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  1. Article: Editorial: Traditional medicine and phytochemicals for neurodegenerative diseases treatment: application of interdisciplinary technologies in novel therapeutic target and drug discovery.

    Cai, Chuipu / Fang, Jiansong / Ke, Hanzhong

    Frontiers in neuroscience

    2023  Volume 17, Page(s) 1268710

    Language English
    Publishing date 2023-08-08
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2023.1268710
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  2. Article ; Online: Developing a taxonomy for colorectal cancer.

    Fang, Jiansong / Wang, Dawei / Fan, Xiude

    eLife

    2022  Volume 11

    Abstract: Analyzing how gene interaction networks are perturbed in individuals can help identify different types of colorectal cancers, paving the way towards personalized care. ...

    Abstract Analyzing how gene interaction networks are perturbed in individuals can help identify different types of colorectal cancers, paving the way towards personalized care.
    MeSH term(s) Humans ; Colorectal Neoplasms/genetics ; Gene Regulatory Networks
    Language English
    Publishing date 2022-11-11
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.84025
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  3. Article ; Online: Developing a taxonomy for colorectal cancer

    Jiansong Fang / Dawei Wang / Xiude Fan

    eLife, Vol

    2022  Volume 11

    Abstract: Analyzing how gene interaction networks are perturbed in individuals can help identify different types of colorectal cancers, paving the way towards personalized care. ...

    Abstract Analyzing how gene interaction networks are perturbed in individuals can help identify different types of colorectal cancers, paving the way towards personalized care.
    Keywords biological network ; gene interaction ; colorectal cancer ; molecular subtype ; precision medicine ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Alkali-Driven Photoinduced N-Dealkylation of Aryl Tertiary Amines and Amides.

    Lian, Qi / Chen, Jinke / Huang, Kaipeng / Hou, Keqiang / Fang, Jiansong / Wei, Wentao / Zhou, Jingwei

    Organic letters

    2023  Volume 25, Issue 46, Page(s) 8387–8392

    Abstract: By extending the photoinduced oxidative mechanism of aryl tertiary amines proposed earlier to an alkaline environment based on the prediction of quantum mechanics computations and the validation of meticulous experiments, we discovered a photoinduced ... ...

    Abstract By extending the photoinduced oxidative mechanism of aryl tertiary amines proposed earlier to an alkaline environment based on the prediction of quantum mechanics computations and the validation of meticulous experiments, we discovered a photoinduced oxidative N-dealkylation method for both aryl tertiary amines and amides. The dealkylation was achieved in an alkaline environment under mild conditions accompanied by excellent functional group tolerance.
    Language English
    Publishing date 2023-11-15
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c03519
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  5. Article ; Online: Inflammatory microenvironment in gastric premalignant lesions: implication and application.

    Zhang, Shengxiong / Shen, Yang / Liu, Hao / Zhu, Di / Fang, Jiansong / Pan, Huafeng / Liu, Wei

    Frontiers in immunology

    2023  Volume 14, Page(s) 1297101

    Abstract: Gastric precancerous lesions (GPL) are a major health concern worldwide due to their potential to progress to gastric cancer (GC). Understanding the mechanism underlying the transformation from GPL to GC can provide a fresh insight for the early ... ...

    Abstract Gastric precancerous lesions (GPL) are a major health concern worldwide due to their potential to progress to gastric cancer (GC). Understanding the mechanism underlying the transformation from GPL to GC can provide a fresh insight for the early detection of GC. Although chronic inflammation is prevalent in the GPL, how the inflammatory microenvironment monitored the progression of GPL-to-GC are still elusive. Inflammation has been recognized as a key player in the progression of GPL. This review aims to provide an overview of the inflammatory microenvironment in GPL and its implications for disease progression and potential therapeutic applications. We discuss the involvement of inflammation in the progression of GPL, highlighting
    MeSH term(s) Humans ; Stomach Neoplasms ; Precancerous Conditions/pathology ; Inflammation ; Helicobacter pylori ; Antioxidants ; Tumor Microenvironment
    Chemical Substances Antioxidants
    Language English
    Publishing date 2023-11-15
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1297101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Inhalable Bottlebrush Polymer Bioconjugates as Vectors for Efficient Pulmonary Delivery of Oligonucleotides.

    Fang, Yang / Cai, Jiansong / Ren, Mengqi / Zhong, Tongtong / Wang, Dali / Zhang, Ke

    ACS nano

    2023  Volume 18, Issue 1, Page(s) 592–599

    Abstract: Antisense oligonucleotides hold therapeutic promise for various lung disorders, but their efficacy is limited by suboptimal delivery. To address this challenge, we explored the use of inhaled bottlebrush polymer-DNA conjugates, named pacDNA, as a ... ...

