LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 7 of total 7

Search options

  1. Article: Preliminary investigation of the use of newborn dried blood spots for screening pyridoxine-dependent epilepsy by LC-MS/MS

    Jung, Sunhee / Tran, Nguyen-Thao B / Gospe, Sidney M., Jr / Hahn, Si Houn

    Molecular genetics and metabolism. 2013 Nov., v. 110, no. 3

    2013  

    Abstract: α-AASA and P6C were measured retrospectively in original newborn DBS of five patients with PDE using a LC-MS/MS method we developed previously. Both α-AASA and P6C were elevated markedly in the three newborn DBS stored at −20°C. At room temperature, α- ... ...

    Abstract α-AASA and P6C were measured retrospectively in original newborn DBS of five patients with PDE using a LC-MS/MS method we developed previously. Both α-AASA and P6C were elevated markedly in the three newborn DBS stored at −20°C. At room temperature, α-AASA and P6C in DBS appeared stable for 3days and then decreased by up to 70% after 14days but remained much higher than control, indicating newborn screening for PDE is feasible.
    Keywords blood ; epilepsy ; neonates ; patients ; screening ; temperature
    Language English
    Dates of publication 2013-11
    Size p. 237-240.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 1418518-0
    ISSN 1096-7206 ; 1096-7192
    ISSN (online) 1096-7206
    ISSN 1096-7192
    DOI 10.1016/j.ymgme.2013.07.017
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 617: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Exposure to environmental tobacco smoke during pregnancy in rats yields less effect on indices of brain cell number and size than does postnatal exposure.

    Gospe, Sidney M / Joyce, John A / Siebert, Joseph R / Jack, Rhona M / Pinkerton, Kent E

    Reproductive toxicology (Elmsford, N.Y.)

    2009  Volume 27, Issue 1, Page(s) 22–27

    Abstract: While there is evidence that human perinatal exposure to environmental tobacco smoke (ETS) can result in an increased risk of respiratory disorders and sudden infant death syndrome, evidence linking ETS exposure to neurodevelopmental handicaps is ... ...

    Abstract While there is evidence that human perinatal exposure to environmental tobacco smoke (ETS) can result in an increased risk of respiratory disorders and sudden infant death syndrome, evidence linking ETS exposure to neurodevelopmental handicaps is suggestive but less compelling. We previously noted that postnatal ETS exposure, rather than prenatal exposure, resulted in reduced concentration of hindbrain DNA and increased protein/DNA ratio when rat brain tissue was studied at 9 weeks postnatal age. We have now evaluated the effects of ETS exposure during pregnancy on brain development by assaying brain tissue at term. ETS exposure had no detectable effects on regional brain concentrations of DNA, protein and cholesterol or on protein/DNA and cholesterol/DNA ratios. While ETS exposure during pregnancy also had no detectable effects on the weights of the individual fetuses or on the weights of various organs, certain regions of the fetal skeleton demonstrated accelerated ossification. The findings of this study are contrasted to the developmental effects of both nicotine and ETS in Rhesus macaques. Additional studies designed specifically to assess the risk of prenatal ETS exposure on brain development in non-human primates and other precocial species are warranted.
    MeSH term(s) Amniotic Fluid/chemistry ; Animals ; Bone and Bones/drug effects ; Bone and Bones/embryology ; Brain/abnormalities ; Brain/drug effects ; Brain Chemistry/drug effects ; Cell Count ; Cell Size/drug effects ; Cotinine/analysis ; Female ; Fetal Development/drug effects ; Fetal Weight/drug effects ; Male ; Maternal Exposure/adverse effects ; Nicotine/adverse effects ; Nicotine/analysis ; Organ Size/drug effects ; Postpartum Period ; Pregnancy ; Rats ; Rats, Sprague-Dawley ; Smoking/adverse effects ; Smoking/metabolism
    Chemical Substances Nicotine (6M3C89ZY6R) ; Cotinine (K5161X06LL)
    Language English
    Publishing date 2009-01
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639342-1
    ISSN 1873-1708 ; 0890-6238
    ISSN (online) 1873-1708
    ISSN 0890-6238
    DOI 10.1016/j.reprotox.2008.11.049
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2316: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Pyridoxine dependent epilepsy and antiquitin deficiency Clinical and molecular characteristics and recommendations for diagnosis, treatment and follow-up

