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  1. Article: Understanding evolution of the products and emissions during chemical activation of furfural residue with varied potassium salts

    Fu, Zhaobing / Sun, Kai / Fan, Huailin / Li, Chao / Liu, Hong / Zhang, Shu / Ding, Kuan / Gao, Guanggang / Hu, Xun

    Journal of cleaner production. 2022 July 10, v. 357

    2022  

    Abstract: Furfural residue is a solid waste produced in manufacturing furfural from biomass like corncob, which can be converted into liquid/gaseous fuel and activated carbon via chemical activation. In this study, in addition the pore structure of activated ... ...

    Abstract Furfural residue is a solid waste produced in manufacturing furfural from biomass like corncob, which can be converted into liquid/gaseous fuel and activated carbon via chemical activation. In this study, in addition the pore structure of activated carbon, the impacts of varied potassium salts (KCl, KOH, K₂CO₃ and K₂C₂O₄) on the properties of gases and bio-oil formed during activation of Furfural residue was studied. The results showed that the potassium salts suppressed cracking of condensable volatiles into gases, producing more bio-oil at expense of gases. KOH showed the highest activity for cracking, producing the lowest yield of activated carbon (4.8%) without activator with lower degree of crystallization than that K₂CO₃ and K₂C₂O₄ as activators (20.1% and 26.9%). The activated carbon activated with K₂CO₃ or K₂C₂O₄ showed the flaky membrane structure packed with varied layers, but not with KOH as the activator. K₂C₂O₄, KOH and K₂CO₃ as the activators could promote cracking, deoxygenation, dehydrogenation and aromatization reactions, generating abundant micropores, while KCl could not. In addition, K₂C₂O₄ as the activator of furfural residue showed the least energy consumption and environmental impacts, while with KCl was highest. The results herein demonstrated the potential of furfural residue as feedstock for the production of activated carbon and liquid fuels.
    Keywords activated carbon ; aromatization ; biofuels ; biomass ; corn cobs ; crystallization ; dehydrogenation ; energy ; feedstocks ; furfural ; liquids ; micropores ; potassium ; solid wastes
    Language English
    Dates of publication 2022-0710
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 0959-6526
    DOI 10.1016/j.jclepro.2022.131936
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Dielectrics for Two-Dimensional Transition-Metal Dichalcogenide Applications.

    Lau, Chit Siong / Das, Sarthak / Verzhbitskiy, Ivan A / Huang, Ding / Zhang, Yiyu / Talha-Dean, Teymour / Fu, Wei / Venkatakrishnarao, Dasari / Johnson Goh, Kuan Eng

    ACS nano

    2023  Volume 17, Issue 11, Page(s) 9870–9905

    Abstract: Despite over a decade of intense research efforts, the full potential of two-dimensional transition-metal dichalcogenides continues to be limited by major challenges. The lack of compatible and scalable dielectric materials and integration techniques ... ...

    Abstract Despite over a decade of intense research efforts, the full potential of two-dimensional transition-metal dichalcogenides continues to be limited by major challenges. The lack of compatible and scalable dielectric materials and integration techniques restrict device performances and their commercial applications. Conventional dielectric integration techniques for bulk semiconductors are difficult to adapt for atomically thin two-dimensional materials. This review provides a brief introduction into various common and emerging dielectric synthesis and integration techniques and discusses their applicability for 2D transition metal dichalcogenides. Dielectric integration for various applications is reviewed in subsequent sections including nanoelectronics, optoelectronics, flexible electronics, valleytronics, biosensing, quantum information processing, and quantum sensing. For each application, we introduce basic device working principles, discuss the specific dielectric requirements, review current progress, present key challenges, and offer insights into future prospects and opportunities.
    Language English
    Publishing date 2023-05-31
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c03455
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Network Rewiring in Cancer: Applications to Melanoma Cell Lines and the Cancer Genome Atlas Patients.

    Ding, Kuan-Fu / Finlay, Darren / Yin, Hongwei / Hendricks, William P D / Sereduk, Chris / Kiefer, Jeffrey / Sekulic, Aleksandar / LoRusso, Patricia M / Vuori, Kristiina / Trent, Jeffrey M / Schork, Nicholas J

    Frontiers in genetics

    2018  Volume 9, Page(s) 228

    Abstract: Genes do not work in isolation, but rather as part of networks that have many feedback and redundancy mechanisms. Studying the properties of genetic networks and how individual genes contribute to overall network functions can provide insight into ... ...

