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Article: Interrelationships among vitamins A, E and K when added to the rations of fattening beef cattle.

Perry, T W / Beeson, W M / Smith, W H / Harrington, R B / Mohler, M T

1968 Volume 27, Issue 1, Page(s) 190–194

MeSH term(s)	Animal Feed ; Animals ; Cattle/metabolism ; Liver/analysis ; Male ; Vitamin A/analysis ; Vitamin A/blood ; Vitamin E/blood ; Vitamin K
Chemical Substances	Vitamin A (11103-57-4) ; Vitamin K (12001-79-5) ; Vitamin E (1406-18-4)
Language	English
Publishing date	1968-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	390959-1
ISSN	1525-3163 ; 0021-8812
ISSN (online)	1525-3163
ISSN	0021-8812
DOI	10.2527/jas1968.271190x
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Article: Mapping yield and yield-related traits using diverse common bean germplasm.

Reinprecht, Yarmilla / Schram, Lyndsay / Perry, Gregory E / Morneau, Emily / Smith, Thomas H / Pauls, K Peter

Frontiers in genetics

2024 Volume 14, Page(s) 1246904

Abstract: Common bean (bean) is one of the most important legume crops, and mapping genes for yield and yield-related traits is essential for its improvement. However, yield is a complex trait that is typically controlled by many loci in crop genomes. The ... ...

Abstract	Common bean (bean) is one of the most important legume crops, and mapping genes for yield and yield-related traits is essential for its improvement. However, yield is a complex trait that is typically controlled by many loci in crop genomes. The objective of this research was to identify regions in the bean genome associated with yield and a number of yield-related traits using a collection of 121 diverse bean genotypes with different yields. The beans were evaluated in replicated trials at two locations, over two years. Significant variation among genotypes was identified for all traits analyzed in the four environments. The collection was genotyped with the BARCBean6K_3 chip (5,398 SNPs), two yield/antiyield gene-based markers, and seven markers previously associated with resistance to common bacterial blight (CBB), including a Niemann-Pick polymorphism (NPP) gene-based marker. Over 90% of the single-nucleotide polymorphisms (SNPs) were polymorphic and separated the panel into two main groups of small-seeded and large-seeded beans, reflecting their Mesoamerican and Andean origins. Thirty-nine significant marker-trait associations (MTAs) were identified between 31 SNPs and 15 analyzed traits on all 11 bean chromosomes. Some of these MTAs confirmed genome regions previously associated with the yield and yield-related traits in bean, but a number of associations were not reported previously, especially those with derived traits. Over 600 candidate genes with different functional annotations were identified for the analyzed traits in the 200-Kb region centered on significant SNPs. Fourteen SNPs were identified within the gene model sequences, and five additional SNPs significantly associated with five different traits were located at less than 0.6 Kb from the candidate genes. The work confirmed associations between two yield/antiyield gene-based markers (AYD1m and AYD2m) on chromosome Pv09 with yield and identified their association with a number of yield-related traits, including seed weight. The results also confirmed the usefulness of the NPP marker in screening for CBB resistance. Since disease resistance and yield measurements are environmentally dependent and labor-intensive, the three gene-based markers (CBB- and two yield-related) and quantitative trait loci (QTL) that were validated in this work may be useful tools for simplifying and accelerating the selection of high-yielding and CBB-resistant bean cultivars.
Language	English
Publishing date	2024-01-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2023.1246904
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Article ; Online: Gender differences in health-seeking behaviour, diagnosis and treatment for TB.

Danarastri, S / Perry, K E / Hastomo, Y E / Priyonugroho, K

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

2022 Volume 26, Issue 6, Page(s) 568–570

MeSH term(s)	Humans ; Health Behavior ; Patient Acceptance of Health Care ; Sex Factors ; Tuberculosis/therapy
Language	English
Publishing date	2022-06-01
Publishing country	France
Document type	Letter ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1385624-8
ISSN	1815-7920 ; 1027-3719
ISSN (online)	1815-7920
ISSN	1027-3719
DOI	10.5588/ijtld.21.0735
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Article ; Online: Prevalence of Malnutrition in People with Dementia in Long-Term Care: A Systematic Review and Meta-Analysis.

Perry, Emma / Walton, Karen / Lambert, Kelly

Nutrients

2023 Volume 15, Issue 13

Abstract: Dementia is a common syndrome in older people. Dementia alters eating behaviors, hunger and thirst cues, swallow function, ability to self-feed, and recognition and interest in food. There is significant variation in the reported prevalence of ... ...