    Stockler, Sylvia / Plecko, Barbara / Gospe, Sidney M., Jr / Coulter-Mackie, Marion / Connolly, Mary / van Karnebeek, Clara / Mercimek-Mahmutoglu, Saadet / Hartmann, Hans / Scharer, Gunter / Struijs, Eduard / Tein, Ingrid / Jakobs, Cornelis / Clayton, Peter / Van Hove, Johan L.K

    Molecular genetics and metabolism. 2011 , v. 104, no. 1-2

    2011  

    Abstract: Antiquitin (ATQ) deficiency is the main cause of pyridoxine dependent epilepsy characterized by early onset epileptic encephalopathy responsive to large dosages of pyridoxine. Despite seizure control most patients have intellectual disability. Folinic ... ...

    Abstract Antiquitin (ATQ) deficiency is the main cause of pyridoxine dependent epilepsy characterized by early onset epileptic encephalopathy responsive to large dosages of pyridoxine. Despite seizure control most patients have intellectual disability. Folinic acid responsive seizures (FARS) are genetically identical to ATQ deficiency. ATQ functions as an aldehyde dehydrogenase (ALDH7A1) in the lysine degradation pathway. Its deficiency results in accumulation of α-aminoadipic semialdehyde (AASA), piperideine-6-carboxylate (P6C) and pipecolic acid, which serve as diagnostic markers in urine, plasma, and CSF. To interrupt seizures a dose of 100mg of pyridoxine-HCl is given intravenously, or orally/enterally with 30mg/kg/day. First administration may result in respiratory arrest in responders, and thus treatment should be performed with support of respiratory management. To make sure that late and masked response is not missed, treatment with oral/enteral pyridoxine should be continued until ATQ deficiency is excluded by negative biochemical or genetic testing. Long-term treatment dosages vary between 15 and 30mg/kg/day in infants or up to 200mg/day in neonates, and 500mg/day in adults. Oral or enteral pyridoxal phosphate (PLP), up to 30mg/kg/day can be given alternatively. Prenatal treatment with maternal pyridoxine supplementation possibly improves outcome. PDE is an organic aciduria caused by a deficiency in the catabolic breakdown of lysine. A lysine restricted diet might address the potential toxicity of accumulating αAASA, P6C and pipecolic acid. A multicenter study on long term outcomes is needed to document potential benefits of this additional treatment. The differential diagnosis of pyridoxine or PLP responsive seizure disorders includes PLP-responsive epileptic encephalopathy due to PNPO deficiency, neonatal/infantile hypophosphatasia (TNSALP deficiency), familial hyperphosphatasia (PIGV deficiency), as well as yet unidentified conditions and nutritional vitamin B6 deficiency. Commencing treatment with PLP will not delay treatment in patients with pyridox(am)ine phosphate oxidase (PNPO) deficiency who are responsive to PLP only.
    Keywords adults ; aldehyde dehydrogenase ; diet ; encephalopathy ; epilepsy ; intravenous injection ; lysine ; neonates ; oral administration ; patients ; pipecolic acid ; pyridoxal phosphate ; pyridoxine ; seizures ; toxicity ; urine
    Language English
    Dates of publication 2011-09
    Size p. 48-60.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 1418518-0
    ISSN 1096-7206 ; 1096-7192
    ISSN (online) 1096-7206
    ISSN 1096-7192
    DOI 10.1016/j.ymgme.2011.05.014
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 617: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Membrane attachment is key to protecting transducin GTPase-activating complex from intracellular proteolysis in photoreceptors.

    Gospe, Sidney M / Baker, Sheila A / Kessler, Christopher / Brucato, Martha F / Winter, Joan R / Burns, Marie E / Arshavsky, Vadim Y

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2011  Volume 31, Issue 41, Page(s) 14660–14668

    Abstract: The members of the R7 regulator of G-protein signaling (RGS) protein subfamily are versatile regulators of G-protein signaling throughout the nervous system. Recent studies indicate that they are often found in complexes with membrane anchor proteins ... ...

