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Article ; Online: Urinary cadmium levels in China (1982-2021): Regional trends and influential factors.

Yang, Yadi / Zhang, Yanni / Zhou, Qing / Gu, Yi / Yao, Yijun

2024 Volume 251, Issue Pt 1, Page(s) 118618

Abstract: Despite the significant threat of cadmium exposure in China, a national-level assessment has been conspicuously absent. This study bridges this critical gap by collecting, geospatial analyzing and multivariable regression analyzing published studies on ... ...

Abstract	Despite the significant threat of cadmium exposure in China, a national-level assessment has been conspicuously absent. This study bridges this critical gap by collecting, geospatial analyzing and multivariable regression analyzing published studies on urinary cadmium levels in Chinese from 1982 to 2021. Our research reveals a notable decline trend in cadmium exposure among Chinese populations. However, this trend varies by region, age and gender group, higher levels are seen in the South (1.04 μg/g cr) compared to the North (0.48 μg/g cr), and in adults (1.08 μg/g cr) relative to children (0.33 μg/g cr), with higher levels being more pronounced in females (6.17 μg/g cr). Urinary cadmium is significantly correlated with rice consumption (P < 0.001), while mining activities have been identified as the dominant factor for cadmium exposure in most regions of China, a trend that is evident both in past decades and is expected to continue into the next decade. These findings underscore the need for region-specific environmental and public health strategies, designed to effectively address the distinct cadmium exposure risks in various regions and among different population groups, thus enhancing protection against the adverse effects of cadmium.
Language	English
Publishing date	2024-03-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2024.118618
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Article ; Online: Ultrasonic features of superficial angiomyxoma in the scrotum: A case image.

Xu, Yadi / Duan, Yun / Zhou, Heng / Chen, Haoyi / Yan, Wei

Journal of clinical ultrasound : JCU

2023 Volume 51, Issue 7, Page(s) 1273–1275

Abstract: Superficial angiomyxoma in the scrotum is a well-circumscribed, ovoid-shaped, heterogeneously echogenic mass in the ultrasonography. On Doppler ultrasonography, vascular flow signals are visible in and around the mass(M). ...

Abstract	Superficial angiomyxoma in the scrotum is a well-circumscribed, ovoid-shaped, heterogeneously echogenic mass in the ultrasonography. On Doppler ultrasonography, vascular flow signals are visible in and around the mass(M).
MeSH term(s)	Male ; Humans ; Scrotum/diagnostic imaging ; Ultrasonics ; Ultrasonography ; Myxoma/diagnostic imaging ; Myxoma/surgery ; Angiography
Language	English
Publishing date	2023-05-23
Publishing country	United States
Document type	Case Reports
ZDB-ID	189393-2
ISSN	1097-0096 ; 0091-2751
ISSN (online)	1097-0096
ISSN	0091-2751
DOI	10.1002/jcu.23487
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Article ; Online: Sediment transport trend and its influencing factors in coastal bedrock island sea areas-a case study of Chudao island, China

Yadi Zhou / Hu Wang / Yuru Yan

Frontiers in Marine Science, Vol

2023 Volume 10

Abstract: Coastal bedrock islands sea areas have a unique natural environment, frequent human activities, and complex sedimentary dynamic processes. In this paper, we select the Chudao Island sea area off the coast of Shandong Peninsula, China, as a typical ... ...