Abstract	Dementia is a common syndrome in older people. Dementia alters eating behaviors, hunger and thirst cues, swallow function, ability to self-feed, and recognition and interest in food. There is significant variation in the reported prevalence of malnutrition among older people who live in long-term care. The aim was to conduct a systematic literature review and meta-analysis of the prevalence of malnutrition in those with dementia living in long-term care using a validated nutrition assessment tool. Scopus, Web of Science, CINAHL, and Medline were searched. A random effects model was used to determine the prevalence and risk of malnutrition. Data were retrieved from 24 studies. Most of the studies were from Europe or South Asia. The prevalence of malnutrition ranged from 6.8 to 75.6%, and the risk of malnutrition was 36.5-90.4%. The pooled prevalence of malnutrition in those with dementia in long-term care was 26.98% (95% CI 22.0-32.26,
MeSH term(s)	Humans ; Aged ; Long-Term Care ; Prevalence ; Malnutrition/epidemiology ; Nutrition Assessment ; Dementia/epidemiology
Language	English
Publishing date	2023-06-28
Publishing country	Switzerland
Document type	Systematic Review ; Meta-Analysis ; Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15132927
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Article ; Online: First Responders' Views of Naloxone: Does Stigma Matter?

Kruis, Nathan E / McLean, Katherine / Perry, Payton / Nackley, Marielle K

Substance use & misuse

2022 Volume 57, Issue 10, Page(s) 1534–1544

Abstract: ... United States. Bivariate and multivariable analyses assessed the relationship between variants of stigma (e.g ...

Abstract	Background: Prior work has suggested that first responders have mixed feelings about harm reduction strategies used to fight the opioid epidemic, such as the use of naloxone to reverse opioid overdose. Researchers have also noted that provider-based stigma of people who use opioids (PWUO) may influence perceptions of appropriate interventions for opioid use disorder (OUD). This study examined first responders' perceptions of naloxone and the relationship between stigma of OUD and perceptions of naloxone. Methods: A web-based survey assessing perceptions of PWUO and naloxone was administered to 282 police officers and students enrolled in EMT and paramedic training courses located in the Northeastern United States. Bivariate and multivariable analyses assessed the relationship between variants of stigma (e.g., perceived dangerousness, blame, social distance, and fatalism) and self-reported perceptions of naloxone. Results: Participants, in the aggregate, held slightly negative attitudes toward the use of naloxone. Findings from multivariable modeling suggest that stigma of OUD, living in a rural area, and prior experience administering naloxone, were significantly and inversely related to support for the use of naloxone. Support for the disease model of addiction and associating drug use with low socioeconomic status were positively related to support for the use of naloxone. Conclusion: Efforts to alleviate perceptions of PWUO as dangerous, blameworthy, or incapable of recovery may increase first responders' support for naloxone. To this end, first responder training programs should include instruction on the disease model of addiction, and more broadly, attempt to foster familiarity between PWUO and the professionals who serve them.
MeSH term(s)	Analgesics, Opioid/therapeutic use ; Drug Overdose ; Emergency Responders ; Humans ; Naloxone/therapeutic use ; Narcotic Antagonists/therapeutic use ; Opioid-Related Disorders/complications ; Opioid-Related Disorders/drug therapy
Chemical Substances	Analgesics, Opioid ; Narcotic Antagonists ; Naloxone (36B82AMQ7N)
Language	English
Publishing date	2022-07-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1310358-1
ISSN	1532-2491 ; 1082-6084
ISSN (online)	1532-2491
ISSN	1082-6084
DOI	10.1080/10826084.2022.2092150
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Zs.B 935: Show issues

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Article ; Online: Low-density lipoprotein cholesterol in adolescents and young adults with type 1 diabetes: Data from the Australasian Diabetes Data Network registry.

James, S / Donaghue, K C / Perry, L / Lowe, J / Colman, P G / Craig, M E

Diabetic medicine : a journal of the British Diabetic Association

2023 Volume 40, Issue 11, Page(s) e15184

Abstract: Aim: To determine low-density lipoprotein cholesterol (LDL-C) screening frequency and levels, and factors associated with elevated LDL-C, in Australasian youth with type 1 diabetes (T1D).: Methods: Data were extracted from the Australasian Diabetes ... ...