    Abstract The members of the R7 regulator of G-protein signaling (RGS) protein subfamily are versatile regulators of G-protein signaling throughout the nervous system. Recent studies indicate that they are often found in complexes with membrane anchor proteins that serve as versatile modulators of their activity, intracellular targeting, and stability. One striking example is the interplay between the membrane anchor R9AP and the RGS9-1 · Gβ5 GTPase-activating complex responsible for the rapid inactivation of the G-protein transducin in vertebrate photoreceptor cells during their recovery from light excitation. The amount of this complex in photoreceptors sets their temporal resolution and is precisely regulated by the expression level of R9AP, which serves to protect the RGS9-1 and Gβ5 subunits from intracellular proteolysis. In this study, we investigated the mechanism by which R9AP performs its protective function in mouse rods and found that it is entirely confined to recruiting RGS9-1 · Gβ5 to cellular membranes. Furthermore, membrane attachment of RGS9-1 · Gβ5 is sufficient for its stable expression in rods even in the absence of R9AP. Our second finding is that RGS9-1 · Gβ5 possesses targeting information that specifies its exclusion from the outer segment and that this information is neutralized by association with R9AP to allow outer segment targeting. Finally, we demonstrate that the ability of R9AP · RGS9-1 · Gβ5 to accelerate GTP hydrolysis on transducin is independent of its means of membrane attachment, since replacing the transmembrane domain of R9AP with a site for lipid modification did not impair the catalytic activity of this complex.
    MeSH term(s) Animals ; Cell Membrane/metabolism ; Dark Adaptation/genetics ; Dose-Response Relationship, Radiation ; Electroporation/methods ; GTP-Binding Protein beta Subunits/genetics ; GTP-Binding Protein beta Subunits/metabolism ; Gene Expression Regulation/genetics ; Intracellular Fluid/metabolism ; Light ; Membrane Proteins/deficiency ; Membrane Proteins/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Mutation/genetics ; Photoreceptor Cells, Vertebrate/cytology ; Photoreceptor Cells, Vertebrate/metabolism ; Proteolysis ; RGS Proteins/genetics ; RGS Proteins/metabolism ; Retina/cytology ; SNARE Proteins/genetics ; SNARE Proteins/metabolism ; Signal Transduction/physiology
    Chemical Substances GTP-Binding Protein beta Subunits ; Gnb5 protein, mouse ; Membrane Proteins ; R9AP protein, mouse ; RGS Proteins ; SNARE Proteins ; regulator of g-protein signaling 9
    Language English
    Publishing date 2011-10-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.3516-11.2011
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1668: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Lysine restricted diet for pyridoxine-dependent epilepsy: First evidence and future trials

    van Karnebeek, Clara D.M / Hartmann, Hans / Jaggumantri, Sravan / Bok, Levinus A / Cheng, Barb / Connolly, Mary / Coughlin, Curtis R., II / Das, Anibh M / Gospe, Sidney M., Jr / Jakobs, Cornelis / van der Lee, Johanna H / Mercimek-Mahmutoglu, Saadet / Meyer, Uta / Struys, Eduard / Sinclair, Graham / Van Hove, Johan / Collet, Jean-Paul / Plecko, Barbara R / Stockler, Sylvia

    Molecular genetics and metabolism. 2012 Nov., v. 107, no. 3

    2012  

    Abstract: OBJECTIVE: To evaluate the efficacy and safety of dietary lysine restriction as an adjunct to pyridoxine therapy on biochemical parameters, seizure control, and developmental/cognitive outcomes in children with pyridoxine-dependent epilepsy (PDE) caused ... ...

