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  1. Article: Optimizing Invasive Neonatal Respiratory Care: A Systematic Review of Invasive Neurally Adjusted Ventilatory Assist.

    Balasundaram, Palanikumar / Sakr, Mohamed

    Healthcare (Basel, Switzerland)

    2024  Volume 12, Issue 6

    Abstract: Background: Mechanical ventilation in preterm neonates aims for synchrony, preventing complications such as lung injury. Neurally Adjusted Ventilatory Assist (NAVA) is a unique mode relying on diaphragmatic electrical signals for synchronization. We ... ...

    Abstract Background: Mechanical ventilation in preterm neonates aims for synchrony, preventing complications such as lung injury. Neurally Adjusted Ventilatory Assist (NAVA) is a unique mode relying on diaphragmatic electrical signals for synchronization. We conducted a review focusing on the long-term consequences of using invasive NAVA in neonates with a focus on bronchopulmonary dysplasia (BPD).
    Methods: A systematic review following PRISMA explored invasive NAVA in preterm neonates. Primary objectives compared NAVA to conventional ventilation, assessing BPD incidence, ventilation duration, length of stay, and adverse events. Secondary objectives analyzed ventilator parameters.
    Results: After screening 282 records, the review incorporated two randomized controlled trials for primary outcomes and seven trials for secondary outcomes, including two randomized crossovers, four prospective crossovers, and one retrospective study. NAVA showed reduced oxygen requirement at 28 days but no significant differences in oxygen need at 36 weeks postmenstrual age, total length of stay, or ventilator days. Substantial variations were not observed in adverse events. Ventilator variables favored NAVA, indicating decreased peak inspiratory pressure, tidal volume, work of breathing, and respiratory severity score.
    Conclusion: Our study found no significant reduction in BPD with NAVA despite short-term benefits. Future large-scale trials are essential to assess NAVA's impact on long-term outcomes comprehensively.
    Language English
    Publishing date 2024-03-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare12060632
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  2. Article ; Online: 15 years of Airbnb's authenticity that influenced activity participation

    Mohamed Ahmed Qotb Sakr / Mohamed H. Elsharnouby / Gamal Sayed AbdelAziz

    Journal of Humanities and Applied Social Sciences, Vol 6, Iss 1, Pp 55-

    a systematic literature review

    2024  Volume 99

    Abstract: Purpose – This paper aims to address three research questions (1) Who is the main stakeholder that shapes Airbnb experience, (2) Does Airbnb offers an authentic travel experience? and (3) What should be the future research trends in Airbnb? Design/ ... ...

    Abstract Purpose – This paper aims to address three research questions (1) Who is the main stakeholder that shapes Airbnb experience, (2) Does Airbnb offers an authentic travel experience? and (3) What should be the future research trends in Airbnb? Design/methodology/approach – This paper uses the systematic literature review (SLR) with a well-defined protocol, research strategy and methods to answer the research questions. Findings – The review revealed that while Airbnb plays a significant role as the platform provider, the stakeholders influencing the experiences are multifaceted. Hosts, guests, local communities and even regulatory bodies all contribute to shaping the overall Airbnb Experience ecosystem. Hosts, in particular, have a crucial role in curating and delivering unique experiences, which significantly impacts the quality and authenticity of the offerings. On the question of whether Airbnb offers an authentic travel experience, the review uncovered mixed findings. For examples, some studies emphasized the potential for Airbnb to provide authentic and local experiences, allowing travelers to engage with the community and cultural aspects of a destination. However, other studies raised concerns about the commodification and standardization of experiences, leading to a potential loss of authenticity. Originality/value – This paper is different from previous SLR where previous research systematically reviewed; motivations to use and choose Airbnb, institutionalization of Airbnb, stakeholders of Airbnb. This paper addresses authentic experience as a factor that influences activity participation.
    Keywords Sharing economy ; P2P accommodations ; AirBnB ; Authenticity ; Customer experience ; Guest-host relationship ; Social sciences (General) ; H1-99
    Subject code 306
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Emerald Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: The efficacy of insulin degludec and insulin glargine over NPH insulin among toddlers and preschoolers with type 1 diabetes using glycemic variability and time in range.