    Abstract Genes do not work in isolation, but rather as part of networks that have many feedback and redundancy mechanisms. Studying the properties of genetic networks and how individual genes contribute to overall network functions can provide insight into genetically-mediated disease processes. Most analytical techniques assume a network topology based on normal state networks. However, gene perturbations often lead to the rewiring of relevant networks and impact relationships among other genes. We apply a suite of analysis methodologies to assess the degree of transcriptional network rewiring observed in different sets of melanoma cell lines using whole genome gene expression microarray profiles. We assess evidence for network rewiring in melanoma patient tumor samples using RNA-sequence data available from The Cancer Genome Atlas. We make a distinction between "unsupervised" and "supervised" network-based methods and contrast their use in identifying consistent differences in networks between subsets of cell lines and tumor samples. We find that different genes play more central roles within subsets of genes within a broader network and hence are likely to be better drug targets in a disease state. Ultimately, we argue that our results have important implications for understanding the molecular pathology of melanoma as well as the choice of treatments to combat that pathology.
    Language English
    Publishing date 2018-07-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2018.00228
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Nonlinear mixed effects dose response modeling in high throughput drug screens: application to melanoma cell line analysis.

    Ding, Kuan-Fu / Petricoin, Emanuel F / Finlay, Darren / Yin, Hongwei / Hendricks, William P D / Sereduk, Chris / Kiefer, Jeffrey / Sekulic, Aleksandar / LoRusso, Patricia M / Vuori, Kristiina / Trent, Jeffrey M / Schork, Nicholas J

    Oncotarget

    2017  Volume 9, Issue 4, Page(s) 5044–5057

    Abstract: Cancer cell lines are often used in high throughput drug screens (HTS) to explore the relationship between cell line characteristics and responsiveness to different therapies. Many current analysis methods infer relationships by focusing on one aspect of ...

    Abstract Cancer cell lines are often used in high throughput drug screens (HTS) to explore the relationship between cell line characteristics and responsiveness to different therapies. Many current analysis methods infer relationships by focusing on one aspect of cell line drug-specific dose-response curves (DRCs), the concentration causing 50% inhibition of a phenotypic endpoint (IC
    Language English
    Publishing date 2017-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.23495
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Liquid-Metal-Printed Ultrathin Oxides for Atomically Smooth 2D Material Heterostructures.

    Zhang, Yiyu / Venkatakrishnarao, Dasari / Bosman, Michel / Fu, Wei / Das, Sarthak / Bussolotti, Fabio / Lee, Rainer / Teo, Siew Lang / Huang, Ding / Verzhbitskiy, Ivan / Jiang, Zhuojun / Jiang, Zhuoling / Chai, Jianwei / Tong, Shi Wun / Ooi, Zi-En / Wong, Calvin Pei Yu / Ang, Yee Sin / Goh, Kuan Eng Johnson / Lau, Chit Siong

    ACS nano

    2023  Volume 17, Issue 8, Page(s) 7929–7939

    Abstract: Two-dimensional (2D) semiconductors are promising channel materials for continued downscaling of complementary metal-oxide-semiconductor (CMOS) logic circuits. However, their full potential continues to be limited by a lack of scalable high- ...

    Abstract Two-dimensional (2D) semiconductors are promising channel materials for continued downscaling of complementary metal-oxide-semiconductor (CMOS) logic circuits. However, their full potential continues to be limited by a lack of scalable high-
    Language English
    Publishing date 2023-04-06
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c02128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Astrocytes exhibit diverse Ca

    Ding, Fusheng / Liang, Shanshan / Li, Ruijie / Yang, Zhiqi / He, Yong / Yang, Shaofan / Duan, Qingtian / Zhang, Jianxiong / Lyu, Jing / Zhou, Zhenqiao / Huang, Mingzhu / Wang, Haoyu / Li, Jin / Yang, Chuanyan / Wang, Yuxia / Gong, Mingyue / Chen, Shangbin / Jia, Hongbo / Chen, Xiaowei /
    Liao, Xiang / Fu, Ling / Zhang, Kuan

    Frontiers in aging neuroscience

    2022  Volume 14, Page(s) 1029533

    Abstract: Astrocytic ... ...