    Abstract OBJECTIVE: To evaluate the efficacy and safety of dietary lysine restriction as an adjunct to pyridoxine therapy on biochemical parameters, seizure control, and developmental/cognitive outcomes in children with pyridoxine-dependent epilepsy (PDE) caused by antiquitin (ATQ) deficiency. METHODS: In this observational study, seven children with confirmed ATQ deficiency were started on dietary lysine restriction with regular nutritional monitoring. Biochemical outcomes were evaluated using pipecolic acid and α-aminoadipic semialdehyde (AASA) levels in body fluids; developmental/cognitive outcomes were evaluated using age-appropriate tests and parental observations. RESULTS: Lysine restriction was well tolerated with good compliance; no adverse events were reported. Reduction in biomarker levels (measurement of the last value before and first value after initiation of dietary lysine restriction) ranged from 20 to 67% for plasma pipecolic acid, 13 to 72% for urinary AASA, 45% for plasma AASA and 42% for plasma P6C. For the 1 patient in whom data were available and who showed clinical deterioration upon interruption of diet, cerebrospinal fluid levels decreased by 87.2% for pipecolic acid and 81.7% for AASA. Improvement in age-appropriate skills was observed in 4 out of 5 patients showing pre-diet delays, and seizure control was maintained or improved in 6 out 7 children. CONCLUSIONS: This observational study provides Level 4 evidence that lysine restriction is well tolerated with significant decrease of potentially neurotoxic biomarkers in different body compartments, and with the potential to improve developmental outcomes in children with PDE caused by ATQ deficiency. To generate a strong level of evidence before this potentially burdensome dietary therapy becomes the mainstay treatment, we have established: an international PDE consortium to conduct future studies with an all-inclusive integrated study design; a website containing up-to-date information on PDE; a methodological toolbox; and an online registry to facilitate the participation of interested physicians, scientists, and families in PDE research.
    Keywords Internet ; biomarkers ; cerebrospinal fluid ; children ; cognition ; compliance ; diet ; diet therapy ; epilepsy ; experimental design ; lysine ; monitoring ; neurotoxicity ; observational studies ; patients ; pipecolic acid ; pyridoxine
    Language English
    Dates of publication 2012-11
    Size p. 335-344.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 1418518-0
    ISSN 1096-7206 ; 1096-7192
    ISSN (online) 1096-7206
    ISSN 1096-7192
    DOI 10.1016/j.ymgme.2012.09.006
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 617: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Clinical and genetic characterization of manifesting carriers of DMD mutations.

    Soltanzadeh, Payam / Friez, Michael J / Dunn, Diane / von Niederhausern, Andrew / Gurvich, Olga L / Swoboda, Kathryn J / Sampson, Jacinda B / Pestronk, Alan / Connolly, Anne M / Florence, Julaine M / Finkel, Richard S / Bönnemann, Carsten G / Medne, Livija / Mendell, Jerry R / Mathews, Katherine D / Wong, Brenda L / Sussman, Michael D / Zonana, Jonathan / Kovak, Karen /
    Gospe, Sidney M / Gappmaier, Eduard / Taylor, Laura E / Howard, Michael T / Weiss, Robert B / Flanigan, Kevin M

    Neuromuscular disorders : NMD

    2010  Volume 20, Issue 8, Page(s) 499–504

    Abstract: Manifesting carriers of DMD gene mutations may present diagnostic challenges, particularly in the absence of a family history of dystrophinopathy. We review the clinical and genetic features in 15 manifesting carriers identified among 860 subjects within ...

    Abstract Manifesting carriers of DMD gene mutations may present diagnostic challenges, particularly in the absence of a family history of dystrophinopathy. We review the clinical and genetic features in 15 manifesting carriers identified among 860 subjects within the United Dystrophinopathy Project, a large clinical dystrophinopathy cohort whose members undergo comprehensive DMD mutation analysis. We defined manifesting carriers as females with significant weakness, excluding those with only myalgias/cramps. DNA extracted from peripheral blood was used to study X-chromosome inactivation patterns. Among these manifesting carriers, age at symptom onset ranged from 2 to 47 years. Seven had no family history and eight had male relatives with Duchenne muscular dystrophy (DMD). Clinical severity among the manifesting carriers varied from a DMD-like progression to a very mild Becker muscular dystrophy-like phenotype. Eight had exonic deletions or duplications and six had point mutations. One patient had two mutations (an exonic deletion and a splice site mutation), consistent with a heterozygous compound state. The X-chromosome inactivation pattern was skewed toward non-random in four out of seven informative deletions or duplications but was random in all cases with nonsense mutations. We present the results of DMD mutation analysis in this manifesting carrier cohort, including the first example of a presumably compound heterozygous DMD mutation. Our results demonstrate that improved molecular diagnostic methods facilitate the identification of DMD mutations in manifesting carriers, and confirm the heterogeneity of mutational mechanisms as well as the wide spectrum of phenotypes.
    MeSH term(s) Adolescent ; Adult ; Cardiomyopathy, Dilated/genetics ; Cardiomyopathy, Dilated/pathology ; Child ; Child, Preschool ; DNA Mutational Analysis ; Dystrophin/genetics ; Female ; Heart Function Tests ; Heterozygote ; Humans ; Male ; Middle Aged ; Muscle Weakness/genetics ; Muscle Weakness/physiopathology ; Muscle, Skeletal/pathology ; Muscular Dystrophy, Duchenne/genetics ; Muscular Dystrophy, Duchenne/pathology ; Mutation/genetics ; Mutation/physiology ; X Chromosome Inactivation/genetics ; Young Adult
    Chemical Substances DMD protein, human ; Dystrophin
    Language English
    Publishing date 2010-07-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1077681-3
    ISSN 1873-2364 ; 0960-8966
    ISSN (online) 1873-2364
    ISSN 0960-8966
    DOI 10.1016/j.nmd.2010.05.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3258: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Editorial by concerned physicians: Unintended effect of the orphan drug act on the potential cost of 3,4-diaminopyridine.