    Elhabashy, Safinaz Adel / Sakr, Eman Mohamed / Salah, Nouran Yousef

    European journal of pediatrics

    2023  Volume 182, Issue 4, Page(s) 1857–1868

    Abstract: Optimizing glycemic control without risking hypoglycemia is crucial in toddlers and preschoolers with type 1 diabetes (T1D) to avoid cognitive impairment later in life. Hence, this study aims to compare glycemic parameters among toddlers and preschoolers ...

    Abstract Optimizing glycemic control without risking hypoglycemia is crucial in toddlers and preschoolers with type 1 diabetes (T1D) to avoid cognitive impairment later in life. Hence, this study aims to compare glycemic parameters among toddlers and preschoolers with T1D in relation to different basal insulins. Sixty toddlers and preschoolers with T1D with mean age of 3.53 ± 1.17 years (range, 2-6) and mean diabetes duration of 9.37 ± 1.85 months were randomly assigned into three equal groups; group A received insulin degludec, group B received insulin glargine, and group C were on NPH. At baseline, the three groups were matched regarding clinical and laboratory parameters (p > 0.05). They were followed up at 3 and 6 months for insulin daily dose (IDD), hypoglycemia and severe-hypoglycemia frequency, and glycated hemoglobin (HbA1c). At the study endpoint, continuous glucose monitoring (CGM) was assessed in a random sample of 10 patients from each group. The mean time in range (TIR) of the studied cohort was 55.07 ± 24.05%, and their mean coefficient of variation (CV) was 42.82 ± 11.69%. The TIR was significantly higher in the degludec group (69.36 ± 18.54) and the glargine group (55.43 ± 26.51) than the NPH group (32.56 ± 9.11), p < 0.001. Meanwhile, the CV was significantly lower in the degludec group (35.12 ± 6.47) than the gargine (44.1 ± 13.13) and the NPH (53.8 ± 7.54) groups, p < 0.001. The insulin degludec and glargine groups had significantly lower HbA1c (p = 0.002), hypoglycemia (p = 0.006), severe hypoglycemia (p = 0.029), and IDD (p = 0.015) than the NPH group.
    Conclusion: Insulin degludec and glargine resulted in better HbA1c and TIR with reduced hypoglycemia and IDD than NPH among toddlers and preschoolers with T1D. Moreover, CV was lowest in the insulin degludec group.
    What is known: • Insulin therapy is the mainstay of T1D management. • Optimal insulin therapy for young children with T1D should provide effective glycemic.
    What is new: • Insulin degludec and insulin glargine have better efficacy than NPH insulin among toddlers and preschoolers with T1D in the term of significantly lower coefficient of variation, HbA1c and IDD and significantly higher time in range. • Insulin degludec and insulin glargine have better safety in the term of less hypoglycemia and severe hypoglycemia episodes than NPH insulin among toddlers and preschoolers with T1D.
    MeSH term(s) Humans ; Child, Preschool ; Insulin Glargine/adverse effects ; Diabetes Mellitus, Type 1/drug therapy ; Insulin, Isophane/therapeutic use ; Hypoglycemic Agents/adverse effects ; Glycated Hemoglobin ; Blood Glucose Self-Monitoring ; Blood Glucose ; Hypoglycemia/chemically induced ; Hypoglycemia/drug therapy ; Insulin/adverse effects
    Chemical Substances Insulin Glargine (2ZM8CX04RZ) ; insulin degludec (54Q18076QB) ; Insulin, Isophane (53027-39-7) ; Hypoglycemic Agents ; Glycated Hemoglobin ; Blood Glucose ; Insulin
    Language English
    Publishing date 2023-02-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 194196-3
    ISSN 1432-1076 ; 0340-6199 ; 0943-9676
    ISSN (online) 1432-1076
    ISSN 0340-6199 ; 0943-9676
    DOI 10.1007/s00431-023-04857-w
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  4. Article: Adipokine (adiponectin-rs1501299) Gene Variant and Patient Characteristics in Relation to Metabolic-associated Fatty Liver Disease.

    Mohamed, Amal A / Hassanin, Soha / Mohamed, Ahmed A / Zaafar, Dalia / Mohamed, Rasha / Hassan, Mohamed B / Hassanin, Al-Shaymaa A / Alsayed Abouahmad, Eman / Sakr, Mohamed A / Abd El Salam, Soha M / Abdelghafour, Reem A M / Muharram, Nashwa M / Darwish, Marwa K / Faried, Saadia / Nasraldin, Karmia / Hafez, Wael

    Journal of clinical and experimental hepatology

    2024  Volume 14, Issue 5, Page(s) 101409

    Abstract: Background: Several genetic and metabolic variables, most notably the variation in the adipokine gene rs1501298, have been linked to metabolic-associated fatty liver disease etiopathogenesis (MAFLD). Liver biopsy, the gold standard for diagnosing MAFLD, ...

