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Article ; Online: Relapsing Tubulointerstitial Nephritis with Antimitochondrial M2 Antibody Accompanied by Pulmonary Involvement.

Nakamori, Aya / Akagaki, Fuyuko / Yamaguchi, Yoshito / Sugiura, Toshihiro

2020 Volume 59, Issue 9, Page(s) 1179–1187

Abstract: We herein report a 50-year-old woman who suffered from tubulointerstitial nephritis with antimitochondrial M2 antibody, distal renal tubular acidosis, and Fanconi syndrome. Our case also had interstitial pneumonia. After initially successful ... ...

Abstract	We herein report a 50-year-old woman who suffered from tubulointerstitial nephritis with antimitochondrial M2 antibody, distal renal tubular acidosis, and Fanconi syndrome. Our case also had interstitial pneumonia. After initially successful glucocorticoid therapy, tubulointerstitial nephritis and interstitial pneumonia relapsed. After the second successful round of glucocorticoid therapy, tubulointerstitial nephritis relapsed again and responded to glucocorticoid and azathioprine. This case might indicate (1) the association between pulmonary involvement and tubulointerstitial nephritis with antimitochondrial antibodies and (2) the need for a maintenance dose of glucocorticoid and immunosuppressants in tubulointerstitial nephritis with antimitochondrial antibodies.
MeSH term(s)	Acidosis, Renal Tubular/complications ; Acidosis, Renal Tubular/diagnosis ; Acidosis, Renal Tubular/drug therapy ; Autoantibodies/blood ; Diagnosis, Differential ; Fanconi Syndrome/complications ; Fanconi Syndrome/diagnosis ; Fanconi Syndrome/drug therapy ; Female ; Glucocorticoids/therapeutic use ; Humans ; Lung Diseases, Interstitial/complications ; Lung Diseases, Interstitial/diagnosis ; Lung Diseases, Interstitial/drug therapy ; Middle Aged ; Mitochondria/immunology ; Nephritis, Interstitial/complications ; Nephritis, Interstitial/diagnosis ; Nephritis, Interstitial/drug therapy ; Recurrence
Chemical Substances	Autoantibodies ; Glucocorticoids
Language	English
Publishing date	2020-02-12
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.4048-19
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Article ; Online: To Be in Remission or in Corticosteroid-free Remission: That Is the Question for Women With Inflammatory Bowel Disease at Conception.

Kunisaki, Reiko / Ikeda, Aya / Yaguchi, Katsuki / Onishi, Misa / Shibui, Shunsuke / Nishida, Daisuke / Madarame, Akira / Toritani, Kenichiro / Nakamori, Yoshinori / Nishio, Masafumi / Ogashiwa, Tsuyoshi / Fujii, Ayako / Kimura, Hideaki / Suzuki, Ryoichi / Aoki, Shigeru / Maeda, Shin

Inflammatory bowel diseases

2023 Volume 29, Issue 6, Page(s) e20–e21

MeSH term(s)	Pregnancy ; Female ; Humans ; Colitis, Ulcerative ; Pregnant Women ; Inflammatory Bowel Diseases/drug therapy ; Crohn Disease ; Adrenal Cortex Hormones/therapeutic use
Chemical Substances	Adrenal Cortex Hormones
Language	English
Publishing date	2023-03-06
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	1340971-2
ISSN	1536-4844 ; 1078-0998
ISSN (online)	1536-4844
ISSN	1078-0998
DOI	10.1093/ibd/izad023
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Article ; Online: Prediction of Acute Glomerular Filtration Rate Reductions Following Renin-angiotensin System Blockade in Chronic Kidney Disease: A Possible Application of Ultrasonography in Clinical Practice.

Sugiura, Toshihiro / Akagaki, Fuyuko / Yamaguchi, Yoshito / Nakamori, Aya

Internal medicine (Tokyo, Japan)

2019 Volume 58, Issue 9, Page(s) 1233–1241

Abstract: Objective Renal arteriolosclerosis is a risk factor for acute reductions in the glomerular filtration rate (GFR) when renin-angiotensin system (RAS) inhibitors are administered. Renal arteriolosclerosis can be detected by an increase in the resistive ... ...

