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Article: A novel and practical care process framework to inform model of care development.

Meadows, Donna / Maclaren, Joanne / Morton, Alec / Ross, Darcy

2023 Volume 36, Issue 4, Page(s) 249–255

Abstract: Breaking free of pre-existing assumptions to achieve transformative change in care delivery remains challenging. This article presents a care process framework using a rapid task analysis tested with healthcare teams across five communities in British ... ...

Abstract	Breaking free of pre-existing assumptions to achieve transformative change in care delivery remains challenging. This article presents a care process framework using a rapid task analysis tested with healthcare teams across five communities in British Columbia, Canada, to provide leaders a novel and practical approach to care model development. The study's goals were to determine if the framework was replicable even though the population care needs differed for each community. The results showed the framework was replicable, informed the care model development, and identified ideal scopes of practice and team composition given the context of care. The framework also captured expert tacit knowledge and decision-making to build capacity given our current workforce challenges. For operational leaders and government agencies, the use of the framework may influence a shift in historical approaches that better aligns health and human resources capacity to population health and service needs.
MeSH term(s)	Humans ; Delivery of Health Care ; British Columbia ; Population Groups ; Patient Care Team
Language	English
Publishing date	2023-03-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2140831-2
ISSN	2352-3883 ; 0840-4704
ISSN (online)	2352-3883
ISSN	0840-4704
DOI	10.1177/08404704231157215
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Zs.A 5895: Show issues

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Article ; Online: Ramsay Hunt syndrome.

Montague, Steven J / Morton, A Ross

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

2017 Volume 189, Issue 8, Page(s) E320

MeSH term(s)	Aged, 80 and over ; Dementia/complications ; Female ; Herpes Zoster Oticus/complications ; Herpes Zoster Oticus/diagnosis ; Humans
Language	English
Publishing date	2017--27
Publishing country	Canada
Document type	Case Reports ; Journal Article
ZDB-ID	215506-0
ISSN	1488-2329 ; 0008-4409 ; 0820-3946
ISSN (online)	1488-2329
ISSN	0008-4409 ; 0820-3946
DOI	10.1503/cmaj.160483
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Article: Images - Acute urinary retention due to urethral steinstrasse.

Morton, Andrew / Gordon, Lachlan / Fowler, Ross / Esler, Rachel / Dunglison, Nigel / Roberts, Matthew J

Canadian Urological Association journal = Journal de l'Association des urologues du Canada

2020 Volume 15, Issue 5, Page(s) E299–E300

Language	English
Publishing date	2020-10-29
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2431403-1
ISSN	1911-6470
ISSN	1911-6470
DOI	10.5489/cuaj.6725
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Article: 'All Aboriginal and Torres Strait Islander children should have access to the ASQ-TRAK': Shared vision of an implementation support model for the ASQ-TRAK developmental screener.

D'Aprano, Anita / Hunter, Sue-Anne / Fry, Rebecca / Savaglio, Melissa / Carmody, Sarah / Boffa, John / Cooke, Louise / Dent, Abigail / Docksey, Amanda / Douglas, Josie / Dunn, Adam / Halfpenny, Nick / Hewett, Meg / Lipscomb, Adrienne / Manahan, Esmai / Morton, Belinda / Mosse, Holly / Ross, Dawn / Skouteris, Helen

Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals

2023 Volume 35, Issue 2, Page(s) 433–443

Abstract: Issue addressed: The ASQ-TRAK, a strengths-based approach to developmental screening, has high acceptability and utility across varied Aboriginal and Torres Strait Islander contexts. While substantive knowledge translation has seen many services utilise ...