    Burns, Ted M / Smith, Gordon A / Allen, Jeffrey A / Amato, Anthony A / Arnold, W David / Barohn, Richard / Benatar, Michael / Bird, Shawn J / Bromberg, Mark / Chahin, Nizar / Ciafaloni, Emma / Cohen, Jeffrey A / Corse, Andrea / Crum, Brian A / David, William S / Dimberg, Elliot / Sousa, Eduardo A De / Donofrio, Peter D / Dyck, P James B /
    Engel, Andrew G / Ensrud, Erik R / Ferrante, Mark / Freimer, Miriam / Gable, Karissa L / Gibson, Summer / Gilchrist, James M / Goldstein, Jonathan M / Gooch, Clifton L / Goodman, Brent P / Gorelov, Dmitri / Gospe, Sidney M / Goyal, Namita A / Guidon, Amanda C / Guptill, Jeffrey T / Gutmann, Laurie / Gutmann, Ludwig / Gwathmey, Kelly / Harati, Yadollah / Harper, C Michel / Hehir, Michael K / Hobson-Webb, Lisa D / Howard, James F / Jackson, Carlayne E / Johnson, Nicholas / Jones, Sarah M / Juel, Vern C / Kaminski, Henry J / Karam, Chafic / Kennelly, Kathleen D / Khella, Sami / Khoury, Julie / Kincaid, John C / Kissel, John T / Kolb, Noah / Lacomis, David / Ladha, Shafeeq / Larriviere, Daniel / Lewis, Richard A / Li, Yuebing / Litchy, William J / Logigian, Eric / Lou, Jau-Shin / MacGowen, Daniel J L / Maselli, Ricardo / Massey, Janice M / Mauermann, Michelle L / Mathews, Katherine D / Meriggioli, Matthew N / Miller, Robert G / Moon, Joon-Shik / Mozaffar, Tahseen / Nations, Sharon P / Nowak, Richard J / Ostrow, Lyle W / Pascuzzi, Robert M / Peltier, Amanda / Ruzhansky, Katherine / Richman, David P / Ross, Mark A / Rubin, Devon I / Russell, James A / Sachs, George M / Salajegheh, Mohammad Kian / Saperstein, David S / Scelsa, Stephen / Selcen, Duygu / Shaibani, Aziz / Shieh, Perry B / Silvestri, Nicholas J / Singleton, J Rob / Smith, Benn E / So, Yuen T / Solorzano, Guillermo / Sorenson, Eric J / Srinivasen, Jayashri / Tavee, Jinny / Tawil, Rabi / Thaisetthawatkul, Pariwat / Thornton, Charles / Trivedi, Jaya / Vernino, Steven / Wang, Annabel K / Webb, Tyler A / Weiss, Michael D / Windebank, Anthony J / Wolfe, Gil I

    Muscle & nerve

    2016  Volume 53, Issue 2, Page(s) 165–168

    MeSH term(s) 4-Aminopyridine/analogs & derivatives ; 4-Aminopyridine/therapeutic use ; Humans ; Neuromuscular Junction Diseases/drug therapy ; Neuromuscular Junction Diseases/economics ; Orphan Drug Production/economics ; Orphan Drug Production/methods ; Physicians/psychology ; Potassium Channel Blockers/therapeutic use
    Chemical Substances Potassium Channel Blockers ; 4-Aminopyridine (BH3B64OKL9) ; 3,4-diaminopyridine (RU4S6E2G0J)
    Language English
    Publishing date 2016-02
    Publishing country United States
    Document type Editorial
    ZDB-ID 438353-9
    ISSN 1097-4598 ; 0148-639X
    ISSN (online) 1097-4598
    ISSN 0148-639X
    DOI 10.1002/mus.25009
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1449: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 551: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top