Abstract	Coastal bedrock islands sea areas have a unique natural environment, frequent human activities, and complex sedimentary dynamic processes. In this paper, we select the Chudao Island sea area off the coast of Shandong Peninsula, China, as a typical research area to investigate the sediment transport trends and influencing factors by means of high-precision bathymetric survey, high-density sediment sampling, grain-size trend analysis and hydrodynamic numerical modeling. Results and analysis indicate that the grain size parameters including mean grain-size, sorting coefficient and skewness are zonal distributed, roughly parallel to the isobaths. While the overall sediment transport trend is from island shore to sea, with several convergence centers near the loop centers of bottom flow and at the edge of the agriculture area. The near-bottom flow velocity is primary factor that controlling the significance of sediment transport trend, while the flow decides the general patterns of sediment transport trend and sediment distribution. Submarine topography can either directly transport sediments down its slope, or indirectly affect the direction of sediment transport by constraining the near-bottom flow from shallow to deep waters. Besides the natural factors of bottom flow and submarine topography, human activities represented by aquaculture also affect the sediment transport trend in coastal bedrock island sea areas. First, the increased sedimentation rate caused by organic matters and the diffusion of scallop fragments may cause sediment coarsening. Second, the artificial aquaculture facilities can reduce flow velocity and therefore hinder the initiation, suspension and transport of sediment near the aquaculture areas. Our methods and findings provide high-resolution details to insight into the sediment transport trends to improve the understanding of the modern sediment dynamics in small-scale coastal bedrock island sea areas and provide reference for corresponding engineering and agriculture activities.
Keywords	sediment transport ; grain size trend analysis ; hydrodynamic numerical modeling ; coastal bedrock island sea areas ; bathymetric survey and sediment sampling ; Science ; Q ; General. Including nature conservation ; geographical distribution ; QH1-199.5
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Preparation and Improvement of Physicochemical and Functional Properties of Dietary Fiber from Corn Cob Fermented by

Zhou, Yadi / Sun, Qijie / Teng, Chao / Zhou, Mingchun / Fan, Guangsen / Qu, Penghui

Journal of microbiology and biotechnology

2023 Volume 34, Issue 2, Page(s) 330–339

Abstract: Corn cobs were fermented ... ...

Abstract	Corn cobs were fermented with
MeSH term(s)	Aspergillus niger ; Zea mays/metabolism ; Spectroscopy, Fourier Transform Infrared ; Dietary Fiber/metabolism ; Water
Chemical Substances	Dietary Fiber ; Water (059QF0KO0R)
Language	English
Publishing date	2023-10-16
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2412195-2
ISSN	1738-8872 ; 1738-8872
ISSN (online)	1738-8872
ISSN	1738-8872
DOI	10.4014/jmb.2308.08010
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: How do the older adults in nursing homes live with dignity? A protocol for a meta-synthesis of qualitative research.

Sunzi, Kejimu / Li, Yadi / Lei, Cheng / Zhou, Xin

BMJ open

2023 Volume 13, Issue 4, Page(s) e067223

Abstract: Introduction: As the population continuous to age and family sizes decrease, residing in nursing homes has emerged as a crucial option for older adults' care. Ensuring a dignified life for older adults in nursing homes is critical for enhancing their ... ...

Abstract	Introduction: As the population continuous to age and family sizes decrease, residing in nursing homes has emerged as a crucial option for older adults' care. Ensuring a dignified life for older adults in nursing homes is critical for enhancing their overall quality of life. The primary objective of this study is to synthesise the evidence of qualitative research on the feelings and experiences of dignity among older adults living in nursing homes. This will enable a better understanding of the factors influencing the perception of dignity and its preservation, ultimately assisting older adults in achieving a more comfortable and fulfilling experience in nursing homes. Methods and analysis: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses will guide this meta-synthesis. We conducted an initial search on 1 June 2022, for studies published between the inception of each database and 2022, using the population exposure-outcome nomenclature. We searched the Embase, Web of Science, CINAHL, Cochrane Library and PubMed databases for relevant studies. For data synthesis, we will employ the Ritchie and Spencer framework, and the Supporting the Use of Research Evidence Framework will be used for data analysis. To minimise the risk of bias, we will critically appraise the selected studies using the Qualitative Assessment and Review Instrument. Ethics and dissemination: This review does not involve human participants and, therefore, does not necessitate ethical approval. We plan to disseminate the protocol and findings through relevant channels, including publication in pertinent journals, presentations at conferences and symposia, and engagement with local and international health stakeholders. Prospero registration number: CRD42022343983. Conclusion: This study aims to offer comprehensive evidence to guide nursing staff in providing dignity-focused interventions for older adult residents in nursing homes.
MeSH term(s)	Humans ; Aged ; Quality of Life ; Respect ; Nursing Homes ; Palliative Care ; Qualitative Research ; Review Literature as Topic
Language	English
Publishing date	2023-04-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2022-067223
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Article: Association between the triglyceride glucose index and diabetic retinopathy in type 2 diabetes: a meta-analysis.