Abstract	Issue addressed: The ASQ-TRAK, a strengths-based approach to developmental screening, has high acceptability and utility across varied Aboriginal and Torres Strait Islander contexts. While substantive knowledge translation has seen many services utilise ASQ-TRAK, we now need to move beyond distribution and support evidence-based scale-up to ensure access. Through a co-design approach, we aimed to (1) understand community partners' perspectives of barriers and enablers to ASQ-TRAK implementation and (2) develop an ASQ-TRAK implementation support model to inform scale-up. Methods: The co-design process had four phases: (i) partnership development with five community partners (two Aboriginal Community Controlled Organisations); (ii) workshop planning and recruitment; (iii) co-design workshops; and (iv) analysis, draft model and feedback workshops. Results: Seven co-design meetings and two feedback workshops with 41 stakeholders (17 were Aboriginal and Torres Strait Islander), identified seven key barriers and enablers, and a shared vision - all Aboriginal and Torres Strait Islander children and their families have access to the ASQ-TRAK. Implementation support model components agreed on were: (i) ASQ-TRAK training, (ii) ASQ-TRAK support, (iii) local implementation support, (iv) engagement and communications, (v) continuous quality improvement and (vi) coordination and partnerships. Conclusions: This implementation support model can inform ongoing processes necessary for sustainable ASQ-TRAK implementation nationally. This will transform the way services provide developmental care to Aboriginal and Torres Strait Islander children, ensuring access to high quality, culturally safe developmental care. SO WHAT?: Well-implemented developmental screening leads to more Aboriginal and Torres Strait Islander children receiving timely early childhood intervention services, improving developmental trajectories and optimising long-term health and wellbeing.
MeSH term(s)	Child ; Child, Preschool ; Humans ; Australian Aboriginal and Torres Strait Islander Peoples ; Health Services, Indigenous ; Child Development
Language	English
Publishing date	2023-07-11
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2250864-8
ISSN	2201-1617 ; 1036-1073
ISSN (online)	2201-1617
ISSN	1036-1073
DOI	10.1002/hpja.773
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Zs.A 6384: Show issues

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Article ; Online: Whole blood transfusion versus component therapy in adult trauma patients with acute major haemorrhage.

Avery, Pascale / Morton, Sarah / Tucker, Harriet / Green, Laura / Weaver, Anne / Davenport, Ross

Emergency medicine journal : EMJ

2020 Volume 37, Issue 6, Page(s) 370–378

Abstract: Objective: In the era of damage control resuscitation of trauma patients with acute major haemorrhage, transfusion practice has evolved to blood component (component therapy) administered in a ratio that closely approximates whole blood (WB). However, ... ...

Abstract	Objective: In the era of damage control resuscitation of trauma patients with acute major haemorrhage, transfusion practice has evolved to blood component (component therapy) administered in a ratio that closely approximates whole blood (WB). However, there is a paucity of evidence supporting the optimal transfusion strategy in these patients. The primary objective was therefore to establish if there is an improvement in survival at 30 days with the use of WB transfusion compared with blood component therapy in adult trauma patients with acute major haemorrhage. Methodology: A systematic literature search was performed on 15 December 2019 to identify studies comparing WB transfusion with component therapy in adult trauma patients and mortality at 30 days. Studies which did not report mortality were excluded. Methodological quality of included studies was interpreted using the Cochrane risk of bias tool, and rated using the Grading of Recommendations Assessment, Development and Evaluation approach. Results: Search of the databases identified 1885 records, and six studies met the inclusion criteria involving 3255 patients. Of the three studies reporting 30-day mortality (one randomised controlled trial (moderate evidence) and two retrospective (low and very low evidence, respectively)), only one study demonstrated a statistically significant difference between WB and component therapy, and two found no statistical difference. Two retrospective studies reporting in-hospital mortality found no statistical difference in unadjusted mortality, but both reported statistically significant logistic regression analyses demonstrating that those with a WB transfusion strategy were less likely to die. Conclusion: Recognising the limitations of this systematic review relating to the poor-quality evidence and limited number of included trials, it does not provide evidence to support or reject use of WB transfusion compared with component therapy for adult trauma patients with acute major haemorrhage. Prospero registration number: CRD42019131406.
MeSH term(s)	Adult ; Blood Component Transfusion/methods ; Blood Component Transfusion/standards ; Blood Component Transfusion/trends ; Blood Transfusion/methods ; Blood Transfusion/standards ; Blood Transfusion/trends ; Hemorrhage/etiology ; Hemorrhage/physiopathology ; Hemorrhage/therapy ; Humans ; Resuscitation/instrumentation ; Resuscitation/methods ; Wounds and Injuries/complications ; Wounds and Injuries/therapy
Language	English
Publishing date	2020-05-06
Publishing country	England
Document type	Journal Article ; Systematic Review
ZDB-ID	2040124-3
ISSN	1472-0213 ; 1472-0205
ISSN (online)	1472-0213
ISSN	1472-0205
DOI	10.1136/emermed-2019-209040
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Article: Less is more: a rationalization of daily labwork.

