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Article ; Online: Parental consent and neonatal delivery room trials: walking an ethical tightrope.

Owen, Louise S / Davis, Peter G

Archives of disease in childhood. Fetal and neonatal edition

2021 Volume 106, Issue 2, Page(s) 116–117

MeSH term(s)	Delivery Rooms ; Humans ; Infant, Newborn ; Neonatology/ethics ; Parental Consent/ethics ; Research Design ; Research Subjects ; Resuscitation/methods
Language	English
Publishing date	2021-01-12
Publishing country	England
Document type	Editorial
ZDB-ID	2007331-8
ISSN	1468-2052 ; 1359-2998
ISSN (online)	1468-2052
ISSN	1359-2998
DOI	10.1136/archdischild-2020-319355
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Um IV Zs.106 -F.N.Ed.-: Show issues

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Article ; Online: Nasal High-Flow Therapy during Neonatal Endotracheal Intubation. Reply.

Hodgson, Kate A / Owen, Louise S / Manley, Brett J

The New England journal of medicine

2022 Volume 387, Issue 4, Page(s) 382

MeSH term(s)	Humans ; Infant, Newborn ; Intubation, Intratracheal ; Trachea
Language	English
Publishing date	2022-08-08
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2207316
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Article ; Online: Nasal Intermittent Positive Pressure Ventilation for Neonatal Respiratory Distress Syndrome.

Rüegger, Christoph M / Owen, Louise S / Davis, Peter G

Clinics in perinatology

2021 Volume 48, Issue 4, Page(s) 725–744

Abstract: Nasal or noninvaisve intermittent positive pressure ventilation (NIPPV) refers to well-established noninvasive respiratory support strategies combining a continuous distending pressure with intermittent pressure increases. Uncertainty remains regarding ... ...

Abstract	Nasal or noninvaisve intermittent positive pressure ventilation (NIPPV) refers to well-established noninvasive respiratory support strategies combining a continuous distending pressure with intermittent pressure increases. Uncertainty remains regarding the benefits provided by the various devices and techniques used to generate NIPPV. Our included meta-analyses of trials comparing NIPPV with continuous positive airway pressure (CPAP) in preterm infants demonstrate that both primary and postextubation NIPPV are superior to CPAP to prevent respiratory failure leading to additional ventilatory support. This short-term benefit is associated with a reduction in bronchopulmonary dysplasia, but not with mortality. Benefits are greatest when ventilator-generated, synchronized NIPPV is used.
MeSH term(s)	Bronchopulmonary Dysplasia/therapy ; Continuous Positive Airway Pressure ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Intermittent Positive-Pressure Ventilation ; Noninvasive Ventilation ; Respiratory Distress Syndrome, Newborn/therapy
Language	English
Publishing date	2021-10-02
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Review
ZDB-ID	193116-7
ISSN	1557-9840 ; 0095-5108
ISSN (online)	1557-9840
ISSN	0095-5108
DOI	10.1016/j.clp.2021.07.004
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Article ; Online: Impact of early respiratory care for extremely preterm infants.

Owen, Louise S / Manley, Brett J / Hodgson, Kate A / Roberts, Calum T

Seminars in perinatology

2021 Volume 45, Issue 8, Page(s) 151478

Abstract: Despite advances in neonatal intensive care, more than half of surviving infants born extremely preterm (EP; < 28 weeks' gestation) develop bronchopulmonary dysplasia (BPD). Prevention of BPD is critical because of its associated mortality and morbidity, ...