Abstract	Objective Renal arteriolosclerosis is a risk factor for acute reductions in the glomerular filtration rate (GFR) when renin-angiotensin system (RAS) inhibitors are administered. Renal arteriolosclerosis can be detected by an increase in the resistive index (RI) on Doppler ultrasonography. The purpose of the present study is to determine whether or not the RI can predict acute GFR reductions following RAS blockade in chronic kidney disease (CKD). Methods We surveyed all CKD patients who were hospitalized in Otemae Hospital from January 2008 to December 2017. One hundred and eight patients who had been newly treated with RAS inhibitors were able to be followed for 14 weeks. The end point was an acute reduction in the GFR, defined as a decrease of ≥30%. Results Twenty-three of the 108 patients presented with acute GFR reductions. The cumulative probability of acute GFR reductions was 3.3% and 53% in patients with RI ≤0.70 and RI >0.70, respectively (p<0.001). A univariate Cox proportional-hazards analysis showed that the RI, age, GFR, systolic blood pressure, urinary protein excretion, diabetic kidney disease, coronary artery disease, and use of diuretics were significant variables. Multivariate hazard ratios were calculated from the RI and three established variables (age, GFR, diuretics), and the RI and use of diuretics were shown to be significant risk factors for acute GFR reductions. Conclusion These results suggest that an increase in the RI, as well as the use of diuretics, may be risk factors for acute GFR reductions following RAS blockade.
MeSH term(s)	Aged ; Angiotensin II Type 1 Receptor Blockers/adverse effects ; Angiotensin II Type 1 Receptor Blockers/pharmacology ; Angiotensin II Type 1 Receptor Blockers/therapeutic use ; Arteriosclerosis/chemically induced ; Arteriosclerosis/diagnostic imaging ; Blood Pressure/physiology ; Diabetic Nephropathies/complications ; Diuretics/adverse effects ; Female ; Glomerular Filtration Rate/drug effects ; Glomerular Filtration Rate/physiology ; Humans ; Kidney/diagnostic imaging ; Male ; Middle Aged ; Renal Artery/diagnostic imaging ; Renal Insufficiency, Chronic/drug therapy ; Renal Insufficiency, Chronic/physiopathology ; Renin-Angiotensin System/drug effects ; Renin-Angiotensin System/physiology ; Retrospective Studies ; Risk Factors ; Ultrasonography, Doppler/methods
Chemical Substances	Angiotensin II Type 1 Receptor Blockers ; Diuretics
Language	English
Publishing date	2019-01-10
Publishing country	Japan
Document type	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.1444-18
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Article: [Surgical ulcerative colitis complicated by multiple lung abscesses secondary to septic pulmonary embolism after multidrug immunosuppressive therapies].

Araki, Kentaro / Kimura, Hideaki / Nakamori, Yoshinori / Madarame, Akira / Ikeda, Aya / Hirayama, Atsuhiro / Kunisaki, Reiko / Endo, Itaru

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology

2022 Volume 119, Issue 11, Page(s) 1029–1035

Abstract: This is a case implying a serious infectious complication risk during intensive severe ulcerative colitis treatment. A 26-year-old man developed diarrhea and bloody stool who was diagnosed with ulcerative colitis in 2018. He was managed with 5- ... ...