    Abstract Antisense oligonucleotides hold therapeutic promise for various lung disorders, but their efficacy is limited by suboptimal delivery. To address this challenge, we explored the use of inhaled bottlebrush polymer-DNA conjugates, named pacDNA, as a delivery strategy. Inhaled pacDNA exhibits superior mucus penetration, achieving a uniform and sustained lung distribution in mice. Targeting the 5' splice site of an aberrant enhanced green fluorescence protein (
    MeSH term(s) Mice ; Animals ; Oligonucleotides ; Polymers ; Carcinoma, Non-Small-Cell Lung ; Proto-Oncogene Proteins p21(ras) ; Lung Neoplasms ; Lung ; DNA
    Chemical Substances Oligonucleotides ; Polymers ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; DNA (9007-49-2)
    Language English
    Publishing date 2023-12-26
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c08660
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    Inter-library loan at ZB MED

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  7. Article ; Online: Coronaviruses RNA interacts with host miR-500a-5p and miR-501-5p to regulate multiple pathways.

    Guo, Qi / Tan, Linghui / Pan, Jiajia / Wu, Songfang / Huang, Jiansong / Yu, Fang / Wang, Jinghan

    Genes & diseases

    2022  Volume 10, Issue 2, Page(s) 385–388

    Language English
    Publishing date 2022-08-06
    Publishing country China
    Document type Journal Article
    ZDB-ID 2821806-1
    ISSN 2352-3042 ; 2352-3042
    ISSN (online) 2352-3042
    ISSN 2352-3042
    DOI 10.1016/j.gendis.2022.07.008
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  8. Article ; Online: Acidic/hypoxia dual-alleviated nanoregulators for enhanced treatment of tumor chemo-immunotherapy.

    Guo, Xiaoju / Chen, Xiaoxiao / Ding, Jiayi / Zhang, Feng / Chen, Shunyang / Hu, Xin / Fang, Shiji / Shen, Lin / Lu, Chenying / Zhao, Zhongwei / Tu, Jianfei / Shu, Gaofeng / Chen, Minjiang / Ji, Jiansong

    Asian journal of pharmaceutical sciences

    2024  Volume 19, Issue 2, Page(s) 100905

    Abstract: Chemotherapy plays a crucial role in triple-negative breast cancer (TNBC) treatment as it not only directly kills cancer cells but also induces immunogenic cell death. However, the chemotherapeutic efficacy was strongly restricted by the acidic and ... ...

    Abstract Chemotherapy plays a crucial role in triple-negative breast cancer (TNBC) treatment as it not only directly kills cancer cells but also induces immunogenic cell death. However, the chemotherapeutic efficacy was strongly restricted by the acidic and hypoxic tumor environment. Herein, we have successfully formulated PLGA-based nanoparticles concurrently loaded with doxorubicin (DOX), hemoglobin (Hb) and CaCO
    Language English
    Publishing date 2024-03-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2650931-3
    ISSN 2221-285X ; 1818-0876 ; 2221-285X
    ISSN (online) 2221-285X
    ISSN 1818-0876 ; 2221-285X
    DOI 10.1016/j.ajps.2024.100905
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  9. Article: DenovoProfiling: A webserver for

    Liu, Zhihong / Du, Jiewen / Lin, Ziying / Li, Ze / Liu, Bingdong / Cui, Zongbin / Fang, Jiansong / Xie, Liwei

    Computational and structural biotechnology journal

    2022  Volume 20, Page(s) 4082–4097

    Abstract: Various deep learning-based architectures for molecular generation have been proposed ... ...

    Abstract Various deep learning-based architectures for molecular generation have been proposed for
    Language English
    Publishing date 2022-08-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2694435-2
    ISSN 2001-0370
    ISSN 2001-0370
    DOI 10.1016/j.csbj.2022.07.045
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  10. Article ; Online: Biomaterials evolution: from inert to instructive.

    Iqbal, Sajid / Sohail, Muhammad / Fang, Shiji / Ding, Jiayi / Shen, Lin / Chen, Minjiang / Shu, Gaofeng / Du, Yong-Zhong / Ji, Jiansong

    Biomaterials science

    2023  Volume 11, Issue 18, Page(s) 6109–6115

    Abstract: The field of biomaterials has experienced substantial evolution in recent years, driven by advancements in materials science and engineering. This has led to an expansion of the biomaterials definition to include biocompatibility, bioactivity, bioderived ...

    Abstract The field of biomaterials has experienced substantial evolution in recent years, driven by advancements in materials science and engineering. This has led to an expansion of the biomaterials definition to include biocompatibility, bioactivity, bioderived materials, and biological tissues. Consequently, the intended performance of biomaterials has shifted from a passive role wherein a biomaterial is merely accepted by the body to an active role wherein a biomaterial instructs its biological environment. In the future, the integration of bioinspired designs and dynamic behavior into fabrication technologies will revolutionize the field of biomaterials. This perspective presents the recent advances in the evolution of biomaterials in fabrication technologies and provides a brief insight into smart biomaterials.
    MeSH term(s) Biocompatible Materials ; Engineering
    Chemical Substances Biocompatible Materials
    Language English
    Publishing date 2023-09-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d3bm00322a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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