Abstract	Despite advances in neonatal intensive care, more than half of surviving infants born extremely preterm (EP; < 28 weeks' gestation) develop bronchopulmonary dysplasia (BPD). Prevention of BPD is critical because of its associated mortality and morbidity, including adverse neurodevelopmental outcomes and respiratory health in later childhood and beyond. The respiratory care of EP infants begins before birth, then continues in the delivery room and throughout the primary hospitalization. This chapter will review the evidence for interventions after birth that might improve outcomes for infants born EP, including the timing of umbilical cord clamping, strategies to avoid or minimize exposure to mechanical ventilation, modes of mechanical ventilation and non-invasive respiratory support, oxygen saturation targets, postnatal corticosteroids and other adjunct therapies.
MeSH term(s)	Bronchopulmonary Dysplasia/prevention & control ; Child ; Female ; Glucocorticoids ; Humans ; Infant ; Infant, Extremely Premature ; Infant, Newborn ; Oxygen Saturation ; Pregnancy ; Umbilical Cord Clamping
Chemical Substances	Glucocorticoids
Language	English
Publishing date	2021-08-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752403-1
ISSN	1558-075X ; 0146-0005
ISSN (online)	1558-075X
ISSN	0146-0005
DOI	10.1016/j.semperi.2021.151478
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Article ; Online: Evaluation of a person-centred, nurse-led model of care delivering hepatitis C testing and treatment in priority settings: a mixed-methods evaluation of the Tasmanian Eliminate Hepatitis C Australia Outreach Project, 2020-2022.

Dawe, Joshua / Hughes, Megan / Christensen, Shannon / Walsh, Louisa / Richmond, Jacqueline A / Pedrana, Alisa / Wilkinson, Anna L / Owen, Louise / Doyle, Joseph S

BMC public health

2023 Volume 23, Issue 1, Page(s) 2289

Abstract: Introduction: Australia has experienced sustained reductions in hepatitis C testing and treatment and may miss its 2030 elimination targets. Addressing gaps in community-based hepatitis C prescribing in priority settings that did not have, or did not ... ...

Abstract	Introduction: Australia has experienced sustained reductions in hepatitis C testing and treatment and may miss its 2030 elimination targets. Addressing gaps in community-based hepatitis C prescribing in priority settings that did not have, or did not prioritise, hepatitis C testing and treatment care pathways is critical. Methods: The Tasmanian Eliminate Hepatitis C Australia Outreach Project delivered a nurse-led outreach model of care servicing hepatitis C priority populations in the community through the Tasmanian Statewide Sexual Health Service, supported by the Eliminating Hepatitis C Australia partnership. Settings included alcohol and other drug services, needle and syringe programs and mental health services. The project provided clients with clinical care across the hepatitis C cascade of care, including testing, treatment, and post-treatment support and hepatitis C education for staff. Results: Between July 2020 and July 2022, a total of 43 sites were visited by one Clinical Nurse Consultant. There was a total of 695 interactions with clients across 219 days of service delivery by the Clinical Nurse Consultant. A total of 383 clients were tested for hepatitis C (antibody, RNA, or both). A total of 75 clients were diagnosed with hepatitis C RNA, of which 95% (71/75) commenced treatment, 83% (62/75) completed treatment and 52% (39/75) received a negative hepatitis C RNA test at least 12 weeks after treatment completion. Conclusions: Providing outreach hepatitis C services in community-based services was effective in engaging people living with and at-risk of hepatitis C, in education, testing, and care. Nurse-led, person-centred care was critical to the success of the project. Our evaluation underscores the importance of employing a partnership approach when delivering hepatitis C models of care in community settings, and incorporating workforce education and capacity-building activities when working with non-specialist healthcare professionals.
MeSH term(s)	Humans ; Nurse's Role ; Substance Abuse, Intravenous/psychology ; Australia ; Hepatitis C/diagnosis ; Hepatitis C/drug therapy ; Hepacivirus ; RNA/therapeutic use ; Antiviral Agents/therapeutic use
Chemical Substances	RNA (63231-63-0) ; Antiviral Agents
Language	English
Publishing date	2023-11-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-023-17066-9
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Article ; Online: Neonatal Golden Hour: A survey of Australian and New Zealand Neonatal Network units' early stabilisation practices for very preterm infants.

Hodgson, Kate A / Owen, Louise S / Lui, Kei / Shah, Vibhuti

Journal of paediatrics and child health

2021 Volume 57, Issue 7, Page(s) 990–997

Abstract: Aim: To identify current 'Golden Hour' practices for initial stabilisation of very preterm infants <32 weeks' gestational age (GA) within tertiary neonatal intensive care units (NICUs) in the Australian and New Zealand Neonatal Network (ANZNN).: ... ...

