Article ; Online: Type I interferon production elicits differential CD4+ T-cell responses in mice infected with Plasmodium berghei ANKA and P. chabaudi.
2021 Volume 34, Issue 1, Page(s) 21–33
Abstract: ... the CD4+ T-cell immune responses in mice infected with P. berghei ANKA (PbA) or P. chabaudi chabaudi ... of infection, CD4+ T-cell responses in PbA-infected mice showed a lower involvement of Th1 cells and a lower ... proportion of Ly6Clo effector CD4+ T cells than those in Pcc-infected mice. Transcriptome analysis of PbT-II ...
| Abstract | Plasmodium parasites that infect humans are highly polymorphic, and induce various infections ranging from an asymptomatic state to life-threatening diseases. However, how the differences between the parasites affect host immune responses during blood-stage infection remains largely unknown. We investigated the CD4+ T-cell immune responses in mice infected with P. berghei ANKA (PbA) or P. chabaudi chabaudi AS (Pcc) using PbT-II cells, which recognize a common epitope of these parasites. In the acute phase of infection, CD4+ T-cell responses in PbA-infected mice showed a lower involvement of Th1 cells and a lower proportion of Ly6Clo effector CD4+ T cells than those in Pcc-infected mice. Transcriptome analysis of PbT-II cells indicated that type I interferon (IFN)-regulated genes were expressed at higher levels in both Th1- and Tfh-type PbT-II cells from PbA-infected mice than those from Pcc-infected mice. Moreover, IFN-α levels were considerably higher in PbA-infected mice than in Pcc-infected mice. Inhibition of type I IFN signaling increased PbT-II and partially reversed the Th1 over Tfh bias of the PbT-II cells in both PbA- and Pcc-infected mice. In the memory phase, PbT-II cells in PbA-primed mice maintained higher numbers and exhibited a better recall response to the antigen. However, recall responses were not significantly different between the infection groups after re-challenge with PbA, suggesting the effect of the inflammatory environment by the infection. These observations suggest that the differences in Plasmodium-specific CD4+ T-cell responses between PbA- and Pcc-infected mice were associated with the difference in type I IFN production during the early phase of the infection. |
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| MeSH term(s) | Animals ; CD4-Positive T-Lymphocytes/immunology ; Cells, Cultured ; Interferon Type I/biosynthesis ; Malaria/immunology ; Mice ; Mice, Transgenic ; Plasmodium berghei/immunology ; Plasmodium chabaudi/immunology |
| Chemical Substances | Interferon Type I |
| Language | English |
| Publishing date | 2021-10-15 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 1013745-2 |
| ISSN | 1460-2377 ; 0953-8178 |
| ISSN (online) | 1460-2377 |
| ISSN | 0953-8178 |
| DOI | 10.1093/intimm/dxab090 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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