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  1. Article: Neonatal encephalopathy and cerebral palsy.

    Yazawa, Keijiro

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi

    2002  Volume 72, Issue 2, Page(s) 85–88

    MeSH term(s) Apgar Score ; Brain Diseases/physiopathology ; Cerebral Palsy/etiology ; Cerebral Palsy/physiopathology ; Humans ; Infant, Newborn
    Language English
    Publishing date 2002-06-15
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 2091563-9
    ISSN 1347-3409 ; 1345-4676
    ISSN (online) 1347-3409
    ISSN 1345-4676
    DOI 10.1272/jnms.72.85
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 620: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Flow-Mediated Vasodilation and Reactive Hyperemia Index in Heart Failure with Reduced or Preserved Ejection Fraction.

    Waku, Ryutaro / Tokoi, Seiko / Toyoda, Shigeru / Kitahara, Keijiro / Naganuma, Jin / Yazawa, Hiroko / Sakuma, Masashi / Abe, Shichiro / Nakajima, Toshiaki / Inoue, Teruo

    The Tohoku journal of experimental medicine

    2020  Volume 252, Issue 1, Page(s) 85–93

    Abstract: Vascular endothelial dysfunction is part of the underlying pathophysiology of heart failure. However, there are no reports in which vascular endothelial function of both conduit arteries and microvasculature was assessed in patients with heart failure. ... ...

    Abstract Vascular endothelial dysfunction is part of the underlying pathophysiology of heart failure. However, there are no reports in which vascular endothelial function of both conduit arteries and microvasculature was assessed in patients with heart failure. This study was aimed to assess vascular endothelial function separately in heart failure with reduced (HFrEF) and preserved ejection fraction (HFpEF). We performed simultaneous measurement of both flow-mediated vasodilation for endothelial function of conduit arteries and reactive hyperemia-peripheral arterial tonometry for that of microvasculature in 88 consecutive patients with chronic heart failure. In 55 patients with ischemic heart disease as an underlying cause of heart failure, flow-mediated vasodilation value was comparable between the two groups of HFrEF (left ventricular ejection fraction < 50%, n = 31) and HFpEF (left ventricular ejection fraction ≥ 50%, n = 24). Reactive hyperemia index measured by reactive hyperemia peripheral arterial tonometry, however, was lower in HFrEF patients compared to HFpEF patients (P = 0.014). In contrast, among 33 patients with non-ischemic heart disease, the degree of flow-mediated vasodilation was lower in HFpEF patients (n = 18) compared with HFrEF patients (n = 15) (P = 0.009), while reactive hyperemia index was comparable between the two groups. The clinical and pathophysiological significance of endothelial function in heart failure differs between conduit artery and microvasculature, and these differences may contribute to the underlying pathophysiology of HFpEF and HFrEF, as well as in ischemic heart disease and non-ischemic heart disease.
    Keywords covid19
    Language English
    Publishing date 2020-09-07
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 123477-8
    ISSN 1349-3329 ; 0040-8727
    ISSN (online) 1349-3329
    ISSN 0040-8727
    DOI 10.1620/tjem.252.85
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.155: Show issues Location:
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  3. Article ; Online: Effects of switching from clopidogrel to prasugrel at the chronic phase after coronary stenting on antiplatelet action and vascular endothelial function: Switch-Pras study.

    Masuyama, Taiki / Sakuma, Masashi / Waku, Ryutaro / Hirose, Suguru / Kitahara, Keijiro / Naganuma, Jin / Yazawa, Hiroko / Toyoda, Shigeru / Abe, Shichiro / Nakajima, Toshiaki / Inoue, Teruo

    Heart and vessels

    2020  Volume 36, Issue 4, Page(s) 442–451

    Abstract: Compared to clopidogrel, prasugrel has a lower incidence of ischemic events following percutaneous coronary intervention (PCI) because of an early reduction during the acute phase in P2Y12 reaction units (PRU). The objective of this study was to compare ... ...

    Abstract Compared to clopidogrel, prasugrel has a lower incidence of ischemic events following percutaneous coronary intervention (PCI) because of an early reduction during the acute phase in P2Y12 reaction units (PRU). The objective of this study was to compare the antiplatelet effect and vascular endothelial function of both drugs during the chronic phase after PCI. Patients who had undergone PCI and were confirmed to have no restenosis by follow-up coronary angiography under dual anti-platelet therapy with clopidogrel (75 mg/day) and aspirin (100 mg/day) were randomized to either continue clopidogrel or switch to prasugrel (3.75 mg/day). At baseline, prior to randomization we determined the CYP2C19 genotype. At the baseline and 24 weeks after randomization, the P2Y12 reactivity unit (PRU) was measured using the VerifyNow™ P2Y12 assay. Endothelial function was evaluated by flow-mediated vasodilation (FMD) and reactive hyperemia peripheral arterial tonometry (RH-PAT), while and circulating CD34+/CD133+/CD45
    MeSH term(s) Acute Coronary Syndrome/physiopathology ; Acute Coronary Syndrome/surgery ; Aged ; Clopidogrel/therapeutic use ; Drug Substitution ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/physiopathology ; Female ; Humans ; Male ; Percutaneous Coronary Intervention ; Platelet Aggregation/drug effects ; Platelet Aggregation Inhibitors/therapeutic use ; Prasugrel Hydrochloride/therapeutic use ; Prospective Studies ; Recurrence ; Stents ; Treatment Outcome
    Chemical Substances Platelet Aggregation Inhibitors ; Clopidogrel (A74586SNO7) ; Prasugrel Hydrochloride (G89JQ59I13)
    Language English
    Publishing date 2020-10-28
    Publishing country Japan
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 89678-0
    ISSN 1615-2573 ; 0910-8327 ; 0935-736X
    ISSN (online) 1615-2573
    ISSN 0910-8327 ; 0935-736X
    DOI 10.1007/s00380-020-01714-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2049: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Allo-anti-M: Detection peaks around 2 years of age, but may be attenuated by red blood cell transfusion.