Zhou, Jianlong / Zhu, Lv / Li, Yadi

Frontiers in endocrinology

2023 Volume 14, Page(s) 1302127

Abstract: The triglyceride-glucose (TyG) index is an accessible and reliable surrogate indicator of insulin resistance and is strongly associated with diabetes. However, its relationship with diabetic retinopathy (DR) remains controversial. This meta-analysis ... ...

Abstract	The triglyceride-glucose (TyG) index is an accessible and reliable surrogate indicator of insulin resistance and is strongly associated with diabetes. However, its relationship with diabetic retinopathy (DR) remains controversial. This meta-analysis aimed to assess the relationship between the TyG index and the prevalence of DR. Initial studies were searched from PubMed, Embase, Web of Science, and China National Knowledge Infrastructure (CNKI) electronic databases. The retrieval time range was from the establishment of the database to June 2023. Pooled estimates were derived using a random-effects model and reported as odds ratio (OR) with 95% confidence intervals (CIs). Two researchers independently assessed the methodological quality of the included studies. The Newcastle-Ottawa Quality Scale (NOS) was utilized to assess cohort studies or case-control studies. The Agency for Healthcare Research and Quality (AHRQ) methodology checklist was applied to assess cross-sectional studies. Ten observational studies encompassing 13716 patients with type 2 diabetes were included in the meta-analysis. The results showed that a higher TyG index increased the risk of DR compared with a low TyG index (OR: 2.34, 95% CI: 1.31-4.19, P < 0.05). When the index was analyzed as a continuous variable, consistent results were observed (OR: 1.48, 95% CI: 1.12-1.97, P < 0.005). There was no significant effect on the results of the sensitivity analyses excluding one study at a time (P all < 0.05). A higher TyG index may be associated with an increased prevalence of DR in patients with type 2 diabetes. However, high-quality cohort or case-control studies are needed to further substantiate this evidence. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023432747.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/complications ; Diabetic Retinopathy/diagnosis ; Diabetic Retinopathy/epidemiology ; Diabetic Retinopathy/etiology ; Glucose ; Triglycerides ; United States ; Observational Studies as Topic
Chemical Substances	Glucose (IY9XDZ35W2) ; Triglycerides
Language	English
Publishing date	2023-12-07
Publishing country	Switzerland
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1302127
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Article ; Online: [No title information]

Cummings, Jeffrey / Zhou, Yadi / Lee, Garam / Zhong, Kate / Fonseca, Jorge / Cheng, Feixiong

Alzheimer's & dementia (New York, N. Y.)

2024 Volume 10, Issue 2, Page(s) e12465

Abstract: Introduction: New therapies to prevent or delay the onset of symptoms, slow progression, or improve cognitive and behavioral symptoms of Alzheimer's disease (AD) are needed.: Methods: We interrogated clinicaltrials.gov including all clinical trials ... ...