Abstract	Aim: To determine low-density lipoprotein cholesterol (LDL-C) screening frequency and levels, and factors associated with elevated LDL-C, in Australasian youth with type 1 diabetes (T1D). Methods: Data were extracted from the Australasian Diabetes Data Network (ADDN), a prospective clinical quality registry, on all T1D healthcare visits attended by young people aged 16-25 years (with T1D duration of >1 year) between January 2011 and December 2020. The primary outcomes were elevated LDL-C > 2.6 mmol/L (100 mg/dL) and threshold for treatment: >3.4 mmol/L (130 mg/dL), according to consensus guidelines. Multivariable Generalised Estimated Equations (GEE) were used to examine factors associated with elevated LDL-C across all visits. Results: A cohort of 6338 young people (52.6% men) were identified, of whom 1603 (25.3%) had ≥1 LDL-C measurement documented. At last measurement, mean age, age at T1D diagnosis and T1D duration were 18.3 ± 2.4, 8.8 ± 4.5 and 8.9 ± 4.8 years, respectively. LDL-C was elevated in 737 (46.0%) and at the treatment threshold in 250 (15.6%). In multivariable GEE elevated LDL-C continuously was associated with older age (OR = 0.07; 0.01-0.13, p = 0.02), female sex (OR = 0.31; 0.18-0.43; p < 0.001), higher HbA1c (OR = 0.04; 0.01-0.08; p = 0.01) and having an elevated BMI (OR = 0.17, 0.06-0.39, p < 0.001). Conclusions: LDL-C screening and levels are suboptimal in this cohort, increasing future cardiovascular complication risk. There is an urgent need to understand how healthcare services can support improved screening and management of dyslipidaemia in this population.
MeSH term(s)	Male ; Humans ; Adolescent ; Female ; Young Adult ; Diabetes Mellitus, Type 1/drug therapy ; Cholesterol, LDL ; Prospective Studies ; Dyslipidemias/epidemiology ; Dyslipidemias/drug therapy ; Cardiovascular Diseases/epidemiology
Chemical Substances	Cholesterol, LDL
Language	English
Publishing date	2023-07-27
Publishing country	England
Document type	Journal Article
ZDB-ID	605769-x
ISSN	1464-5491 ; 0742-3071 ; 1466-5468
ISSN (online)	1464-5491
ISSN	0742-3071 ; 1466-5468
DOI	10.1111/dme.15184
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Zs.A 1954: Show issues

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Article ; Online: Sex- and age-based comparison of serum immunoglobulins following liver transplantation.

Perry, Whitney A / Martino, Audrey E A / Garcia, Marta Rodriguez / Chow, Jennifer K / Snydman, David R

Transplant immunology

2023 Volume 78, Page(s) 101826

Abstract: Background: Over a quarter of organ transplant recipients have low immunoglobulin levels in their early post-transplant course, which is associated with increased risk of infection and mortality. Although immunoglobulin level varies by sex among healthy ...

Abstract	Background: Over a quarter of organ transplant recipients have low immunoglobulin levels in their early post-transplant course, which is associated with increased risk of infection and mortality. Although immunoglobulin level varies by sex among healthy individuals, it is unknown how such differences are affected by transplant-related immunosuppression. This study compared post-liver transplant immunoglobulin G (IgG) between sexes at varying ages. Methods: Serum specimens from a prospective cohort of 130 liver transplant recipients were analyzed. IgG was measured at time of transplant and from one-month post-transplant samples. Post-transplant IgG was compared between sexes using multivariable linear regression. Four age and sex categories were created (women<50, women≥50, men<50, men≥50) and the model repeated with this as the explanatory variable. The relationship between sex hormone concentrations and post-transplant IgG was also explored. Infection type and incidence were examined within groups. Results: The cohort included 99 men, 31 women (mean age 53). In adjusted linear regression, post-transplant IgG was not significantly different by sex (p = 0.92). However, when broken into four categories by age and sex, the contrast in IgG levels between younger versus older patients was strikingly greater among women than among men. An interaction term including age and sex was statistically significant (p = 0.03). The combined age-sex categorical variable was also significantly associated with post-transplant IgG (p = 0.01). Finally, an association was identified between baseline estradiol level and post-transplant change in IgG (p = 0.04). Conclusions: Sex and age have an important relationship with post-transplant IgG with older women demonstrating lowest concentrations. Immunoglobulin levels have previously demonstrated association with post-transplant outcomes.
MeSH term(s)	Male ; Humans ; Female ; Aged ; Middle Aged ; Liver Transplantation ; Prospective Studies ; Immunoglobulin G ; Immunosuppression Therapy
Chemical Substances	Immunoglobulin G
Language	English
Publishing date	2023-03-17
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1160846-8
ISSN	1878-5492 ; 0966-3274
ISSN (online)	1878-5492
ISSN	0966-3274
DOI	10.1016/j.trim.2023.101826
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Article ; Online: Role of cytosolic carbonic anhydrase Ca17a in cardiorespiratory responses to CO<sub>2</sub> in developing zebrafish (<i>Danio rerio)</i>.

