LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 48654

Search options

  1. Article: N

    Vesely, Elisa M / Williams, Robert B / Konopka, James B / Lorenz, Michael C

    mSphere

    2017  Volume 2, Issue 5

    Abstract: Phagocytosis by innate immune cells is one of the most effective barriers against the multiplication and dissemination of microbes within the mammalian host. ...

    Abstract Phagocytosis by innate immune cells is one of the most effective barriers against the multiplication and dissemination of microbes within the mammalian host.
    Language English
    Publishing date 2017-09
    Publishing country United States
    Document type Journal Article
    ISSN 2379-5042
    ISSN 2379-5042
    DOI 10.1128/mSphere.00357-17
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: N

    Conway, Leslie C / Cardarelli, Ross A / Moore, Yvonne E / Jones, Karen / McWilliams, Lisa J / Baker, David J / Burnham, Matthew P / Bürli, Roland W / Wang, Qi / Brandon, Nicholas J / Moss, Stephen J / Deeb, Tarek Z

    The Journal of biological chemistry

    2017  Volume 292, Issue 52, Page(s) 21253–21263

    Abstract: ... ...

    Abstract K
    MeSH term(s) Animals ; Cell Membrane/metabolism ; Embryo, Mammalian ; Ethylmaleimide/metabolism ; Humans ; Membrane Transport Modulators/metabolism ; Neurons/metabolism ; Phosphorylation/physiology ; Rats ; Rats, Sprague-Dawley ; Receptors, GABA/metabolism ; Symporters/metabolism ; Symporters/physiology ; K Cl- Cotransporters
    Chemical Substances Membrane Transport Modulators ; Receptors, GABA ; Symporters ; Ethylmaleimide (O3C74ACM9V)
    Language English
    Publishing date 2017-11-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.M117.817841
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.108: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Adopting Duplex Sequencing™ Technology for Genetic Toxicity Testing: A Proof-of-Concept Mutagenesis Experiment with N-Ethyl-N-Nitrosourea (ENU)-Exposed Rats.

    Smith-Roe, Stephanie L / Hobbs, Cheryl A / Hull, Victoria / Auman, J Todd / Recio, Leslie / Streicker, Michael A / Rivas, Miriam V / Pratt, Gabriel A / Lo, Fang Yin / Higgins, Jacob E / Schmidt, Elizabeth K / Williams, Lindsey N / Nachmanson, Daniela / Valentine, Charles C / Salk, Jesse J / Witt, Kristine L

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Duplex sequencing (DuplexSeq) is an error-corrected next-generation sequencing (ecNGS) method in which molecular barcodes informatically link PCR-copies back to their source DNA strands, enabling computational removal of errors by comparing grouped ... ...

    Abstract Duplex sequencing (DuplexSeq) is an error-corrected next-generation sequencing (ecNGS) method in which molecular barcodes informatically link PCR-copies back to their source DNA strands, enabling computational removal of errors by comparing grouped strand sequencing reads. The resulting background of less than one artifactual mutation per 10
    Highlights: DuplexSeq is an ultra-accurate NGS technology that directly quantifies mutationsENU-dependent mutagenesis was detected 24 h post-exposure in proliferative tissuesMultiple tissues exhibited the canonical ENU mutation spectrum 7 d after exposureResults obtained with DuplexSeq were highly concordant between laboratoriesThe Rat-50 Mutagenesis Assay is promising for applications in genetic toxicology.
    Language English
    Publishing date 2023-05-09
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.05.08.539833
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Adopting duplex sequencing technology for genetic toxicity testing: A proof-of-concept mutagenesis experiment with N-ethyl-N-nitrosourea (ENU)-exposed rats.

    Smith-Roe, Stephanie L / Hobbs, Cheryl A / Hull, Victoria / Todd Auman, J / Recio, Leslie / Streicker, Michael A / Rivas, Miriam V / Pratt, Gabriel A / Lo, Fang Yin / Higgins, Jacob E / Schmidt, Elizabeth K / Williams, Lindsey N / Nachmanson, Daniela / Valentine Iii, Charles C / Salk, Jesse J / Witt, Kristine L

    Mutation research. Genetic toxicology and environmental mutagenesis

    2023  Volume 891, Page(s) 503669

    Abstract: Duplex sequencing (DS) is an error-corrected next-generation sequencing method in which molecular barcodes informatically link PCR-copies back to their source DNA strands, enabling computational removal of errors in consensus sequences. The resulting ... ...

