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  1. Article ; Online: Inactivated enterovirus A71 vaccines and moving forward.

    Shimizu, Hiroyuki

    The Lancet regional health. Western Pacific

    2021  Volume 16, Page(s) 100292

    Language English
    Publishing date 2021-10-20
    Publishing country England
    Document type Journal Article
    ISSN 2666-6065
    ISSN (online) 2666-6065
    DOI 10.1016/j.lanwpc.2021.100292
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  2. Article ; Online: Inactivated enterovirus A71 vaccines and moving forward

    Hiroyuki Shimizu

    The Lancet Regional Health. Western Pacific, Vol 16, Iss , Pp 100292- (2021)

    2021  

    Keywords Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Pathway crosstalk between the central metabolic and heme biosynthetic pathways in Phanerochaete chrysosporium.

    Miura, Daisuke / Tsurigami, Ryoga / Kato, Hiroyuki / Wariishi, Hiroyuki / Shimizu, Motoyuki

    Applied microbiology and biotechnology

    2024  Volume 108, Issue 1, Page(s) 37

    Abstract: A comprehensive analysis to survey heme-binding proteins produced by the white-rot fungus Phanerochaete chrysosporium was achieved using a biotinylated heme-streptavidin beads system. Mitochondrial citrate synthase (PcCS), glyceraldehyde 3-phosphate ... ...

    Abstract A comprehensive analysis to survey heme-binding proteins produced by the white-rot fungus Phanerochaete chrysosporium was achieved using a biotinylated heme-streptavidin beads system. Mitochondrial citrate synthase (PcCS), glyceraldehyde 3-phosphate dehydrogenase (PcGAPDH), and 2-Cys thioredoxin peroxidase (mammalian HBP23 homolog) were identified as putative heme-binding proteins. Among these, PcCS and PcGAPDH were further characterized using heterologously expressed recombinant proteins. Difference spectra of PcCS titrated with hemin exhibited an increase in the Soret absorbance at 414 nm, suggesting that the axial ligand of the heme is a His residue. The activity of PcCS was strongly inhibited by hemin with Ki oxaloacetate of 8.7 μM and Ki acetyl-CoA of 5.8 μM. Since the final step of heme biosynthesis occurred at the mitochondrial inner membrane, the inhibition of PcCS by heme is thought to be a physiological event. The inhibitory mode of the heme was similar to that of CoA analogues, suggesting that heme binds to PcCS at His
    MeSH term(s) Animals ; Biosynthetic Pathways ; Heme ; Phanerochaete/genetics ; Hemin ; Heme-Binding Proteins ; Mammals
    Chemical Substances Heme (42VZT0U6YR) ; Hemin (743LRP9S7N) ; Heme-Binding Proteins
    Language English
    Publishing date 2024-01-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 392453-1
    ISSN 1432-0614 ; 0171-1741 ; 0175-7598
    ISSN (online) 1432-0614
    ISSN 0171-1741 ; 0175-7598
    DOI 10.1007/s00253-023-12846-0
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  4. Article ; Online: Effects of graphical presentation of benefits on cognitive judgments induced by affect heuristic: Focusing on the acceptance of genetically modified foods.

    Nagaya, Kazuhisa / Shimizu, Hiroyuki

    Appetite

    2023  Volume 182, Page(s) 106450

    Abstract: Genetically modified (GM) foods have been assumed to be seen through intuitive and affective routes (i.e., affect heuristics) rather than analytical and deliberative routes. We examined the impact of the graphical presentation of benefits derived from GM ...

    Abstract Genetically modified (GM) foods have been assumed to be seen through intuitive and affective routes (i.e., affect heuristics) rather than analytical and deliberative routes. We examined the impact of the graphical presentation of benefits derived from GM or conventionally bred foods on the acceptance of these varieties. In the two experiments (n = 266 for study 1 and n = 402 for study 2), no differences emerged in the estimation of farmers' benefits resulting from the introduction of improved varieties by the type of improvement. However, there were statistically significant differences in the magnitude of risk and the degree of acceptance of the improved varieties. Therefore, despite presenting identical benefits as a graphical figure, GM foods were consistently evaluated as providing higher risk and were less frequently accepted than conventionally bred foods. These results suggest that while the graphical presentation of benefits may promote comprehension of some advantages of the introduction of GM varieties, this may not lead to acceptance from the consumer's point of view. Based on the current findings, as well as previous studies on trust in risk managers, we discuss the specific factors that might promote acceptance of GM products.
    MeSH term(s) Humans ; Plants, Genetically Modified ; Food, Genetically Modified ; Heuristics ; Judgment ; Cognition
    Language English
    Publishing date 2023-01-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1461347-5
    ISSN 1095-8304 ; 0195-6663
    ISSN (online) 1095-8304
    ISSN 0195-6663
    DOI 10.1016/j.appet.2023.106450
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  5. Article: From cradle to grave: seamless management of chronic pancreatitis but consider the special requests for children.