    Abstract Astrocytic Ca
    Language English
    Publishing date 2022-10-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2022.1029533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Chemical synthesis of a synthetically useful L-galactosaminuronic acid building block.

    Qin, Chun-Jun / Hou, Hong-Li / Ding, Mei-Ru / Qi, Yi-Kuan / Tian, Guang-Zong / Zou, Xiao-Peng / Fu, Jun-Jie / Hu, Jing / Yin, Jian

    Chinese journal of natural medicines

    2022  Volume 20, Issue 5, Page(s) 387–392

    Abstract: Most bacterial cell surface glycans are structurally unique, and have been considered as ideal target molecules for the developments of detection and diagnosis techniques, as well as vaccines. Chemical synthesis has been a promising approach to prepare ... ...

    Abstract Most bacterial cell surface glycans are structurally unique, and have been considered as ideal target molecules for the developments of detection and diagnosis techniques, as well as vaccines. Chemical synthesis has been a promising approach to prepare well-defined oligosaccharides, facilitating the structure-activity relationship exploration and biomedical applications of bacterial glycans. L-Galactosaminuronic acid is a rare sugar that has been only found in cell surface glycans of gram-negative bacteria. Here, an orthogonally protected L-galactosaminuronic acid building block was designed and chemically synthesized. A synthetic strategy based on glycal addition and TEMPO/BAIB-mediated C6 oxidation served well for the transformation of commercial L-galactose to the corresponding L-galactosaminuronic acid. Notably, the C6 oxidation of the allyl glycoside was more efficient than that of the selenoglycoside. In addition, a balance between the formation of allyl glycoside and the recovery of selenoglycoside was essential to improve efficiency of the NIS/TfOH-catalyzed allylation. This synthetically useful L-galactosaminuronic acid building block will provide a basis for the syntheses of complex bacterial glycans.
    MeSH term(s) Carbohydrates ; Glycosides ; Oligosaccharides ; Oxidation-Reduction ; Polysaccharides/chemistry
    Chemical Substances Carbohydrates ; Glycosides ; Oligosaccharides ; Polysaccharides
    Language English
    Publishing date 2022-05-12
    Publishing country China
    Document type Journal Article
    ZDB-ID 2192577-X
    ISSN 1875-5364 ; 2095-6975 ; 1672-3651
    ISSN (online) 1875-5364
    ISSN 2095-6975 ; 1672-3651
    DOI 10.1016/S1875-5364(22)60149-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6113: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Chemical synthesis of a synthetically useful L-galactosaminuronic acid building block

    QIN, Chun-Jun / HOU, Hong-Li / DING, Mei-Ru / QI, Yi-Kuan / TIAN, Guang-Zong / ZOU, Xiao-Peng / FU, Jun-Jie / HU, Jing / YIN, Jian

    Chinese journal of natural medicines. 2022 May, v. 20, no. 5

    2022  

    Abstract: Most bacterial cell surface glycans are structurally unique, and have been considered as ideal target molecules for the developments of detection and diagnosis techniques, as well as vaccines. Chemical synthesis has been a promising approach to prepare ... ...

    Abstract Most bacterial cell surface glycans are structurally unique, and have been considered as ideal target molecules for the developments of detection and diagnosis techniques, as well as vaccines. Chemical synthesis has been a promising approach to prepare well-defined oligosaccharides, facilitating the structure-activity relationship exploration and biomedical applications of bacterial glycans. L-Galactosaminuronic acid is a rare sugar that has been only found in cell surface glycans of gram-negative bacteria. Here, an orthogonally protected L-galactosaminuronic acid building block was designed and chemically synthesized. A synthetic strategy based on glycal addition and TEMPO/BAIB-mediated C6 oxidation served well for the transformation of commercial L-galactose to the corresponding L-galactosaminuronic acid. Notably, the C6 oxidation of the allyl glycoside was more efficient than that of the selenoglycoside. In addition, a balance between the formation of allyl glycoside and the recovery of selenoglycoside was essential to improve efficiency of the NIS/TfOH-catalyzed allylation. This synthetically useful L-galactosaminuronic acid building block will provide a basis for the syntheses of complex bacterial glycans.
    Keywords allylation ; galactose ; glycosides ; oligosaccharides ; oxidation ; polysaccharides ; structure-activity relationships ; synthesis
    Language English
    Dates of publication 2022-05
    Size p. 387-392.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2192577-X
    ISSN 1875-5364 ; 2095-6975 ; 1672-3651
    ISSN (online) 1875-5364
    ISSN 2095-6975 ; 1672-3651
    DOI 10.1016/S1875-5364(22)60149-3
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6113: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: [Comparison Test Between On-line Monitoring of Water-soluble Ions and Filter-based Manual Methods for PM

