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  1. Book: Urea transporters

    Yang, Baoxue / Sands, Jeff M.

    (Subcellular biochemistry ; 73)

    2014  

    Author's details Baoxue Yang ; Jeff M. Sands ed
    Series title Subcellular biochemistry ; 73
    Collection
    Keywords Urea / metabolism ; Membrane Transport Proteins ; Kidney / metabolism ; Biological Transport / physiology
    Subject code 612.4/61
    Language English
    Size X, 265 S. : Ill., graph. Darst., 24 cm
    Publisher Springer
    Publishing place Dordrecht u.a.
    Publishing country Netherlands
    Document type Book
    Note Includes bibliographical references ; Overview and historical perspective / Baoxue Yang and Jeff M. Sands -- Urea / Hongkai Wang, Jianhua Ran and Tao Jiang -- Mathematical modeling of urea transport in the kidney / Anita T. Layton -- Genes and proteins of urea transporters / Jeff M. Sands and Mitsi A. Blount -- Structure of urea transporters / Elena J. Levin and Ming Zhou -- Expression of urea transporters and their regulation / Janet D. Klein -- Biochemical properties of urea transporters / Guangping Chen -- Transport characteristics of urea transporter-B / Baoxue Yang -- Urea transporter knockout mice and their renal phenotypes. / Robert A. Fenton and Baoxue Yang -- Extrarenal phenotypes of the UT-B knockout mouse / Baoxue Yang, Xin Li, Lirong Guo, Yan Meng, Zixun Dong and Xuejian Zhao -- Small-molecule inhibitors of urea transporters / Alan S. Verkman, Cristina Esteva-Font, Onur Cil, Marc O. anderson, Fei Li, Min Li, Tianluo Lei,Huiwen Ren and Baoxue Yang -- Clinical aspects of urea transporters / Jianhua Ran, Hongkai Wang and Tinghai Hu -- Active urea transport in lower vertebrates and mammals / Lise Bankir -- Urea transport mediated by aquaporin water channel proteins / Chunling Li and Weidong Wang
    HBZ-ID HT018795140
    ISBN 978-94-017-9342-1 ; 9789401793438 ; 94-017-9342-5 ; 9401793433
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2015 A 3668 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Translating kidney fibrosis: Role of the EP

    Sands, Jeff M

    Acta physiologica (Oxford, England)

    2019  Volume 227, Issue 1, Page(s) e13318

    MeSH term(s) Animals ; Dinoprostone ; Fibrosis ; Humans ; Kidney ; Mice ; Receptors, Prostaglandin ; Ureter
    Chemical Substances Receptors, Prostaglandin ; Dinoprostone (K7Q1JQR04M)
    Language English
    Publishing date 2019-06-19
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2218636-0
    ISSN 1748-1716 ; 1748-1708
    ISSN (online) 1748-1716
    ISSN 1748-1708
    DOI 10.1111/apha.13318
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  3. Article ; Online: Phosphatases Decrease Water and Urea Permeability in Rat Inner Medullary Collecting Ducts.

    Wang, Yanhua / Klein, Janet D / Sands, Jeff M

    International journal of molecular sciences

    2023  Volume 24, Issue 7

    Abstract: We previously showed that the phosphatases PP1/PP2A and PP2B dephosphorylate the water channel, AQP2, suggesting their role in water reabsorption. In this study, we investigated whether protein phosphatase 2A (PP2A) and protein phosphatase 2B (PP2B or ... ...