    Isayama, Hiroyuki / Ishii, Shigeto / Suzuki, Mitsuyoshi / Shimizu, Toshiaki

    Hepatobiliary surgery and nutrition

    2023  Volume 12, Issue 4, Page(s) 585–589

    Language English
    Publishing date 2023-07-06
    Publishing country China (Republic : 1949- )
    Document type Editorial ; Comment
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn-23-236
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  6. Article ; Online: Biomarkers as predicting factors for relapse in polymyalgia rheumatica: the importance of alkaline phosphatase.

    Ishiguro, Kenji / Yamashita, Hiroyuki / Shimizu, Yosuke / Kaneko, Hiroshi

    Rheumatology (Oxford, England)

    2023  Volume 62, Issue 10, Page(s) e288–e290

    MeSH term(s) Humans ; Polymyalgia Rheumatica/diagnosis ; Polymyalgia Rheumatica/drug therapy ; Alkaline Phosphatase ; Giant Cell Arteritis ; Biomarkers ; Recurrence ; Chronic Disease
    Chemical Substances Alkaline Phosphatase (EC 3.1.3.1) ; Biomarkers
    Language English
    Publishing date 2023-04-04
    Publishing country England
    Document type Letter
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kead137
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  7. Article: Critical Roles of the Sphingolipid Metabolic Pathway in Liver Regeneration, Hepatocellular Carcinoma Progression and Therapy.

    Nojima, Hiroyuki / Shimizu, Hiroaki / Murakami, Takashi / Shuto, Kiyohiko / Koda, Keiji

    Cancers

    2024  Volume 16, Issue 5

    Abstract: The sphingolipid metabolic pathway, an important signaling pathway, plays a crucial role in various physiological processes including cell proliferation, survival, apoptosis, and immune regulation. The liver has the unique ability to regenerate using ... ...

    Abstract The sphingolipid metabolic pathway, an important signaling pathway, plays a crucial role in various physiological processes including cell proliferation, survival, apoptosis, and immune regulation. The liver has the unique ability to regenerate using bioactive lipid mediators involving multiple sphingolipids, including ceramide and sphingosine 1-phosphate (S1P). Dysregulation of the balance between sphingomyelin, ceramide, and S1P has been implicated in the regulation of liver regeneration and diseases, including liver fibrosis and hepatocellular carcinoma (HCC). Understanding and modulating this balance may have therapeutic implications for tumor proliferation, progression, and metastasis in HCC. For cancer therapy, several inhibitors and activators of sphingolipid signaling, including ABC294640, SKI-II, and FTY720, have been discussed. Here, we elucidate the critical roles of the sphingolipid pathway in the regulation of liver regeneration, fibrosis, and HCC. Regulation of sphingolipids and their corresponding enzymes may considerably influence new insights into therapies for various liver disorders and diseases.
    Language English
    Publishing date 2024-02-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16050850
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  8. Article ; Online: Diagnostic Value of sLR11 and sIL-2R in the Cerebrospinal Fluid for Malignant Central Nervous System Lymphoma.

    Shimizu, Naomi / Nakao, Sanshiro / Hasunuma, Hidekazu / Nakaseko, Chiaki / Shimizu, Tomo / Ebinuma, Hiroyuki / Bujo, Hideaki

    Internal medicine (Tokyo, Japan)

    2024  

    Abstract: Objective We previously reported that patients with acute leukemia and malignant lymphoma (ML) demonstrated significantly increased serum soluble LR11 (sLR11) levels compared to normal controls. Accurately diagnosing ML of the central nervous system (CNS ...

    Abstract Objective We previously reported that patients with acute leukemia and malignant lymphoma (ML) demonstrated significantly increased serum soluble LR11 (sLR11) levels compared to normal controls. Accurately diagnosing ML of the central nervous system (CNS ML) using cytology is frequently difficult. Therefore, we evaluated the use of cerebrospinal fluid (CSF) sLR11 and soluble interleukin-2 receptor (sIL-2R) as diagnostic and treatment response markers for CNS ML. Methods We retrospectively evaluated the CSF results for CNS ML using clinical data at our institution, and then analyzed the usefulness of sLR11 and sIL-2R in CSF for both the diagnosis and as surrogate markers that reflect the therapeutic effect. Patients We enrolled patients with CNS ML who received intrathecal anticancer drugs between 2017 and 2023. We analyzed the sLR11 and sIL-2R levels in CSF and cytological malignant grades. We studied 22 patients, including 17 with central nervous system (CNS) clinical conditions and five who received prevention treatment. Results The CSF sLR11 levels were significantly and positively correlated with CSF sIL-2R levels. The CSF sLR11 and sIL-2R levels in patients with CNS ML were significantly higher than those in the prevention group. A receiver operating characteristic (ROC) curve analysis showed the cut-off value of sLR11 for CNS invasion to be 21.7 ng/mL. Moreover, the chemotherapy-responder group demonstrated significantly decreased CSF sLR11 and sIL-2R levels after treatment. Conclusion CSF sLR11 and sIL-2R of CSF were found to be useful biomarkers for the diagnostic and treatment response evaluation in patients with CNS ML.
    Language English
    Publishing date 2024-03-04
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.3325-23
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    Zs.A 240: Show issues Location:
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  9. Article ; Online: Outbreaks of Circulating Vaccine-Derived Poliovirus in the World Health Organization Western Pacific Region, 2000-2021.