    Abstract Background: Several genetic and metabolic variables, most notably the variation in the adipokine gene rs1501298, have been linked to metabolic-associated fatty liver disease etiopathogenesis (MAFLD). Liver biopsy, the gold standard for diagnosing MAFLD, is an invasive procedure; therefore, alternative diagnostic methods are required. Consequently, the integration of these metabolic variables with some of the patients' characteristics may facilitate the development of noninvasive diagnostic methods that aid in the early detection of MAFLD, identification of at-risk individuals and planning of management strategies.
    Methods: This study included 224 Egyptians (107 healthy individuals and 117 MAFLD patients). Age, sex, BMI, clinical and laboratory characteristics, and rs1501299 adipokine gene polymorphisms were examined. The rs1501299 variant, insulin resistance, hypertension, obesity, blood pressure, lipid profile, hemoglobin A1C level, and hepatic fibrosis predictors were evaluated for MAFLD risk. The feasibility and effectiveness of developing non-invasive MAFLD diagnostic models will be investigated.
    Results: The +276G/T (rs1501299) polymorphism (GG vs GT/TT) was linked with MAFLD (OR: 0.43, CI: 0.26-0.69,
    Conclusion: The Adipokine variant rs1501299 increased the risk of MAFLD. Identifying and genotyping this variation and other metabolic variables allow for a noninvasive diagnostic model for early MAFLD diagnosis and identification of those at risk. This study illuminates the prevention and management of MAFLD. Further research with more participants is needed to verify these models and to prove their MAFLD diagnostic efficacy.
    Language English
    Publishing date 2024-04-08
    Publishing country India
    Document type Journal Article
    ISSN 0973-6883
    ISSN 0973-6883
    DOI 10.1016/j.jceh.2024.101409
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  5. Article: ECG-COVID: An end-to-end deep model based on electrocardiogram for COVID-19 detection.

    Sakr, Ahmed S / Pławiak, Paweł / Tadeusiewicz, Ryszard / Pławiak, Joanna / Sakr, Mohamed / Hammad, Mohamed

    Information sciences

    2022  Volume 619, Page(s) 324–339

    Abstract: The early and accurate detection of COVID-19 is vital nowadays to avoid the vast and rapid spread of this virus and ease lockdown restrictions. As a result, researchers developed methods to diagnose COVID-19. However, these methods have several ... ...

    Abstract The early and accurate detection of COVID-19 is vital nowadays to avoid the vast and rapid spread of this virus and ease lockdown restrictions. As a result, researchers developed methods to diagnose COVID-19. However, these methods have several limitations. Therefore, presenting new methods is essential to improve the diagnosis of COVID-19. Recently, investigation of the electrocardiogram (ECG) signals becoming an easy way to detect COVID-19 since the ECG process is non-invasive and easy to use. Therefore, we proposed in this paper a novel end-to-end deep learning model (ECG-COVID) based on ECG for COVID-19 detection. We employed several deep Convolutional Neural Networks (CNNs) on a dataset of 1109 ECG images, which is built for screening the perception of COVID-19 and cardiac patients. After that, we selected the most efficient model as our model for evaluation. The proposed model is end-to-end where the input ECG images are fed directly to the model for the final decision without using any additional stages. The proposed method achieved an average accuracy of 98.81%, Precision of 98.8%, Sensitivity of 98.8% and, F1-score of 98.81% for COVID-19 detection. As cases of corona continue to rise and hospitalizations continue again, hospitals may find our study helpful when dealing with these patients who did not get significantly worse.
    Language English
    Publishing date 2022-11-18
    Publishing country United States
    Document type Journal Article
    ISSN 0020-0255
    ISSN 0020-0255
    DOI 10.1016/j.ins.2022.11.069
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  6. Article ; Online: Correction: Effect of swimming exercise on premenstrual syndrome.