Abstract	Aim: To identify current 'Golden Hour' practices for initial stabilisation of very preterm infants <32 weeks' gestational age (GA) within tertiary neonatal intensive care units (NICUs) in the Australian and New Zealand Neonatal Network (ANZNN). Methods: A 76-question survey regarding delivery room (DR) and NICU stabilisation practices was distributed electronically to directors of tertiary perinatal NICUs in the ANZNN in January 2019. Responses were categorised into GA subgroups: 23-24, 25-27 and 28-31 weeks' GA. Results: The response rate was 100% (24/24 units). Delayed cord clamping (DCC) was practised 'always' or 'often' by 21 units (88%). All units used oximetry to target oxygen saturations, and 23/24 (96%) commenced resuscitation in <40% oxygen. Ten units (42%) routinely used DR electrocardiography monitoring. CPAP was preferred as primary respiratory support in one-third of units for infants born 23-24 weeks' GA, compared with 19 units (79%) at 25-27 weeks' GA and 23 units (96%) at 28-31 weeks' GA. DR skin-to-skin care was uncommon, particularly at lower GAs. Five units (21%) used minimally invasive surfactant therapy for non-intubated infants at 23-24 weeks' GA, 13 units (54%) at 25-27 weeks' GA and 16 units (67%) at 28-31 weeks' GA. Conclusions: Most Golden Hour stabilisation practices align with international guidelines. Consistency exists with respect to DCC, oxygen saturation targeting and primary CPAP use for infants 25 weeks' GA and above. Where evidence is less certain, practices vary across ANZNN NICUs. Time targets for stabilisation measures may help standardise practice for this population.
MeSH term(s)	Australia ; Female ; Gestational Age ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Infant, Very Low Birth Weight ; Intensive Care Units, Neonatal ; New Zealand ; Pregnancy
Language	English
Publishing date	2021-02-05
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1024476-1
ISSN	1440-1754 ; 1034-4810
ISSN (online)	1440-1754
ISSN	1034-4810
DOI	10.1111/jpc.15360
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Zs.A 227: Show issues

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Article ; Online: Bronchopulmonary dysplasia as a trial endpoint: time for re-evaluation?

Owen, Louise S / Cheong, Jeanie L Y / Davis, Peter G

The Lancet. Child & adolescent health

2019 Volume 3, Issue 12, Page(s) 842–844

MeSH term(s)	Bronchopulmonary Dysplasia/classification ; Bronchopulmonary Dysplasia/mortality ; Bronchopulmonary Dysplasia/physiopathology ; Child ; Child, Preschool ; Clinical Decision Rules ; Gestational Age ; Humans ; Infant ; Infant, Newborn ; Neurodevelopmental Disorders/epidemiology ; Outcome Assessment, Health Care ; Severity of Illness Index ; Ventilation/methods ; Ventilation/statistics & numerical data ; Ventilator-Induced Lung Injury/complications ; Ventilator-Induced Lung Injury/epidemiology
Language	English
Publishing date	2019-10-01
Publishing country	England
Document type	Journal Article
ISSN	2352-4650
ISSN (online)	2352-4650
DOI	10.1016/S2352-4642(19)30321-9
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Article ; Online: RNA helicase EIF4A1-mediated translation is essential for the GC response.

Screen, Michael / Matheson, Louise S / Howden, Andrew Jm / Strathdee, Douglas / Willis, Anne E / Bushell, Martin / Sansom, Owen / Turner, Martin

Life science alliance

2023 Volume 7, Issue 2

Abstract: EIF4A1 and cofactors EIF4B and EIF4H have been well characterised in cancers, including B cell malignancies, for their ability to promote the translation of oncogenes with structured 5' untranslated regions. However, very little is known of their roles ... ...