    Yang, Dong-Yan / Liu, Bao-Xian / Shi, Ai-Jun / Zhang, Da-Wei / Ding, Meng-Meng / Zhou, Jian-Nan / Fu, Jia-Ming / Jing, Kuan

    Huan jing ke xue= Huanjing kexue

    2018  Volume 37, Issue 10, Page(s) 3730–3736

    Abstract: Concentrations of water-soluble ions were measured in Beijing during 2014 for comparison of URG online monitoring systems and filter-based manual methods. The differences of four main ions components in spring, summer, autumn and winter were compared. ... ...

    Abstract Concentrations of water-soluble ions were measured in Beijing during 2014 for comparison of URG online monitoring systems and filter-based manual methods. The differences of four main ions components in spring, summer, autumn and winter were compared. The total concentrations of eight ions measured by URG online were higher than those of filter-based manual method. There was no significant differences among the annual concentrations of Cl
    Language Chinese
    Publishing date 2018-06-30
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 0250-3301
    ISSN 0250-3301
    DOI 10.13227/j.hjkx.2016.10.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Analysis of variability in high throughput screening data: applications to melanoma cell lines and drug responses.

    Ding, Kuan-Fu / Finlay, Darren / Yin, Hongwei / Hendricks, William P D / Sereduk, Chris / Kiefer, Jeffrey / Sekulic, Aleksandar / LoRusso, Patricia M / Vuori, Kristiina / Trent, Jeffrey M / Schork, Nicholas J

    Oncotarget

    2014  Volume 8, Issue 17, Page(s) 27786–27799

    Abstract: High-throughput screening (HTS) strategies and protocols have undergone significant development in the last decade. It is now possible to screen hundreds of thousands of compounds, each exploring multiple biological phenotypes and parameters, against ... ...

    Abstract High-throughput screening (HTS) strategies and protocols have undergone significant development in the last decade. It is now possible to screen hundreds of thousands of compounds, each exploring multiple biological phenotypes and parameters, against various cell lines or model systems in a single setting. However, given the vast amount of data such studies generate, the fact that they use multiple reagents, and are often technician-intensive, questions have been raised about the variability, reliability and reproducibility of HTS results. Assessments of the impact of the multiple factors in HTS studies could arguably lead to more compelling insights into the robustness of the results of a particular screen, as well as the overall quality of the study. We leveraged classical, yet highly flexible, analysis of variance (ANOVA)-based linear models to explore how different factors contribute to the variation observed in a screening study of four different melanoma cell lines and 120 drugs over nine dosages studied in two independent academic laboratories. We find that factors such as plate effects, appropriate dosing ranges, and to a lesser extent, the laboratory performing the screen, are significant predictors of variation in drug responses across the cell lines. Further, we show that when sources of variation are quantified and controlled for, they contextualize claims of inconsistencies and reveal the overall quality of the HTS studies performed at each participating laboratory. In the context of the broader screening study, we show that our analysis can also elucidate the robust effects of drugs, even those within specific cell lines.
    MeSH term(s) Analysis of Variance ; Antinematodal Agents/pharmacology ; Antinematodal Agents/therapeutic use ; Cell Line, Tumor ; Drug Discovery/methods ; High-Throughput Screening Assays/methods ; Humans ; Melanoma/drug therapy ; Reproducibility of Results
    Chemical Substances Antinematodal Agents
    Language English
    Publishing date 2014-06-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.15347
    Database MEDical Literature Analysis and Retrieval System OnLINE

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