Title translation	Alzheimer's disease drug development pipeline: 2024.
Abstract	Introduction: New therapies to prevent or delay the onset of symptoms, slow progression, or improve cognitive and behavioral symptoms of Alzheimer's disease (AD) are needed. Methods: We interrogated clinicaltrials.gov including all clinical trials assessing pharmaceutical therapies for AD active in on January 1, 2024. We used the Common Alzheimer's Disease Research Ontology (CADRO) to classify the targets of therapies in the pipeline. Results: There are 164 trials assessing 127 drugs across the 2024 AD pipeline. There were 48 trials in Phase 3 testing 32 drugs, 90 trials in Phase 2 assessing 81 drugs, and 26 trials in Phase 1 testing 25 agents. Of the 164 trials, 34% ( Discussion: Compared to the 2023 pipeline, there are fewer trials (164 vs. 187), fewer drugs (127 vs. 141), fewer new chemical entities (88 vs. 101), and a similar number of repurposed agents (39 vs. 40). Highlights: In the 2024 Alzheimer's disease drug development pipeline, there are 164 clinical trials assessing 127 drugs.The 2024 Alzheimer's disease drug development pipeline has contracted compared to the 2023 Alzheimer pipeline with fewer trials, fewer drugs, and fewer new chemical entities.Drugs in the Alzheimer's disease drug development pipeline target a wide array of targets; the most common processes targeted include neurotransmitter receptors, inflammation, amyloid, and synaptic plasticity.The total development time for a potential Alzheimer's disease therapy to progress from nonclinical studies to FDA review is approximately 13 years.
Language	Dutch
Publishing date	2024-04-24
Publishing country	United States
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	2832891-7
ISSN	2352-8737 ; 2352-8737
ISSN (online)	2352-8737
ISSN	2352-8737
DOI	10.1002/trc2.12465
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Article ; Online: Relationship between systemic immune inflammation index and mortality among US adults with different diabetic status

Yujie Tang / Xiaojin Feng / Na Liu / Yuan Zhou / Yadi Wang / Zhenna Chen / Yongping Liu

Experimental Gerontology, Vol 185, Iss , Pp 112350- (2024)

Evidence from NHANES 1999-2018

2024

Abstract: Objective: To investigate the association between systemic immune inflammation index (SII) and all-cause or cardiovascular diseases (CVDs) mortality in US adults with different diabetic status based on the National Health and Nutrition Examination Survey ...

Abstract	Objective: To investigate the association between systemic immune inflammation index (SII) and all-cause or cardiovascular diseases (CVDs) mortality in US adults with different diabetic status based on the National Health and Nutrition Examination Survey (NHANES) database. Study design and setting: Adults with follow-up data in the NHANES 1999–2018 cycles were included in this study. The SII was calculated based on blood cells counts (including neutrophils, lymphocytes, and platelets) measured in the laboratory data. According to the quartiles of SII, population were divided into four groups (Q1-Q4). Mortality data was determined by linking NHANES survey participants to the National Death Index records, which collect mortality data and determine their vital status. Cox regression models were also performed to explore the hazard ratio (HR) and the corresponding 95 % confidence interval (95 % CI) of SII related with all-cause and CVDs mortality. In addition, restricted cubic spline was used to explore the nonlinear relationship between SII and mortality. Subgroup analysis and sensitivity analysis were performed to confirm the robustness of our results. Results: In this study, there were 45,454 participants were enrolled (50.43 % females), with a mean age of 47.35 ± 0.19 years. Among of which, 7971 were diabetes patients and 3281 were pre-diabetes. With the mean 9.89 ± 0.08 follow-up years, there were 6935 (15.26 %) deaths occurred. Of which, 1795 deaths were caused by CVDs. The age-adjusted death rates were higher in participants with high SII levels compared to those with low SII levels. Cox regression analysis, after adjusting for covariates, revealed that SII levels were associated with an increased risk of all-cause mortality (HR, 1.02; 95 % CI, 1.02–1.03, P < 0.0001) and CVDs mortality (HR, 1.05; 95 % CI, 1.02–1.08, P = 0.002) in the fully adjusted Model. Moreover, there was a slight increase in HR values with the progression of diabetes status. Restricted cubic spline analysis demonstrated a “U-shaped” ...
Keywords	Systemic immune-inflammation index ; Diabetes ; Mortality ; NHANES ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	310
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: What do older people who have attempted suicide experience? Study protocol for a qualitative meta-synthesis among older adults, family caregivers and healthcare professionals

Hui Luo / Xin Zhou / Cheng Lei / Kejimu Sunzi / Yadi Li

BMJ Open, Vol 13, Iss

2023 Volume 12

Abstract: Introduction Attempted suicide among older adults represents a significant mental health concern that has witnessed a rising incidence within this demographic in recent years. Research indicates that attempted suicide among the older population serves as ...