Kunert, E / Joyce, W / Pan, Y K / Chen, A / Perry, S F / Gilmour, K M

American journal of physiology. Regulatory, integrative and comparative physiology

2022 Volume 323, Issue 4, Page(s) R532–R546

Abstract: The sensing of environmental fluctuations and initiation of appropriate physiological responses is crucial to homeostasis. Neuroepithelial cells (NECs) in fishes are putative chemoreceptors, resembling mammalian Type I (glomus) cells, that respond in ... ...

Abstract	The sensing of environmental fluctuations and initiation of appropriate physiological responses is crucial to homeostasis. Neuroepithelial cells (NECs) in fishes are putative chemoreceptors, resembling mammalian Type I (glomus) cells, that respond in vitro to changes in O<sub>2</sub>, CO<sub>2</sub>, NH<sub>3</sub>, and pH. Cytosolic carbonic anhydrase (Ca17a) is thought to be involved in CO<sub>2</sub> sensing owing to its presence in NECs. Zebrafish (Danio rerio) lacking functional Ca17a were generated via CRISPR/Cas9 technology and used to assess the role of Ca17a in initiating the cardiorespiratory responses to elevated CO<sub>2</sub> (hypercapnia). Unfortunately, the homozygous knockout mutants (ca17a<sup>-/-</sup>) did not survive more than ∼12-14 days postfertilization (dpf), restricting experiments to early developmental stages (4-8 dpf). Changes in ventilation (f<sub>V</sub>) and cardiac (f<sub>H</sub>) frequency in response to hypercapnia (1% CO<sub>2</sub>) in wild-type (ca17a<sup>+/+</sup>), heterozygous (ca17a<sup>+/-</sup>) and ca17a<sup>-/-</sup> fish were used to investigate Ca17a-dependent CO<sub>2</sub> sensing and downstream signaling. Wild-type fish exhibited hyperventilation during hypercapnia as indicated by an increase in f<sub>V</sub>. In the ca17a<sup>-/-</sup> fish, the hyperventilatory response was attenuated markedly but only at 8 dpf. Hypercapnic tachycardia was observed for all genotypes and did not appear to be influenced by the absence of Ca17a. Interestingly, ca17a<sup>-/-</sup> fish exhibited a significantly lower resting f<sub>H</sub> that became more pronounced as the fish aged. The decrease in resting f<sub>H</sub> was prevented ("rescued") when ca17a<sup>-/-</sup> embryos were injected with ca17a mRNA. Collectively, the results of this study support a role for Ca17a in promoting hyperventilation during hypercapnia in larval zebrafish and suggest a previously unrecognized role for Ca17a in determining resting heart rate.
MeSH term(s)	Animals ; Carbon Dioxide ; Carbonic Anhydrases/genetics ; Gills/physiology ; Hypercapnia ; Hyperventilation ; Mammals ; RNA, Messenger ; Zebrafish/physiology
Chemical Substances	RNA, Messenger ; Carbon Dioxide (142M471B3J) ; Carbonic Anhydrases (EC 4.2.1.1)
Language	English
Publishing date	2022-08-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603839-6
ISSN	1522-1490 ; 0363-6119
ISSN (online)	1522-1490
ISSN	0363-6119
DOI	10.1152/ajpregu.00050.2022
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Article ; Online: Dilated cardiomyopathy of possible dietary origin in a cat.

DuPerry, B / Lopez, K E / Rush, J E / Berridge, B R / Mitchell, R N / Breitschwerdt, E B / Freeman, L M

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology

2023 Volume 51, Page(s) 172–178

Abstract: ... dilated cardiomyopathy (DCM) and congestive heart failure. The cat had been eating cat foods that were high in pulses (e ...

