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  1. Article ; Online: A Rose Amongst the Thorns: the Mission of the J Project in a Conflictual World.

    Maródi, László

    Journal of clinical immunology

    2022  Volume 42, Issue 6, Page(s) 1151–1155

    Language English
    Publishing date 2022-05-09
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 779361-3
    ISSN 1573-2592 ; 0271-9142
    ISSN (online) 1573-2592
    ISSN 0271-9142
    DOI 10.1007/s10875-022-01285-7
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    Zs.A 1640: Show issues Location:
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  2. Article ; Online: COVID-19 in patients with primary immunodeficiency.

    Maródi, László

    Orvosi hetilap

    2022  Volume 163, Issue 5, Page(s) 166–170

    Abstract: Összefoglaló. Az új típusú koronavírus (SARS-CoV-2) okozta pandémia súlyos terhet és nagy kihívást jelent a fertőzésekkel szemben általában is fogékony, szerteágazó immunológiai és genetikai hátterű, primer immundeficiens (PID-) betegek számára. Az ... ...

    Title translation COVID-19 primer immunhiányos betegekben.
    Abstract Összefoglaló. Az új típusú koronavírus (SARS-CoV-2) okozta pandémia súlyos terhet és nagy kihívást jelent a fertőzésekkel szemben általában is fogékony, szerteágazó immunológiai és genetikai hátterű, primer immundeficiens (PID-) betegek számára. Az eddigi megfigyelések arra utalnak, hogy a SARS-CoV-2-fertőzés és a súlyos COVID-19 mortalitása nem elsősorban az immunológiai alapbetegséggel, hanem sokkal inkább egyéb, a PID talaján megelőzően kialakult (például bronchiectasia, asthma, autoimmun betegség stb.) vagy attól független krónikus társbetegséggel (például diabetes, krónikus szív- és érrendszeri vagy vesebetegség) és szervi károsodással függ össze. A betegek egy kis csoportjában az I. típusú interferon-immunitás zavarát okozhatják génmutációk vagy autoantitestek termelése. A közleményben az eddig közölt adatok alapján beszámolunk a SARS-CoV-2-fertőzés és a COVID-19 lefolyásáról és mortalitásáról PID-betegekben. Orv Hetil. 2022; 163(5): 166-170. Summary. The pandemic caused by the novel coronavirus (SARS-CoV-2) has resulted in tremendous challenges to the management of patients with primary immunodeficiencies (PIDs) representing a wide range of immunological and genetic entities. Preliminary data suggest that patients with PID would be at increased risk of severe disease and mortality from this newly emerged coronavirus. However, morbidity and mortality by SARS-CoV-2 may depend only partly on specific defect of immunity. Most of disease morbidity and mortality has been published to be related to previous damage of organs and tissues that had developed on the bases of PID before contracting SARS-CoV-2 or other, PID-independent disorders. In a small fraction of patients, impaired type I interferon immunity was found to predispose PID patients to severe coronavirus disease. In this review, we provide an update on published data about SARS-CoV-2 infections and COVID-19 in various PIDs. Orv Hetil. 2022; 163(5): 166-170.
    MeSH term(s) Antiviral Agents ; COVID-19 ; Humans ; Interferons ; SARS-CoV-2
    Chemical Substances Antiviral Agents ; Interferons (9008-11-1)
    Language Hungarian
    Publishing date 2022-01-30
    Publishing country Hungary
    Document type Journal Article ; Review
    ZDB-ID 123879-6
    ISSN 1788-6120 ; 0030-6002
    ISSN (online) 1788-6120
    ISSN 0030-6002
    DOI 10.1556/650.2022.32395
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: SARS-CoV-2 infection and COVID‒19 in Gaucher disease: indications for vaccination

    Maródi, László

    Orvosi hetilap

    2021  Volume 162, Issue 24, Page(s) 938–942

    Abstract: At the start of the pandemic caused by the novel coronavirus (SARS-CoV-2), the Gaucher disease community anticipated that infection with this emerging viral pathogen would be associated with high morbidity and mortality in individuals with this chronic ... ...

    Title translation SARS-CoV-2-fertőzés és COVID-19 Gaucher-kóros betegekben: a védőoltás javallata.
    Abstract At the start of the pandemic caused by the novel coronavirus (SARS-CoV-2), the Gaucher disease community anticipated that infection with this emerging viral pathogen would be associated with high morbidity and mortality in individuals with this chronic metabolic disorder. Surprisingly, however, preliminary studies suggest that Gaucher disease does not confer a higher risk of severe, life-threatening effects of SARS-CoV-2 infection, and no severe cases have been reported in large cohorts of patients from the United States, Europe and Israel. It is thought that the accumulation of glucocerebroside in the cells of Gaucher patients may promote immune tolerance rather than inflammation on exposure to SARS-CoV-2. We review here the current concepts of Gaucher disease and SARS-CoV-2 infection, focusing particularly on general prevention and vaccination. We also discuss the susceptibility to COVID-19 of patients with inborn errors of type 1 interferon (IFNα and IFNω) immunity. Orv Hetil. 2021; 162(24): 938-942.
    MeSH term(s) COVID-19 ; Europe ; Gaucher Disease ; Humans ; Male ; SARS-CoV-2 ; Vaccination
    Language Hungarian
    Publishing date 2021-06-13
    Publishing country Hungary
    Document type Journal Article ; Review
    ZDB-ID 123879-6
    ISSN 1788-6120 ; 0030-6002
    ISSN (online) 1788-6120
    ISSN 0030-6002
    DOI 10.1556/650.2021.32272
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  4. Article ; Online: The Konya Declaration for Patients with Primary Immunodeficiencies.