    Tamai, Yoshiko / Ohto, Hitoshi / Yasuda, Hiroyasu / Takeshita, Akihiro / Fujii, Nobuharu / Ogo, Hiroaki / Yazawa, Yurika / Hato, Takaaki / Mitani, Kinuko / Suzuki, Keijiro / Yokohama, Akihiko / Kato, Yoko / Abe, Misao / Kumagawa, Midori / Ueda, Yasunori / Nollet, Kenneth E / Cooling, Laura / Kitazawa, Junichi

    Transfusion

    2021  Volume 61, Issue 9, Page(s) 2718–2726

    Abstract: Background: Anti-M is frequently observed as a naturally occurring antibody of little clinical significance. Naturally occurring anti-M is often found in children although the specific triggers of production, persistence, and evanescence of anti-M have ... ...

    Abstract Background: Anti-M is frequently observed as a naturally occurring antibody of little clinical significance. Naturally occurring anti-M is often found in children although the specific triggers of production, persistence, and evanescence of anti-M have yet to be elucidated.
    Methods: In a retrospective, multicenter, nationwide cohort survey conducted from 2001 to 2015, alloantibody screening was performed before and after transfusion in 18,944 recipients younger than 20 years. Recipients were categorized into six cohorts based on their age at transfusion; within and among these cohorts, allo-anti-M was analyzed in regard to its production, persistence, and evanescence.
    Results: In 44 patients, anti-M detected before and/or after transfusion was an age-related phenomenon, with a median age of 2 years and an interquartile range of 1-3 years; anti-M was most frequently detected in a cohort of children 1 to <5 years (0.77%, 31 of 4035). At least five patients were presumed to have concurrent infections. Among 1575 adolescents/young adults (15 to <20 years), no anti-M was detected. Of 29 patients with anti-M prior to transfusion, the antibody fell to undetectable levels in 17 recipients (89.5%, of whom at least 13 received only M-negative red cells) after anywhere from 5 days to 5.8 years; anti-M persisted in 2, and was not tested in 10. Only 15 recipients (0.08%) produced new anti-M after transfusion.
    Conclusion: Naturally occurring anti-M is a phenomenon of younger ages, predominantly between 1 and 3 years. After transfusion, it often falls to undetectable levels.
    MeSH term(s) Child, Preschool ; Erythrocyte Transfusion/adverse effects ; Female ; Humans ; Infant ; Isoantibodies/blood ; Isoantibodies/immunology ; MNSs Blood-Group System/blood ; MNSs Blood-Group System/immunology ; Male ; Retrospective Studies
    Chemical Substances Isoantibodies ; MNSs Blood-Group System
    Language English
    Publishing date 2021-07-21
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.16594
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 284: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Flow-Mediated Vasodilation and Reactive Hyperemia Index in Heart Failure with Reduced or Preserved Ejection Fraction

    Waku, Ryutaro / Tokoi, Seiko / Toyoda, Shigeru / Kitahara, Keijiro / Naganuma, Jin / Yazawa, Hiroko / Sakuma, Masashi / Abe, Shichiro / Nakajima, Toshiaki / Inoue, Teruo

    Tohoku J Exp Med

    Abstract: Vascular endothelial dysfunction is part of the underlying pathophysiology of heart failure. However, there are no reports in which vascular endothelial function of both conduit arteries and microvasculature was assessed in patients with heart failure. ... ...

    Abstract Vascular endothelial dysfunction is part of the underlying pathophysiology of heart failure. However, there are no reports in which vascular endothelial function of both conduit arteries and microvasculature was assessed in patients with heart failure. This study was aimed to assess vascular endothelial function separately in heart failure with reduced (HFrEF) and preserved ejection fraction (HFpEF). We performed simultaneous measurement of both flow-mediated vasodilation for endothelial function of conduit arteries and reactive hyperemia-peripheral arterial tonometry for that of microvasculature in 88 consecutive patients with chronic heart failure. In 55 patients with ischemic heart disease as an underlying cause of heart failure, flow-mediated vasodilation value was comparable between the two groups of HFrEF (left ventricular ejection fraction < 50%, n = 31) and HFpEF (left ventricular ejection fraction ≥ 50%, n = 24). Reactive hyperemia index measured by reactive hyperemia peripheral arterial tonometry, however, was lower in HFrEF patients compared to HFpEF patients (P = 0.014). In contrast, among 33 patients with non-ischemic heart disease, the degree of flow-mediated vasodilation was lower in HFpEF patients (n = 18) compared with HFrEF patients (n = 15) (P = 0.009), while reactive hyperemia index was comparable between the two groups. The clinical and pathophysiological significance of endothelial function in heart failure differs between conduit artery and microvasculature, and these differences may contribute to the underlying pathophysiology of HFpEF and HFrEF, as well as in ischemic heart disease and non-ischemic heart disease.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32893258
    Database COVID19

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