    Abstract We previously showed that the phosphatases PP1/PP2A and PP2B dephosphorylate the water channel, AQP2, suggesting their role in water reabsorption. In this study, we investigated whether protein phosphatase 2A (PP2A) and protein phosphatase 2B (PP2B or calcineurin), which are present in the inner medullary collecting duct (IMCD), are regulators of urea and water permeability. Inhibition of calcineurin by tacrolimus increased both basal and vasopressin-stimulated osmotic water permeability in perfused rat IMCDs. However, tacrolimus did not affect osmotic water permeability in the presence of aldosterone. Inhibition of PP2A by calyculin increased both basal and vasopressin-stimulated osmotic water permeability, and aldosterone reversed the increase by calyculin. Previous studies showed that adrenomedullin (ADM) activates PP2A and decreases osmotic water permeability. Inhibition of PP2A by calyculin prevented the ADM-induced decrease in water reabsorption. ADM reduced the phosphorylation of AQP2 at serine 269 (pSer269 AQP2). Urea is linked to water reabsorption by building up hyperosmolality in the inner medullary interstitium. Calyculin increased urea permeability and phosphorylated UT-A1. Our results indicate that phosphatases regulate water reabsorption. Aldosterone and adrenomedullin decrease urea or osmotic water permeability by acting through calcineurin and PP2A, respectively. PP2A may regulate water reabsorption by dephosphorylating pSer269, AQP2, and UT-A1.
    MeSH term(s) Rats ; Animals ; Rats, Sprague-Dawley ; Membrane Transport Proteins/metabolism ; Phosphoric Monoester Hydrolases/metabolism ; Tacrolimus/pharmacology ; Water/metabolism ; Adrenomedullin ; Aquaporin 2/metabolism ; Calcineurin/metabolism ; Urea/pharmacology ; Urea/metabolism ; Aldosterone/metabolism ; Vasopressins/metabolism ; Permeability ; Kidney Tubules, Collecting/metabolism
    Chemical Substances Membrane Transport Proteins ; Phosphoric Monoester Hydrolases (EC 3.1.3.2) ; Tacrolimus (WM0HAQ4WNM) ; Water (059QF0KO0R) ; Adrenomedullin (148498-78-6) ; Aquaporin 2 ; Calcineurin (EC 3.1.3.16) ; Urea (8W8T17847W) ; Aldosterone (4964P6T9RB) ; Vasopressins (11000-17-2)
    Language English
    Publishing date 2023-03-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24076537
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  4. Article ; Online: Phosphatases Decrease Water and Urea Permeability in Rat Inner Medullary Collecting Ducts

    Yanhua Wang / Janet D. Klein / Jeff M. Sands

    International Journal of Molecular Sciences, Vol 24, Iss 6537, p

    2023  Volume 6537

    Abstract: We previously showed that the phosphatases PP1/PP2A and PP2B dephosphorylate the water channel, AQP2, suggesting their role in water reabsorption. In this study, we investigated whether protein phosphatase 2A (PP2A) and protein phosphatase 2B (PP2B or ... ...

    Abstract We previously showed that the phosphatases PP1/PP2A and PP2B dephosphorylate the water channel, AQP2, suggesting their role in water reabsorption. In this study, we investigated whether protein phosphatase 2A (PP2A) and protein phosphatase 2B (PP2B or calcineurin), which are present in the inner medullary collecting duct (IMCD), are regulators of urea and water permeability. Inhibition of calcineurin by tacrolimus increased both basal and vasopressin-stimulated osmotic water permeability in perfused rat IMCDs. However, tacrolimus did not affect osmotic water permeability in the presence of aldosterone. Inhibition of PP2A by calyculin increased both basal and vasopressin-stimulated osmotic water permeability, and aldosterone reversed the increase by calyculin. Previous studies showed that adrenomedullin (ADM) activates PP2A and decreases osmotic water permeability. Inhibition of PP2A by calyculin prevented the ADM-induced decrease in water reabsorption. ADM reduced the phosphorylation of AQP2 at serine 269 (pSer269 AQP2). Urea is linked to water reabsorption by building up hyperosmolality in the inner medullary interstitium. Calyculin increased urea permeability and phosphorylated UT-A1. Our results indicate that phosphatases regulate water reabsorption. Aldosterone and adrenomedullin decrease urea or osmotic water permeability by acting through calcineurin and PP2A, respectively. PP2A may regulate water reabsorption by dephosphorylating pSer269, AQP2, and UT-A1.
    Keywords phosphatase ; aldosterone ; calcineurin ; adrenomedullin ; protein phosphatase 2A ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Book ; Conference proceedings: Water Channel Physiology and Pathophysiology Symposium

    Sands, Jeff M.