    Maged, Ahmed Mohamed / Abbassy, Amr H / Sakr, Hend R S / Elsawah, Heba / Wagih, Heba / Ogila, Asmaa I / Kotb, Amal

    Archives of gynecology and obstetrics

    2024  

    Language English
    Publishing date 2024-04-01
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 896455-5
    ISSN 1432-0711 ; 0932-0067
    ISSN (online) 1432-0711
    ISSN 0932-0067
    DOI 10.1007/s00404-024-07429-x
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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: The potential impact and diagnostic value of inflammatory markers on diabetic foot progression in type II diabetes mellitus: A case-control study.

    Mohamed, Amal Ahmed / Elmotaleb Hussein, Mona Abd / Nabil Hanna, Ihab / Japer Nashwan, Abdulqadir Jeprel / Saleh, Mohamed / Abdel Wahed, Wafaa Yousif / Mohamed Mansour, Asmaa Mohamed / Ezz Al Arab, Mohamed Ramadan / Fawzy, Naglaa / Sakr, Yasser / Shalby, Hassan / AlHussain, Eman / Kamal Darwish, Marwa / El-Osaily, Heba / Naguib, Mervat / Mohamed, Ahmed Ali / Farouk Mohamed, Waleed / Hafez, Wael

    Medicina clinica

    2024  

    Abstract: Background: The wound-healing process in diabetic foot is affected by pro and anti-inflammatory markers, and any disruption in the inflammatory reaction interferes with tissue homeostasis, leading to chronic non-wound healing.: Aim: This study aimed ... ...

    Abstract Background: The wound-healing process in diabetic foot is affected by pro and anti-inflammatory markers, and any disruption in the inflammatory reaction interferes with tissue homeostasis, leading to chronic non-wound healing.
    Aim: This study aimed to determine the diagnostic value and effect of CRP, IL-6, TNF, and HbA1c on initiation the and progression of diabetic foot ulcers.
    Method: ELISA was used to quantify IL-6, TNF, CRP, and HbA1c in 205 patients with diabetes, and 105 were diabetic foot free. The prevalence and progression of diabetic foot were also evaluated. The area under the curve (AUC) was calculated using the receiver operating characteristic (ROC) curve to analyze the predictive values. Forward stepwise logistic regression analysis was used to compute the odds ratio (OR) and the corresponding 95% confidence intervals (CIs).
    Results: CRP, IL-6, and FBS were found to be significant predictors of diabetic foot (OR=1.717, 95% CI=1.250-2.358, P=0.001; OR=1.434, 95% CI=1.142-1.802, P=0.002; and OR=1.040, 95% CI=1.002-1.080, P=0.037), respectively. The AUCs for CRP, IL-6, and HbA1c in predicting diabetic foot were 0.839, 0.728, and 0.834, respectively, demonstrating a good predictive value for each diagnostic marker.
    Conclusion: The current study demonstrated that IL-6, CRP, and HbA1c may be useful biomarkers to indicate diabetic foot progression. Furthermore, our findings showed a substantial relationship between CRP and HbA1c in individuals with diabetic foot conditions.
    Language Spanish
    Publishing date 2024-03-07
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2024.01.009
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  8. Article ; Online: Carbon disulfide removal from gasoline fraction using zinc-carbon composite synthesized using microwave-assisted homogenous precipitation.

    Sakr, Ayat A-E / Amr, Nouran / Bakry, Mohamed / El-Azab, Waleed I M / Ebiad, Mohamed A

    Environmental science and pollution research international

    2023  Volume 30, Issue 34, Page(s) 82014–82030

    Abstract: Carbon disulfide ( ... ...

    Abstract Carbon disulfide (CS
    MeSH term(s) Carbon Disulfide/analysis ; Carbon Disulfide/chemistry ; Carbon Disulfide/toxicity ; Gasoline ; Zinc/chemistry ; Carbon/chemistry ; Microwaves ; Adsorption ; Hazardous Substances/analysis ; Hazardous Substances/chemistry ; Hazardous Substances/toxicity
    Chemical Substances Carbon Disulfide (S54S8B99E8) ; Gasoline ; Zinc (J41CSQ7QDS) ; Carbon (7440-44-0) ; Hazardous Substances
    Language English
    Publishing date 2023-06-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-27905-2
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    In stock of ZB MED Bonn / Germany

    Z 5915: Show issues

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  9. Article ; Online: A Quality Improvement Initiative to Minimize Unnecessary Chest X-Ray Utilization in Pediatric Asthma Exacerbations.