Abstract	Introduction Attempted suicide among older adults represents a significant mental health concern that has witnessed a rising incidence within this demographic in recent years. Research indicates that attempted suicide among the older population serves as a primary risk factor for completed suicide. Consequently, the objective of this study is to provide a comprehensive overview of the prevailing factors that influence suicide attempts among older adults, thereby offering evidence to guide healthcare professionals in designing targeted interventions.Methods and analysis This study will adhere to the Joanna Briggs Institute framework and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols. We will synthesise qualitative studies using a comprehensive and inclusive bibliographic search strategy. The following databases will be searched: PubMed, Embase, Web of Science, CINAHL and the Cochrane Library. The quality of the articles will be assessed using the 10-item Joanna Briggs Institute Critical Appraisal Checklist for Qualitative Research. At the same time, data extraction will be performed using the Qualitative Assessment and Review Instrument data extraction form proposed by the Joanna Briggs Institute for Evidence-Based Practice. The synthesis of findings will adhere to the principles and procedures of Thomas and Hardens' three-stage thematic synthesis approach.Ethics and dissemination Ethical approval will not be required for this study, as it solely encompasses data derived from previously published research. The findings will be disseminated through publication in a peer-reviewed journal. Moreover, the results will be presented at relevant academic conferences to guarantee that the study’s outcomes reach pertinent stakeholders. This protocol is registered with the PROSPERO prospective database for systematic review.PROSPERO registration number CRD42023408385.
Keywords	Medicine ; R
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The efficacy and safety of acupoint catgut embedding therapy for depression: a protocol for systematic review and meta-analysis.

Li, Yadi / Zhou, Jianlong / Wei, Zheng / He, Xia / Liang, Lizhu / Sunzi, Kejimu

Frontiers in psychiatry

2024 Volume 14, Page(s) 1331780

Abstract: Background: Depression is a common public health problem, characterized by persistent low mood, lack of pleasure and exhaustion. Conventional treatments such as antidepressants and psychotherapy have some limitations, including variable efficacy, ... ...

Abstract	Background: Depression is a common public health problem, characterized by persistent low mood, lack of pleasure and exhaustion. Conventional treatments such as antidepressants and psychotherapy have some limitations, including variable efficacy, adverse side effects and high costs. Acupoint catgut embedding (ACE) therapy, as a subtype of acupuncture, has gained increasing clinical application due to its long-term effects, higher patient compliance, and cost-effectiveness. This study aims to conduct a meta-analysis to evaluate the efficacy and safety of ACE for depression. Methods: Electronic searches will be conducted in 12 databases (both in English and Chinese databases), encompassing from inception to April 2022, without language restrictions. Randomized controlled trials (RCTs) that involve ACE for treating depression will be included. The primary outcome measures will include the response rate, Hamilton Depression Rating Scale (HAMD), Beck Depression Inventory (BDI), and Traditional Chinese Medicine Symptom Scale (TCMSSS). The secondary outcome measure will include Quality of Life scale score (QoL) and the incidence of adverse events. Results will be presented as risk ratios for dichotomous data and mean differences for continuous data. Two reviewers will independently conduct study selection, data extraction, and quality assessment. The methodological quality of eligible studies will be evaluated according to the criteria specified by the Cochrane Handbook for Systematic Reviews of Interventions (Version 5.1.0). Meta-analysis will be performed by RevMan 5.3 software. Discussion: Due to the limitations, a safer, high-efficacy and non-pharmacological intervention with minimal side effects is required for treating depression. ACE has the advantages of longer-lasting effects, improved patient compliance, and reduced treatment costs. This protocol represents a meta-analysis and systematic review, aiming to present the current evidence regarding the efficacy and safety of ACE for depression. It seeks to provide clinicians with a theoretical basis and valuable references for complementary and alternative medicine therapies in their treatment approaches. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/#recordDetails, Identifier CRD42022325966.
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2023.1331780
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