    [circa 1998]

    1998  

    Institution Water Channel Physiology and Pathophysiology Symposium
    Author's details Jeff M. Sands, [guest ed.]
    Language English
    Publishing country United States
    Document type Book ; Conference proceedings
    Note In: The American journal of medical sciences. - ISSN 0002-9629. - 316 (1998),5, S. 289 - 328
    HBZ-ID HT009420899
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ua VI Zs 2/10 -316- verfügbar in Königswinter Königswinter

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  6. Article ; Online: Progress in the Detection of Erythropoietin in Blood, Urine, and Tissue.

    Yasuoka, Yukiko / Izumi, Yuichiro / Sands, Jeff M / Kawahara, Katsumasa / Nonoguchi, Hiroshi

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 11

    Abstract: Detection of erythropoietin (Epo) was difficult until a method was developed by the World Anti-Doping Agency (WADA). WADA recommended the Western blot technique using isoelectric focusing (IEF)-PAGE to show that natural Epo and injected erythropoiesis- ... ...

    Abstract Detection of erythropoietin (Epo) was difficult until a method was developed by the World Anti-Doping Agency (WADA). WADA recommended the Western blot technique using isoelectric focusing (IEF)-PAGE to show that natural Epo and injected erythropoiesis-stimulating agents (ESAs) appear in different pH areas. Next, they used sodium N-lauroylsarcosinate (SAR)-PAGE for better differentiation of pegylated proteins, such as epoetin β pegol. Although WADA has recommended the use of pre-purification of samples, we developed a simple Western blotting method without pre-purification of samples. Instead of pre-purification, we used deglycosylation of samples before SDS-PAGE. The double detection of glycosylated and deglycosylated Epo bands increases the reliability of the detection of Epo protein. All of the endogenous Epo and exogenous ESAs shift to 22 kDa, except for Peg-bound epoetin β pegol. All endogenous Epo and exogenous ESAs were detected as 22 kDa deglycosylated Epo by liquid chromatography/mass spectrum (LC/MS) analysis. The most important factor for the detection of Epo is the selection of the antibody against Epo. WADA recommended clone AE7A5, and we used sc-9620. Both antibodies are useful for the detection of Epo protein by Western blotting.
    MeSH term(s) Reproducibility of Results ; Erythropoietin ; Body Fluids ; Isoelectric Focusing/methods ; Blotting, Western ; Antibodies ; Electrophoresis, Polyacrylamide Gel ; Substance Abuse Detection/methods ; Recombinant Proteins
    Chemical Substances Erythropoietin (11096-26-7) ; Antibodies ; Recombinant Proteins
    Language English
    Publishing date 2023-05-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28114446
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    Zs.MO 81: Show issues

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  7. Article ; Online: Water, Water Everywhere: A New Cause and a New Treatment for Nephrogenic Diabetes Insipidus.

    Sands, Jeff M

    Journal of the American Society of Nephrology : JASN

    2015  Volume 27, Issue 7, Page(s) 1872–1874

    MeSH term(s) Aquaporin 2/genetics ; Aquaporins/genetics ; Diabetes Insipidus, Nephrogenic ; Humans ; Mutation ; Receptors, Vasopressin/genetics ; Water
    Chemical Substances Aquaporin 2 ; Aquaporins ; Receptors, Vasopressin ; Water (059QF0KO0R)
    Language English
    Publishing date 2015-12-28
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2015111223
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    Zs.A 3344: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Understanding renal physiology leads to therapeutic advances in renal disease.

    Sands, Jeff M

    Physiology (Bethesda, Md.)

    2015  Volume 30, Issue 3, Page(s) 171–172

    MeSH term(s) Animals ; Humans ; Kidney ; Mutation ; Polycystic Kidney, Autosomal Dominant/genetics ; Polycystic Kidney, Autosomal Dominant/therapy ; TRPP Cation Channels/genetics
    Chemical Substances TRPP Cation Channels ; polycystic kidney disease 1 protein ; polycystic kidney disease 2 protein
    Language English
    Publishing date 2015-05
    Publishing country United States
    Document type Comment ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2158667-6
    ISSN 1548-9221 ; 1548-9213
    ISSN (online) 1548-9221
    ISSN 1548-9213
    DOI 10.1152/physiol.00005.2015
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    Zs.A 2164: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Tubular Endogenous Erythropoietin Protects Renal Function against Ischemic Reperfusion Injury.