Abstract	This is a case implying a serious infectious complication risk during intensive severe ulcerative colitis treatment. A 26-year-old man developed diarrhea and bloody stool who was diagnosed with ulcerative colitis in 2018. He was managed with 5-aminosalicylic acid, but intolerance reaction resulted in discontinuation of treatment. He relapsed with severe abdominal pain and bloody stools in February 2019. He was referred to our department for intensive therapy. He had been treated with steroids, tacrolimus, granulocyte and monocyte apheresis, infliximab or tofacitinib, which temporarily improved his clinical symptoms. However, his medical condition could not be controlled. Hand-assisted laparoscopic subtotal colectomy was then performed in October 2019. He developed intermittent fever on postoperative day 3. Enhanced computed tomography (CT) revealed multiple deep vein thromboses and pulmonary embolism. Antibiotics and anticoagulation therapy were initiated, but postoperative day 13 CT showed multiple pulmonary cavities containing fluids and air, which were diagnosed as pulmonary abscess. His intermittent fever was over 38.0°C. Severe cough and hemoptysis lasted 3 weeks, the clinical symptoms and laboratory data then gradually improved after the fourth week.
MeSH term(s)	Male ; Humans ; Adult ; Colitis, Ulcerative/drug therapy ; Lung Abscess/complications ; Lung Abscess/drug therapy ; Infliximab/therapeutic use ; Immunosuppression Therapy ; Pulmonary Embolism/diagnostic imaging ; Pulmonary Embolism/drug therapy ; Pulmonary Embolism/etiology
Chemical Substances	Infliximab (B72HH48FLU)
Language	Japanese
Publishing date	2022-11-07
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	708695-7
ISSN	1349-7693 ; 0446-6586
ISSN (online)	1349-7693
ISSN	0446-6586
DOI	10.11405/nisshoshi.119.1029
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Article: Detailed findings of videofluoroscopic examination among patients with Parkinson's disease on the effect of cervical percutaneous interferential current stimulation.

Nakamori, Masahiro / Toko, Megumi / Yamada, Hidetada / Hayashi, Yuki / Haruta, Azusa / Hiraoka, Aya / Yoshikawa, Mineka / Nagasaki, Toshikazu / Ushio, Kai / Yoshikawa, Kohei / Shimizu, Yoshitaka / Mikami, Yukio / Maruyama, Hirofumi

Frontiers in neurology

2023 Volume 14, Page(s) 1279161

Abstract: Introduction: Parkinson's disease (PD) leads to various types of swallowing disorders. We investigated the effect of cervical percutaneous interferential current stimulation on dysphagia. By conducting detailed qualitative and quantitative analysis of ... ...

Abstract	Introduction: Parkinson's disease (PD) leads to various types of swallowing disorders. We investigated the effect of cervical percutaneous interferential current stimulation on dysphagia. By conducting detailed qualitative and quantitative analysis of videofluoroscopic examination, we aimed to understand dysphagia in patients with PD and investigate its effects on swallowing function. Methods: Patients received cervical percutaneous interferential current stimulation for 20 min twice a week for 8 weeks. In this exploratory study, we evaluated aspiration/laryngeal penetration, oral cavity residue, vallecular residue, and pharyngeal residue. In addition, we performed temporal analysis. Results: Twenty-five patients were completely evaluated. At baseline, the proportions of laryngeal penetration/aspiration, oral cavity residue, epiglottic vallecula residue, and pharyngeal residue were 40.0, 88.0, 72.0, 60.0, and 16.0%, respectively. Conversely, pharyngeal transit time, laryngeal elevation delay time, pharyngeal delay time, and swallowing reflex delay were nearly within the normal ranges. Cervical percutaneous interferential current sensory stimulation improved only oral cavity residue at the end of the intervention, from 88.0 to 56.0%. Discussion: Patients with PD demonstrated remarkably high frequencies of residues in the oral and pharyngeal regions. The usefulness of cervical interferential current stimulation was partially demonstrated for oral cavity residue. Considering that PD exhibits diverse symptoms, further accumulation of cases and knowledge is warranted. Trial registration: jRCTs062220013.
Language	English
Publishing date	2023-11-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2023.1279161
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Article ; Online: Impact of neck percutaneous interferential current sensory stimulation on swallowing function in patients with Parkinson's disease: A single-arm, open-label study protocol.

Nakamori, Masahiro / Toko, Megumi / Yamada, Hidetada / Hayashi, Yuki / Yoshikawa, Kohei / Yoshikawa, Mineka / Nagasaki, Toshikazu / Hiraoka, Aya / Shimizu, Yoshitaka / Mikami, Yukio / Maruyama, Hirofumi

Contemporary clinical trials communications

2023 Volume 33, Page(s) 101158

Abstract: Background: Parkinson's disease (PD) can lead to swallowing dysfunction, resulting in aspiration pneumonia. Among the types of swallowing disorders, a characteristic and serious problem associated with PD is silent aspiration due to pharyngeal and ... ...