    Kitamura, Kouichi / Shimizu, Hiroyuki

    Japanese journal of infectious diseases

    2022  Volume 75, Issue 5, Page(s) 431–444

    Abstract: The World Health Organization Western Pacific Region (WPR) has maintained a polio-free status for more than two decades. At the global level, there were only six confirmed polio cases due to wild type 1 poliovirus in Pakistan, Afghanistan, and Malawi in ... ...

    Abstract The World Health Organization Western Pacific Region (WPR) has maintained a polio-free status for more than two decades. At the global level, there were only six confirmed polio cases due to wild type 1 poliovirus in Pakistan, Afghanistan, and Malawi in 2021; therefore, the risk of wild poliovirus importation from endemic countries to the WPR is considerably lower than that in the past. However, the risk of polio outbreaks associated with circulating vaccine-derived polioviruses (cVDPVs) cannot be ignored even in the WPR. Since the late 2010s, cVDPV outbreaks in the WPR have increased in frequency and magnitude. Moreover, the emergence of concomitant polio outbreaks of type 1 and type 2 cVDPVs in the Philippines and Malaysia during 2019-2020 highlighted the potential risk of cVDPV outbreaks in high-risk areas and/or communities in the WPR. Previous cVDPV outbreaks in the WPR have been rapidly and effectively controlled. However, future polio outbreak risks associated with cVDPVs must be reconsidered, and polio immunization and surveillance strategies should be updated accordingly.
    MeSH term(s) Disease Outbreaks ; Global Health ; Humans ; Poliomyelitis/epidemiology ; Poliomyelitis/prevention & control ; Poliovirus ; Poliovirus Vaccine, Oral/adverse effects ; World Health Organization
    Chemical Substances Poliovirus Vaccine, Oral
    Language English
    Publishing date 2022-08-31
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1478383-6
    ISSN 1884-2836 ; 1344-6304
    ISSN (online) 1884-2836
    ISSN 1344-6304
    DOI 10.7883/yoken.JJID.2022.312
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  10. Article ; Online: Electrical pulse stimulation-induced tetanic exercise simulation increases the secretion of extracellular vesicles from C2C12 myotubes.

    Murata, Akari / Akiyama, Hirokazu / Honda, Hiroyuki / Shimizu, Kazunori

    Biochemical and biophysical research communications

    2023  Volume 672, Page(s) 177–184

    Abstract: Extracellular vesicles (EVs) released into the blood during exercise mediate its whole-body health effects. The differentiation of EVs released by skeletal muscle cells in vivo from those released by other cells is challenging, therefore, it is unclear ... ...

    Abstract Extracellular vesicles (EVs) released into the blood during exercise mediate its whole-body health effects. The differentiation of EVs released by skeletal muscle cells in vivo from those released by other cells is challenging, therefore, it is unclear whether exercise increases the number of EVs secreted by skeletal muscle cells. In this study, we investigated whether exercise affects the quantity of EVs released from skeletal muscle cells using in vitro exercise models. C2C12 myotubes were cultured on a gel layer with 1 or 30 Hz electrical pulse stimulation (EPS) to induce contractions as an artificial simulating exercise. We found that tetanic contraction induced by 30 Hz EPS increased the number of secreted EVs. MicroRNA (miRNA)-seq analysis revealed that 30 Hz EPS altered the miRNA in the secreted EVs. Furthermore, expression analysis of genes related to the biogenesis and transport of EVs revealed that the expression of ALG-2 interacting protein X (Alix) was increased in response to 30 Hz EPS, and the peak value of intracellular Ca
    MeSH term(s) Muscle Fibers, Skeletal/metabolism ; Cell Line ; Cells, Cultured ; Extracellular Vesicles ; Electric Stimulation ; MicroRNAs/metabolism ; Muscle, Skeletal/metabolism ; Muscle Contraction/physiology
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2023-06-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2023.06.054
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