    Yasuoka, Yukiko / Izumi, Yuichiro / Fukuyama, Takashi / Oshima, Tomomi / Yamazaki, Taiga / Uematsu, Takayuki / Kobayashi, Noritada / Nanami, Masayoshi / Shimada, Yoshitaka / Nagaba, Yasushi / Mukoyama, Masashi / Sands, Jeff M / Takahashi, Noriko / Kawahara, Katsumasa / Nonoguchi, Hiroshi

    International journal of molecular sciences

    2024  Volume 25, Issue 2

    Abstract: Many large-scale studies show that exogenous erythropoietin, erythropoiesis-stimulating agents, lack any renoprotective effects. We investigated the effects of endogenous erythropoietin on renal function in kidney ischemic reperfusion injury (IRI) using ... ...

    Abstract Many large-scale studies show that exogenous erythropoietin, erythropoiesis-stimulating agents, lack any renoprotective effects. We investigated the effects of endogenous erythropoietin on renal function in kidney ischemic reperfusion injury (IRI) using the prolyl hydroxylase domain (PHD) inhibitor, Roxadustat (ROX). Four h of hypoxia (7% O
    MeSH term(s) Humans ; Erythropoietin/pharmacology ; Kidney ; Epoetin Alfa/pharmacology ; Prolyl-Hydroxylase Inhibitors/pharmacology ; Reperfusion Injury/drug therapy ; Reperfusion Injury/prevention & control ; Hypoxia
    Chemical Substances Erythropoietin (11096-26-7) ; Epoetin Alfa (64FS3BFH5W) ; Prolyl-Hydroxylase Inhibitors
    Language English
    Publishing date 2024-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25021223
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  10. Article ; Online: Progress in the Detection of Erythropoietin in Blood, Urine, and Tissue

    Yukiko Yasuoka / Yuichiro Izumi / Jeff M. Sands / Katsumasa Kawahara / Hiroshi Nonoguchi

    Molecules, Vol 28, Iss 4446, p

    2023  Volume 4446

    Abstract: Detection of erythropoietin (Epo) was difficult until a method was developed by the World Anti-Doping Agency (WADA). WADA recommended the Western blot technique using isoelectric focusing (IEF)-PAGE to show that natural Epo and injected erythropoiesis- ... ...

    Abstract Detection of erythropoietin (Epo) was difficult until a method was developed by the World Anti-Doping Agency (WADA). WADA recommended the Western blot technique using isoelectric focusing (IEF)-PAGE to show that natural Epo and injected erythropoiesis-stimulating agents (ESAs) appear in different pH areas. Next, they used sodium N-lauroylsarcosinate (SAR)-PAGE for better differentiation of pegylated proteins, such as epoetin β pegol. Although WADA has recommended the use of pre-purification of samples, we developed a simple Western blotting method without pre-purification of samples. Instead of pre-purification, we used deglycosylation of samples before SDS-PAGE. The double detection of glycosylated and deglycosylated Epo bands increases the reliability of the detection of Epo protein. All of the endogenous Epo and exogenous ESAs shift to 22 kDa, except for Peg-bound epoetin β pegol. All endogenous Epo and exogenous ESAs were detected as 22 kDa deglycosylated Epo by liquid chromatography/mass spectrum (LC/MS) analysis. The most important factor for the detection of Epo is the selection of the antibody against Epo. WADA recommended clone AE7A5, and we used sc-9620. Both antibodies are useful for the detection of Epo protein by Western blotting.
    Keywords erythropoietin ; glycoprotein ; deglycosylation ; Western blotting ; doping ; HIF2α ; Organic chemistry ; QD241-441
    Subject code 616
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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