Article: The mitochondrial thiolase ACAT1 regulates monocyte/macrophage type I interferon
bioRxiv : the preprint server for biology
2024
Abstract: Lipid-derived acetyl-CoA is shown to be the major carbon source for histone acetylation. However, there is no direct evidence demonstrating lipid metabolic pathway contribututions to this process. Mitochondrial acetyl-CoA acetyltransferase 1 (ACAT1) ... ...
Abstract | Lipid-derived acetyl-CoA is shown to be the major carbon source for histone acetylation. However, there is no direct evidence demonstrating lipid metabolic pathway contribututions to this process. Mitochondrial acetyl-CoA acetyltransferase 1 (ACAT1) catalyzes the final step of ß-oxidation, the aerobic process catabolizing fatty acids (FA) into acetyl-CoA. To investigate this in the context of immunometabolism, we generated macrophage cell line lacking ACAT1. |
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Language | English |
Publishing date | 2024-01-31 |
Publishing country | United States |
Document type | Preprint |
DOI | 10.1101/2024.01.29.577773 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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