Abstract	Background: Parkinson's disease (PD) can lead to swallowing dysfunction, resulting in aspiration pneumonia. Among the types of swallowing disorders, a characteristic and serious problem associated with PD is silent aspiration due to pharyngeal and laryngeal hypoesthesia. Methods: This single-arm, open-label study aims to evaluate the effectiveness of percutaneous neck interferential current sensory stimulation in enhancing swallowing function in patients with PD. The efficacy and safety of percutaneous neck interferential current sensory stimulation will be investigated for patients diagnosed with PD, based on the Movement Disorder Society criteria, of Hoehn-Yahr stages 2-4. The patients will receive neck percutaneous interferential current sensory stimulation for 20 min twice a week for 8 weeks using a Gentle Stim® (FoodCare Co., Ltd., Kanagawa, Japan) device. Once the intervention is initiated, evaluations will be performed every 4 weeks for a 16-week period. The primary endpoint to be assessed is the proportion of patients with normal cough with 1% citric acid at the end of the intervention (8 weeks after intervention initiation) compared with that at the beginning. This clinical trial will examine the usefulness of percutaneous neck interferential current sensory stimulation in patients with PD. In addition, this study will use novel instruments, such as multichannel surface electromyography and electronic stethoscope, to evaluate swallowing function. Discussion: This novel evaluation can provide insights into dysphagia in patients with PD and the usefulness of percutaneous neck interferential current stimulation. This exploratory study is limited by its single-arm, open-label design and small size. Trial registration number: jRCTs062220013; pre-results.
Language	English
Publishing date	2023-06-10
Publishing country	Netherlands
Document type	Journal Article
ISSN	2451-8654
ISSN (online)	2451-8654
DOI	10.1016/j.conctc.2023.101158
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Article ; Online: Swallowing sound index analysis using electronic stethoscope and artificial intelligence for patients with Parkinson's disease.

Nakamori, Masahiro / Shimizu, Yoshitaka / Takahashi, Tamayo / Toko, Megumi / Yamada, Hidetada / Hayashi, Yuki / Ushio, Kai / Yoshikawa, Kohei / Hiraoka, Aya / Yoshikawa, Mineka / Nagasaki, Toshikazu / Mikami, Yukio / Maruyama, Hirofumi

Journal of the neurological sciences

2023 Volume 454, Page(s) 120831

Abstract: Background and purpose: Several noninvasive tools assess swallowing disorders, including electronic stethoscope artificial intelligence (AI) analysis for remote diagnosis, with the potential for telemedicine. This study investigated the swallowing sound ...

Abstract	Background and purpose: Several noninvasive tools assess swallowing disorders, including electronic stethoscope artificial intelligence (AI) analysis for remote diagnosis, with the potential for telemedicine. This study investigated the swallowing sound index in patients with Parkinson's disease (PD). Methods: This single-arm, open-label trial assessed the impact of cervical percutaneous interferential current stimulation on swallowing in patients with PD classified as Hoehn-Yahr stages 2-4. Stimulation was conducted for 8 weeks. Baseline data were used to examine the link between the swallowing sound index and indicators such as videofluoroscopy (VF). Furthermore, we examined changes in the swallowing sound index after the intervention. Results: Twenty-five patients were included. The swallowing sound index in patients with PD was higher than that in those with amyotrophic lateral sclerosis but considerably lower than that in healthy controls. The number of patients with normal EAT-10 scores positively correlated with the swallowing sound index, whereas elevated C-reactive protein levels were negatively correlated with the swallowing sound index. However, the index displayed no correlation with other indicators, including the VF results. Despite the intervention, the index remained unchanged throughout the study. Conclusion: In patients with PD, a decrease in the swallowing sound index suggests a potential association between swallowing disorders and the risk of aspiration pneumonia. Trial registration number: jRCTs062220013.
MeSH term(s)	Humans ; Deglutition/physiology ; Parkinson Disease/diagnosis ; Parkinson Disease/diagnostic imaging ; Deglutition Disorders/diagnostic imaging ; Deglutition Disorders/etiology ; Artificial Intelligence ; Stethoscopes ; Electronics
Language	English
Publishing date	2023-10-10
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80160-4
ISSN	1878-5883 ; 0022-510X ; 0374-8642
ISSN (online)	1878-5883
ISSN	0022-510X ; 0374-8642
DOI	10.1016/j.jns.2023.120831
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Article ; Online: Association between motor symptoms of Parkinson's disease and swallowing disorders.