    Abstract Duplex sequencing (DS) is an error-corrected next-generation sequencing method in which molecular barcodes informatically link PCR-copies back to their source DNA strands, enabling computational removal of errors in consensus sequences. The resulting background of less than one artifactual mutation per 10
    MeSH term(s) Rats ; Male ; Animals ; Ethylnitrosourea/toxicity ; Reproducibility of Results ; Rats, Sprague-Dawley ; Mutagenesis ; Mutation ; Nitrosourea Compounds ; Mutagens/toxicity
    Chemical Substances Ethylnitrosourea (P8M1T4190R) ; Nitrosourea Compounds ; Mutagens
    Language English
    Publishing date 2023-08-03
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1879-3592
    ISSN (online) 1879-3592
    DOI 10.1016/j.mrgentox.2023.503669
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article: N

    Ai, Teng / Willett, Rose / Williams, Jessica / Ding, Rui / Wilson, Daniel J / Xie, Jiashu / Kim, Do-Hyung / Puertollano, Rosa / Chen, Liqiang

    ACS medicinal chemistry letters

    2016  Volume 8, Issue 1, Page(s) 90–95

    Abstract: Guided by antiproliferative activity in MIA PaCa-2 cells, we have performed preliminary structure-activity relationship studies ... ...

    Abstract Guided by antiproliferative activity in MIA PaCa-2 cells, we have performed preliminary structure-activity relationship studies on
    Language English
    Publishing date 2016-11-28
    Publishing country United States
    Document type Journal Article
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.6b00392
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Author Correction: Transcriptional regulation of N

    Salisbury, David A / Casero, David / Zhang, Zhengyi / Wang, Dan / Kim, Jason / Wu, Xiaohui / Vergnes, Laurent / Mirza, Aashiq H / Leon-Mimila, Paola / Williams, Kevin J / Huertas-Vazquez, Adriana / Jaffrey, Samie R / Reue, Karen / Chen, Jianjun / Sallam, Tamer

    Nature metabolism

    2023  Volume 5, Issue 3, Page(s) 530

    Language English
    Publishing date 2023-02-23
    Publishing country Germany
    Document type Published Erratum
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-023-00748-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Discovery of novel N-acylpyrazoles as potent and selective thrombin inhibitors.

    Short, Kevin M / Estiarte, M Angels / Pham, Son M / Williams, David C / Igoudin, Lev / Dash, Subhadra / Sandoval, Nichole / Datta, Anirban / Pozzi, Nicola / Di Cera, Enrico / Kita, David B

    European journal of medicinal chemistry

    2022  Volume 246, Page(s) 114855

    Abstract: ... heparin. This article describes the discovery and profiling of a novel series of N-acylpyrazoles ... stability issues associated with this chemotype and, importantly, demonstrate that N-acylpyrazoles ... of the DTIs and factor Xa inhibitors. We propose that the N-acylpyrazole chemotype shows intriguing promise ...

    Abstract Direct oral anticoagulants (DOACs), which includes thrombin and factor Xa inhibitors, have emerged as the preferred therapeutics for thrombotic disorders, penetrating a market previously dominated by warfarin and heparin. This article describes the discovery and profiling of a novel series of N-acylpyrazoles, which act as selective, covalent, reversible, non-competitive inhibitors of thrombin. We describe in vitro stability issues associated with this chemotype and, importantly, demonstrate that N-acylpyrazoles successfully act in vivo as anticoagulants in basic thrombotic animal models. Crucially, this anticoagulant nature is unaccompanied by the higher bleeding risk profile that has become an undesirable characteristic of the DTIs and factor Xa inhibitors. We propose that the N-acylpyrazole chemotype shows intriguing promise as next-generation oral anticoagulants.
    Language English
    Publishing date 2022-10-27
    Publishing country France
    Document type Journal Article
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2022.114855
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 784: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: WDR5 facilitates recruitment of N-MYC to conserved WDR5 gene targets in neuroblastoma cell lines.