Chan, Barry / Nazerali-Maitland, Alasdair / Hopman, Wilma / Zelt, David / Morton, Ross

Canadian medical education journal

2018 Volume 9, Issue 4, Page(s) e135–e137

Language	English
Publishing date	2018-11-12
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2689512-2
ISSN	1923-1202
ISSN	1923-1202
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Article ; Online: A 10-year update to the principles for clinical trial data sharing by pharmaceutical companies: perspectives based on a decade of literature and policies.

Modi, Natansh D / Kichenadasse, Ganessan / Hoffmann, Tammy C / Haseloff, Mark / Logan, Jessica M / Veroniki, Areti A / Venchiarutti, Rebecca L / Smit, Amelia K / Tuffaha, Haitham / Jayasekara, Harindra / Manning-Bennet, Arkady / Morton, Erin / McKinnon, Ross A / Rowland, Andrew / Sorich, Michael J / Hopkins, Ashley M

BMC medicine

2023 Volume 21, Issue 1, Page(s) 400

Abstract: Data sharing is essential for promoting scientific discoveries and informed decision-making in clinical practice. In 2013, PhRMA/EFPIA recognised the importance of data sharing and supported initiatives to enhance clinical trial data transparency and ... ...

Abstract	Data sharing is essential for promoting scientific discoveries and informed decision-making in clinical practice. In 2013, PhRMA/EFPIA recognised the importance of data sharing and supported initiatives to enhance clinical trial data transparency and promote scientific advancements. However, despite these commitments, recent investigations indicate significant scope for improvements in data sharing by the pharmaceutical industry. Drawing on a decade of literature and policy developments, this article presents perspectives from a multidisciplinary team of researchers, clinicians, and consumers. The focus is on policy and process updates to the PhRMA/EFPIA 2013 data sharing commitments, aiming to enhance the sharing and accessibility of participant-level data, clinical study reports, protocols, statistical analysis plans, lay summaries, and result publications from pharmaceutical industry-sponsored trials. The proposed updates provide clear recommendations regarding which data should be shared, when it should be shared, and under what conditions. The suggested improvements aim to develop a data sharing ecosystem that supports science and patient-centred care. Good data sharing principles require resources, time, and commitment. Notwithstanding these challenges, enhancing data sharing is necessary for efficient resource utilization, increased scientific collaboration, and better decision-making for patients and healthcare professionals.
MeSH term(s)	Humans ; Information Dissemination ; Policy ; Drug Industry ; Clinical Trials as Topic
Language	English
Publishing date	2023-10-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2131669-7
ISSN	1741-7015 ; 1741-7015
ISSN (online)	1741-7015
ISSN	1741-7015
DOI	10.1186/s12916-023-03113-0
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Article ; Online: Next-generation sequencing and molecular therapy.

Morton, Cienne / Sarker, Debashis / Ross, Paul

Clinical medicine (London, England)

2023 Volume 23, Issue 1, Page(s) 65–69

Abstract: Cancers contain a plethora of mutations, few of which are critical to maintaining a state of malignancy. With our ever-expanding understanding of the genomic complexity of cancer, potentially actionable biomarkers whose inhibition could cripple cancer ... ...