Nakamori, Masahiro / Toko, Megumi / Yamada, Hidetada / Hayashi, Yuki / Ushio, Kai / Yoshikawa, Kohei / Haruta, Azusa / Hiraoka, Aya / Yoshikawa, Mineka / Nagasaki, Toshikazu / Mikami, Yukio / Maruyama, Hirofumi

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2023 Volume 45, Issue 5, Page(s) 2021–2026

Abstract: Background: Parkinson's disease (PD) presents with motor symptoms that hinder physical activity. This study aimed to thoroughly investigate swallowing dysfunction in patients with PD using videofluoroscopy (VF) and the Movement Disorder Society (MDS)- ... ...

Abstract	Background: Parkinson's disease (PD) presents with motor symptoms that hinder physical activity. This study aimed to thoroughly investigate swallowing dysfunction in patients with PD using videofluoroscopy (VF) and the Movement Disorder Society (MDS)-Unified PD Rating Scale (UPDRS) sub-scores. Methods: This study was part of an intervention project to evaluate the effectiveness of cervical percutaneous interferential current stimulation in patients with Hoehn and Yahr stages 2-4 PD. Baseline data, including swallowing-related indicators such as VF, were obtained and compared to the MDS-UPDRS sub-scores including rigidity, tremor, postural instability/gait difficulty, and limb scores. Results: Twenty-seven patients were included in this study. In the VF analysis, laryngeal penetration/aspiration, oral cavity residue, epiglottic vallecular residue, and pharyngeal residue were observed with remarkable frequency. The multivariate analysis revealed that the mean rigidity score of UPDRS was an independent and significantly correlated factor with laryngeal penetration/aspiration during the ingestion of 10 mL of water (odds ratio 1.294, 95% confidence interval 1.035-1.617; p = 0.024). Conclusion: This study revealed a correlation between muscle rigidity and laryngeal penetration or aspiration risk. The detailed comparative analysis of various individual PD symptoms and swallowing disorders was substantial, which enabled early detection of the risk of swallowing disorder and the implementation of appropriate measures. Trial registration number: jRCTs062220013.
MeSH term(s)	Humans ; Parkinson Disease/complications ; Parkinson Disease/diagnostic imaging ; Deglutition Disorders/etiology ; Deglutition Disorders/complications ; Tremor/complications ; Mental Status and Dementia Tests
Language	English
Publishing date	2023-12-06
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-023-07238-1
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Article ; Online: Chronological renal resistive index increases related to atherosclerotic factors, and effect of renin-angiotensin system inhibitors.

Yamaguchi, Yoshito / Akagaki, Fuyuko / Nakamori, Aya / Sugiura, Toshihiro

Clinical and experimental nephrology

2018 Volume 23, Issue 4, Page(s) 513–520

Abstract: Background: Renal resistive index (RI) calculated using renal Doppler ultrasonography (RDU) has recently been considered a clinically important indicator of renal outcome, survival, and systemic arteriosclerotic disorders. However, the cause of RI ... ...