    Sakr, Mohamed / Al Kanjo, Mohamed / Balasundaram, Palanikumar / Kupferman, Fernanda / Al-Mulaabed, Sharef / Scott, Sandra / Viswanathan, Kusum / Basak, Ratna B

    Pediatric quality & safety

    2024  Volume 9, Issue 2, Page(s) e721

    Abstract: Background: Current national guidelines recommend against chest X-rays (CXRs) for patients with acute asthma exacerbation (AAE). The overuse of CXRs in AAE has become a concern, prompting the need for a quality improvement (QI) project to decrease CXR ... ...

    Abstract Background: Current national guidelines recommend against chest X-rays (CXRs) for patients with acute asthma exacerbation (AAE). The overuse of CXRs in AAE has become a concern, prompting the need for a quality improvement (QI) project to decrease CXR usage through guideline-based interventions. We aimed to reduce the percentage of CXRs not adhering to national guidelines obtained for pediatric patients presenting to the Emergency Department (ED) with AAE by 50% within 12 months of project initiation.
    Methods: We conducted this study at a New York City urban level-2 trauma center. The team was composed of members from the ED and pediatric departments. Electronic medical records of children aged 2 to 18 years presenting with AAE were evaluated. Monthly data on CXR utilization encompassing instances where the ordered CXR did not adhere to guidelines was collected before and after implementing interventions. The interventions included provider education, visual reminders, printed cards, grand-round presentations, and electronic medical records modifications.
    Results: The study encompassed 887 eligible patients with isolated AAE. Baseline data revealed a mean preintervention CXR noncompliance rate of 37.5% among children presenting to the ED with AAE. The interventions resulted in a notable decrease in unnecessary CXR utilization, reaching 16.7%, a reduction sustained throughout subsequent months.
    Conclusions: This QI project successfully reduced unnecessary CXR utilization in pediatric AAE. A multi-faceted approach involving education, visual aids, and electronic reminders aligned clinical practice with evidence-based guidelines. This QI initiative is a potential template for other healthcare institutions seeking to curtail unnecessary CXR usage in pediatric AAE.
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ISSN 2472-0054
    ISSN (online) 2472-0054
    DOI 10.1097/pq9.0000000000000721
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  10. Article ; Online: Promising sensors for pharmaceutical pollutant adsorption using Clar's goblet-based 2D membranes.

    Sakr, Mahmoud A S / Saad, Mohamed A / Abd-Elkader, Omar H / Abdelsalam, Hazem / Zhang, Qinfang

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 889

    Abstract: This study focuses on the design of new 2D membranes from connected Clar's Goblet as a potential sensor for pharmaceutical pollutants, specifically the painkiller drugs aspirin, paracetamol, ibuprofen, and diclofenac. The electronic, optical, and ... ...

    Abstract This study focuses on the design of new 2D membranes from connected Clar's Goblet as a potential sensor for pharmaceutical pollutants, specifically the painkiller drugs aspirin, paracetamol, ibuprofen, and diclofenac. The electronic, optical, and interaction properties are investigated using density functional theory calculations. The Clar's Goblet membranes (CGMs) that were chosen are semiconductors with an energy gap of around 1.5 eV, according to energy gap calculations and density of states. Molecular electrostatic potential (ESP) analysis shows that CGMs have electrophilic and nucleophilic sites, suggesting their suitability for interacting with pharmaceutical pollutants. The adsorption energies confirm the chemical adsorption of pharmaceutical pollutants with diclofenac showing the strongest adsorption. The UV-Vis absorption spectra of CGMs-drug complexes are analyzed, revealing a redshift compared to the absorption spectrum of CGMs alone, confirming the adsorption of these drugs. Further analysis using hole/electron examinations indicates that the type of excitation is local excitation rather than charge transfer excitation. This study quantitatively characterized hole and electron distribution in excited states using various indices. The analysis revealed local excitation transitions and significant charge transfer between the CGMs molecule and pharmaceutical pollutants. Additionally, non-covalent interaction analysis indicates the presence of van der Waals interactions, highlighting the adsorption behavior of the drugs. These results demonstrate the potential of CGMs as a highly sensitive sensor for pharmaceutical pollutants.
    MeSH term(s) Adsorption ; Diclofenac ; Acetaminophen ; Environmental Pollutants ; Pharmaceutical Preparations
    Chemical Substances Diclofenac (144O8QL0L1) ; Acetaminophen (362O9ITL9D) ; Environmental Pollutants ; Pharmaceutical Preparations
    Language English
    Publishing date 2024-01-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-50802-0
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