    Maródi, László

    Journal of clinical immunology

    2020  Volume 40, Issue 5, Page(s) 770–773

    MeSH term(s) Communication ; Consensus ; Delivery of Health Care ; Europe, Eastern/epidemiology ; Humans ; International Cooperation ; National Health Programs ; Primary Immunodeficiency Diseases/epidemiology ; Primary Immunodeficiency Diseases/immunology
    Language English
    Publishing date 2020-06-15
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 779361-3
    ISSN 1573-2592 ; 0271-9142
    ISSN (online) 1573-2592
    ISSN 0271-9142
    DOI 10.1007/s10875-020-00797-4
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    Zs.A 1640: Show issues Location:
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  5. Article ; Online: Fifteen Years of the J Project.

    Maródi, László

    Journal of clinical immunology

    2019  Volume 39, Issue 4, Page(s) 363–369

    Language English
    Publishing date 2019-05-17
    Publishing country Netherlands
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 779361-3
    ISSN 1573-2592 ; 0271-9142
    ISSN (online) 1573-2592
    ISSN 0271-9142
    DOI 10.1007/s10875-019-00633-4
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  6. Article: Nobel-díj a cirkadián ritmus genetikai szabályozásának felfedezéséért.

    Maródi, László

    Orvosi hetilap

    2018  Volume 159, Issue 6, Page(s) 239

    Title translation Nobel Prize for the discoveries of genetic mechanisms controlling the circadian rythm.
    MeSH term(s) Animals ; Circadian Rhythm ; DNA Repair ; Drosophila melanogaster ; History, 20th Century ; Humans ; Nobel Prize
    Language Hungarian
    Publishing date 2018-02
    Publishing country Hungary
    Document type Historical Article ; Journal Article
    ZDB-ID 123879-6
    ISSN 1788-6120 ; 0030-6002
    ISSN (online) 1788-6120
    ISSN 0030-6002
    DOI 10.1556/650.2018.HO2590
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  7. Article: Szerkesztői kommentár. Interdiszciplináris immundeficientia: új szemlélet a primer immunhiány-betegségek értelmezésében.

    Maródi, László

    Orvosi hetilap

    2018  Volume 159, Issue 23, Page(s) 895–897

    Title translation Editor's commentary. Interdisciplinary immunodeficiency: a novel approach to understanding primary immunodeficiency disorders.
    MeSH term(s) Humans ; Immunologic Deficiency Syndromes ; Interdisciplinary Communication
    Language Hungarian
    Publishing date 2018-05-28
    Publishing country Hungary
    Document type Journal Article
    ZDB-ID 123879-6
    ISSN 1788-6120 ; 0030-6002
    ISSN (online) 1788-6120
    ISSN 0030-6002
    DOI 10.1556/650.2018.31110
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  8. Article ; Online: From Ignác Semmelweis to Primary Immunodeficiencies: a Bicentenary Commemoration.

    Maródi, László

    Journal of clinical immunology

    2018  Volume 38, Issue 3, Page(s) 247–250

    MeSH term(s) Communicable Diseases/etiology ; Famous Persons ; History, 19th Century ; Humans ; Hungary ; Immunologic Deficiency Syndromes/complications ; Immunologic Deficiency Syndromes/epidemiology ; Immunologic Deficiency Syndromes/history
    Language English
    Publishing date 2018-04-13
    Publishing country Netherlands
    Document type Biography ; Historical Article ; Letter
    ZDB-ID 779361-3
    ISSN 1573-2592 ; 0271-9142
    ISSN (online) 1573-2592
    ISSN 0271-9142
    DOI 10.1007/s10875-018-0495-x
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  9. Article ; Online: Inborn errors of T cell immunity underlying autoimmune diseases.

    Maródi, László

    Expert review of clinical immunology

    2016  Volume 13, Issue 2, Page(s) 97–99

    MeSH term(s) Autoimmune Diseases/immunology ; Autoimmune Diseases/pathology ; Humans ; Immunologic Deficiency Syndromes/immunology ; Immunologic Deficiency Syndromes/pathology ; T-Lymphocytes/immunology ; T-Lymphocytes/pathology
    Language English
    Publishing date 2016-11-18
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2274260-8
    ISSN 1744-8409 ; 1744-666X
    ISSN (online) 1744-8409
    ISSN 1744-666X
    DOI 10.1080/1744666X.2017.1256204
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  10. Article ; Online: Editorial: Advances in primary immunodeficiencies (inborn errors of immunity) in Central-Eastern Europe, volume II.

    Pac, Malgorzata / Casanova, Jean-Laurent / Tuzankina, Irina / Maródi, László

    Frontiers in immunology

    2023  Volume 14, Page(s) 1221137

    MeSH term(s) Europe ; Europe, Eastern ; Primary Immunodeficiency Diseases ; Humans
    Language English
    Publishing date 2023-06-13
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1221137
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