Abstract	Cancers contain a plethora of mutations, few of which are critical to maintaining a state of malignancy. With our ever-expanding understanding of the genomic complexity of cancer, potentially actionable biomarkers whose inhibition could cripple cancer growth are increasingly being elucidated. Modern cancer drug development has largely switched from cytotoxic agents to targeted therapies and immunotherapy, with noteworthy success in several cancer types including non-small-cell lung cancer (NSCLC), breast cancer and melanoma. Next-generation sequencing offers high-throughput, widescale genomic interrogation in a far more efficient and affordable manner than previous sequencing methods. This facilitates detection of potentially actionable mutations and fusions for individual patients and contributes to the identification of novel predictive and prognostic biomarkers in a population. Challenges in the technical aspects of biopsy and sequencing, interpretation, and development of targeted therapies against common genomic aberrations will need to be addressed for personalised medicine to become a reality for more patients with cancer.
MeSH term(s)	Humans ; Female ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Melanoma/drug therapy ; Melanoma/genetics ; Breast Neoplasms ; Mutation ; High-Throughput Nucleotide Sequencing ; Biomarkers, Tumor/genetics ; Molecular Targeted Therapy
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2023-01-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2048646-7
ISSN	1473-4893 ; 1470-2118
ISSN (online)	1473-4893
ISSN	1470-2118
DOI	10.7861/clinmed.2022-0514
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Article: Composition of human breast milk in acute kidney injury.

Chruscicki, Adam / Morton, Alexander Ross / Akbari, Ayub / White, Christine Anne

Obstetric medicine

2017 Volume 10, Issue 2, Page(s) 79–82

Abstract: Background: Breastfeeding is a widely encouraged practice due to its benefits for mother and the infant. Little is known about the impact of disease states, such as kidney dysfunction and childbirth complications, on the composition of breast milk.: ... ...

Abstract	Background: Breastfeeding is a widely encouraged practice due to its benefits for mother and the infant. Little is known about the impact of disease states, such as kidney dysfunction and childbirth complications, on the composition of breast milk. Methods: We describe a case of a 35-year-old woman who suffered a postpartum hemorrhage, was administered a contrast dye prior to computer tomography, and developed an acute kidney injury. Using nuclear magnetic resonance spectrometry, we measured composition of milk in acute kidney injury. The amount of dye secreted into milk was determined using a spectroscopic assay. Results: Here we show that acute kidney injury results in changes in milk composition, but it does not significantly affect major macronutrients. We also determine that iodinated computer tomography contrast dye does not accumulate in milk in appreciable amounts. Conclusion: Acute kidney injury has impact on breast milk. Intravenous administration of computer tomography contrast dye does not result in significantly elevated levels in milk.
Language	English
Publishing date	2017-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2612229-7
ISSN	1753-4968 ; 1753-495X
ISSN (online)	1753-4968
ISSN	1753-495X
DOI	10.1177/1753495X16686276
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Article ; Online: Human brains preserve in diverse environments for at least 12 000 years.

Morton-Hayward, Alexandra L / Anderson, Ross P / Saupe, Erin E / Larson, Greger / Cosmidis, Julie G

Proceedings. Biological sciences

2024 Volume 291, Issue 2019, Page(s) 20232606

Abstract: The brain is thought to be among the first human organs to decompose after death. The discovery of brains preserved in the archaeological record is therefore regarded as unusual. Although mechanisms such as dehydration, freezing, saponification, and ... ...

Abstract	The brain is thought to be among the first human organs to decompose after death. The discovery of brains preserved in the archaeological record is therefore regarded as unusual. Although mechanisms such as dehydration, freezing, saponification, and tanning are known to allow for the preservation of the brain on short time scales in association with other soft tissues (≲4000 years), discoveries of older brains, especially in the absence of other soft tissues, are rare. Here, we collated an archive of more than 4400 human brains preserved in the archaeological record across approximately 12 000 years, more than 1300 of which constitute the only soft tissue preserved amongst otherwise skeletonized remains. We found that brains of this type persist on time scales exceeding those preserved by other means, which suggests an unknown mechanism may be responsible for preservation particular to the central nervous system. The untapped archive of preserved ancient brains represents an opportunity for bioarchaeological studies of human evolution, health and disease.
MeSH term(s)	Humans ; Brain ; Central Nervous System ; Head
Language	English
Publishing date	2024-03-20
Publishing country	England
Document type	Journal Article
ZDB-ID	209242-6
ISSN	1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
ISSN (online)	1471-2954
ISSN	0080-4649 ; 0962-8452 ; 0950-1193
DOI	10.1098/rspb.2023.2606
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