but was discharged without parental consent for a diagnostic test. This case report describes the clinical course of four live born infants, born to pregnant women with the COVID-19 infection.
    Keywords newborns ; clinical course ; China ; COVID-19 infected mothers ; vertical transmission ; Pediatrics ; RJ1-570 ; covid19
    Subject code 610
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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