    Bumpous, Leigh A / Moe, Kylie C / Wang, Jing / Carver, Logan A / Williams, Alexandria G / Romer, Alexander S / Scobee, Jesse D / Maxwell, Jack N / Jones, Cheyenne A / Chung, Dai H / Tansey, William P / Liu, Qi / Weissmiller, April M

    Oncogenesis

    2023  Volume 12, Issue 1, Page(s) 32

    Abstract: ... recruiter. Here, we focus on N-MYC amplified neuroblastoma to determine the extent of colocalization between ... N-MYC and WDR5 on chromatin while also demonstrating that like c-MYC, WDR5 can facilitate ... the recruitment of N-MYC to conserved WDR5-bound genes. We conclude based on this analysis that N-MYC and WDR5 ...

    Abstract Collectively, the MYC family of oncoprotein transcription factors is overexpressed in more than half of all malignancies. The ability of MYC proteins to access chromatin is fundamental to their role in promoting oncogenic gene expression programs in cancer and this function depends on MYC-cofactor interactions. One such cofactor is the chromatin regulator WDR5, which in models of Burkitt lymphoma facilitates recruitment of the c-MYC protein to chromatin at genes associated with protein synthesis, allowing for tumor progression and maintenance. However, beyond Burkitt lymphoma, it is unknown whether these observations extend to other cancers or MYC family members, and whether WDR5 can be deemed as a "universal" MYC recruiter. Here, we focus on N-MYC amplified neuroblastoma to determine the extent of colocalization between N-MYC and WDR5 on chromatin while also demonstrating that like c-MYC, WDR5 can facilitate the recruitment of N-MYC to conserved WDR5-bound genes. We conclude based on this analysis that N-MYC and WDR5 colocalize invariantly across cell lines at predicted sites of facilitated recruitment associated with protein synthesis genes. Surprisingly, we also identify N-MYC-WDR5 cobound genes that are associated with DNA repair and cell cycle processes. Dissection of chromatin binding characteristics for N-MYC and WDR5 at all cobound genes reveals that sites of facilitated recruitment are inherently different than most N-MYC-WDR5 cobound sites. Our data reveals that WDR5 acts as a universal MYC recruiter at a small cohort of previously identified genes and highlights novel biological functions that may be coregulated by N-MYC and WDR5 to sustain the neuroblastoma state.
    Language English
    Publishing date 2023-06-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2674437-5
    ISSN 2157-9024
    ISSN 2157-9024
    DOI 10.1038/s41389-023-00477-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Enantiopure cycloplatinated pentahelicenic N-heterocyclic carbenic complexes that display long-lived circularly polarized phosphorescence.

    Kundu, Debsouri / Del Rio, Natalia / Cordier, Marie / Vanthuyne, Nicolas / Puttock, Emma V / Meskers, Stefan C J / Williams, J A Gareth / Srebro-Hooper, Monika / Crassous, Jeanne

    Dalton transactions (Cambridge, England : 2003)

    2023  Volume 52, Issue 19, Page(s) 6484–6493

    Abstract: The preparation of the first enantiopure cycloplatinated complexes bearing a bidentate, helicenic N ...

    Abstract The preparation of the first enantiopure cycloplatinated complexes bearing a bidentate, helicenic N-heterocyclic carbene and a diketonate ancillary ligand is presented, along with their structural and spectroscopic characterization based on both experimental and computational studies. The systems exhibit long-lived circularly polarized phosphorescence in solution and in doped films at room temperature, and also in a frozen glass at 77 K, with dissymmetry factor
    Language English
    Publishing date 2023-05-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d3dt00577a
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Modulation of Chiroptical and Photophysical Properties in Helicenic Rhenium(I) Systems: The Use of an N-(Aza[6]helicenyl)-NHC Ligand.

    Gauthier, Etienne S / Abella, Laura / Caytan, Elsa / Roisnel, Thierry / Vanthuyne, Nicolas / Favereau, Ludovic / Srebro-Hooper, Monika / Williams, J A Gareth / Autschbach, Jochen / Crassous, Jeanne

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2023  Volume 29, Issue 21, Page(s) e202203477

    Abstract: ... an N-(aza[6]helicenyl)-benzimidazolylidene ligand are described, showing its ability to emit yellow ...

    Abstract The photophysical and chiroptical properties of a novel, chiral helicene-NHC-Re(I) complex bearing an N-(aza[6]helicenyl)-benzimidazolylidene ligand are described, showing its ability to emit yellow circularly polarized luminescence. A comparative analysis of this new system with other helicene-Re(I) complexes reported to date illustrates the impact of structural modifications on the emissive and absorptive properties.
    Language English
    Publishing date 2023-03-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202203477
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top