Abstract	Background: Renal resistive index (RI) calculated using renal Doppler ultrasonography (RDU) has recently been considered a clinically important indicator of renal outcome, survival, and systemic arteriosclerotic disorders. However, the cause of RI elevation remains unclear. The present study was an effort to first, identify the factors related to RI elevation, and second, understand the effect of renin-angiotensin system inhibitors (RAS-Is) on renal RI elevation. Methods: We carried out this single-center case-control study among 100 CKD patients, recruited from outpatients who underwent RDU more than twice, at least a year apart. The rate of renal RI change per year (dRIpy) was chosen as the dependent variable: [(last examined renal RI-initial examined renal RI)/(initial examined renal RI × period of observation) × 100 (%/year)]. We examined the association between dRIpy and other clinical and biological data. Results: Among 100 CKD patients, the average serum creatinine and eGFR were 1.76 ± 0.84 mg/dL and 37.0 ± 18.2 ml/min/1.73 m Conclusions: This study demonstrated that the elevation of RI was related to DM, eGFR, high LDL, and the use of RAS-Is. In particular, RAS-Is could contribute towards suppressing the elevation of RI in CKD patients and towards preventing the development of renal failure in CKD patients.
MeSH term(s)	Aged ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Antihypertensive Agents/therapeutic use ; Arteriosclerosis/physiopathology ; Blood Flow Velocity ; Blood Pressure ; Case-Control Studies ; Cholesterol, LDL/blood ; Creatinine/blood ; Diabetes Complications/complications ; Diabetes Complications/physiopathology ; Disease Progression ; Female ; Follow-Up Studies ; Glomerular Filtration Rate ; Humans ; Male ; Middle Aged ; Renal Circulation ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/physiopathology ; Renin-Angiotensin System/drug effects ; Time Factors ; Ultrasonography, Doppler, Color ; Vascular Resistance
Chemical Substances	Angiotensin-Converting Enzyme Inhibitors ; Antihypertensive Agents ; Cholesterol, LDL ; Creatinine (AYI8EX34EU)
Language	English
Publishing date	2018-11-13
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1338768-6
ISSN	1437-7799 ; 1342-1751
ISSN (online)	1437-7799
ISSN	1342-1751
DOI	10.1007/s10157-018-1667-y
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Article ; Online: Appropriate Preconception Corticosteroid-Free Remission Period in Pregnant Women With Ulcerative Colitis.

Ikeda, Aya / Kunisaki, Reiko / Aoki, Shigeru / Yaguchi, Katsuki / Madarame, Akira / Nishio, Masafumi / Ogashiwa, Tsuyoshi / Nakamori, Yoshinori / Kimura, Hideaki / Suzuki, Ryoichi / Saigusa, Yusuke / Maeda, Shin

Inflammatory bowel diseases

2023 Volume 30, Issue 5, Page(s) 726–734

Abstract: Background: In women with inflammatory bowel disease, at least 3 months of preconception corticosteroid-free remission (CFREM) is recommended by experts in current consensus statements. However, data are lacking on the appropriate preconception ... ...

Abstract	Background: In women with inflammatory bowel disease, at least 3 months of preconception corticosteroid-free remission (CFREM) is recommended by experts in current consensus statements. However, data are lacking on the appropriate preconception remission period. We investigated the appropriate preconception CFREM period in women with ulcerative colitis to reduce maternal disease activity and adverse pregnancy outcomes (ie, preterm birth, low birth weight, and small for gestational age). Methods: We retrospectively examined 141 pregnancies in women with ulcerative colitis at 2 institutions. We categorized the patients into 3 subgroups by their preconception CFREM period (≥3 months, >0 to <3 months, and non-CFREM). We also investigated disease activity during pregnancy and postpartum and adverse pregnancy outcomes in each group. Results: During pregnancy, the rate of active disease was significantly lower in the ≥3 months and >0 to <3 months CFREM groups compared with that in the non-CFREM group (P < .001 and P = .0257, respectively). Postpartum, the rate of active disease was significantly lower in the ≥3 months CFREM group compared with that in the non-CFREM group (P = .0087). The preconception CFREM period of ≥3 months was an independent inhibitory factor for active disease during pregnancy and postpartum (adjusted odds ratio, 0.15; P = .0035; and adjusted odds ratio, 0.33; P = .027, respectively). Adverse pregnancy outcomes were less common in the >3 months CFREM group compared with those in the other groups, but this difference was not significant. Conclusions: A preconception CFREM period of more than 3 months may be appropriate for better maternal and adverse pregnancy outcomes, as recommended in consensus statements.
MeSH term(s)	Humans ; Pregnancy ; Female ; Colitis, Ulcerative/drug therapy ; Retrospective Studies ; Adult ; Pregnancy Outcome ; Pregnancy Complications ; Remission Induction ; Preconception Care/methods ; Infant, Newborn ; Adrenal Cortex Hormones/therapeutic use ; Premature Birth ; Young Adult ; Postpartum Period
Chemical Substances	Adrenal Cortex Hormones
Language	English
Publishing date	2023-01-25
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	1340971-2
ISSN	1536-4844 ; 1078-0998
ISSN (online)	1536-4844
ISSN	1078-0998
DOI	10.1093/ibd/izac270
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