Abstract	An 11-year-old spayed female domestic shorthaired cat was diagnosed with severe dilated cardiomyopathy (DCM) and congestive heart failure. The cat had been eating cat foods that were high in pulses (e.g. peas, lentils, chickpeas). Neither plasma nor whole blood taurine concentrations were deficient. Primary treatment included furosemide, pimobendan, and clopidogrel, and changing to diets that did not contain pulses (a taurine supplements was not administered). The cat's clinical signs improved, high-sensitivity cardiac troponin I concentrations decreased, and echocardiographic measurements stayed relatively stable for over one year after initiating cardiac medications and changing the diet. Ultimately, the cat was euthanized for worsening congestive heart failure 374 days after the diagnosis of DCM. Infectious disease testing during the time of clinical surveillance was negative. Routine histopathology of the heart was unremarkable, but electron microscopy of the left ventricle showed large numbers of mitochondria of variable size and structure. A moderate number of lamellar bodies and autophagic vacuoles also were noted. This case report illustrates an unusual case of a cat with DCM unrelated to taurine deficiency. The relative roles of diet change, cardiac medications, and a dedicated owner are unclear, but this cat's relatively long survival time is similar to that seen after diet change in dogs and cats with DCM eating high-pulse diets.
MeSH term(s)	Cats ; Female ; Animals ; Dogs ; Cardiomyopathy, Dilated/veterinary ; Cardiomyopathy, Dilated/diagnosis ; Cat Diseases/diagnosis ; Cat Diseases/drug therapy ; Dog Diseases/diagnosis ; Diet/veterinary ; Taurine/therapeutic use ; Heart Failure/complications ; Heart Failure/veterinary
Chemical Substances	Taurine (1EQV5MLY3D)
Language	English
Publishing date	2023-11-10
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2198278-8
ISSN	1875-0834 ; 1760-2734
ISSN (online)	1875-0834
ISSN	1760-2734
DOI	10.1016/j.jvc.2023.11.003
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Article ; Online: Ophthalmic findings associated with Australian tick paralysis (holocyclotoxicity) in hospitalized domestic dogs and cats.

Reynolds, B D / Nagel, H G / Perry, E / Whittaker, C J / Caruso, K A / Annear, M J / Irving, W M / McCarthy, P M / Dion, A / Yi, J M S / Hall, E / Smith, J S

Veterinary ophthalmology

2024

Abstract: Objective: To describe ophthalmic findings in hospitalized canine and feline patients with tick paralysis (TP) and investigate possible predisposing factors.: Animals studied: Forty-seven dogs and 28 cats hospitalized with TP assessed with an ... ...

Abstract	Objective: To describe ophthalmic findings in hospitalized canine and feline patients with tick paralysis (TP) and investigate possible predisposing factors. Animals studied: Forty-seven dogs and 28 cats hospitalized with TP assessed with an ophthalmic examination performed by an ABVO resident. Methods: Dogs and cats were hospitalized with TP from October 2021 to January 2022 and had an ophthalmic examination performed by an ABVO resident. Patient signalment data, information regarding tick number and location, hospitalization duration, medications used, and patient paralysis grades were recorded. Statistical analysis was performed to correlate findings. Results: Corneal ulcers developed in up to 34.8% of dogs and up to 42.9% of cats hospitalized with TP. An absent palpebral reflex ipsilaterally increased the odds of a concurrent corneal ulcer being present by 14.7× in dogs and 20.1× in cats (p < .0001). Palpebral reflexes were absent in 38.3% of dogs and 35.7% of cats hospitalized with TP and were correlated with more severe gait paralysis (p = .01) and respiratory paralysis (p = .005) in dogs, and respiratory paralysis in cats (p = .041). STT-1 findings <10 mm/min were present in 27.7% of dogs and 57.1% of cats examined and were associated with increasing gait paralysis (p = .017) and respiratory paralysis (p = .007) in dogs, and increasing gait paralysis in cats (p = .017). Conclusions: Simple corneal ulcers, loss of a complete palpebral reflex, and reduced STT-1 scores frequently occurred in dogs and cats hospitalized for TP. The frequency of these findings increased as the degree of patient paralysis increased.
Language	English
Publishing date	2024-03-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2011043-1
ISSN	1463-5224 ; 1463-5216
ISSN (online)	1463-5224
ISSN	1463-5216
DOI	10.1111/vop.13205
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