Abstract	EIF4A1 and cofactors EIF4B and EIF4H have been well characterised in cancers, including B cell malignancies, for their ability to promote the translation of oncogenes with structured 5' untranslated regions. However, very little is known of their roles in nonmalignant cells. Using mouse models to delete
MeSH term(s)	Animals ; Mice ; Eukaryotic Initiation Factor-4A/genetics ; Eukaryotic Initiation Factor-4A/metabolism ; RNA Helicases/metabolism ; B-Lymphocytes
Chemical Substances	Eukaryotic Initiation Factor-4A (EC 2.7.7.-) ; RNA Helicases (EC 3.6.4.13)
Language	English
Publishing date	2023-11-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2575-1077
ISSN (online)	2575-1077
DOI	10.26508/lsa.202302301
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Article ; Online: Nasal high flow therapy for neonates: Current evidence and future directions.

Hodgson, Kate A / Davis, Peter G / Owen, Louise S

Journal of paediatrics and child health

2019 Volume 55, Issue 3, Page(s) 285–290

Abstract: Nasal high flow (nHF) therapy is a commonly used method of providing non-invasive respiratory support for neonates. It has several potential mechanisms of action: continuous distending pressure, nasopharyngeal dead space washout, provision of heated and ... ...

Abstract	Nasal high flow (nHF) therapy is a commonly used method of providing non-invasive respiratory support for neonates. It has several potential mechanisms of action: continuous distending pressure, nasopharyngeal dead space washout, provision of heated and humidified gases and reduction of work of breathing. nHF is used in a number of clinical scenarios for preterm and term infants, including primary respiratory and post-extubation support. In recent years, large trials have generated evidence pertinent to these indications. Novel applications for nHF in neonates warrant further research: during endotracheal intubation, for initial delivery room stabilisation of preterm infants and in conjunction with minimally invasive surfactant therapy.
MeSH term(s)	Administration, Intranasal ; Humans ; Infant, Newborn ; Infant, Premature ; Oxygen Inhalation Therapy/methods
Language	English
Publishing date	2019-01-07
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	1024476-1
ISSN	1440-1754 ; 1034-4810
ISSN (online)	1440-1754
ISSN	1034-4810
DOI	10.1111/jpc.14374
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Article ; Online: Delivery room emergencies: Respiratory emergencies in the DR.

Owen, Louise S / Manley, Brett J / Davis, Peter G

Seminars in fetal & neonatal medicine

2019 Volume 24, Issue 6, Page(s) 101039

Abstract: The majority of newborns transition to extra uterine life without support. However, respiratory emergencies in the delivery room are a common occurrence. Whilst some situations are predictable e.g. the anticipated birth of an extremely preterm infant, ... ...

Abstract	The majority of newborns transition to extra uterine life without support. However, respiratory emergencies in the delivery room are a common occurrence. Whilst some situations are predictable e.g. the anticipated birth of an extremely preterm infant, others are less so. In this chapter we address the most frequent scenarios that result in delivery room respiratory emergencies and discuss the latest recommendations for their management. We outline the need for a trained resuscitation team and appropriate equipment to provide respiratory support at every birth. We address the basic care that all infants should receive, the detailed application of non-invasive ventilation and the use of advanced airway techniques. We discuss the unique challenges presented by extreme prematurity including umbilical cord management, use of supplemental oxygen, initial modes of respiratory support and surfactant delivery. We will explore optimal techniques in the management of infants with lung hypoplasia, pneumothorax and meconium aspiration.
MeSH term(s)	Airway Management/methods ; Continuous Positive Airway Pressure/methods ; Delivery Rooms/organization & administration ; Emergencies ; Humans ; Infant, Extremely Premature/physiology ; Infant, Newborn ; Meconium Aspiration Syndrome/diagnosis ; Meconium Aspiration Syndrome/physiopathology ; Meconium Aspiration Syndrome/therapy ; Noninvasive Ventilation/methods ; Pulmonary Surfactants/therapeutic use ; Respiratory Distress Syndrome, Newborn/diagnosis ; Respiratory Distress Syndrome, Newborn/physiopathology ; Respiratory Distress Syndrome, Newborn/therapy ; Resuscitation/methods
Chemical Substances	Pulmonary Surfactants
Language	English
Publishing date	2019-10-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2174416-6
ISSN	1878-0946 ; 1744-165X
ISSN (online)	1878-0946
ISSN	1744-165X
DOI	10.1016/j.siny.2019.101039
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